Interactions Between the Intestinal Microbiome and Liver Diseases
Open accessAbstract
The human intestine harbors a diverse community of microbes that promote metabolism and digestion in their symbiotic relationship with the host. Disturbance of its homeostasis can result in disease. We review factors that disrupt intestinal homeostasis and contribute to nonalcoholic fatty liver disease, steatohepatitis, alcoholic liver disease, and cirrhosis. Liver disease has long been associated with qualitative and quantitative (overgrowth) dysbiotic changes in the intestinal microbiota. Extrinsic factors, such as the Western diet and alcohol, contribute to these changes. Dysbiosis results in intestinal inflammation, a breakdown of the intestinal barrier, and translocation of microbial products in animal models. However, the contribution of the intestinal microbiome to liver disease goes beyond simple translocation of bacterial products that promote hepatic injury and inflammation. Microbial metabolites produced in a dysbiotic intestinal environment and host factors are equally important in the pathogenesis of liver disease. We review how the combination of liver insult and disruptions in intestinal homeostasis contribute to liver disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Changes to the composition and function of the microbiome in NASH include altered bile acid metabolism and loss of integrity of the gut-vascular barrier, precipitating leakage of LPS and bacteria into the liver via the portal circulation.
“the impact of changes to the composition and function of the microbiome in NASH include altered bile acid metabolism and loss of integrity of the gut-vascular barrier, precipitating leakage of LPS and bacteria into the liver via the portal circulation (14–16).”
From Hepatic Stellate Cell-Immune Interactions in NASH (2022) · cites this paper as [14]
Changes in gut microbiota (dysbiosis) may play a key role in the pathogenesis of NAFLD/NASH and cholestasis and may impact on BA composition and signalling.
“Changes in gut microbiota (dysbiosis) may play a key role in the pathogenesis of NAFLD/NASH and cholestasis52–54 and may also impact on BA composition and signalling.51 55”
From Novel therapeutic targets for cholestatic and fatty liver disease (2022) · cites this paper as [54]
In chronic liver disease, a failing gut barrier and altered gut microbiota drive chronic inflammation and liver disease progression, which raises the risk of hepatocellular carcinoma.
“However, a failing gut barrier and alterations of the gut microbiota in chronic liver disease (CLD) contribute to chronic inflammation and the progression of liver diseases12, and thereby increase risk for the development of hepatocellular carcinoma (HCC) as the final stage of the disease process 13–15.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [12]
Metagenomic studies have revealed substantial alterations in gut microbiota composition across a range of chronic liver diseases and in patients with cirrhosis.
“Metagenomic studies have revealed substantial alterations in the composition of the gut microbiota in a range of CLD as well as in patients with cirrhosis12,32.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [12]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works
Linking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513 · see citing works
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176 · see citing works
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597 · see citing works
Intestinal mucosal barrier function in health and disease
Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952 · see citing works
Prevalence of Hepatic Steatosis in An Urban Population in the United States: Impact of Ethnicity
Browning, J. D., Szczepaniak, L. S., Dobbins, R., Nuremberg, P., Horton, J. D., Cohen, J. C., Grundy, S. M., & Hobbs, H. H. (2004) · Hepatology · doi:10.1002/hep.20466 · Cited by 3,664 · see citing works
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
Tang, W. H. W., Wang, Z., Levison, B. S., Koeth, R. A., Britt, E. B., Fu, X., Wu, Y., & Hazen, S. L. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1109400 · Cited by 3,402 · see citing works
Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
Bäckhed, F., Manchester, J. K., Semenkovich, C. F., & Gordon, J. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605374104 · Cited by 2,615 · see citing works
