Cellular senescence biomarker p16INK4a+ cell burden in thigh adipose is associated with poor physical function in older women
Open accessAbstract
Background: Ample evidence implicates cellular senescence as a contributor to frailty and functional decline in rodents, but considerable effort remains to translate these findings to human aging. Methods: We quantified senescence biomarker p16INK4a-expressing cells in thigh adipose tissue obtained from older women previously enrolled in a 5-month resistance training intervention, with or without caloric restriction (RT ± CR, n = 11 baseline, 8 pre-post-intervention pairs). Women in this subsample were older (72.9 ± 3.4 y) and overweight/obese (body mass index: 30.6 ± 2.4 kg/m2). p16INK4a+ cells were identified from 12 to 20 random visual fields/sample at 20× magnification (immunohistochemical, nuclear staining) and were present in all adipose samples. Results: Cross-sectional associations were observed between p16INK4a+ cell burden and physical function, including grip strength (r = -0.74), 400-m walk time (r = 0.74), 4-m gait speed (r = -0.73), and self-perceived mobility (r = -0.78) (p ≤ .05). These relationships remained significant after independent adjustments for age and adiposity (p ≤ .05). p16INK4a+ cell abundance was lower following the intervention (pre: 5.47 ± 3.4%, post: 2.17 ± 1.1% count p16INK4a+ cells, p ≤ .05). Conclusions: These results provide proof-of-concept that p16INK4a+ cells in thigh adipose are associated with physical function, and may be sensitive to change with RT ± CR in overweight/obese older women.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The biomarker analyses included cytokines, chemo-attractants, MMPs, TIMPs, adhesion molecules, growth factors, binding proteins, and senescence markers measured in CD3 positive T lymphocytes.
“Blood biomarkers included cytokines and chemo-attractants, matrix metalloproteinases (MMP), tissue inhibitors of MMPs (TIMPs), adhesion molecules, growth factors, and their binding proteins.20,23,29 Expression of senescence markers (e.g., ARF, p16, p21, p16INK4a)41, 42, 43, 44 in CD3 positive T lymphocytes was measured by rt-PCR.”
From A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer's disease (2025) · cites this paper as [20]
The Quantification of Adipose p16INK4a section describes measuring a senescence marker, but in thigh adipose biopsies by immunohistochemical staining, not in CD3-positive T lymphocytes by rt-PCR. The Discussion mentions T-cell p16INK4a expression as a finding from earlier work and proposes combining it with adipose measurements in future studies. The blood-biomarker categories appear in a separately cited sentence and are not attributed to this source. (LLM, conf=0.85)
Experimental — accuracy not yet measuredOther studies have shown reductions in p16INK4a in adipose tissue following senolytic treatment.
“Other studies have shown reductions in p16INK4a in adipose tissue following senolytic treatment.20,30”
From A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer's disease (2025) · cites this paper as [20]
The Discussion reports that senolytic drugs reduce p16INK4a-expressing cells, but does not specify that those reductions were measured in adipose tissue. This paper measured adipose p16INK4a+ cells before and after resistance training with or without caloric restriction, not senolytic treatment (Participants and Study Design; Discussion). (LLM, conf=0.85)
Experimental — accuracy not yet measuredExercise can effectively reduce the appearance of age-related markers, such as p16, so as to achieve the effect of delaying aging.
“These evidence suggest that exercise can effectively reduce the appearance of age-related markers, such as p16, so as to achieve the effect of delaying aging.”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [334]
The Abstract reports that p16INK4a-positive cell abundance in thigh adipose was lower after five months of resistance training with or without caloric restriction in a small sample of older women. The intervention-results section says physical function was unchanged, and the paper describes the biomarker finding as preliminary; it does not establish that exercise alone caused the reduction or delayed aging. Page numbers were not available in our copy. (LLM, conf=0.90)
Experimental — accuracy not yet measuredResistance training for five months in older overweight or obese women reduced the number of P16-expressing cells in their thigh fat tissue.
“Correspondingly, resistance training for five months in older overweight or obese women reduced the number of P16-expressing cells in their thigh fat tissue.334”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [334]
The Abstract and ‘Thigh Adipose p16INK4a+ Cell Burden Before and After RT ± CR’ section report lower p16-expressing cell abundance after five months in older overweight or obese women. The analysis combined resistance-training-only and resistance-training-plus-caloric-restriction participants, so it does not establish that resistance training alone caused the reduction. Page numbers were not provided. (LLM, conf=0.86)
Experimental — accuracy not yet measuredSenescent cells and their SASPs contribute to the pathogenesis of many other age-related diseases.
“There is growing evidence that senescent cells and their SASPs contribute to the pathogenesis of many other age-related diseases as well”
From Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain (2020) · cites this paper as Justice et al. 2018
The opening section describes senescent-cell accumulation as potentially harmful to health and function, and the Discussion reports that adipose p16INK4a+ cells express inflammatory SASP products. But the paper does not establish that senescent cells and their SASPs cause the pathogenesis of many age-related diseases; it says the role of SASP remains uncertain, and its human findings concern an association with physical function in older women. Page numbers are unavailable in our copy. (LLM, conf=0.82)
Experimental — accuracy not yet measured
Oxidative stress and macromolecular damage in aged cells induce cellular senescence, which can cause or exacerbate aging and several age-related pathologies.
“Oxidative stress and macromolecular damage in aged cells induce a complex stress response termed cellular senescence, which has been shown to cause or exacerbate aging and several age-related pathologies”
From Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain (2020) · cites this paper as Justice et al. 2018
The Abstract (page unavailable) says DNA damage and oxidative stress can trigger cellular senescence and that the resulting phenotype has deleterious effects on health and function in animal models of aging. It does not establish that senescence causes or exacerbates aging and several age-related pathologies broadly; it says the clinical consequences in humans have yet to be determined. (LLM, conf=0.86)
Experimental — accuracy not yet measuredSenescent cell abundance is increased in multiple age-related diseases and disorders in experimental animals and humans.
