Kirkland, James L.

BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of NAFLD/NASH

Baboota, R. K., Rawshani, A., Bonnet, L., Li, X., Yang, H., Mardinoglu, A., Tchkonia, T., Kirkland, J. L., Hoffmann, A., Dietrich, A., et al. (2022) · Nature Metabolism

Liver Disease Diagnosis and TreatmentTelomeres, Telomerase, and Senescence

Cited by 99

Perspective: Targeting the JAK/STAT pathway to fight age-related dysfunction

Xu, M., Tchkonia, T., & Kirkland, J. L. (2016) · Pharmacological Research

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 99

Healthspan, Translation, and New Outcomes for Animal Studies of Aging

Kirkland, J. L., & Peterson, C. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 98

Frameworks for proof-of-concept clinical trials of interventions that target fundamental aging processes

Justice, J., Miller, J. D., Newman, J. C., Hashmi, S. K., Halter, J., Austad, S. N., Barzilai, N., & Kirkland, J. L. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 96

SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3

Tripathi, U., Nchioua, R., Prata, L. G. P. L., Zhu, Y., Gerdes, E. O. W., Giorgadze, N., Pirtskhalava, T., Parker, E., Xue, A., Espindola-Netto, J. M., et al. (2021) · Aging

Telomeres, Telomerase, and SenescenceSARS-CoV-2 and COVID-19 Research

Cited by 88

A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer's disease

Millar, C. L., Iloputaife, I., Baldyga, K., Norling, A. M., Boulougoura, A., Vichos, T., Tchkonia, T., Deisinger, A., Pirtskhalava, T., Kirkland, J. L., et al. (2025) · EBioMedicine

Telomeres, Telomerase, and SenescenceDementia and Cognitive Impairment Research

Cited by 88

Local senolysis in aged mice only partially replicates the benefits of systemic senolysis

Farr, J. N., Saul, D., Doolittle, M. L., Kaur, J., Rowsey, J. L., Vos, S. J., Froemming, M. N., Lagnado, A. B., Zhu, Y., Weivoda, M., et al. (2023) · Journal of Clinical Investigation

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 81

Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice

Cavalcante, M. B., Saccon, T. D., Nunes, A. D. C., Kirkland, J. L., Tchkonia, T., Schneider, A., & Masternak, M. M. (2020) · Aging

Telomeres, Telomerase, and SenescenceUterine Myomas and Treatments

Cited by 80

Translating the Science of Aging into Therapeutic Interventions

Kirkland, J. L. (2016) · Cold Spring Harbor Perspectives in Medicine

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 78

Transplanting cells from old but not young donors causes physical dysfunction in older recipients

Wang, B., Liu, Z., Chen, V. P., Wang, L., Inman, C. L., Zhou, Y., Guo, C., Tchkonia, T., Rowe, D. W., Kuchel, G. A., et al. (2020) · Aging Cell

Mesenchymal stem cell researchTelomeres, Telomerase, and Senescence

Cited by 76

Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia

Suvakov, S., Cubro, H., White, W. M., Butler Tobah, Y. S., Weissgerber, T. L., Jordan, K. L., Zhu, X. Y., Woollard, J. R., Chebib, F. T., Milic, N. M., et al. (2019) · Biology of Sex Differences

Mesenchymal stem cell researchPregnancy and preeclampsia studies

Cited by 76

Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice

Stojakovic, A., Trushin, S., Sheu, A., Khalili, L., Chang, S.-Y., Li, X., Christensen, T., Salisbury, J. L., Geroux, R. E., Gateno, B., et al. (2021) · Communications Biology

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 72

Roadmap for alleviating the manifestations of ageing in the cardiovascular system

Liberale, L., Tual-Chalot, S., Sedej, S., Ministrini, S., Georgiopoulos, G., Grunewald, M., Bäck, M., Bochaton-Piallat, M.-L., Boon, R. A., Ramos, G. C., et al. (2025) · Nature Reviews Cardiology