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
Henao-Mejia, J., Elinav, E., Jin, C., Hao, L., Mehal, W. Z., Strowig, T., Thaiss, C. A., Kau, A. L., Eisenbarth, S. C., Jurczak, M. J., et al. (2012) · Nature · doi:10.1038/nature10809 · Cited by 2,435 · see citing works
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., et al. (2006) · Nature · doi:10.1038/nature04330 · Cited by 2,220 · see citing works
Williams, C. D., Stengel, J. Z., Asike, M., Torres, D. M., Shaw, J. C., Contreras, M., Landt, C. L., & Harrison, S. A. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.09.038 · Cited by 2,146 · see citing works
TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis
Thomas, C., Gioiello, A., Noriega, L., Strehle, A., Oury, J., Rizzo, G., Macchiarulo, A., Yamamoto, H., Mataki, C., Pruzanski, M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.001 · Cited by 1,885 · see citing works
Zhu, L., Baker, S. S., Gill, C., Liu, W., Alkhouri, R., Baker, R. D., & Gill, S. R. (2013) · Hepatology · doi:10.1002/hep.26093 · Cited by 1,708 · see citing works
Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease
Miele, L., Valenza, V., La Torre, G., Montalto, M., Cammarota, G., Ricci, R., Mascianà, R., Forgione, A., Gabrieli, M. L., Perotti, G., et al. (2009) · Hepatology · doi:10.1002/hep.22848 · Cited by 1,434 · see citing works
Rifaximin Treatment in Hepatic Encephalopathy
Bass, N. M., Mullen, K. D., Sanyal, A., Poordad, F., Neff, G., Leevy, C. B., Sigal, S., Sheikh, M. Y., Beavers, K., Frederick, T., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0907893 · Cited by 1,300 · see citing works
Arvaniti, V., D’Amico, G., Fede, G., Manousou, P., Tsochatzis, E. A., Pleguezuelo, M., & Burroughs, A. K. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.06.019 · Cited by 1,172 · see citing works
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
Inagaki, T., Moschetta, A., Lee, Y.-K., Peng, L., Zhao, G., Downes, M., Yu, R. T., Shelton, J. M., Richardson, J. A., Repa, J. J., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509592103 · Cited by 1,164 · see citing works
Dumas, M.-E., Barton, R. H., Toye, A., Cloarec, O., Blancher, C., Rothwell, A., Fearnside, J., Tatoud, R., Blanc, V., Lindon, J. C., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601056103 · Cited by 1,042 · see citing works
Characterization of fecal microbial communities in patients with liver cirrhosis
Chen, Y., Yang, F., Lu, H., Wang, B., Chen, Y., Lei, D., Wang, Y., Zhu, B., & Li, L. (2011) · Hepatology · doi:10.1002/hep.24423 · Cited by 1,038 · see citing works
Mudaliar, S., Henry, R. R., Sanyal, A. J., Morrow, L., Marschall, H., Kipnes, M., Adorini, L., Sciacca, C. I., Clopton, P., Castelloe, E., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.05.042 · Cited by 931 · see citing works
Wigg, A. J., Roberts-Thomson, I. C., Dymock, R. B., McCarthy, P. J., Grose, R. H., & Cummins, A. G. (2001) · Gut · doi:10.1136/gut.48.2.206 · Cited by 836 · see citing works
Pathological bacterial translocation in liver cirrhosis
Wiest, R., Lawson, M. A., & Geuking, M. B. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.07.044 · Cited by 815 · see citing works
Yang, S. Q., Lin, H. Z., Lane, M. D., Clemens, M. G., & Diehl, A. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2557 · Cited by 808 · see citing works
Enteric dysbiosis associated with a mouse model of alcoholic liver disease
Yan, A. W., Fouts, D. E., Brandl, J., Stärkel, P., Torralba, M., Schott, E., Tsukamoto, H., Nelson, K. E., Brenner, D. A., & Schnabl, B. (2011) · Hepatology · doi:10.1002/hep.24018 · Cited by 791 · see citing works
Self-citationModulation of the fecal bile acid profile by gut microbiota in cirrhosis
Kakiyama, G., Pandak, W. M., Gillevet, P. M., Hylemon, P. B., Heuman, D. M., Daita, K., Takei, H., Muto, A., Nittono, H., Ridlon, J. M., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.01.003 · Cited by 782 · see citing works
Colonic microbiome is altered in alcoholism
Mutlu, E. A., Gillevet, P. M., Rangwala, H., Sikaroodi, M., Naqvi, A., Engen, P. A., Kwasny, M., Lau, C. K., & Keshavarzian, A. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00380.2011 · Cited by 775 · see citing works
Management of Cirrhosis and Ascites
Ginès, P., Cárdenas, A., Arroyo, V., & Rodés, J. (2004) · New England Journal of Medicine · doi:10.1056/nejmra035021 · Cited by 768 · see citing works
Intestinal microbiota in patients with nonalcoholic fatty liver disease