“Senescent cell abundance is increased in multiple age-related diseases and disorders in experimental animals and humans.30, 31, 32”
From Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans (2022) · cites this paper as [32]
The paper reports greater senescent-cell accumulation in adipose tissue from obese versus non-obese adults and elevated burden in aging or diet-exposed rodents (Abstract; page unavailable). It also links a senescence marker to poor physical function in older women (Discussion; page unavailable). These passages support increased abundance in some human and animal conditions, but do not establish it across multiple age-related diseases and disorders in both groups. (LLM, conf=0.83)
Experimental — accuracy not yet measuredBlood biomarkers included cytokines, chemo-attractants, MMPs, TIMPs, adhesion molecules, growth factors, and their binding proteins.
“Blood biomarkers included cytokines and chemo-attractants, matrix metalloproteinases (MMP), tissue inhibitors of MMPs (TIMPs), adhesion molecules, growth factors, and their binding proteins.20,23,29”
From A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer's disease (2025) · cites this paper as [20]
The Discussion says circulating SASP products and other blood-based biomarkers should be assessed in future work, not that the listed biomarkers were included in this study. Searches for the biomarker categories, including MMPs and TIMPs, found no passage in our copy specifying that panel. (LLM, conf=0.75)
Experimental — accuracy not yet measuredUsing P16-expressing cells, Justice et al. showed a very strong link between the abundance of senescent-like cells and IMAT, and that this was strongly and inversely associated with functional measures like gait speed and SPPB score.
“Using P16-expressing cells (associated with cellular senescence), Justice et al. (2018) showed a very strong link between the abundance of senescent-like cells and IMAT, and that this was strongly and inversely associated with functional measures like gait speed and Short Physical Performance Battery (SPPB) score.”
From Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging (2020) · cites this paper as Justice et al., 2018
Frequency of P16-expressing cells in IMAT is strongly and inversely associated with functional measures like gait speed and SPPB score.
“IMAT in older persons can also be a source of senescent cells; as reported previously, the frequency of P16-expressing cells in IMAT was strongly and inversely associated with functional measures like gait speed and SPPB score (Justice et al., 2018).”
From Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging (2020) · cites this paper as Justice et al., 2018
Five months of resistance training in older (~73 yr) overweight/obese women reduced P16-expressing cells in thigh adipose tissue.
“Five months of resistance training in older (~73 yr) overweight/obese women reduced P16-expressing cells in thigh adipose tissue, and P16+ cell content was negatively associated with several parameters of physical function, including grip strength and 400-m walk time (65).”
From Exercise Counters the Age-Related Accumulation of Senescent Cells (2022) · cites this paper as [65]
P16+ cell content in thigh adipose tissue was negatively associated with several parameters of physical function, including grip strength and 400-m walk time, in older overweight/obese women.
“Five months of resistance training in older (~73 yr) overweight/obese women reduced P16-expressing cells in thigh adipose tissue, and P16+ cell content was negatively associated with several parameters of physical function, including grip strength and 400-m walk time (65).”
From Exercise Counters the Age-Related Accumulation of Senescent Cells (2022) · cites this paper as [65]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442 · see citing works
Gait speed and survival in older adults.
Studenski, S. (2011) · JAMA · doi:10.1001/jama.2010.1923 · Cited by 4,558 · see citing works
Cellular senescence: when bad things happen to good cells
Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441 · see citing works
Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability
Guralnik, J. M., Ferrucci, L., Simonsick, E. M., Salive, M. E., & Wallace, R. B. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503023320902 · Cited by 4,083 · see citing works
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · cited 3× · see citing works
“The physiologic effect of p16INK4a-expressing cells has been examined in a transgenic mouse model (INK-ATTAC), in which p16INK4a-expressing cell apoptosis can be induced (26,27).”
BackgroundSelf-citationNaturally occurring p16Ink4a-positive cells shorten healthy lifespan
Baker, D. J., Childs, B. G., Durik, M., Wijers, M. E., Sieben, C. J., Zhong, J., A. Saltness, R., Jeganathan, K. B., Verzosa, G. C., Pezeshki, A., et al. (2016) · Nature · doi:10.1038/nature16932 · Cited by 2,891 · see citing works
Geroscience: Linking Aging to Chronic Disease
Kennedy, B. K., Berger, S. L., Brunet, A., Campisi, J., Cuervo, A. M., Epel, E. S., Franceschi, C., Lithgow, G. J., Morimoto, R. I., Pessin, J. E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.039 · Cited by 2,764 · see citing works
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., et al. (2015) · Aging Cell · doi:10.1111/acel.12344 · Cited by 2,562 · cited 1× · see citing works
“This is further supported by the discovery that senolytic drugs reduce p16INK4a-expressing cells in tandem with declines in other markers of cellular senescence, and affects on multiple ageand senescence-related phenotypes parallel those of genetic clearance from INK-ATTAC mice (4,12,13).”
