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Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2

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Activated H-ras Rescues E1A-Induced Apoptosis and Cooperates with E1A To Overcome p53-Dependent Growth Arrest

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MDM2, MDMX and p53 in oncogenesis and cancer therapy

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MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin

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MDMX: from bench to bedside

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Identification and Characterization of the First Small Molecule Inhibitor of MDMX

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Levels of HdmX expression dictate the sensitivity of normal and transformed cells to Nutlin-3

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The role of ubiquitin modification in the regulation of p53

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MDMX regulation of p53 response to ribosomal stress

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DNA Damage-Induced Phosphorylation of MdmX at Serine 367 Activates p53 by Targeting MdmX for Mdm2-Dependent Degradation

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Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3

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Potential for treatment of liposarcomas with the MDM2 antagonist Nutlin-3A

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Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation

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Haploinsufficiency of <i>Mdm2</i> and <i>Mdm4</i> in Tumorigenesis and Development

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A Small-Molecule Inhibitor of MDMX Activates p53 and Induces Apoptosis

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MdmX is a substrate for the deubiquitinating enzyme USP2a

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Small-molecule MDM2/X inhibitors and PROTAC degraders for cancer therapy: advances and perspectives

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Validation of MdmX as a therapeutic target for reactivating p53 in tumors

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Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4

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Regulation of MDMX Expression by Mitogenic Signaling

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Phosphorylation of MDMX Mediated by Akt Leads to Stabilization and Induces 14-3-3 Binding

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The regulation of MDM2 by multisite phosphorylation—opportunities for molecular-based intervention to target tumours?

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Nutlin-3a Is a Potential Therapeutic for Ewing Sarcoma

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Mdmx promotes genomic instability independent of p53 and Mdm2

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Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death

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c-Abl Phosphorylates Hdmx and Regulates Its Interaction with p53

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Phosphorylation and Degradation of MdmX Is Inhibited by Wip1 Phosphatase in the DNA Damage Response

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Identification of an Aberrantly Spliced Form of HDMX in Human Tumors: A New Mechanism for HDM2 Stabilization

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MdmX Promotes Bipolar Mitosis To Suppress Transformation and Tumorigenesis in p53-Deficient Cells and Mice

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HDMX-L Is Expressed from a Functional p53-responsive Promoter in the First Intron of the HDMX Gene and Participates in an Autoregulatory Feedback Loop to Control p53 Activity

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Secondary interaction between MDMX and p53 core domain inhibits p53 DNA binding.

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Role of Mdm4 in drug sensitivity of breast cancer cells

Lam, S., Lodder, K., Teunisse, A. F. A. S., Rabelink, M. J. W. E., Schutte, M., & Jochemsen, A. G. (2010) · Oncogene · doi:10.1038/onc.2009.522 · Cited by 52 · see citing works

BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death

Wade, M., Rodewald, L. W., Espinosa, J. M., & Wahl, G. M. (2008) · Cell Cycle · doi:10.4161/cc.7.13.6072 · Cited by 48 · see citing works

Full-length hdmX transcripts decrease following genotoxic stress

Markey, M., & Berberich, S. J. (2008) · Oncogene · doi:10.1038/onc.2008.266 · Cited by 38 · see citing works

Widespread Overexpression of Epitope-Tagged Mdm4 Does Not Accelerate Tumor Formation <i>In Vi</i><i>vo</i>

De Clercq, S., Gembarska, A., Denecker, G., Maetens, M., Naessens, M., Haigh, K., Haigh, J. J., & Marine, J.-C. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00330-10 · Cited by 35 · see citing works

Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2

Ohtsubo, C., Shiokawa, D., Kodama, M., Gaiddon, C., Nakagama, H., Jochemsen, A. G., Taya, Y., & Okamoto, K. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01180.x · Cited by 32 · see citing works

Abnormal MDMX degradation in tumor cells due to ARF deficiency

Li, X., Gilkes, D., Li, B., Cheng, Q., Pernazza, D., Lawrence, H., Lawrence, N., & Chen, J. (2012) · Oncogene · doi:10.1038/onc.2011.534 · Cited by 32 · see citing works

<scp>TP</scp>53 pathway analysis in paediatric <scp>B</scp>urkitt lymphoma reveals increased <i><scp>MDM</scp>4</i> expression as the only <scp>TP</scp>53 pathway abnormality detected in a subset of cases

Leventaki, V., Rodic, V., Tripp, S. R., Bayerl, M. G., Perkins, S. L., Barnette, P., Schiffman, J. D., & Miles, R. R. (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2012.09243.x · Cited by 26 · see citing works

Affinity-based screening of MDM2/MDMX–p53 interaction inhibitors by chemical array: Identification of novel peptidic inhibitors

Noguchi, T., Oishi, S., Honda, K., Kondoh, Y., Saito, T., Kubo, T., Kaneda, M., Ohno, H., Osada, H., & Fujii, N. (2013) · Bioorganic &amp; Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.04.094 · Cited by 24 · see citing works

Oncogenic functions of hMDMX in in vitro transformation of primary human fibroblasts and embryonic retinoblasts

Lenos, K., de Lange, J., Teunisse, A. F., Lodder, K., Verlaan-de Vries, M., Wiercinska, E., van der Burg, M. J., Szuhai, K., & Jochemsen, A. G. (2011) · Molecular Cancer · doi:10.1186/1476-4598-10-111 · Cited by 16 · see citing works

Inhibitors of MDM2 and MDMX: A Structural Perspective

Riedinger, C., & McDonnell, J. M. (2009) · Future Medicinal Chemistry · doi:10.4155/fmc.09.75 · Cited by 32 · see citing works

Sprouty4 is required for Mdm2 regulation of invasion, focal adhesion formation and metastasis in cells lacking p53Preprint

de Queiroz, R. M., Efe, G., Guzman, A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.08.539890

New insight into the role of MDMX in MDM2-mediated p53 degradation and anti-cancer drug development

Yang, J., & Zhang, Y. (2021) · Oncoscience · doi:10.18632/oncoscience.542

Elevated MDM2 boosts the apoptotic activity of p53-MDM2 binding inhibitors by facilitating MDMX degradation

Xia, M., Knezevic, D., Tovar, C., Huang, B., Heimbrook, D. C., & Vassilev, L. T. (2008) · Cell Cycle · doi:10.4161/cc.7.11.5929 · Cited by 75 · see citing works

MYCN and the p53-MDM2/MDMX-p14ARF network in neuroblastoma amd response to MDM2-p53 antagonists

Gamble, L. D. (2012) · OpenGrey (Institut de l'Information Scientifique et Technique)