Kirkland, James L.

Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability

Nambiar, A., Kellogg, D., Justice, J., Goros, M., Gelfond, J., Pascual, R., Hashmi, S., Masternak, M., Prata, L., LeBrasseur, N., et al. (2023) · eBioMedicine

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisTelomeres, Telomerase, and Senescence

Cited by 298

Adipose tissue endothelial cells from obese human subjects: differences among depots in angiogenic, metabolic, and inflammatory gene expression and cellular senescence

Villaret, A., Galitzky, J., Decaunes, P., Estève, D., Marques, M.-A., Sengenès, C., Chiotasso, P., Tchkonia, T., Lafontan, M., Kirkland, J. L., et al. (2010) · Diabetes

Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and Adiposity

Cited by 282

Cellular senescence and the senescent secretory phenotype in age-related chronic diseases

Zhu, Y., Armstrong, J. L., Tchkonia, T., & Kirkland, J. L. (2014) · Current Opinion in Clinical Nutrition and Metabolic Care

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 273

Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty

Stout, M. B., Justice, J. N., Nicklas, B. J., & Kirkland, J. L. (2017) · Physiology

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 272

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue

Schafer, M. J., White, T. A., Evans, G., Tonne, J. M., Verzosa, G. C., Stout, M. B., Mazula, D. L., Palmer, A. K., Baker, D. J., Jensen, M. D., et al. (2016) · Diabetes

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 267

Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice

Saccon, T. D., Nagpal, R., Yadav, H., Cavalcante, M. B., Nunes, A. D. D. C., Schneider, A., Gesing, A., Hughes, B., Yousefzadeh, M., Tchkonia, T., et al. (2021) · The Journals of Gerontology: Series A

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 247

Senescence and Cancer: A Review of Clinical Implications of Senescence and Senotherapies

Wyld, L., Bellantuono, I., Tchkonia, T., Morgan, J., Turner, O., Foss, F., George, J., Danson, S., & Kirkland, J. L. (2020) · Cancers

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 235

Aging and Regional Differences in Fat Cell Progenitors – A Mini-Review

Sepe, A., Tchkonia, T., Thomou, T., Zamboni, M., & Kirkland, J. L. (2011) · Gerontology

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 232

Biology of premature ageing in survivors of cancer

Cupit-Link, M. C., Kirkland, J. L., Ness, K. K., Armstrong, G. T., Tchkonia, T., LeBrasseur, N. K., Armenian, S. H., Ruddy, K. J., & Hashmi, S. K. (2017) · ESMO Open

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 214

Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner

Lagnado, A., Leslie, J., Ruchaud‐Sparagano, M., Victorelli, S., Hirsova, P., Ogrodnik, M., Collins, A. L., Vizioli, M. G., Habiballa, L., Saretzki, G., et al. (2021) · The EMBO Journal

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 211

Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation

Iske, J., Seyda, M., Heinbokel, T., Maenosono, R., Minami, K., Nian, Y., Quante, M., Falk, C. S., Azuma, H., Martin, F., et al. (2020) · Nature Communications

Telomeres, Telomerase, and SenescenceTransplantation: Methods and Outcomes

Cited by 211

Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD): A Pilot Clinical Trial

Gonzales, M. M., Garbarino, V. R., Marques Zilli, E., Petersen, R. C., Kirkland, J. L., Tchkonia, T., Musi, N., Seshadri, S., Craft, S., & Orr, M. E. (2022) · The Journal of Prevention of Alzheimer's Disease

Alzheimer's disease research and treatmentsTelomeres, Telomerase, and Senescence

Cited by 203

Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases

Song, S., Lam, E. W.-F., Tchkonia, T., Kirkland, J. L., & Sun, Y. (2020) · Trends in Biochemical Sciences

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 195

Frailty in childhood cancer survivors

Ness, K. K., Armstrong, G. T., Kundu, M., Wilson, C. L., Tchkonia, T., & Kirkland, J. L. (2015) · Cancer

Childhood Cancer Survivors' Quality of LifeFrailty in Older Adults

Cited by 188

Activin A Plays a Critical Role in Proliferation and Differentiation of Human Adipose Progenitors

Zaragosi, L.-E., Wdziekonski, B., Villageois, P., Keophiphath, M., Maumus, M., Tchkonia, T., Bourlier, V., Mohsen-Kanson, T., Ladoux, A., Elabd, C., et al. (2010) · Diabetes

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 184

Age, anatomic site, and the replication and differentiation of adipocyte precursors

Kirkland, J. L., Hollenberg, C. H., & Gillon, W. S. (1990) · American Journal of Physiology-Cell Physiology

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 180

Reducing Senescent Cell Burden in Aging and Disease

Pignolo, R. J., Passos, J. F., Khosla, S., Tchkonia, T., & Kirkland, J. L. (2020) · Trends in Molecular Medicine

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 177

Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging

Hadley, E. C., Kuchel, G. A., Newman, A. B., Allore, H. G., Bartley, J. M., Bergeman, C. S., Blinov, M. L., Colon-Emeric, C. S., Dabhar, F. S., Dugan, L. L., et al. (2017) · The Journals of Gerontology: Series A

Resilience and Mental HealthGenetics, Aging, and Longevity in Model Organisms

Cited by 173

Clinical strategies and animal models for developing senolytic agents

Kirkland, J. L., & Tchkonia, T. (2015) · Experimental Gerontology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 168

TNFα-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion

Kandhaya-Pillai, R., Miro-Mur, F., Alijotas-Reig, J., Tchkonia, T., Kirkland, J. L., & Schwartz, S. (2017) · Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 165

Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity

Wang, L., Wang, B., Gasek, N. S., Zhou, Y., Cohn, R. L., Martin, D. E., Zuo, W., Flynn, W. F., Guo, C., Jellison, E. R., et al. (2022) · Cell Metabolism

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 163

Effects of dihydrotestosterone on differentiation and proliferation of human mesenchymal stem cells and preadipocytes

Gupta, V., Bhasin, S., Guo, W., Singh, R., Miki, R., Chauhan, P., Choong, K., Tchkonia, T., Lebrasseur, N. K., Flanagan, J. N., et al. (2008) · Molecular and Cellular Endocrinology

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 162

Insulin‐like growth factor‐1 regulates the SIRT 1‐p53 pathway in cellular senescence

Tran, D., Bergholz, J., Zhang, H., He, H., Wang, Y., Zhang, Y., Li, Q., Kirkland, J. L., & Xiao, Z. (2014) · Aging Cell

Telomeres, Telomerase, and SenescenceSirtuins and Resveratrol in Medicine

Cited by 161

Discovery, development, and future application of senolytics: theories and predictions

Wissler Gerdes, E. O., Zhu, Y., Tchkonia, T., & Kirkland, J. L. (2020) · The FEBS Journal

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 160