Schaffer, David V.

Engineering adeno-associated viruses for clinical gene therapy

Kotterman, M. A., & Schaffer, D. V. (2014) · Nature Reviews Genetics

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 761

In Vivo–Directed Evolution of a New Adeno-Associated Virus for Therapeutic Outer Retinal Gene Delivery from the Vitreous

Dalkara, D., Byrne, L. C., Klimczak, R. R., Visel, M., Yin, L., Merigan, W. H., Flannery, J. G., & Schaffer, D. V. (2013) · Science Translational Medicine

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 734

Directed evolution of adeno-associated virus yields enhanced gene delivery vectors

Maheshri, N., Koerber, J. T., Kaspar, B. K., & Schaffer, D. V. (2006) · Nature Biotechnology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 538

PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation

Peltier, J., O'Neill, A., & Schaffer, D. V. (2007) · Developmental Neurobiology

Neurogenesis and neuroplasticity mechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 443

Inner limiting membrane barriers to aav-mediated retinal transduction from the vitreous

Dalkara, D., Kolstad, K. D., Caporale, N., Visel, M., Klimczak, R. R., Schaffer, D. V., & Flannery, J. G. (2009) · Molecular Therapy

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 357

Quantitative Magnetic Particle Imaging Monitors the Transplantation, Biodistribution, and Clearance of Stem Cells In Vivo

Zheng, B., von See, M. P., Yu, E., Gunel, B., Lu, K., Vazin, T., Schaffer, D. V., Goodwill, P. W., & Conolly, S. M. (2016) · Theranostics

Characterization and Applications of Magnetic NanoparticlesMesenchymal stem cell research

Cited by 322

The delivery challenge: fulfilling the promise of therapeutic genome editing

van Haasteren, J., Li, J., Scheideler, O. J., Murthy, N., & Schaffer, D. V. (2020) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 285

Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast

Zheng, B., Vazin, T., Goodwill, P. W., Conway, A., Verma, A., Ulku Saritas, E., Schaffer, D., & Conolly, S. M. (2015) · Scientific Reports

Characterization and Applications of Magnetic NanoparticlesAdvanced MRI Techniques and Applications

Cited by 274

Relative roles of TGF‐β1 and Wnt in the systemic regulation and aging of satellite cell responses

Carlson, M. E., Conboy, M. J., Hsu, M., Barchas, L., Jeong, J., Agrawal, A., Mikels, A. J., Agrawal, S., Schaffer, D. V., & Conboy, I. M. (2009) · Aging Cell

Muscle Physiology and DisordersTGF-β signaling in diseases

Cited by 244

Designing synthetic materials to control stem cell phenotype

Saha, K., Pollock, J. F., Schaffer, D. V., & Healy, K. E. (2007) · Current Opinion in Chemical Biology

Cellular Mechanics and InteractionsTissue Engineering and Regenerative Medicine

Cited by 219

Intravitreal injection of AAV2 transduces macaque inner retina

Yin, L., Greenberg, K., Hunter, J. J., Dalkara, D., Kolstad, K. D., Masella, B. D., Wolfe, R., Visel, M., Stone, D., Libby, R. T., et al. (2011) · Investigative Opthalmology & Visual Science

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 212

A Novel Adeno-Associated Viral Variant for Efficient and Selective Intravitreal Transduction of Rat Müller Cells

Klimczak, R. R., Koerber, J. T., Dalkara, D., Flannery, J. G., & Schaffer, D. V. (2009) · PLoS ONE

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 210

In vivo genome editing improves motor function and extends survival in a mouse model of ALS

Gaj, T., Ojala, D. S., Ekman, F. K., Byrne, L. C., Limsirichai, P., & Schaffer, D. V. (2017) · Science Advances

Amyotrophic Lateral Sclerosis ResearchCRISPR and Genetic Engineering

Cited by 185

Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes

Hester, M. E., Murtha, M. J., Song, S., Rao, M., Miranda, C. J., Meyer, K., Tian, J., Boulting, G., Schaffer, D. V., Zhu, M. X., et al. (2011) · Molecular Therapy

Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 183

Molecular evolution of adeno-associated virus for enhanced glial gene delivery

Koerber, J. T., Klimczak, R., Jang, J.-H., Dalkara, D., Flannery, J. G., & Schaffer, D. V. (2009) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 181

DNA Shuffling of Adeno-associated Virus Yields Functionally Diverse Viral Progeny

Koerber, J. T., Jang, J.-H., & Schaffer, D. V. (2008) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 181

PEG conjugation moderately protects adeno‐associated viral vectors against antibody neutralization

Lee, G. K., Maheshri, N., Kaspar, B., & Schaffer, D. V. (2005) · Biotechnology and Bioengineering

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 169

Antibody neutralization poses a barrier to intravitreal adeno-associated viral vector gene delivery to non-human primates

Kotterman, M. A., Yin, L., Strazzeri, J. M., Flannery, J. G., Merigan, W. H., & Schaffer, D. V. (2015) · Gene Therapy

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 169

Directed evolution of adeno-associated virus for enhanced gene delivery and gene targeting in human pluripotent stem cells

Asuri, P., Bartel, M. A., Vazin, T., Jang, J.-H., Wong, T. B., & Schaffer, D. V. (2012) · Molecular Therapy

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 119

Thermoreversible Hyaluronic Acid‐PNIPAAm Hydrogel Systems for 3D Stem Cell Culture

Ekerdt, B. L., Fuentes, C. M., Lei, Y., Adil, M. M., Ramasubramanian, A., Segalman, R. A., & Schaffer, D. V. (2018) · Advanced Healthcare Materials

Hydrogels: synthesis, properties, applicationsPluripotent Stem Cells Research

Cited by 117

In vivo–directed evolution of adeno-associated virus in the primate retina

Byrne, L. C., Day, T. P., Visel, M., Strazzeri, J. A., Fortuny, C., Dalkara, D., Merigan, W. H., Schaffer, D. V., & Flannery, J. G. (2020) · JCI Insight

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 104

In vivo selection of a computationally designed SCHEMA AAV library yields a novel variant for infection of adult neural stem cells in the SVZ

Ojala, D. S., Sun, S., Santiago-Ortiz, J. L., Shapiro, M. G., Romero, P. A., & Schaffer, D. V. (2018) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 97

Retinoschisin gene therapy in photoreceptors, Müller glia or all retinal cells in the Rs1h−/− mouse

Byrne, L. C., Öztürk, B. E., Lee, T., Fortuny, C., Visel, M., Dalkara, D., Schaffer, D. V., & Flannery, J. G. (2014) · Gene Therapy

Retinal Development and DisordersVirus-based gene therapy research

Cited by 96

Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery

Gaj, T., Staahl, B. T., Rodrigues, G. M. C., Limsirichai, P., Ekman, F. K., Doudna, J. A., & Schaffer, D. V. (2017) · Nucleic Acids Research

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 89