BackgroundSelf-citationReplication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes
Zeggini, E., Weedon, M. N., Lindgren, C. M., Frayling, T. M., Elliott, K. S., Lango, H., Timpson, N. J., Perry, J. R. B., Rayner, N. W., Freathy, R. M., et al. (2007) · Science · doi:10.1126/science.1142364 · Cited by 2,194 · see citing works
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
Tchkonia, T., Zhu, Y., van Deursen, J., Campisi, J., & Kirkland, J. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64098 · Cited by 1,774 · see citing works
Self-citationCellular senescence mediates fibrotic pulmonary disease
Schafer, M. J., White, T. A., Iijima, K., Haak, A. J., Ligresti, G., Atkinson, E. J., Oberg, A. L., Birch, J., Salmonowicz, H., Zhu, Y., et al. (2017) · Nature Communications · doi:10.1038/ncomms14532 · Cited by 1,613 · see citing works
Self-citationInk4a/Arf expression is a biomarker of aging
Krishnamurthy, J., Torrice, C., Ramsey, M. R., Kovalev, G. I., Al-Regaiey, K., Su, L., & Sharpless, N. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22475 · Cited by 1,486 · see citing works
Forging a signature of in vivo senescence
Sharpless, N. E., & Sherr, C. J. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3960 · Cited by 1,104 · see citing works
Fat tissue, aging, and cellular senescence
Tchkonia, T., Morbeck, D. E., Von Zglinicki, T., Van Deursen, J., Lustgarten, J., Scrable, H., Khosla, S., Jensen, M. D., & Kirkland, J. L. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00608.x · Cited by 1,094 · see citing works
Self-citationXu, M., Tchkonia, T., Ding, H., Ogrodnik, M., Lubbers, E. R., Pirtskhalava, T., White, T. A., Johnson, K. O., Stout, M. B., Mezera, V., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515386112 · Cited by 915 · cited 3× · see citing works
“In rodents, elevated adipose senescent cell burden induced by aging or “fast-food” westernized-diet accompanies systemic inflammation and physical dysfunction (4,11), but even modest reductions in the number of senescent cells can positively impact health and function.”
BackgroundSelf-citationRoos, C. M., Zhang, B., Palmer, A. K., Ogrodnik, M. B., Pirtskhalava, T., Thalji, N. M., Hagler, M., Jurk, D., Smith, L. A., Casaclang‐Verzosa, G., et al. (2016) · Aging Cell · doi:10.1111/acel.12458 · Cited by 738 · see citing works
Self-citationHelgadóttir, A., Þorleifsson, G., Magnússon, K. P., Grétarsdóttir, S., Steinthórsdóttir, V., Manolescu, A. R., Jones, G. T., Rinkel, G. J. E., Blankensteijn, J. D., Ronkainen, A., et al. (2008) · Nature Genetics · doi:10.1038/ng.72 · Cited by 724 · see citing works
Targeting senescent cells enhances adipogenesis and metabolic function in old age
Xu, M., Palmer, A. K., Ding, H., Weivoda, M. M., Pirtskhalava, T., White, T. A., Sepe, A., Johnson, K. O., Stout, M. B., Giorgadze, N., et al. (2015) · eLife · doi:10.7554/elife.12997 · Cited by 604 · see citing works
Self-citationLiu, Y., Sanoff, H. K., Cho, H., Burd, C. E., Torrice, C., Ibrahim, J. G., Thomas, N. E., & Sharpless, N. E. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00489.x · Cited by 509 · see citing works
Coppé, J.-P., Rodier, F., Patil, C. K., Freund, A., Desprez, P.-Y., & Campisi, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.257071 · Cited by 506 · see citing works
Obesity and mobility disability in the older adult
Vincent, H. K., Vincent, K. R., & Lamb, K. M. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00703.x · Cited by 382 · see citing works
Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity
Seals, D. R., Justice, J. N., & LaRocca, T. J. (2015) · The Journal of Physiology · doi:10.1113/jphysiol.2014.282665 · Cited by 312 · see citing works
Self-citationOhtani, N., Yamakoshi, K., Takahashi, A., & Hara, E. (2004) · The Journal of Medical Investigation · doi:10.2152/jmi.51.146 · Cited by 276 · see citing works
Cellular senescence and the senescent secretory phenotype in age-related chronic diseases
Zhu, Y., Armstrong, J. L., Tchkonia, T., & Kirkland, J. L. (2014) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0000000000000065 · Cited by 273 · see citing works
Self-citationPhysiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty
Stout, M. B., Justice, J. N., Nicklas, B. J., & Kirkland, J. L. (2017) · Physiology · doi:10.1152/physiol.00012.2016 · Cited by 272 · see citing works
Self-citationExercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue
Schafer, M. J., White, T. A., Evans, G., Tonne, J. M., Verzosa, G. C., Stout, M. B., Mazula, D. L., Palmer, A. K., Baker, D. J., Jensen, M. D., et al. (2016) · Diabetes · doi:10.2337/db15-0291 · Cited by 267 · see citing works
Self-citationBeavers, K. M., Beavers, D. P., Houston, D. K., Harris, T. B., Hue, T. F., Koster, A., Newman, A. B., Simonsick, E. M., Studenski, S. A., Nicklas, B. J., et al. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.047860 · Cited by 259 · see citing works
Self-citationCellular Senescence and the Biology of Aging, Disease, and Frailty
LeBrasseur, N. K., Tchkonia, T., & Kirkland, J. L. (2015) · Nestlé Nutrition Institute Workshop Series · doi:10.1159/000382054 · Cited by 147 · see citing works
Self-citationNicklas, B. J., Chmelo, E., Delbono, O., Carr, J. J., Lyles, M. F., & Marsh, A. P. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.105270 · Cited by 144 · cited 2× · see citing works
“To gain initial insight, we leveraged previously collected cryopreserved thigh adipose tissue (intermuscular or perimuscular) from well-characterized overweight/obese older women previously enrolled in a clinical study (15).”