Mouzaki, M., Comelli, E. M., Arendt, B. M., Bonengel, J., Fung, S. K., Fischer, S. E., McGilvray, I. D., & Allard, J. P. (2013) · Hepatology · doi:10.1002/hep.26319 · Cited by 749 · see citing works
Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice
Miura, K., Kodama, Y., Inokuchi, S., Schnabl, B., Aoyama, T., Ohnishi, H., Olefsky, J. M., Brenner, D. A., & Seki, E. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.03.052 · Cited by 741 · see citing works
Self-citationSystemic gut microbial modulation of bile acid metabolism in host tissue compartments
Swann, J. R., Want, E. J., Geier, F. M., Spagou, K., Wilson, I. D., Sidaway, J. E., Nicholson, J. K., & Holmes, E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006734107 · Cited by 726 · see citing works
Ding, S., Chi, M. M., Scull, B. P., Rigby, R., Schwerbrock, N. M. J., Magness, S., Jobin, C., & Lund, P. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012191 · Cited by 713 · see citing works
Rivera, C. A., Adegboyega, P., van Rooijen, N., Tagalicud, A., Allman, M., & Wallace, M. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2007.04.019 · Cited by 693 · see citing works
Antibiotics prevent liver injury in rats following long-term exposure to ethanol
Adachi, Y., Moore, L. E., Bradford, B. U., Gao, W., & Thurman, R. G. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90027-6 · Cited by 692 · see citing works
Raman, M., Ahmed, I., Gillevet, P. M., Probert, C. S., Ratcliffe, N. M., Smith, S., Greenwood, R., Sikaroodi, M., Lam, V., Crotty, P., et al. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.02.015 · Cited by 672 · see citing works
Parlesak, A., Schäfer, C., Schütz, T., Bode, J. C., & Bode, C. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80242-1 · Cited by 647 · see citing works
Spencer, M. D., Hamp, T. J., Reid, R. W., Fischer, L. M., Zeisel, S. H., & Fodor, A. A. (2011) · Gastroenterology · doi:10.1053/j.gastro.2010.11.049 · Cited by 593 · see citing works
Linkage of gut microbiome with cognition in hepatic encephalopathy
Bajaj, J. S., Ridlon, J. M., Hylemon, P. B., Thacker, L. R., Heuman, D. M., Smith, S., Sikaroodi, M., & Gillevet, P. M. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00190.2011 · Cited by 547 · see citing works
Bajaj, J. S., Hylemon, P. B., Ridlon, J. M., Heuman, D. M., Daita, K., White, M. B., Monteith, P., Noble, N. A., Sikaroodi, M., & Gillevet, P. M. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00152.2012 · Cited by 525 · see citing works
Toll–Like Receptor 4 Is Involved in the Mechanism of Early Alcohol–Induced Liver Injury in Mice
Uesugi, T., Froh, M., Arteel, G. E., Bradford, B. U., & Thurman, R. G. (2001) · Hepatology · doi:10.1053/jhep.2001.25350 · Cited by 488 · see citing works
Kirpich, I., Solovieva, N., Leikhter, S., Shidakova, N. A., Lebedeva, O. V., Sidorov, P., Bazhukova, T. A., Soloviev, A., Barve, S., McClain, C., et al. (2008) · Alcohol · doi:10.1016/j.alcohol.2008.08.006 · Cited by 464 · see citing works
Saberi, M., Woods, N.-B., de Luca, C., Schenk, S., Lu, J. C., Bandyopadhyay, G., Verma, I. M., & Olefsky, J. M. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.09.006 · Cited by 456 · see citing works
Lactobacillus Feeding Reduces Endotoxemia and Severity of Experimental Alcoholic Liver (Disease)
Nanji, A. A., Khettry, U., & Sadrzadeh, S. M. H. (1994) · Experimental Biology and Medicine · doi:10.3181/00379727-205-43703 · Cited by 436 · see citing works
Forsyth, C. B., Farhadi, A., Jakate, S. M., Tang, Y., Shaikh, M. W., & Keshavarzian, A. (2009) · Alcohol · doi:10.1016/j.alcohol.2008.12.009 · Cited by 395 · see citing works
Cope, K. A., Risby, T. H., & Diehl, A. M. (2000) · Gastroenterology · doi:10.1053/gast.2000.19267 · Cited by 356 · see citing works
Rao, R. K., Seth, A., & Sheth, P. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00006.2004 · Cited by 340 · see citing works
Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity
Prawitt, J., Abdelkarim, M., Stroeve, J. H. M., Popescu, I. R., Duez, H., Velagapudi, V., Dumont, J., Bouchaert, E., van Dijk, T. H., Lucas, A., et al. (2011) · Diabetes · doi:10.2337/db11-0030 · Cited by 327 · see citing works
Lorenzo-Zúñiga, V., Bartolí, R., Planas, R., Hofmann, A. F., Viñado, B., Hagey, L. R., Hernández, J. M., Mañé, J., Alvarez, M. A., Ausina, V., et al. (2003) · Hepatology · doi:10.1053/jhep.2003.50116 · Cited by 321 · see citing works
Jejunal microflora in patients with chronic alcohol abuse.
