Sagare, Abhay P.

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2018) · Nature Reviews Neurology

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 3,076

Blood-brain barrier breakdown in the aging human hippocampus

Montagne, A., Barnes, S. R., Sweeney, M. D., Halliday, M. R., Sagare, A. P., Zhao, Z., Toga, A. W., Jacobs, R. E., Liu, C. Y., Amezcua, L., et al. (2015) · Neuron

Barrier Structure and Function StudiesCerebrospinal fluid and hydrocephalus

Cited by 2,102

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

Nation, D. A., Sweeney, M. D., Montagne, A., Sagare, A. P., D’Orazio, L. M., Pachicano, M., Sepehrband, F., Nelson, A. R., Buennagel, D. P., Harrington, M. G., et al. (2019) · Nature Medicine

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 1,728

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

Bell, R. D., Winkler, E. A., Sagare, A. P., Singh, I., LaRue, B., Deane, R., & Zlokovic, B. V. (2010) · Neuron

Barrier Structure and Function StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 1,448

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

Bell, R. D., Winkler, E. A., Singh, I., Sagare, A. P., Deane, R., Wu, Z., Holtzman, D. M., Betsholtz, C., Armulik, A., Sallstrom, J., et al. (2012) · Nature

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 1,293

APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

Montagne, A., Nation, D. A., Sagare, A. P., Barisano, G., Sweeney, M. D., Chakhoyan, A., Pachicano, M., Joe, E., Nelson, A. R., D’Orazio, L. M., et al. (2020) · Nature

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 1,281

LRP/Amyloid β-Peptide Interaction Mediates Differential Brain Efflux of Aβ Isoforms

Deane, R., Wu, Z., Sagare, A., Davis, J., Du Yan, S., Hamm, K., Xu, F., Parisi, M., LaRue, B., Hu, H. W., et al. (2004) · Neuron

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 828

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

Deane, R., Sagare, A., Hamm, K., Parisi, M., Lane, S., Finn, M. B., Holtzman, D. M., & Zlokovic, B. V. (2008) · Journal of Clinical Investigation

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 771

Vascular dysfunction—The disregarded partner of Alzheimer's disease

Sweeney, M. D., Montagne, A., Sagare, A. P., Nation, D. A., Schneider, L. S., Chui, H. C., Harrington, M. G., Pa, J., Law, M., Wang, D. J. J., et al. (2019) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and Treatments

Cited by 711

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

Winkler, E. A., Nishida, Y., Sagare, A. P., Rege, S. V., Bell, R. D., Perlmutter, D., Sengillo, J. D., Hillman, S., Kong, P., Nelson, A. R., et al. (2015) · Nature Neuroscience

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 689

Transport Pathways for Clearance of Human Alzheimer's Amyloid β-Peptide and Apolipoproteins E and J in the Mouse Central Nervous System

Bell, R. D., Sagare, A. P., Friedman, A. E., Bedi, G. S., Holtzman, D. M., Deane, R., & Zlokovic, B. V. (2007) · Journal of Cerebral Blood Flow & Metabolism

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 670

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

Deane, R., Singh, I., Sagare, A. P., Bell, R. D., Ross, N. T., LaRue, B., Love, R., Perry, S., Paquette, N., Deane, R. J., et al. (2012) · Journal of Clinical Investigation

Alzheimer's disease research and treatmentsAdvanced Glycation End Products research

Cited by 619

RETRACTED ARTICLE: Pericyte loss influences Alzheimer-like neurodegeneration in mice

Sagare, A. P., Bell, R. D., Zhao, Z., Ma, Q., Winkler, E. A., Ramanathan, A., & Zlokovic, B. V. (2013) · Nature Communications

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 589

Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease

Nelson, A. R., Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 559

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

Zhong, Z., Deane, R., Ali, Z., Parisi, M., Shapovalov, Y., O'Banion, M. K., Stojanovic, K., Sagare, A., Boillee, S., Cleveland, D. W., et al. (2008) · Nature Neuroscience

Amyotrophic Lateral Sclerosis ResearchBarrier Structure and Function Studies

Cited by 476

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

Zhao, Z., Sagare, A. P., Ma, Q., Halliday, M. R., Kong, P., Kisler, K., Winkler, E. A., Ramanathan, A., Kanekiyo, T., Bu, G., et al. (2015) · Nature Neuroscience

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 410

RETRACTED ARTICLE: Pericyte degeneration causes white matter dysfunction in the mouse central nervous system

Montagne, A., Nikolakopoulou, A. M., Zhao, Z., Sagare, A. P., Si, G., Lazic, D., Barnes, S. R., Daianu, M., Ramanathan, A., Go, A., et al. (2018) · Nature Medicine

Cerebrovascular and genetic disordersBarrier Structure and Function Studies

Cited by 344

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism

Ma, Q., Zhao, Z., Sagare, A. P., Wu, Y., Wang, M., Owens, N. C., Verghese, P. B., Herz, J., Holtzman, D. M., & Zlokovic, B. V. (2018) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 281

Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease

Wu, Z., Guo, H., Chow, N., Sallstrom, J., Bell, R. D., Deane, R., Brooks, A. I., Kanagala, S., Rubio, A., Sagare, A., et al. (2005) · Nature Medicine

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 280

SRF and myocardin regulate LRP-mediated amyloid-β clearance in brain vascular cells

Bell, R. D., Deane, R., Chow, N., Long, X., Sagare, A., Singh, I., Streb, J. W., Guo, H., Rubio, A., Van Nostrand, W., et al. (2009) · Nature Cell Biology

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 261

Low‐density lipoprotein receptor‐related protein‐1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β‐peptide elimination from the brain

Zlokovic, B. V., Deane, R., Sagare, A. P., Bell, R. D., & Winkler, E. A. (2010) · Journal of Neurochemistry

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 261

Neurovascular Dysfunction and Faulty Amyloid -Peptide Clearance in Alzheimer Disease

Sagare, A. P., Bell, R. D., & Zlokovic, B. V. (2012) · Cold Spring Harbor Perspectives in Medicine

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 251

Blood–spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice

Winkler, E. A., Sengillo, J. D., Sagare, A. P., Zhao, Z., Ma, Q., Zuniga, E., Wang, Y., Zhong, Z., Sullivan, J. S., Griffin, J. H., et al. (2014) · Proceedings of the National Academy of Sciences

Amyotrophic Lateral Sclerosis ResearchBarrier Structure and Function Studies

Cited by 238

Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer’s disease: the role, regulation and restoration of LRP1

Ramanathan, A., Nelson, A. R., Sagare, A. P., & Zlokovic, B. V. (2015) · Frontiers in Aging Neuroscience

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 205