BackgroundMethodSelf-citationAdult-onset, short-term dietary restriction reduces cell senescence in mice
Wang, C., Maddick, M., Miwa, S., Jurk, D., Czapiewski, R., Saretzki, G., Langie, S. A. S., Godschalk, R. W. L., Cameron, K., & von Zglinicki, T. (2010) · Aging · doi:10.18632/aging.100196 · Cited by 142 · see citing works
Rantanen, T., Masaki, K., He, Q., Ross, G. W., Willcox, B. J., & White, L. R. (2011) · AGE · doi:10.1007/s11357-011-9256-y · Cited by 136 · see citing works
Cyclin-Dependent Kinases as Coregulators of Inflammatory Gene Expression
Schmitz, M. L., & Kracht, M. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.10.004 · Cited by 95 · see citing works
A common variant of the p16INK4a genetic region is associated with physical function in older people
Melzer, D., Frayling, T. M., Murray, A., Hurst, A. J., Harries, L. W., Song, H., Khaw, K., Luben, R., Surtees, P. G., Bandinelli, S. S., et al. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.03.005 · Cited by 84 · see citing works
Maas, B. M., Francis, O., Mollan, K. R., Lee, C. S. Y., Cottrell, M. L., Prince, H. M. A., Sykes, C., Trezza, C., Torrice, C., White, N., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168709 · Cited by 5 · see citing works
Barbero (2014) · doi:10.1016/j · Cited by 1 · see citing works
(2018) · Digital Commons@Becker (Washington University School of Medicine) · doi:10.1371/journal
Flagged first, then by citations
Research works printed but not linked: 1
- [9]9. Tchkonia T, Giorgadze N, Pirtskhalava T, Thomou T, Villaret A, Bouloumie A, et al. Cellular senescence and inflammation in obesity. Obesity. 2009;17:S57.
Cited by
Sorted by citations
Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Ferrucci, L., & Fabbri, E. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0064-2 · Cited by 3,690 · see citing works
Senolytics improve physical function and increase lifespan in old age
Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0092-9 · Cited by 2,287 · see citing works
Self-citationSarcopenia: Aging-Related Loss of Muscle Mass and Function
Larsson, L., Degens, H., Li, M., Salviati, L., Lee, Y. I., Thompson, W., Kirkland, J. L., & Sandri, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00061.2017 · Cited by 1,797 · see citing works
Self-citationInflammation and aging: signaling pathways and intervention therapies
Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01502-8 · Cited by 1,443 · see citing works
“Correspondingly, resistance training for five months in older overweight or obese women reduced the number of P16expressing cells in their thigh fat tissue.(334) These evidence suggest that exercise can effectively reduce the appearance of age-related markers, such as p16, so as to achieve the effect of delaying aging.”
BackgroundHickson, L. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.08.069 · Cited by 1,383 · see citing works
Self-citationSenolytic drugs: from discovery to translation
Kirkland, J. L., & Tchkonia, T. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13141 · Cited by 1,227 · see citing works
Self-citationCellular senescence and senolytics: the path to the clinic
Chaib, S., Tchkonia, T., & Kirkland, J. L. (2022) · Nature Medicine · doi:10.1038/s41591-022-01923-y · Cited by 1,105 · see citing works
Self-citationMeasuring biological aging in humans: a quest
Ferrucci, L., Gonzalez‐Freire, M., Fabbri, E., Simonsick, E., Tanaka, T., Moore, Z., Salimi, S., Sierra, F., & de Cabo, R. (2020) · Aging Cell · doi:10.1111/acel.13080 · Cited by 781 · see citing works
The role of cellular senescence in ageing and endocrine disease
Khosla, S., Farr, J. N., Tchkonia, T., & Kirkland, J. L. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0335-y · Cited by 523 · see citing works
Self-citationStrategies for targeting senescent cells in human disease
Gasek, N. S., Kuchel, G. A., Kirkland, J. L., & Xu, M. (2021) · Nature Aging · doi:10.1038/s43587-021-00121-8 · Cited by 501 · see citing works
Self-citationSenescent cell clearance by the immune system: Emerging therapeutic opportunities
Prata, L. G. P. L., Ovsyannikova, I. G., Tchkonia, T., & Kirkland, J. L. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2019.04.003 · Cited by 497 · see citing works
Self-citationCorrea-de-Araujo, R., Addison, O., Miljkovic, I., Goodpaster, B. H., Bergman, B. C., Clark, R. V., Elena, J. W., Esser, K. A., Ferrucci, L., Harris-Love, M. O., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00963 · Cited by 468 · see citing works
Self-citationMechanisms and Regulation of Cellular Senescence
Roger, L., Tomas, F., & Gire, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222313173 · Cited by 395 · see citing works
Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span
Robbins, P. D., Jurk, D., Khosla, S., Kirkland, J. L., LeBrasseur, N. K., Miller, J. D., Passos, J. F., Pignolo, R. J., Tchkonia, T., & Niedernhofer, L. J. (2021) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-050120-105018 · Cited by 339 · see citing works
“Correspondingly, in older humans, the number of p16INK4a-expressing cells in thigh adipose tissue is negatively associated with performance-based measures of strength and walking ability (52).”
