Ouwehand, Willem H.

Common genetic variation drives molecular heterogeneity in human iPSCs

Kilpinen, H., Goncalves, A., Leha, A., Afzal, V., Alasoo, K., Ashford, S., Bala, S., Bensaddek, D., Casale, F. P., Culley, O. J., et al. (2017) · Nature

Pluripotent Stem Cells ResearchGenetic Associations and Epidemiology

Cited by 586

Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis

McKerrell, T., Park, N., Moreno, T., Grove, C. S., Ponstingl, H., Stephens, J., Crawley, C., Craig, J., Scott, M. A., Hodkinson, C., et al. (2015) · Cell Reports

Acute Myeloid Leukemia ResearchCancer Genomics and Diagnostics

Cited by 534

New susceptibility locus for coronary artery disease on chromosome 3q22.3

Italian Atherosclerosis, T., Erdmann, J., Myocardial Infarction Genetics Consortium, Wellcome Trust Case Control Consortium, Cardiogenics Consortium, Großhennig, A., Braund, P. S., König, I. R., Hengstenberg, C., Hall, A. S., et al. (2009) · Nature Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 484

Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders

Study, S. S., Singh, T., Study, I., Study, D., UK10 K Consortium, Kurki, M. I., Curtis, D., Purcell, S. M., Crooks, L., McRae, J., et al. (2016) · Nature Neuroscience

Schizophrenia research and treatmentGenomics and Rare Diseases

Cited by 452

Identification of rare sequence variation underlying heritable pulmonary arterial hypertension

Gräf, S., Haimel, M., Bleda, M., Hadinnapola, C., Southgate, L., Li, W., Hodgson, J., Liu, B., Salmon, R. M., Southwood, M., et al. (2018) · Nature Communications

Pulmonary Hypertension Research and TreatmentsVascular Anomalies and Treatments

Cited by 380

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease

The UK-PSC Consortium, Ji, S.-G., The International IBD Genetics Consortium, The International PSC Study Group, Juran, B. D., Mucha, S., Folseraas, T., Jostins, L., Melum, E., Kumasaka, N., et al. (2017) · Nature Genetics

Liver Diseases and ImmunityGenetic Associations and Epidemiology

Cited by 357

Common variants near TERC are associated with mean telomere length

Wellcome Trust Case Control Consortium, Codd, V., Mangino, M., van der Harst, P., Braund, P. S., Kaiser, M., Beveridge, A. J., Rafelt, S., Moore, J., Nelson, C., et al. (2010) · Nature Genetics

Telomeres, Telomerase, and SenescenceGenetic Associations and Epidemiology

Cited by 344

Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression

Cuomo, A. S. E., Seaton, D. D., McCarthy, D. J., Martinez, I., Bonder, M. J., Garcia-Bernardo, J., Amatya, S., Madrigal, P., Isaacson, A., Buettner, F., et al. (2020) · Nature Communications

Pluripotent Stem Cells ResearchSingle-cell and spatial transcriptomics

Cited by 331

Genetic evidence of assortative mating in humans

Robinson, M. R., Kleinman, A., Graff, M., Vinkhuyzen, A. A. E., Couper, D., Miller, M. B., Peyrot, W. J., Abdellaoui, A., Zietsch, B. P., Nolte, I. M., et al. (2017) · Nature Human Behaviour

Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestock

Cited by 326

Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation

Tsaprouni, L. G., Yang, T.-P., Bell, J., Dick, K. J., Kanoni, S., Nisbet, J., Viñuela, A., Grundberg, E., Nelson, C. P., Meduri, E., et al. (2014) · Epigenetics

Epigenetics and DNA MethylationSmoking Behavior and Cessation

Cited by 319

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

Cardiogenics Consortium, Heinig, M., Petretto, E., Wallace, C., Bottolo, L., Rotival, M., Lu, H., Li, Y., Sarwar, R., Langley, S. R., et al. (2010) · Nature

Diabetes and associated disordersGenetic Associations and Epidemiology

Cited by 283

Inherited Variation in Vitamin D Genes Is Associated With Predisposition to Autoimmune Disease Type 1 Diabetes

Cooper, J. D., Smyth, D. J., Walker, N. M., Stevens, H., Burren, O. S., Wallace, C., Greissl, C., Ramos-Lopez, E., Hyppönen, E., Dunger, D. B., et al. (2011) · Diabetes

Vitamin D Research StudiesDiabetes and associated disorders

Cited by 279

Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

Dendrou, C. A., Plagnol, V., Fung, E., Yang, J. H. M., Downes, K., Cooper, J. D., Nutland, S., Coleman, G., Himsworth, M., Hardy, M., et al. (2009) · Nature Genetics

Genetic Associations and EpidemiologyDiabetes and associated disorders

Cited by 274

Chromosome contacts in activated T cells identify autoimmune disease candidate genes

Burren, O. S., Rubio García, A., Javierre, B.-M., Rainbow, D. B., Cairns, J., Cooper, N. J., Lambourne, J. J., Schofield, E., Castro Dopico, X., Ferreira, R. C., et al. (2017) · Genome Biology

Genomics and Chromatin DynamicsGenetic Associations and Epidemiology

Cited by 80

Mitochondrial DNA variants modulate N-formylmethionine, proteostasis and risk of late-onset human diseases

Cai, N., Gomez-Duran, A., Yonova-Doing, E., Kundu, K., Burgess, A. I., Golder, Z. J., Calabrese, C., Bonder, M. J., Camacho, M., Lawson, R. A., et al. (2021) · Nature Medicine

Mitochondrial Function and PathologyGenetic Associations and Epidemiology

Cited by 73

An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability

Schütte, J., Wang, H., Antoniou, S., Jarratt, A., Wilson, N. K., Riepsaame, J., Calero-Nieto, F. J., Moignard, V., Basilico, S., Kinston, S. J., et al. (2016) · eLife

Gene Regulatory Network AnalysisGenomics and Chromatin Dynamics

Cited by 63

De Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures

Ito, Y., Carss, K. J., Duarte, S. T., Hartley, T., Keren, B., Kurian, M. A., Marey, I., Charles, P., Mendonça, C., Nava, C., et al. (2018) · The American Journal of Human Genetics

Genetics and Neurodevelopmental DisordersGenomics and Rare Diseases

Cited by 41

Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis

Benyamin, B., Esko, T., Ried, J. S., Radhakrishnan, A., Vermeulen, S. H., Traglia, M., Gögele, M., Anderson, D., Broer, L., Podmore, C., et al. (2014) · Nature Communications

Iron Metabolism and DisordersGenetic Associations and Epidemiology

Cited by 30