Thyroid Hormone Effects on Mitochondrial Energetics

Harper, Mary-Ellen; Seifert, Erin L.

doi:10.1089/thy.2007.0250

Cited by 194Mitochondrial Function and PathologyThyroid Disorders and TreatmentsAdipose Tissue and Metabolism

Thyroid Hormone Effects on Mitochondrial Energetics

Harper, Mary-Ellen, Seifert, Erin L.·2008·Thyroid

DOI 10.1089/thy.2007.0250

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Abstract

Thyroid hormones are the major endocrine regulators of metabolic rate, and their hypermetabolic effects are widely recognized. The cellular mechanisms underlying these metabolic effects have been the subject of much research. Thyroid hormone status has a profound impact on mitochondria, the organelles responsible for the majority of cellular adenosine triphosphate (ATP) production. However, mechanisms are not well understood. We review the effects of thyroid hormones on mitochondrial energetics and principally oxidative phosphorylation. Genomic and nongenomic mechanisms have been studied. Through the former, thyroid hormones stimulate mitochondriogenesis and thereby augment cellular oxidative capacity. Thyroid hormones induce substantial modifications in mitochondrial inner membrane protein and lipid compositions. Results are consistent with the idea that thyroid hormones activate the uncoupling of oxidative phosphorylation through various mechanisms involving inner membrane proteins and lipids. Increased uncoupling appears to be responsible for some of the hypermetabolic effects of thyroid hormones. ATP synthesis and turnover reactions are also affected. There appear to be complex relationships between mitochondrial proton leak mechanisms, reactive oxygen species production, and thyroid status. As the majority of studies have focused on the effects of thyroid status on rat liver preparations, there is still a need to address fundamental questions regarding thyroid hormone effects in other tissues and species.

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Authors: Harper, M.-E., & Seifert, E. L.
Affiliations: University of Ottawa (CA)
ORCID: Harper, Mary-Ellen
Venue: Thyroid
Publisher: SAGE Publications
Published: 2008-02
Volume: 18
Issue: 2
Pages: 145-156
ISSN: 1050-7256 (ISSN-L)
1557-9077
DOI: 10.1089/thy.2007.0250
OpenAlex: W1965505826
Cited by: 194
References: 99
Citations by year: 2026: 10 · 2025: 11 · 2024: 12 · 2023: 12 · 2022: 18 · 2021: 10 · 2020: 19 · 2019: 4 · 2018: 7 · 2017: 8 · 2016: 12 · 2015: 10 · 2014: 7 · 2013: 7 · 2012: 11
FWCI: 4.94
Type: journal article
Language: en
Open access: closed
Licence: www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations: Thyroid (publishedVersion)
PubMed (publishedVersion)
Funders: Natural Sciences and Engineering Research Council of Canada
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords: thyroid hormones, mitochondrial bioenergetics, oxidative phosphorylation, hypermetabolism, uncoupling, mitochondrial biogenesis, mitochondrial inner membrane proteins, mitochondrial lipids, proton leak, reactive oxygen species, ATP production, genomic mechanisms, liver mitochondria
MeSH terms: Adenosine Triphosphate, Animals, Energy Metabolism, Humans, Membrane Lipids, Mitochondria, Oxidative Phosphorylation, Thyroid Hormones, Reactive Oxygen Species, Mitochondrial Membranes, Mice, Rats

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Thyroid Hormone Effects on Mitochondrial Energetics

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