Jc, B., Bode, C., Heidelbach, R., Hk, D., & Ga, M. (1984) · PubMed · Cited by 303 · see citing works
Bauer, T., Steinbrückner, B., Brinkmann, F., Ditzen, A. K., Schwacha, H., Aponte, J. J., Pelz, K., Kist, M., & Blum, H. E. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.04668.x · Cited by 266 · see citing works
Chang, C., Chen, G., Lien, H., & Yeh, H. (1998) · Hepatology · doi:10.1002/hep.510280504 · Cited by 261 · see citing works
Bellot, P., Francés, R., & Such, J. M. (2012) · Liver International · doi:10.1111/liv.12021 · Cited by 255 · see citing works
Wang, Y., Kirpich, I., Liu, Y., Ma, Z., Barve, S. S., McClain, C. J., & Feng, W. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.08.039 · Cited by 255 · see citing works
Sabaté, J., Jouët, P., Harnois, F., Mechler, C., Msika, S., Grossin, M., & Coffin, B. (2008) · Obesity Surgery · doi:10.1007/s11695-007-9398-2 · Cited by 251 · see citing works
Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis
Tanaka, N., Matsubara, T., Krausz, K. W., Patterson, A. D., & Gonzalez, F. J. (2012) · Hepatology · doi:10.1002/hep.25630 · Cited by 250 · see citing works
Ferrier, L., Bérard, F., Debrauwer, L., Chabo, C., Langella, P., Bueno, L. P., & Fioramonti, J. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.050617 · Cited by 247 · see citing works
Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice
Hartmann, P., Chen, P., Wang, H. J., Wang, L., McCole, D. F., Brandl, K., Stärkel, P., Belzer, C., Hellerbrand, C., Tsukamoto, H., et al. (2013) · Hepatology · doi:10.1002/hep.26321 · Cited by 246 · see citing works
Self-citationSidhu, S. S., Goyal, O., Mishra, B. P., Sood, A., Chhina, R. S., & Soni, R. K. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.455 · Cited by 244 · see citing works
Wang, Y., Liu, Y., Sidhu, A., Ma, Z., McClain, C. J., & Feng, W. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00024.2012 · Cited by 235 · see citing works
Intestinal Microbiota Was Assessed in Cirrhotic Patients with Hepatitis B Virus Infection
Lu, H., Wu, Z., Xu, W., Yang, J., Chen, Y., & Li, L. (2011) · Microbial Ecology · doi:10.1007/s00248-010-9801-8 · Cited by 225 · see citing works
Farhadi, A., Gundlapalli, S., Shaikh, M. W., Frantzides, C. T., Harrell, L. E., Kwasny, M., & Keshavarzian, A. (2008) · Liver International · doi:10.1111/j.1478-3231.2008.01723.x · Cited by 225 · see citing works
Small intestinal bacterial overgrowth in human cirrhosis is associated with systemic endotoxemia
Bauer, T. M., Schwacha, H., Steinbruckner, B., Brinkmann, F. E., Ditzen, A. K., Aponte, J. J., Pelz, K., Berger, D., Kist, M., & Blum, H. E. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05791.x · Cited by 211 · see citing works
Teltschik, Z., Wiest, R., Beisner, J., Nuding, S., Hofmann, C., Schöelmerich, J., Bevins, C. L., Stange, E. F., & Wehkamp, J. (2011) · Hepatology · doi:10.1002/hep.24789 · Cited by 196 · see citing works
Ethanol metabolism and its effects on the intestinal epithelial barrier
Elamin, E. E., Masclee, A., Dekker, J. P., & Jonkers, D. M. A. E. (2013) · Nutrition Reviews · doi:10.1111/nure.12027 · Cited by 187 · see citing works
Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption
Xie, G., Zhong, W., Li, H., Li, Q., Qiu, Y.-P., Zheng, X.-J., Chen, H., Zhao, X., Zhang, S., Zhou, Z.-X., et al. (2013) · The FASEB Journal · doi:10.1096/fj.13-231860 · Cited by 182 · see citing works
du Plessis, J., Vanheel, H., Janssen, C., Roos, L., Slavík, T., Stivaktas, P. I., Nieuwoudt, M., van Wyk, S. G., Vieira, W. A., Pretorius, E., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.01.038 · Cited by 178 · see citing works
