Harper, Mary-Ellen

Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese

Enerbäck, S., Jacobsson, A., Simpson, E. M., Guerra, C., Yamashita, H., Harper, M.-E., & Kozak, L. P. (1997) · Nature

Adipose Tissue and MetabolismMitochondrial Function and Pathology

Cited by 1,379

Role of Glutathione in Cancer: From Mechanisms to Therapies

Kennedy, L., Sandhu, J. K., Harper, M.-E., & Cuperlovic-Culf, M. (2020) · Biomolecules

Sulfur Compounds in BiologyGlutathione Transferases and Polymorphisms

Cited by 880

SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice

Boily, G., Seifert, E. L., Bevilacqua, L., He, X. H., Sabourin, G., Estey, C., Moffat, C., Crawford, S., Saliba, S., Jardine, K., et al. (2008) · PLoS ONE

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 444

MicroRNA-133 Controls Brown Adipose Determination in Skeletal Muscle Satellite Cells by Targeting Prdm16

Yin, H., Pasut, A., Soleimani, V. D., Bentzinger, C. F., Antoun, G., Thorn, S., Seale, P., Fernando, P., van IJcken, W., Grosveld, F., et al. (2013) · Cell Metabolism

Adipose Tissue and MetabolismMuscle Physiology and Disorders

Cited by 293

Galactose Enhances Oxidative Metabolism and Reveals Mitochondrial Dysfunction in Human Primary Muscle Cells

Aguer, C., Gambarotta, D., Mailloux, R. J., Moffat, C., Dent, R., McPherson, R., & Harper, M.-E. (2011) · PLoS ONE

Mitochondrial Function and PathologyMetabolism, Diabetes, and Cancer

Cited by 276

Physiological Increases in Uncoupling Protein 3 Augment Fatty Acid Oxidation and Decrease Reactive Oxygen Species Production Without Uncoupling Respiration in Muscle Cells

MacLellan, J. D., Gerrits, M. F., Gowing, A., Smith, P. J. S., Wheeler, M. B., & Harper, M.-E. (2005) · Diabetes

Mitochondrial Function and PathologyMetabolism, Diabetes, and Cancer

Cited by 213

Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1α

Scimè, A., Grenier, G., Huh, M. S., Gillespie, M. A., Bevilacqua, L., Harper, M.-E., & Rudnicki, M. A. (2005) · Cell Metabolism

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 199

Thyroid Hormone Effects on Mitochondrial Energetics

Harper, M.-E., & Seifert, E. L. (2008) · Thyroid

Mitochondrial Function and PathologyThyroid Disorders and Treatments

Cited by 194

Macrophage mitochondrial energy status regulates cholesterol efflux and is enhanced by anti-miR33 in atherosclerosis

Karunakaran, D., Thrush, A. B., Nguyen, M.-A., Richards, L., Geoffrion, M., Singaravelu, R., Ramphos, E., Shangari, P., Ouimet, M., Pezacki, J. P., et al. (2015) · Circulation Research

Cholesterol and Lipid MetabolismMicroRNA in disease regulation

Cited by 188

Glutathionylation Acts as a Control Switch for Uncoupling Proteins UCP2 and UCP3

Mailloux, R. J., Seifert, E. L., Bouillaud, F., Aguer, C., Collins, S., & Harper, M.-E. (2011) · Journal of Biological Chemistry

Mitochondrial Function and PathologyRedox biology and oxidative stress

Cited by 174

Long-term caloric restriction increases UCP3 content but decreases proton leak and reactive oxygen species production in rat skeletal muscle mitochondria

Bevilacqua, L., Ramsey, J. J., Hagopian, K., Weindruch, R., & Harper, M.-E. (2005) · American Journal of Physiology-Endocrinology and Metabolism

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 172

DNM1L-related mitochondrial fission defect presenting as refractory epilepsy

Care4Rare Consortium, Vanstone, J. R., Smith, A. M., McBride, S., Naas, T., Holcik, M., Antoun, G., Harper, M.-E., Michaud, J., Sell, E., et al. (2016) · European Journal of Human Genetics

