DePinho, Ronald A.

Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression

Chang, S., Khoo, C. M., Naylor, M. L., Maser, R. S., & DePinho, R. A. (2003) · Genes & Development

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 183

Dual Inactivation of RB and p53 Pathways in RAS-Induced Melanomas

Bardeesy, N., Bastian, B. C., Hezel, A., Pinkel, D., DePinho, R. A., & Chin, L. (2001) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysMelanoma and MAPK Pathways

Cited by 166

Telomere Dysfunction Triggers Developmentally Regulated Germ Cell Apoptosis

Hemann, M. T., Rudolph, K. L., Strong, M. A., DePinho, R. A., Chin, L., & Greider, C. W. (2001) · Molecular Biology of the Cell

Telomeres, Telomerase, and SenescenceMicrotubule and mitosis dynamics

Cited by 162

Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells

Allsopp, R. C., Morin, G. B., Horner, J. W., DePinho, R., Harley, C. B., & Weissman, I. L. (2003) · Nature Medicine

Telomeres, Telomerase, and SenescenceHematopoietic Stem Cell Transplantation

Cited by 155

Tumor Microenvironment Remodeling Enables Bypass of Oncogenic KRAS Dependency in Pancreatic Cancer

Hou, P., Kapoor, A., Zhang, Q., Li, J., Wu, C.-J., Li, J., Lan, Z., Tang, M., Ma, X., Ackroyd, J. J., et al. (2020) · Cancer Discovery

Pancreatic and Hepatic Oncology ResearchImmune cells in cancer

Cited by 154

FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis

Schäffner, I., Minakaki, G., Khan, M. A., Balta, E.-A., Schlötzer-Schrehardt, U., Schwarz, T. J., Beckervordersandforth, R., Winner, B., Webb, A. E., DePinho, R. A., et al. (2018) · Neuron

FOXO transcription factor regulationNeurogenesis and neuroplasticity mechanisms

Cited by 145

Collateral lethality: a new therapeutic strategy in oncology

Muller, F. L., Aquilanti, E. A., & DePinho, R. A. (2015) · Trends in Cancer

Cancer-related Molecular PathwaysCancer Genomics and Diagnostics

Cited by 132

Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer

Genovese, G., Carugo, A., Tepper, J., Robinson, F. S., Li, L., Svelto, M., Nezi, L., Corti, D., Minelli, R., Pettazzoni, P., et al. (2017) · Nature

Pancreatic and Hepatic Oncology ResearchCancer Cells and Metastasis

Cited by 131

Mice without telomerase: what can they teach us about human cancer?

Artandi, S. E., & DePinho, R. A. (2000) · Nature Medicine

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 126

Oncogenic KRAS Drives Lipofibrogenesis to Promote Angiogenesis and Colon Cancer Progression

Hsu, W.-H., LaBella, K. A., Lin, Y., Xu, P., Lee, R., Hsieh, C.-E., Yang, L., Zhou, A., Blecher, J. M., Wu, C.-J., et al. (2023) · Cancer Discovery

Cancer Cells and MetastasisAngiogenesis and VEGF in Cancer

Cited by 125

Telomere Dysfunction Drives Aberrant Hematopoietic Differentiation and Myelodysplastic Syndrome

Colla, S., Ong, D. S. T., Ogoti, Y., Marchesini, M., Mistry, N. A., Clise-Dwyer, K., Ang, S. A., Storti, P., Viale, A., Giuliani, N., et al. (2015) · Cancer Cell

Telomeres, Telomerase, and SenescenceAcute Myeloid Leukemia Research

Cited by 105

TERT activation targets DNA methylation and multiple aging hallmarks

Shim, H. S., Iaconelli, J., Shang, X., Li, J., Lan, Z. D., Jiang, S., Nutsch, K., Beyer, B. A., Lairson, L. L., Boutin, A. T., et al. (2024) · Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 104

SF2312 is a natural phosphonate inhibitor of enolase

Leonard, P. G., Satani, N., Maxwell, D., Lin, Y.-H., Hammoudi, N., Peng, Z., Pisaneschi, F., Link, T. M., Lee, G. R., Sun, D., et al. (2016) · Nature Chemical Biology