The Natural History of Non-Alcoholic Fatty Liver Disease
Caldwell, S. H., & Argo, C. K. (2010) · Digestive Diseases · doi:10.1159/000282081 · Cited by 177 · see citing works
Fickert, P., Fuchsbichler, A., Moustafa, T., Wagner, M., Zollner, G., Halilbasic, E., Stöger, U., Arrese, M., Pizarro, M., Solís, N., et al. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.090114 · Cited by 169 · see citing works
Bode, C., & Bode, J. C. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000189280.19073.28 · Cited by 158 · see citing works
Diet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis
Pendyala, S., Neff, L. M., Suárez‐Fariñas, M., & Holt, P. R. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.002683 · Cited by 153 · see citing works
Alcohol's role in gastrointestinal tract disorders.
Bode, C., & Bode, J. C. (1997) · PubMed · Cited by 152 · see citing works
Alisi, A., Manco, M., Vito, R. D., Piemonte, F., & Nobili, V. (2010) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181c7bdf1 · Cited by 147 · see citing works
Xu, M., Wang, B., Fu, Y., Chen, Y., Yang, F., Lu, H., Chen, Y., Xu, J., & Li, L. (2011) · Microbial Ecology · doi:10.1007/s00248-011-9925-5 · Cited by 117 · see citing works
Systemic inflammation and ammonia in hepatic encephalopathy
Tranah, T. H., Vijay, G. K. M., Ryan, J. M., & Shawcross, D. L. (2012) · Metabolic Brain Disease · doi:10.1007/s11011-012-9370-2 · Cited by 114 · see citing works
Natural history of HCV infection
Poynard, T., Ratziu, V., Benhamou, Y., Opolon, P., Cacoub, P., & Bédossa, P. (2000) · Best Practice & Research Clinical Gastroenterology · doi:10.1053/bega.1999.0071 · Cited by 110 · see citing works
Yan, A. W. (2012) · World Journal of Hepatology · doi:10.4254/wjh.v4.i4.110 · Cited by 110 · see citing works
The intestinal microbiome and the leaky gut as therapeutic targets in alcoholic liver disease
Hartmann, P., Chen, W., & Schnabl, B. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00402 · Cited by 109 · see citing works
Self-citationJiang, X.-C., Li, Z., Liu, R., Yang, X. P., Pan, M., Lagrost, L., Fisher, E. A., & Williams, K. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500007200 · Cited by 102 · see citing works
Linking intestinal homeostasis and liver disease
Schnabl, B. (2013) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32835ff948 · Cited by 83 · see citing works
Self-citationGastrointestinal transit of solid-liquid meal in chronic alcoholics
Wegener, M., Schaffstein, J., Dilger, U., Coenen, C., Wedmann, B., & Schmidt, G. (1991) · Digestive Diseases and Sciences · doi:10.1007/bf01297141 · Cited by 66 · see citing works
The Prevention by Choline of Liver Cirrhosis in Rats on High Fat, Low Protein Diets
Blumberg, H., & McCollum, E. V. (1941) · Science · doi:10.1126/science.93.2425.598 · Cited by 65 · see citing works
Muñoz, L., Borrero, M. J., Cantera, M., Lario, M., Díaz, D., Francés, R., Monserrat, J., Pastor, Ó., Aguado-Fraile, E., Such, J. M., et al. (2012) · Hepatology · doi:10.1002/hep.25854 · Cited by 64 · see citing works
Kalambokis, G. N., & Tsianos, E. V. (2011) · Hepatology · doi:10.1002/hep.24751 · Cited by 61 · see citing works
Salaspuro, V. (1999) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655299750025057 · Cited by 56 · see citing works
Wu, Z., Lu, H., Wu, J., Zuo, J., Chen, P., Sheng, J., Zheng, S., & Li, L. (2011) · Microbial Ecology · doi:10.1007/s00248-011-9945-1 · Cited by 44 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism
