Knapp, Stefan

Selective inhibition of BET bromodomains

Filippakopoulos, P., Qi, J., Picaud, S., Shen, Y., Smith, W. B., Fedorov, O., Morse, E. M., Keates, T., Hickman, T. T., Felletar, I., et al. (2010) · Nature

Protein Degradation and InhibitorsChromatin Remodeling and Cancer

Cited by 4,262

The promise and peril of chemical probes

Arrowsmith, C. H., Audia, J. E., Austin, C., Baell, J., Bennett, J., Blagg, J., Bountra, C., Brennan, P. E., Brown, P. J., Bunnage, M. E., et al. (2015) · Nature Chemical Biology

Click Chemistry and ApplicationsComputational Drug Discovery Methods

Cited by 839

Critical Residues for Structure and Catalysis in Short-chain Dehydrogenases/Reductases

Filling, C., Berndt, K. D., Benach, J., Knapp, S., Prozorovski, T., Nordling, E., Ladenstein, R., Jörnvall, H., & Oppermann, U. (2002) · Journal of Biological Chemistry

Enzyme Structure and FunctionProtein Structure and Dynamics

Cited by 583

Accurate calculation of the absolute free energy of binding for drug molecules

Aldeghi, M., Heifetz, A., Bodkin, M. J., Knapp, S., & Biggin, P. C. (2016) · Chemical Science

Computational Drug Discovery MethodsProtein Degradation and Inhibitors

Cited by 347

Comprehensive characterization of the Published Kinase Inhibitor Set

Elkins, J. M., Fedele, V., Szklarz, M., Abdul Azeez, K. R., Salah, E., Mikolajczyk, J., Romanov, S., Sepetov, N., Huang, X.-P., Roth, B. L., et al. (2016) · Nature Biotechnology

Computational Drug Discovery MethodsProtein Kinase Regulation and GTPase Signaling

Cited by 323

Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases

Canning, P., Cooper, C. D. O., Krojer, T., Murray, J. W., Pike, A. C. W., Chaikuad, A., Keates, T., Thangaratnarajah, C., Hojzan, V., Marsden, B. D., et al. (2013) · Journal of Biological Chemistry

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

Cited by 284

Structure of the CaMKIIδ/Calmodulin Complex Reveals the Molecular Mechanism of CaMKII Kinase Activation

Rellos, P., Pike, A. C. W., Niesen, F. H., Salah, E., Lee, W. H., von Delft, F., & Knapp, S. (2010) · PLoS Biology

Protein Kinase Regulation and GTPase SignalingNeuroscience and Neuropharmacology Research

Cited by 279

Predictions of Ligand Selectivity from Absolute Binding Free Energy Calculations

Aldeghi, M., Heifetz, A., Bodkin, M. J., Knapp, S., & Biggin, P. C. (2017) · Journal of the American Chemical Society

Computational Drug Discovery MethodsProtein Degradation and Inhibitors

Cited by 177

Chemoproteomics and Chemical Probes for Target Discovery

Drewes, G., & Knapp, S. (2018) · Trends in Biotechnology

Click Chemistry and ApplicationsAdvanced Proteomics Techniques and Applications

Cited by 132

Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses

Farin, H. F., Mosa, M. H., Ndreshkjana, B., Grebbin, B. M., Ritter, B., Menche, C., Kennel, K. B., Ziegler, P. K., Szabó, L., Bollrath, J., et al. (2023) · Cancer Discovery

Cancer Cells and MetastasisColorectal Cancer Treatments and Studies

Cited by 120

PROTAC degraders as chemical probes for studying target biology and target validation

Němec, V., Schwalm, M. P., Müller, S., & Knapp, S. (2022) · Chemical Society Reviews

Protein Degradation and InhibitorsChemical Synthesis and Analysis

Cited by 98

Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors

Richters, A., Doyle, S. K., Freeman, D. B., Lee, C., Leifer, B. S., Jagannathan, S., Kabinger, F., Koren, J. V., Struntz, N. B., Urgiles, J., et al. (2021) · Cell Chemical Biology

Prostate Cancer Treatment and ResearchProtein Degradation and Inhibitors

Cited by 86

A Specific and Covalent JNK‐1 Ligand Selected from an Encoded Self‐Assembling Chemical Library

Zimmermann, G., Rieder, U., Bajic, D., Vanetti, S., Chaikuad, A., Knapp, S., Scheuermann, J., Mattarella, M., & Neri, D. (2017) · Chemistry – A European Journal

Chemical Synthesis and AnalysisClick Chemistry and Applications

Cited by 77

DNA topoisomerase inhibition with the HIF inhibitor acriflavine promotes transcription of lncRNAs in endothelial cells

Seredinski, S., Boos, F., Günther, S., Oo, J. A., Warwick, T., Izquierdo Ponce, J., Lillich, F. F., Proschak, E., Knapp, S., Gilsbach, R., et al. (2022) · Molecular Therapy Nucleic Acids

Cancer therapeutics and mechanismsCancer-related molecular mechanisms research

Cited by 21

Structure of LRRK1 and mechanisms of autoinhibition and activation

Reimer, J. M., Dickey, A. M., Lin, Y. X., Abrisch, R. G., Mathea, S., Chatterjee, D., Fay, E. J., Knapp, S., Daugherty, M. D., Reck-Peterson, S. L., et al. (2022) · Nature Structural & Molecular Biology

Protein Kinase Regulation and GTPase SignalingParkinson's Disease Mechanisms and Treatments

Cited by 15

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain

Malik, A. U., Karapetsas, A., Nirujogi, R. S., Chatterjee, D., Phung, T. K., Wightman, M., Gourlay, R., Morrice, N., Mathea, S., Knapp, S., et al. (2022) · Biochemical Journal

Protein Kinase Regulation and GTPase SignalingParkinson's Disease Mechanisms and Treatments

Cited by 13

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the COR B GTPase domain

Malik, A. U., Karapetsas, A., Nirujogi, R. S., Chatterjee, D., Phung, T. K., Wightman, M., Gourlay, R., Morrice, N., Mathea, S., Knapp, S., et al. (2022) · Biochemical Journal

Protein Kinase Regulation and GTPase SignalingParkinson's Disease Mechanisms and Treatments

Cited by 13

Development of LRRK2 designed ankyrin-repeat proteins

Dederer, V., Murillo, M. S., Karasmanis, E. P., Hatch, K. S., Chatterjee, D., Preuss, F., Abdul Azeez, K. R., Nguyen, L. V., Galicia, C., Dreier, B., et al. (2023) · Journal of Biological Chemistry

Parkinson's Disease Mechanisms and TreatmentsProtein Kinase Regulation and GTPase Signaling

Cited by 5