Mitochondrial Function and PathologyMetabolism and Genetic Disorders

Cited by 135

Factors affecting weight loss variability in obesity

Dent, R., McPherson, R., & Harper, M.-E. (2020) · Metabolism

Pharmacology and Obesity TreatmentBariatric Surgery and Outcomes

Cited by 131

Decreased Mitochondrial Proton Leak and Reduced Expression of Uncoupling Protein 3 in Skeletal Muscle of Obese Diet-Resistant Women

Harper, M.-E., Dent, R., Monemdjou, S., Bézaire, V., Van Wyck, L., Wells, G., Kavaslar, G. N., Gauthier, A., Tesson, F., & McPherson, R. (2002) · Diabetes

Adipose Tissue and MetabolismMitochondrial Function and Pathology

Cited by 129

The efficiency of cellular energy transduction and its implications for obesity

Harper, M.-E., Green, K., & Brand, M. D. (2008) · Annual Review of Nutrition

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 121

Impaired mitochondrial oxidative phosphorylation and supercomplex assembly in rectus abdominis muscle of diabetic obese individuals

Antoun, G., McMurray, F., Thrush, A. B., Patten, D. A., Peixoto, A. C., Slack, R. S., McPherson, R., Dent, R., & Harper, M.-E. (2015) · Diabetologia

Mitochondrial Function and PathologyMetabolism, Diabetes, and Cancer

Cited by 112

Essential Role for Uncoupling Protein-3 in Mitochondrial Adaptation to Fasting but Not in Fatty Acid Oxidation or Fatty Acid Anion Export

Seifert, E. L., Bézaire, V., Estey, C., & Harper, M.-E. (2008) · Journal of Biological Chemistry

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 104

Genome-wide identification of circulating-miRNA expression quantitative trait loci reveals the role of several miRNAs in the regulation of cardiometabolic phenotypes

Nikpay, M., Beehler, K., Valsesia, A., Hager, J., Harper, M.-E., Dent, R., & McPherson, R. (2019) · Cardiovascular Research

Genetic Associations and EpidemiologyMicroRNA in disease regulation

Cited by 83

Uncoupling Proteins: Role in Insulin Resistance and Insulin Insufficiency

B.Chan, C., & Harper, M.-E. (2006) · Current Diabetes Reviews

Mitochondrial Function and PathologyMetabolism, Diabetes, and Cancer

Cited by 71

Glutathionylation State of Uncoupling Protein-2 and the Control of Glucose-stimulated Insulin Secretion

Mailloux, R. J., Fu, A., Robson-Doucette, C., Allister, E. M., Wheeler, M. B., Screaton, R., & Harper, M.-E. (2012) · Journal of Biological Chemistry

Pancreatic function and diabetesRedox biology and oxidative stress

Cited by 66

Distinct skeletal muscle fiber characteristics and gene expression in diet-sensitive versus diet-resistant obesity

Gerrits, M. F., Ghosh, S., Kavaslar, N., Hill, B., Tour, A., Seifert, E. L., Beauchamp, B., Gorman, S., Stuart, J., Dent, R., et al. (2010) · Journal of Lipid Research

Muscle Physiology and DisordersAdipose Tissue and Metabolism

Cited by 64

Long-term high-fat feeding induces greater fat storage in mice lacking UCP3

Costford, S. R., Chaudhry, S. N., Crawford, S. A., Salkhordeh, M., & Harper, M.-E. (2008) · American Journal of Physiology-Endocrinology and Metabolism

Adipose Tissue and MetabolismMitochondrial Function and Pathology

Cited by 64

The lifecycle of skeletal muscle mitochondria in obesity

Pileggi, C. A., Parmar, G., & Harper, M. (2021) · Obesity Reviews

Mitochondrial Function and PathologyMuscle Physiology and Disorders

Cited by 61

EFFECTS OF 12 MONTHS OF CALORIC RESTRICTION ON MUSCLE MITOCHONDRIAL FUNCTION IN HEALTHY INDIVIDUALS

Sparks, L. M., Redman, L. M., Conley, K. E., Harper, M.-E., Yi, F., Hodges, A., Eroshkin, A., Costford, S. R., Gabriel, M. E., Shook, C., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 45