Wahlstrom, A. M., Sayin, S. I., Marschall, H., & Bäckhed, F. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.005 · Cited by 2,903 · see citing works
Boursier, J., Mueller, O., Barret, M., Machado, M., Fizanne, L., Araujo‐Perez, F., Guy, C. D., Seed, P. C., Rawls, J. F., David, L. A., et al. (2016) · Hepatology · doi:10.1002/hep.28356 · Cited by 1,483 · see citing works
The gut-liver axis and the intersection with the microbiome
Tripathi, A., Debelius, J., Brenner, D. A., Karin, M., Loomba, R., Schnabl, B., & Knight, R. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0011-z · Cited by 1,480 · see citing works
Self-citationLiver inflammation and fibrosis
Koyama, Y., & Brenner, D. A. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88881 · Cited by 1,295 · see citing works
Self-citationHepatic inflammation and fibrosis: Functional links and key pathways
Seki, E., & Schwabe, R. F. (2015) · Hepatology · doi:10.1002/hep.27332 · Cited by 972 · see citing works
Nonalcoholic fatty liver disease
Brunt, E., Wong, V., Nobili, V., Day, C., Sookoian, S., Maher, J., Bugianesi, E., Sirlin, C., Neuschwander-Tetri, B., & Rinella, M. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.80 · Cited by 591 · see citing works
Alcoholic liver disease: mechanisms of injury and targeted treatment
Louvet, A., & Mathurin, P. (2015) · Nature Reviews Gastroenterology &Hepatology · doi:10.1038/nrgastro.2015.35 · Cited by 820 · see citing works
Gut-liver axis: Pathophysiological concepts and clinical implications
Tilg, H., Adolph, T. E., & Trauner, M. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.09.017 · Cited by 843 · see citing works
Ren, Z., Li, A., Jiang, J., Zhou, L., Yu, Z., Lu, H., Xie, H., Chen, X., Shao, L., Zhang, R., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315084 · Cited by 772 · see citing works
Gut–Liver Axis in Alcoholic Liver Disease
Szabo, G. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.10.042 · Cited by 754 · see citing works
Liver — guardian, modifier and target of sepsis
Strnad, P., Tacke, F., Koch, A., & Trautwein, C. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.168 · Cited by 692 · see citing works
Hepatic fibrosis: concept to treatment
Trautwein, C., Friedman, S. L., Schuppan, D., & Pinzani, M. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.02.039 · Cited by 677 · see citing works
Mouries, J., Brescia, P., Silvestri, A., Spadoni, I., Sorribas, M., Wiest, R., Mileti, E., Galbiati, M., Invernizzi, P., Adorini, L., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.08.005 · Cited by 688 · see citing works
Gut microbiome and aging: physiological and mechanistic insights
Nagpal, R., Mainali, R., Ahmadi, S., Wang, S., Singh, R., Kavanagh, K., Kitzman, D. W., Kushugulova, A., Marotta, F., & Yadav, H. (2018) · Nutrition and Healthy Aging · doi:10.3233/nha-170030 · Cited by 670 · see citing works
The gut microbiome and liver cancer: mechanisms and clinical translation
Yu, L.-X., & Schwabe, R. F. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.72 · Cited by 634 · see citing works
Bernardi, M., Moreau, R., Angeli, P., Schnabl, B., & Arroyo, V. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.07.004 · Cited by 633 · see citing works
Self-citationIntestinal transport and metabolism of bile acids
Dawson, P. A., & Karpen, S. J. (2015) · Journal of Lipid Research · doi:10.1194/jlr.r054114 · Cited by 598 · see citing works
Ju, C., & Tacke, F. (2016) · Cellular & Molecular Immunology · doi:10.1038/cmi.2015.104 · Cited by 554 · see citing works