Cancer, Hypoxia, and MetabolismOrganophosphorus compounds synthesis

Cited by 96

USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation

Hou, P., Ma, X., Zhang, Q., Wu, C.-J., Liao, W., Li, J., Wang, H., Zhao, J., Zhou, X., Guan, C., et al. (2019) · Genes & Development

Ubiquitin and proteasome pathwaysPancreatic and Hepatic Oncology Research

Cited by 96

PRKCI promotes immune suppression in ovarian cancer

Sarkar, S., Bristow, C. A., Dey, P., Rai, K., Perets, R., Ramirez-Cardenas, A., Malasi, S., Huang-Hobbs, E., Haemmerle, M., Wu, S. Y., et al. (2017) · Genes & Development

Ovarian cancer diagnosis and treatmentHippo pathway signaling and YAP/TAZ

Cited by 93

Cancer chromosomes in crisis

DePinho, R. A., & Polyak, K. (2004) · Nature Genetics

Telomeres, Telomerase, and SenescenceMicrotubule and mitosis dynamics

Cited by 91

STAT3 Inhibition Combined with CpG Immunostimulation Activates Antitumor Immunity to Eradicate Genetically Distinct Castration-Resistant Prostate Cancers

Moreira, D., Adamus, T., Zhao, X., Su, Y.-L., Zhang, Z., White, S. V., Swiderski, P., Lu, X., DePinho, R. A., Pal, S. K., et al. (2018) · Clinical Cancer Research

Immunotherapy and Immune ResponsesProstate Cancer Treatment and Research

Cited by 80

Neutralization of terminal differentiation in gliomagenesis

Hu, J., Ho, A. L., Yuan, L., Hu, B., Hua, S., Hwang, S. S., Zhang, J., Hu, T., Zheng, H., Gan, B., et al. (2013) · Proceedings of the National Academy of Sciences

Glioma Diagnosis and TreatmentCancer Cells and Metastasis

Cited by 76

Telomerase reverse transcriptase preserves neuron survival and cognition in Alzheimer’s disease models

Shim, H. S., Horner, J. W., Wu, C.-J., Li, J., Lan, Z. D., Jiang, S., Xu, X., Hsu, W.-H., Zal, T., Flores, I. I., et al. (2021) · Nature Aging

Alzheimer's disease research and treatmentsTelomeres, Telomerase, and Senescence

Cited by 73

Ink4a / Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse

Khoo, C. M., Carrasco, D. R., Bosenberg, M. W., Paik, J.-H., & DePinho, R. A. (2007) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 52

Impaired Processing of DNA Photoproducts and Ultraviolet Hypermutability With Loss of p16INK4a or p19ARF

Sarkar-Agrawal, P., Vergilis, I., Sharpless, N. E., DePinho, R. A., & Runger, T. M. (2004) · JNCI Journal of the National Cancer Institute

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 48

USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer

Hou, P., Ma, X., Yang, Z., Zhang, Q., Wu, C.-J., Li, J., Tan, L., Yao, W., Yan, L., Zhou, X., et al. (2021) · Genes & Development

Pancreatic and Hepatic Oncology ResearchUbiquitin and proteasome pathways

Cited by 35

Erratum: Corrigendum: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Son, J., Lyssiotis, C. A., Ying, H., Wang, X., Hua, S., Ligorio, M., Perera, R. M., Ferrone, C. R., Mullarky, E., Shyh-Chang, N., et al. (2013) · Nature

Cancer, Hypoxia, and MetabolismPancreatic and Hepatic Oncology Research

Cited by 10

Therapeutic targeting of syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers

Theardy, M. S., Takeda, M., Sorokin, A., Chen, S., Yang, Z., Wang, X., Kanikarla, P., Coker, O., Nguyen, P., Wei, Y., et al. (2025) · Cell Reports Medicine

Protein Kinase Regulation and GTPase SignalingHippo pathway signaling and YAP/TAZ

Cited by 6