Schaffer, David V.

AAV Ancestral Reconstruction Library Enables Selection of Broadly Infectious Viral Variants

Santiago-Ortiz, J., Ojala, D. S., Westesson, O., Weinstein, J. R., Wong, S. Y., Steinsapir, A., Kumar, S., Holmes, I., & Schaffer, D. V. (2015) · Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 83

Changes in adeno-associated virus-mediated gene delivery in retinal degeneration

Kolstad, K. D., Dalkara, D., Guerin, K., Visel, M., Hoffmann, N., Schaffer, D. V., & Flannery, J. G. (2010) · Human Gene Therapy

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 63

Optimal trade-off control in machine learning–based library design, with application to adeno-associated virus (AAV) for gene therapy

Zhu, D., Brookes, D. H., Busia, A., Carneiro, A., Fannjiang, C., Popova, G., Shin, D., Donohue, K. C., Lin, L. F., Miller, Z. M., et al. (2024) · Science Advances

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 63

Adeno-Associated Virus Vector for Central Nervous System Gene Therapy

Zhu, D., Schieferecke, A. J., Lopez, P. A., & Schaffer, D. V. (2021) · Trends in Molecular Medicine

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 56

Imaging light responses of foveal ganglion cells in the living macaque eye

Yin, L., Masella, B., Dalkara, D., Zhang, J., Flannery, J. G., Schaffer, D. V., Williams, D. R., & Merigan, W. H. (2014) · The Journal of Neuroscience

Retinal Development and DisordersVisual perception and processing mechanisms

Cited by 54

AAV‐mediated gene delivery in Dp71‐null mouse model with compromised barriers

Vacca, O., Darche, M., Schaffer, D. V., Flannery, J. G., Sahel, J., Rendon, A., & Dalkara, D. (2014) · Glia

Retinal Development and DisordersVirus-based gene therapy research

Cited by 48

The Spectrin-Actin-Based Periodic Cytoskeleton as a Conserved Nanoscale Scaffold and Ruler of the Neural Stem Cell Lineage

Hauser, M., Yan, R., Li, W., Repina, N. A., Schaffer, D. V., & Xu, K. (2018) · Cell Reports

Cellular Mechanics and InteractionsNeurogenesis and neuroplasticity mechanisms

Cited by 42

Library Selection and Directed Evolution Approaches to Engineering Targeted Viral Vectors

Jang, J., Lim, K., & Schaffer, D. V. (2007) · Biotechnology and Bioengineering

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 26

Design and Characterization of a Novel Intravitreal Dual-Transgene Genetic Medicine for Neovascular Retinopathies

Calton, M. A., Croze, R. H., Burns, C., Beliakoff, G., Vazin, T., Szymanski, P., Schmitt, C., Klein, A., Leong, M., Quezada, M., et al. (2024) · Investigative Ophthalmology & Visual Science

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 21

Directed Evolution of AAV Targeting Primate Retina by Intravitreal Injection Identifies R100, a Variant Demonstrating Robust Gene Delivery and Therapeutic Efficacy in Non-Human Primates

Kotterman, M., Beliakoff, G., Croze, R., Vazin, T., Schmitt, C., Szymanski, P., Leong, M., Quezada, M., Holt, J., Barglow, K., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory)

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 20