Bile Acid Metabolism in Liver Pathobiology
Chiang, J. Y. L., & Ferrell, J. M. (2018) · Gene Expression · doi:10.3727/105221618x15156018385515 · Cited by 552 · see citing works
De Palma, G., Lynch, M. D. J., Lu, J., Dang, V. T., Deng, Y., Jury, J., Umeh, G., Miranda, P. M., Pigrau Pastor, M., Sidani, S., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf6397 · Cited by 505 · see citing works
Intestinal fungi contribute to development of alcoholic liver disease
Yang, A., Inamine, T., Hochrath, K., Chen, P., Wang, L., Llorente, C., Bluemel, S., Hartmann, P., Xu, J., Koyama, Y., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90562 · Cited by 465 · see citing works
Self-citationThe role of the gut microbiome in the healthy adult status
D’Argenio, V., & Salvatore, F. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.01.003 · Cited by 396 · see citing works
Role of bile acids in metabolic control
Molinaro, A., Wahlström, A., & Marschall, H.-U. (2018) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2017.11.002 · Cited by 447 · see citing works
The Gastrointestinal Microbiome: Alcohol Effects on the Composition of Intestinal Microbiota
Engen, P. A. (2015) · Alcohol research · doi:10.35946/arcr.v37.2.07 · Cited by 439 · see citing works
Low diversity gut microbiota dysbiosis: drivers, functional implications and recovery
Kriss, M. S., Hazleton, K. Z., Nusbacher, N. M., Martin, C. G., & Lozupone, C. (2018) · Current Opinion in Microbiology · doi:10.1016/j.mib.2018.07.003 · Cited by 416 · see citing works
The dormant blood microbiome in chronic, inflammatory diseases
Potgieter, M., Bester, J., Kell, D. B., & Pretorius, E. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv013 · Cited by 377 · see citing works
Alcohol and Gut-Derived Inflammation
Bishehsari, F. (2017) · Alcohol research · doi:10.35946/arcr.v38.2.02 · Cited by 380 · see citing works
Wang, B., Jiang, X., Cao, M., Ge, J., Bao, Q., Tang, L., Chen, Y., & Li, L. (2016) · Scientific Reports · doi:10.1038/srep32002 · Cited by 380 · see citing works
Targeting Inflammation in Cancer Prevention and Therapy
Todoric, J., Antonucci, L., & Karin, M. (2016) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-16-0209 · Cited by 367 · see citing works
Chu, H., Duan, Y., Yang, L., & Schnabl, B. (2019) · Gut · doi:10.1136/gutjnl-2018-316307 · Cited by 354 · see citing works
Self-citationShang, Q., Shan, X., Cai, C., Hao, J., Li, G., & Yu, G. (2016) · Food & Function · doi:10.1039/c6fo00309e · Cited by 359 · see citing works
Malla, M. A., Dubey, A., Kumar, A., Yadav, S., Hashem, A., & Allah, E. F. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02868 · Cited by 350 · see citing works
Altered Bile Acid Metabolome in Patients with Nonalcoholic Steatohepatitis
Ferslew, B. C., Xie, G., Johnston, C., Su, M., Stewart, P. W., Jia, W. P., Brouwer, K. L. R., & Barritt, A. S. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3776-8 · Cited by 336 · see citing works
Lean NAFLD: A Distinct Entity Shaped by Differential Metabolic Adaptation
Chen, F., Esmaili, S., Rogers, G. B., Bugianesi, E., Petta, S., Marchesini, G., Bayoumi, A., Metwally, M., Azardaryany, M. K., Coulter, S., et al. (2019) · Hepatology · doi:10.1002/hep.30908 · Cited by 330 · see citing works
Chen, P., Stärkel, P., Turner, J. R., Ho, S. B., & Schnabl, B. (2015) · Hepatology · doi:10.1002/hep.27489 · Cited by 312 · see citing works
Self-citationRecent advancement of molecular mechanisms of liver fibrosis
Seki, E., & Brenner, D. A. (2015) · Journal of Hepato-Biliary-Pancreatic Sciences · doi:10.1002/jhbp.245 · Cited by 299 · see citing works