Cardiovascular Health and Disease PreventionTelomeres, Telomerase, and Senescence

Cited by 59

Molecular pathology endpoints useful for aging studies

Niedernhofer, L. J., Kirkland, J. L., & Ladiges, W. (2017) · Ageing Research Reviews

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 59

Corrigendum to ‘Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease’ EBioMedicine 47 (2019) 446–456

Hickson, L. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., et al. (2020) · EBioMedicine

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 59

Testosterone plus low-intensity physical training in late life improves functional performance, skeletal muscle mitochondrial biogenesis, and mitochondrial quality control in Male mice

Guo, W., Wong, S., Li, M., Liang, W., Liesa, M., Serra, C., Jasuja, R., Bartke, A., Kirkland, J. L., Shirihai, O., et al. (2012) · PLoS ONE

Hormonal and reproductive studiesMuscle Physiology and Disorders

Cited by 59

Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function

Wang, B., Wang, L., Gasek, N. S., Kuo, C.-L., Nie, J., Kim, T., Yan, P., Zhu, J., Torrance, B. L., Zhou, Y., et al. (2024) · Cell Metabolism

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 59

Evaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for Geroscience

Huffman, D. M., Justice, J. N., Stout, M. B., Kirkland, J. L., Barzilai, N., & Austad, S. N. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 52

Increased cellular senescence in the murine and human stenotic kidney: Effect of mesenchymal stem cells

Kim, S. R., Zou, X., Tang, H., Puranik, A. S., Abumoawad, A. M., Zhu, X., Hickson, L. J., Tchkonia, T., Textor, S. C., Kirkland, J. L., et al. (2021) · Journal of Cellular Physiology

Mesenchymal stem cell researchTelomeres, Telomerase, and Senescence

Cited by 43

Clearance of p21 highly expressing senescent cells accelerates cutaneous wound healing

Gasek, N. S., Yan, P., Zhu, J., Purushothaman, K.-R., Kim, T., Wang, L., Wang, B., Flynn, W. F., Sun, M., Guo, C., et al. (2024) · Nature Aging

Telomeres, Telomerase, and SenescenceWound Healing and Treatments

Cited by 43

Inflammation and the depot-specific secretome of human preadipocytes

Zhu, Y., Tchkonia, T., Stout, M. B., Giorgadze, N., Wang, L., Li, P. W., Heppelmann, C. J., Bouloumié, A., Jensen, M. D., Bergen, H. R., et al. (2015) · Obesity

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 42

The murine dialysis fistula model exhibits a senescence phenotype: pathobiological mechanisms and therapeutic potential

Nath, K. A., O’Brien, D. R., Croatt, A. J., Grande, J. P., Ackerman, A. W., Nath, M. C., Yamada, S., Terzic, A., Tchkonia, T., Kirkland, J. L., et al. (2018) · American Journal of Physiology-Renal Physiology

Central Venous Catheters and HemodialysisTelomeres, Telomerase, and Senescence

Cited by 40

Advancing biological understanding of cellular senescence with computational multiomics

Li, S., Agudelo Garcia, P. A., Aliferis, C., Becich, M. J., Calyeca, J., Cosgrove, B. D., Elisseeff, J., Farzad, N., Fertig, E. J., Glass, C., et al. (2025) · Nature Genetics

Telomeres, Telomerase, and SenescenceSingle-cell and spatial transcriptomics

Cited by 40

Role of senescence in the chronic health consequences of COVID-19

Wissler Gerdes, E. O., Vanichkachorn, G., Verdoorn, B. P., Hanson, G. J., Joshi, A. Y., Murad, M. H., Rizza, S. A., Hurt, R. T., Tchkonia, T., & Kirkland, J. L. (2022) · Translational Research

Telomeres, Telomerase, and SenescenceCOVID-19 Clinical Research Studies

Cited by 38