BackgroundSelf-citationFerrucci, L., Levine, M. E., Kuo, P.-L., & Simonsick, E. M. (2018) · Circulation Research · doi:10.1161/circresaha.118.312816 · Cited by 303 · see citing works
Aging, Cell Senescence, and Chronic Disease: Emerging Therapeutic Strategies
Tchkonia, T., & Kirkland, J. L. (2018) · JAMA · doi:10.1001/jama.2018.12440 · Cited by 302 · see citing works
Self-citationInflammation, Frailty and Cardiovascular Disease
Soysal, P., Arık, F., Smith, L., Jackson, S. E., & Işık, A. T. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-33330-0_7 · Cited by 248 · see citing works
Livshits, G., & Kalinkovich, A. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100980 · Cited by 239 · see citing works
Ubaida‐Mohien, C., Lyashkov, A. E., González‐Freire, M., Tharakan, R., Shardell, M. D., Moaddel, R., Semba, R. D., Chia, C. W., Gorospe, M., Sen, R., et al. (2019) · eLife · doi:10.7554/elife.49874 · Cited by 232 · see citing works
Kiss, T., Nyúl-Tóth, Á., Balasubramanian, P., Tarantini, S., Ahire, C., DelFavero, J., Yabluchanskiy, A., Csipo, T., Farkas, E., Wiley, G., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00177-1 · Cited by 203 · see citing works
Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases
Song, P., An, J., & Zou, M.-H. (2020) · Cells · doi:10.3390/cells9030671 · Cited by 198 · see citing works
Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology
Dehkordi, S. K., Walker, J., Sah, E., Bennett, E., Atrian, F., Frost, B., Woost, B., Bennett, R. E., Orr, T. C., Zhou, Y., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00142-3 · Cited by 169 · see citing works
Discovery, development, and future application of senolytics: theories and predictions
Wissler Gerdes, E. O., Zhu, Y., Tchkonia, T., & Kirkland, J. L. (2020) · The FEBS Journal · doi:10.1111/febs.15264 · Cited by 160 · see citing works
Self-citationNess, K. K., Kirkland, J. L., Gramatges, M. M., Wang, Z., Kundu, M., McCastlain, K., Li-Harms, X., Zhang, J., Tchkonia, T., Pluijm, S. M. F., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2017.76.7467 · Cited by 140 · see citing works
Self-citationThe role of adipose tissue senescence in obesity- and ageing-related metabolic disorders
Liu, Z., Wu, K. K.-L., Jiang, X. X., Xu, A., & Cheng, K. K. Y. (2020) · Clinical Science · doi:10.1042/cs20190966 · Cited by 139 · see citing works
Skeletal muscle transcriptome in healthy aging
Tumasian, R. A., Harish, A., Kundu, G., Yang, J.-H., Ubaida-Mohien, C., Gonzalez-Freire, M., Kaileh, M., Zukley, L. M., Chia, C. W., Lyashkov, A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22168-2 · Cited by 126 · see citing works
Cellular senescence in aging and age-related diseases: Implications for neurodegenerative diseases
(2020) · International Review of Neurobiology · doi:10.1016/bs.irn.2020.03.019 · Cited by 114 · see citing works
Self-citationYabluchanskiy, A., Tarantini, S., Balasubramanian, P., Kiss, T., Csípő, T., Fülöp, G., Lipécz, Á., Ahire, C., DelFavero, J., Nyúl‐Tóth, Á., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00154-8 · Cited by 118 · see citing works
Biological functions of therapy-induced senescence in cancer
Fitsiou, E., Soto-Gamez, A., & Demaria, M. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.03.021 · Cited by 101 · see citing works
The clinical impact and biological mechanisms of skeletal muscle aging
Aversa, Z., Zhang, X., Fielding, R. A., Lanza, I. R., & LeBrasseur, N. K. (2019) · Bone · doi:10.1016/j.bone.2019.05.021 · Cited by 104 · see citing works
Self-citationMolecular basis of ageing in chronic metabolic diseases
Spinelli, R., Parrillo, L., Longo, M., Florese, P., Desiderio, A., Zatterale, F., Miele, C., Raciti, G. A., & Bèguinot, F. (2020) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01255-z · Cited by 100 · see citing works
Tarantini, S., Balasubramanian, P., DelFavero, J., Csípő, T., Yabluchanskiy, A., Kiss, T., Nyúl‐Tóth, Á., Mukli, P., Tóth, P., Ahire, C., et al. (2021) · GeroScience · doi:10.1007/s11357-021-00440-z · Cited by 100 · see citing works
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans
Zhu, Y., Prata, L. G. P. L., Gerdes, E. O. W., Netto, J. M. E., Pirtskhalava, T., Giorgadze, N., Tripathi, U., Inman, C. L., Johnson, K. O., Xue, A., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.103912 · Cited by 96 · see citing works
Self-citationMotoric cognitive risk syndrome: Integration of two early harbingers of dementia in older adults
Semba, R. D., Tian, Q., Carlson, M. C., Xue, Q., & Ferrucci, L. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101022 · Cited by 88 · see citing works
de Carvalho, F. G., Justice, J. N., de Freitas, E. C., Kershaw, E. E., & Sparks, L. M. (2019) · Nutrients · doi:10.3390/nu11112553 · Cited by 87 · see citing works
Self-citationIs exercise a senolytic medicine? A systematic review
Chen, X., Yi, Z., Wong, G. T., Hasan, K. M. M., Kwan, J. S., Ma, A. C., & Chang, R. C. (2021) · Aging Cell · doi:10.1111/acel.13294 · Cited by 88 · see citing works
Millar, C. L., Iloputaife, I., Baldyga, K., Norling, A. M., Boulougoura, A., Vichos, T., Tchkonia, T., Deisinger, A., Pirtskhalava, T., Kirkland, J. L., et al. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105612 · Cited by 88 · see citing works
Self-citationFrailty biomarkers under the perspective of geroscience: A narrative review
Gonçalves, R. S. D. S. A., Maciel, Á. C. C., Rolland, Y., Vellas, B. J., & Barreto, P. D. S. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101737 · Cited by 82 · see citing works
Senescent macrophages in the human adipose tissue as a source of inflammaging
Matacchione, G., Perugini, J., Mercurio, E. D., Sabbatinelli, J., Prattichizzo, F., Senzacqua, M., Storci, G., Dani, C., Lezoche, G., Guerrieri, M., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00536-0 · Cited by 74 · see citing works
Pathological and Inflammatory Consequences of Aging
García‐Domínguez, M. (2025) · Biomolecules · doi:10.3390/biom15030404 · Cited by 75 · see citing works
p16 a biomarker of aging and tolerance for cancer therapy
Muss, H. B., Smitherman, A. B., Wood, W. A., Nyrop, K. A., Tuchman, S. A., Randhawa, P. K., Entwistle, A., Mitin, N., & Shachar, S. S. (2020) · Translational Cancer Research · doi:10.21037/tcr.2020.03.39 · Cited by 68 · see citing works
Kiss, T., Nyúl-Tóth, Á., DelFavero, J., Balasubramanian, P., Tarantini, S., Faakye, J., Gulej, R., Ahire, C., Ungvari, A., Yabluchanskiy, A., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00521-7 · Cited by 66 · see citing works
Lipotoxicity, aging, and muscle contractility: does fiber type matter?
