Kirkland, James L.

COVID-19 and cellular senescence

Schmitt, C. A., Tchkonia, T., Niedernhofer, L. J., Robbins, P. D., Kirkland, J. L., & Lee, S. (2023) · Nature Reviews Immunology

Telomeres, Telomerase, and SenescenceCOVID-19 Clinical Research Studies

Cited by 153

Cellular Senescence and the Biology of Aging, Disease, and Frailty

LeBrasseur, N. K., Tchkonia, T., & Kirkland, J. L. (2015) · Nestlé Nutrition Institute Workshop Series

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 147

An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo

Wang, B., Wang, L., Gasek, N. S., Zhou, Y., Kim, T., Guo, C., Jellison, E. R., Haynes, L., Yadav, S., Tchkonia, T., et al. (2021) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 145

Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin

Kim, S. R., Jiang, K., Ogrodnik, M., Chen, X., Zhu, X.-Y., Lohmeier, H., Ahmed, L., Tang, H., Tchkonia, T., Hickson, L. J., et al. (2019) · Translational Research

Telomeres, Telomerase, and SenescenceSirtuins and Resveratrol in Medicine

Cited by 139

The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline

Chini, C., Hogan, K. A., Warner, G. M., Tarragó, M. G., Peclat, T. R., Tchkonia, T., Kirkland, J. L., & Chini, E. (2019) · Biochemical and Biophysical Research Communications

Sirtuins and Resveratrol in MedicineTelomeres, Telomerase, and Senescence

Cited by 138

Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy-Related Bone Loss

Chandra, A., Lagnado, A. B., Farr, J. N., Monroe, D. G., Park, S., Hachfeld, C., Tchkonia, T., Kirkland, J. L., Khosla, S., Passos, J. F., et al. (2020) · Journal of Bone and Mineral Research

Telomeres, Telomerase, and SenescenceEffects of Radiation Exposure

Cited by 138

Targeting senescent cholangiocytes and activated fibroblasts with B‐cell lymphoma‐extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/− ) mice

Moncsek, A., Al‐Suraih, M. S., Trussoni, C. E., O'Hara, S. P., Splinter, P. L., Zuber, C., Patsenker, E., Valli, P. V., Fingas, C. D., Weber, A., et al. (2018) · Hepatology

Liver Diseases and ImmunityLiver physiology and pathology

Cited by 136

Inhibiting Cellular Senescence: A New Therapeutic Paradigm for Age-Related Osteoporosis

Khosla, S., Farr, J. N., & Kirkland, J. L. (2018) · The Journal of Clinical Endocrinology & Metabolism

Telomeres, Telomerase, and SenescenceBone Metabolism and Diseases

Cited by 130

Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities

Song, S., Tchkonia, T., Jiang, J., Kirkland, J. L., & Sun, Y. (2020) · Advanced Science

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 129

Cellular senescence biomarker p16INK4a+ cell burden in thigh adipose is associated with poor physical function in older women

Justice, J. N., Gregory, H., Tchkonia, T., LeBrasseur, N. K., Kirkland, J. L., Kritchevsky, S. B., & Nicklas, B. J. (2018) · The Journals of Gerontology: Series A

Telomeres, Telomerase, and SenescenceNutrition and Health in Aging

Cited by 129

New Horizons: Novel Approaches to Enhance Healthspan Through Targeting Cellular Senescence and Related Aging Mechanisms

Tchkonia, T., Palmer, A. K., & Kirkland, J. L. (2021) · The Journal of Clinical Endocrinology & Metabolism

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 129

Translating advances from the basic biology of aging into clinical application

Kirkland, J. L. (2013) · Experimental Gerontology

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 128

Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial

Farr, J. N., Atkinson, E. J., Achenbach, S. J., Volkman, T. L., Tweed, A. J., Vos, S. J., Ruan, M., Sfeir, J., Drake, M. T., Saul, D., et al. (2024) · Nature Medicine

Telomeres, Telomerase, and SenescenceBone health and osteoporosis research

Cited by 127

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

Ogrodnik, M., Zhu, Y., Langhi, L. G. P., Tchkonia, T., Krüger, P., Fielder, E., Victorelli, S., Ruswhandi, R. A., Giorgadze, N., Pirtskhalava, T., et al. (2019) · Cell Metabolism

Telomeres, Telomerase, and SenescenceNeurogenesis and neuroplasticity mechanisms

Cited by 125

Targeted clearance of p21 ‐ but not p16 ‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity

Chandra, A., Lagnado, A. B., Farr, J. N., Doolittle, M., Tchkonia, T., Kirkland, J. L., LeBrasseur, N. K., Robbins, P. D., Niedernhofer, L. J., Ikeno, Y., et al. (2022) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 120

TNF ‐α/ IFN ‐γ synergy amplifies senescence‐associated inflammation and SARS‐CoV ‐2 receptor expression via hyper‐activated JAK / STAT1

Kandhaya‐Pillai, R., Yang, X., Tchkonia, T., Martin, G. M., Kirkland, J. L., & Oshima, J. (2022) · Aging Cell

Telomeres, Telomerase, and SenescenceCOVID-19 Clinical Research Studies

Cited by 119

17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization

Stout, M. B., Steyn, F. J., Jurczak, M. J., Camporez, J.-P. G., Zhu, Y., Hawse, J. R., Jurk, D., Palmer, A. K., Xu, M., Pirtskhalava, T., et al. (2017) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Adipose Tissue and MetabolismHormonal and reproductive studies

Cited by 119

The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2

Chaib, S., López-Domínguez, J. A., Lalinde-Gutiérrez, M., Prats, N., Marin, I., Boix, O., García-Garijo, A., Meyer, K., Muñoz, M. I., Aguilera, M., et al. (2024) · Nature Cancer

Telomeres, Telomerase, and SenescenceCancer Immunotherapy and Biomarkers

Cited by 114

Cellular senescence in aging and age-related diseases: Implications for neurodegenerative diseases

Gerdes, E. O. W., Zhu, Y. Z., Weigand, B. M., Tripathi, U., Burns, T. C., Tchkonia, T., & Kirkland, J. L. (2020) · International Review of Neurobiology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 114

Preadipocyte Function and Aging: Links Between Age‐Related Changes in Cell Dynamics and Altered Fat Tissue Function

Kirkland, J. L., & Dobson, D. E. (1997) · Journal of the American Geriatrics Society

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 105

Targeting senescent cells for a healthier longevity: the roadmap for an era of global aging

Sun, Y., Li, Q., & Kirkland, J. L. (2022) · Life Medicine

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 105

Impact of Senescent Cell Subtypes on Tissue Dysfunction and Repair: Importance and Research Questions

Tripathi, U., Misra, A., Tchkonia, T., & Kirkland, J. L. (2021) · Mechanisms of Ageing and Development

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 104

Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance

Zhang, X., Pearsall, V. M., Carver, C. M., Atkinson, E. J., Clarkson, B. D. S., Grund, E. M., Baez-Faria, M., Pavelko, K. D., Kachergus, J. M., White, T. A., et al. (2022) · Nature Communications

Neuroinflammation and Neurodegeneration MechanismsTelomeres, Telomerase, and Senescence

Cited by 102

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans

Zhu, Y., Prata, L. G. P. L., Gerdes, E. O. W., Netto, J. M. E., Pirtskhalava, T., Giorgadze, N., Tripathi, U., Inman, C. L., Johnson, K. O., Xue, A., et al. (2022) · EBioMedicine

Telomeres, Telomerase, and SenescenceParathyroid Disorders and Treatments

Cited by 100