Carter, C. S., Justice, J. N., & Thompson, L. (2019) · GeroScience · doi:10.1007/s11357-019-00077-z · Cited by 66 · see citing works
Self-citationThe effects of myosteatosis on skeletal muscle function in older adults
Dondero, K., Friedman, B., Rekant, J., Landers‐Ramos, R., & Addison, O. (2024) · Physiological Reports · doi:10.14814/phy2.16042 · Cited by 63 · see citing works
Exercise Counters the Age-Related Accumulation of Senescent Cells
Zhang, X., Englund, D. A., Aversa, Z., Jachim, S. K., White, T. A., & LeBrasseur, N. K. (2022) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000302 · Cited by 63 · see citing works
Self-citationIn vivo analysis of γH2AX+ cells in skeletal muscle from aged and obese humans
Dungan, C. M., Peck, B. D., Walton, R. G., Huang, Z., Bamman, M. M., Kern, P. A., & Peterson, C. A. (2020) · The FASEB Journal · doi:10.1096/fj.202000111rr · Cited by 57 · see citing works
Elevated skin senescence in young mice causes delayed wound healing
Thanapaul, R. J. R. S., Shvedova, M., Shin, G. H., Crouch, J. D., & Roh, D. S. (2022) · GeroScience · doi:10.1007/s11357-022-00551-1 · Cited by 52 · see citing works
Aging and Mesenchymal Stem Cells: Therapeutic Opportunities and Challenges in the Older Group
Chen, H., Liu, O., Chen, S., & Zhou, Y. (2021) · Gerontology · doi:10.1159/000516668 · Cited by 51 · see citing works
Mullen, M. T., Nelson, A. L., Goff, A., Billings, J., Kloser, H., Huard, C., Mitchell, J., Hambright, W. S., Ravuri, S. K., & Huard, J. (2023) · Stem Cells · doi:10.1093/stmcls/sxad036 · Cited by 49 · see citing works
Nunes-Pinto, M., de Mello, R. G. B., Pinto, M. N., Moro, C., Vellas, B. J., Martinez, L. O., Rolland, Y., & Barreto, P. D. S. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102587 · Cited by 47 · see citing works
Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions
Wang, T., Zhou, D., & Hong, Z. (2025) · MedComm · doi:10.1002/mco2.70030 · Cited by 46 · see citing works
Role of senescence in the chronic health consequences of COVID-19
Wissler Gerdes, E. O., Vanichkachorn, G., Verdoorn, B. P., Hanson, G. J., Joshi, A. Y., Murad, M. H., Rizza, S. A., Hurt, R. T., Tchkonia, T., & Kirkland, J. L. (2022) · Translational Research · doi:10.1016/j.trsl.2021.10.003 · Cited by 38 · see citing works
Self-citationWhole Body Irradiation Induces Diabetes and Adipose Insulin Resistance in Nonhuman Primates
Bacarella, N., Ruggiero, A. D., Davis, A., Uberseder, B., Davis, M. A., Bracy, D. P., Wasserman, D. H., Cline, J. M., Sherrill, C., & Kavanagh, K. (2019) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2019.11.034 · Cited by 39 · see citing works
Senescent cells in human adipose tissue: A cross‐sectional study
Ycaza, A. E. E. D., Søndergaard, E., Morgan-Bathke, M. E., Leon, B. G. C., Lytle, K. A., Ramos, P. A., Kirkland, J. L., Tchkonia, T., & Jensen, M. D. (2021) · Obesity · doi:10.1002/oby.23202 · Cited by 39 · see citing works
Self-citationBeyond youth: Understanding CAR T cell fitness in the context of immunological aging
Noll, J. H., Levine, B. L., June, C. H., & Fraietta, J. A. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101840 · Cited by 39 · see citing works
Rozenberg, D., Orsso, C. E., Chohan, K., Orchanian‐Cheff, A., Nourouzpour, S., Nicholson, J. M., Elangeswaran, B., Vagaon, A., Fidler, L. M., Singer, L. G., et al. (2020) · Transplant International · doi:10.1111/tri.13749 · Cited by 38 · see citing works
Physiological Systems in Promoting Frailty
Perazza, L. R., Brown‐Borg, H. M., & Thompson, L. V. (2022) · Comprehensive physiology · doi:10.1002/cphy.c210034 · Cited by 64 · see citing works
A geroscience motivated approach to treat Alzheimer’s disease: Senolytics move to clinical trials
Gonzales, M. M., Krishnamurthy, S., Garbarino, V. R., Daeihagh, A. S., Gillispie, G. J., Deep, G., Craft, S., & Orr, M. E. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111589 · Cited by 37 · see citing works
Alharbi, K. S., Afzal, O., Altamimi, A. S. A., Almalki, W. H., Kazmi, I. A., Al-Abbasi, F. A., Alzarea, S. I., Makeen, H. A., & Albratty, M. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14471 · Cited by 36 · see citing works
Kritchevsky, S. B., & Cummings, S. R. (2025) · JAMA · doi:10.1001/jama.2025.11289 · Cited by 38 · see citing works
Self-citationNutrition and cellular senescence in obesity-related disorders
Rubio‐Tomás, T., Rueda‐Robles, A., Plaza‐Díaz, J., & Álvarez‐Mercado, A. I. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108861 · Cited by 37 · see citing works
Spinelli, R., Florese, P., Parrillo, L., Zatterale, F., Longo, M., D’Esposito, V., Desiderio, A., Nerstedt, A., Gustafson, B., Formisano, P., et al. (2022) · Aging Cell · doi:10.1111/acel.13557 · Cited by 36 · see citing works
Aging human abdominal subcutaneous white adipose tissue at single cell resolution
Whytock, K. L., Divoux, A., Sun, Y., Pino, M. F., Yu, G., Jin, C. A., Robino, J. J., Plekhanov, A., Varlamov, O., Smith, S. R., et al. (2024) · Aging Cell · doi:10.1111/acel.14287 · Cited by 34 · see citing works
Measuring Biologic Resilience in Older Cancer Survivors.
Sedrak, M., Gilmore, N., Carroll, J., Muss, H., Cohen, H. J., & Dale, W. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.21.00245 · Cited by 21 · see citing works
Reduced stem cell aging in exercised human skeletal muscle is enhanced by ginsenoside Rg1
Lee, T. X. Y., Wu, J., Jean, W., Condello, G., AlKhatib, A. H., Hsieh, C.-C., Hsieh, Y., Huang, C., & Kuo, C. (2021) · Aging · doi:10.18632/aging.203176 · Cited by 33 · see citing works
Justice, J. N., Leng, X., LeBrasseur, N. K., Tchkonia, T., Kirkland, J. L., Mitin, N., Liu, Y., Kritchevsky, S. B., Nicklas, B. J., & Ding, J. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad214 · Cited by 30 · see citing works
Self-citationA nutrigeroscience approach: Dietary macronutrients and cellular senescence
Calubag, M. F., Robbins, P. D., & Lamming, D. W. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.07.025 · Cited by 32 · see citing works
Gillispie, G. J., Sah, E., Krishnamurthy, S., Ahmidouch, M. Y., Zhang, B., & Orr, M. E. (2021) · Life · doi:10.3390/life11020153 · Cited by 32 · see citing works
Physiological Systems in Promoting Frailty
Perazza, L. R., Brown‐Borg, H. M., & Thompson, L. V. (2022) · Comprehensive physiology · doi:10.1002/j.2040-4603.2022.tb00224.x · Cited by 30 · see citing works
Cardiometabolic implications of adipose tissue aging
Ahmed, B., Farb, M. G., & Gokce, N. (2024) · Obesity Reviews · doi:10.1111/obr.13806 · Cited by 31 · see citing works
Antiaging Vaccines Targeting Senescent Cells
Mendelsohn, A. R., & Larrick, J. W. (2022) · Rejuvenation Research · doi:10.1089/rej.2022.0008 · Cited by 29 · see citing works
Lifestyle interventions to delay senescence
Martel, J., Ojcius, D. M., & Young, J. D. (2023) · Biomedical Journal · doi:10.1016/j.bj.2023.100676 · Cited by 29 · see citing works
DNA Methylation Modulates Aging Process in Adipocytes
Xie, H., Liu, X., Zhou, Q., Huang, T., Zhang, L., Gao, J. L., Wang, Y., Liu, Y., Yan, T., Zhang, S., et al. (2022) · Aging and Disease · doi:10.14336/ad.2021.0904 · Cited by 23 · see citing works
Obesity, Senescence, and Senolytics
Chaib, S., Tchkonia, T., & Kirkland, J. L. (2021) · Handbook of Experimental Pharmacology · doi:10.1007/164_2021_555 · Cited by 22 · see citing works
Self-citationde Lange, P., Lombardi, A., Silvestri, E., Cioffi, F., Giacco, A., Iervolino, S., Petito, G., Senese, R., Lanni, A., & Moreno, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411676 · Cited by 26 · see citing works
Inoue, T., Shinjo, T., Matsuoka, M., Tamashiro, M., Oba, K., Arasaki, O., Moromizato, T., & Arima, H. (2021) · Clinical and Experimental Nephrology · doi:10.1007/s10157-021-02110-y · Cited by 21 · see citing works
Ji, S., Lee, E., Kim, B., Baek, J. Y., Yi, Y., Jang, I., & Jung, H. (2022) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2022.104916 · Cited by 20 · see citing works
Li, B., Sang, N., Zhang, M.-Y., Liu, Z.-R., Fang, R.-X., Liu, W.-J., Wang, D., & Wu, G. (2023) · International Urology and Nephrology · doi:10.1007/s11255-023-03739-2 · Cited by 20 · see citing works
Pax7+ Satellite Cells in Human Skeletal Muscle After Exercise: A Systematic Review and Meta-analysis
Dewi, L., Lin, Y., Nicholls, A., Condello, G., Huang, C., & Kuo, C. (2022) · Sports Medicine · doi:10.1007/s40279-022-01767-z · Cited by 20 · see citing works
Attenuation of frailty in older adults with mesenchymal stem cells
Florea, V., Bagno, L., Rieger, A. C., & Hare, J. M. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.111120 · Cited by 21 · see citing works
Anderson, M. R., Easthausen, I. J., Gallagher, G. B., Udupa, J. K., Tong, Y., Torigian, D. A., Diamond, J. M., Porteous, M. K., Palmer, S. M., Snyder, L. D., et al. (2020) · Thorax · doi:10.1136/thoraxjnl-2019-214461 · Cited by 19 · see citing works
Demaria, M., Bertozzi, B., Veronese, N., Spelta, F., Cava, E., Tosti, V., Piccio, L. M., Early, D. S., & Fontana, L. (2023) · npj Aging · doi:10.1038/s41514-023-00100-w · Cited by 18 · see citing works
Koivunen, K., Sillanpää, E., von Bonsdorff, M. B., Sakari‐Rantala, R., Törmäkangas, T., & Rantanen, T. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz251 · Cited by 17 · see citing works
Biomarkers of senescence in non-human primate adipose depots relate to aging
Kavanagh, K., Sherrill, C., Ruggiero, A. D., Block, M. R., Vemuri, R., Davis, M., & Olivier, A. (2020) · GeroScience · doi:10.1007/s11357-020-00230-z · Cited by 17 · see citing works
Translating cellular senescence research into clinical practice for metabolic disease
Chaib, S., Palmer, A. K., Wyles, S. P., Musi, N., Kirkland, J. L., & Tchkonia, T. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01187-9 · Cited by 14 · see citing works
Self-citationDoan, L., Paine, P., Tran, C., Parsons, B., Hiller, A., Joshua, I., Collaco, N., Vitari, A., de Morrée, A., Ishak, H. D., et al. (2020) · doi:10.21203/rs.3.rs-92962/v1 · Cited by 13 · see citing works
Koons, B., Anderson, M. R., Smith, P. J., Greenland, J. R., & Singer, J. P. (2022) · Current Transplantation Reports · doi:10.1007/s40472-022-00365-2 · Cited by 11 · see citing works
Exploring senescence markers as potential drivers of osteoarthritis pain in aging adults
Abbas, M., Cruz, C. J., Tamargo, J. A., Lipat, A. L., Fareed, R., Deaton, L., Gordon, C., Johnson, A. J., Sharma, B., Leeuwenburgh, C., et al. (2025) · Experimental Gerontology · doi:10.1016/j.exger.2025.112950 · Cited by 12 · see citing works
Hung, Y., Sato, A., Takino, Y., Ishigami, A., & Machida, S. (2024) · GeroScience · doi:10.1007/s11357-024-01338-2 · Cited by 10 · see citing works
Ruple, B. A., Mattingly, M. L., Godwin, J. S., McIntosh, M. C., Kontos, N. J., Agyin-Birikorang, A., Michel, J. M., Plotkin, D. L., Chen, S., Ziegenfuss, T. N., et al. (2024) · The FASEB Journal · doi:10.1096/fj.202302103rrr · Cited by 9 · see citing works
The shades of grey in adipose tissue reprogramming
Qi, Y., & Hui, X. H. (2022) · Bioscience Reports · doi:10.1042/bsr20212358 · Cited by 9 · see citing works
Shaver, A. L., Noyes, K., Platek, M. E., Singh, A. K., Erickson, K. R., Wendel, E., Wilding, G. E., Ochs‐Balcom, H. M., & Ray, A. D. (2022) · Supportive Care in Cancer · doi:10.1007/s00520-022-06808-x · Cited by 8 · see citing works
Goodenough, C. G., Wogksch, M. D., Kundu, M., Lear, M., Thomas, P. G., Srivastava, D. K., Wang, Z., Armstrong, G. T., Hudson, M. M., Robison, L. L., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1014661 · Cited by 8 · see citing works
Zamora, Z., Lui, L., Sparks, L. M., Justice, J. N., Lyles, M. F., Gentle, L., Gregory, H., Yeo, R. X., Kershaw, E. E., Stefanović-Račić, M., et al. (2024) · GeroScience · doi:10.1007/s11357-024-01087-2 · Cited by 7 · see citing works
Self-citationWu, J., Cheng, I.-S., Saovieng, S., Jean, W., Kao, C., Liu, Y.-Y., Huang, C., Lee, T. X. Y., Ivy, J. L., & Kuo, C. (2020) · Aging · doi:10.18632/aging.103763 · Cited by 6 · see citing works
Senescence as a therapeutic target
Meyer, K. R., Lopez-Dominguez, J. A., Maus, M., Kovatcheva, M., & Serrano, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822514-1.00014-6 · Cited by 5 · see citing works
Casso-Chapa, B., González, N. A. V., Le, N., Palaskas, N. L., Nead, K. T., Eutsey, L. P., Samanthapudi, V. S. K., Osborn, A. M., Lee, J., Mejia, G. F., et al. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.319870 · Cited by 5 · see citing works
Self-citationPaneni, V., Gambelunghe, C., Tomassini, L., Buresti, G., Rondinone, B. M., Persechino, B., Fruttini, D., Dell’Omo, M., Pucci, C., & Gambelunghe, A. (2025) · Healthcare · doi:10.3390/healthcare13070702 · Cited by 6 · see citing works
Senolytic Phytocompounds in Redox Signaling
Thirumurugan, K. (2021) · Healthy ageing and longevity · doi:10.1007/978-3-030-84965-8_12 · Cited by 3 · see citing works
A single nuclei atlas of aging human abdominal subcutaneous white adipose tissuePreprint
Sparks, L. M., Whytock, K. L., Divoux, A., Sun, Y., Pino, M., Yu, G., Smith, S. R., & Walsh, M. J. (2023) · Research Square · doi:10.21203/rs.3.rs-3097605/v1 · Cited by 3 · see citing works
- Authors
- Justice, J. N., Gregory, H., Tchkonia, T., LeBrasseur, N. K., Kirkland, J. L., Kritchevsky, S. B., & Nicklas, B. J.
- Affiliations
- Wake Forest University Health Sciences (US)
- Mayo Clinic (US)
- Corresponding author
- Justice, Jamie N
- ORCID
- Venue
- The Journals of Gerontology: Series A
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-06-27
- Volume
- 73
- Issue
- 7
- Pages
- 939-945
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- PMC
- PMC6001887
- OpenAlex
- W2731074566
- Cited by
- 129
- References
- 35
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 8 · 2023: 11 · 2022: 21 · 2021: 22 · 2020: 23 · 2019: 11 · 2018: 9
- FWCI
- 8.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wake Forest Claude D. Pepper Older Americans Independence Center (P30-AG21332)
- National Institutes of Health (R01AG020583 [BJN], T32-AG33534 [SKB, BJN; JNJ trainee], AG52958 [NKL], R37AG13925 [JLK])
- Noaber and Glenn Foundations
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- cellular senescence, p16INK4a, senescence biomarkers, physical function, older women, resistance training, caloric restriction, frailty, grip strength, walking speed, mobility (physical function), obesity, aging
- MeSH terms
- Frailty, Physical Functional Performance, Adipose Tissue, Aged, Aging, Cross-Sectional Studies, Female, Humans, Obesity, Thigh, Biomarkers, Body Mass Index, Frail Elderly, Cellular Senescence, Cyclin-Dependent Kinase Inhibitor p16, Caloric Restriction, Adiposity, Overweight, Resistance Training
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