Self-citationDiabetes mellitus—Progress and opportunities in the evolving epidemic
Abel, E. D., Gloyn, A. L., Evans‐Molina, C., Joseph, J. J., Misra, S., Pajvani, U. B., Simcox, J., Suszták, K., & Drucker, D. J. (2024) · Cell · doi:10.1016/j.cell.2024.06.029 · Cited by 330 · see citing works
Horst, A. K., Neumann, K., Diehl, L., & Tiegs, G. (2016) · Cellular & Molecular Immunology · doi:10.1038/cmi.2015.112 · Cited by 295 · see citing works
Michelena, J., Altamirano, J., Abraldeṣ, J. G., Affò, S., Morales‐Ibanez, O., Sancho‐Bru, P., Domínguez, M., García‐Pagán, J. C., Fernández, J., Arroyo, V., et al. (2015) · Hepatology · doi:10.1002/hep.27779 · Cited by 293 · see citing works
Alcoholic Liver Disease: The Gut Microbiome and Liver Cross Talk
Hartmann, P., Seebauer, C. T., & Schnabl, B. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12704 · Cited by 282 · see citing works
Self-citationThe microbiota in cirrhosis and its role in hepatic decompensation
Trebicka, J., Macnaughtan, J., Schnabl, B., Shawcross, D. L., & Bajaj, J. S. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2020.11.013 · Cited by 276 · see citing works
Self-citationNatural products in licorice for the therapy of liver diseases: Progress and future opportunities
Li, X., Sun, R., & Liu, R. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.04.025 · Cited by 259 · see citing works
Llorente, C., Jepsen, P., Inamine, T., Wang, L., Bluemel, S., Wang, H. J., Loomba, R., Bajaj, J. S., Schubert, M. L., Sikaroodi, M., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00796-x · Cited by 257 · see citing works
Self-citationMethods to determine intestinal permeability and bacterial translocation during liver disease
Wang, L., Llorente, C., Hartmann, P., Yang, A.-M., Chen, P., & Schnabl, B. (2015) · Journal of Immunological Methods · doi:10.1016/j.jim.2014.12.015 · Cited by 257 · see citing works
Self-citationMicrobiota, cirrhosis, and the emerging oral-gut-liver axis
Acharya, C., Sahingur, S. E., & Bajaj, J. S. (2017) · JCI Insight · doi:10.1172/jci.insight.94416 · Cited by 256 · see citing works
Lasker, S., Rahman, M. M., Parvez, F., Zamila, M., Miah, P., Nahar, K., Kabir, F., Mohona, S. B. S., Subhan, N., Ahsan, G. U., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-56538-0 · Cited by 253 · see citing works
Gut-liver crosstalk in sepsis-induced liver injury
Sun, J., Zhang, J., Wang, X., Ji, F., Ronco, C., Tian, J., & Yin, Y. (2020) · Critical Care · doi:10.1186/s13054-020-03327-1 · Cited by 250 · see citing works
Benedé-Ubieto, R., Cubero, F. J., & Nevzorova, Y. A. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2331460 · Cited by 242 · see citing works
Non-alcoholic fatty liver and the gut microbiota
Bashiardes, S., Shapiro, H., Rozin, S., Shibolet, O., & Elinav, E. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.06.003 · Cited by 241 · see citing works
Microbiota and the gut-liver axis: Bacterial translocation, inflammation and infection in cirrhosis
Giannelli, V. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i45.16795 · Cited by 237 · see citing works
Fecal microbiota transplantation broadening its application beyond intestinal disorders
Xu, M.-Q. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i1.102 · Cited by 231 · see citing works
Developmental origins of NAFLD: a womb with a clue
Wesolowski, S. R., Kasmi, K. C. E., Jonscher, K. R., & Friedman, J. E. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.160 · Cited by 231 · see citing works
Gut microbial profile analysis by MiSeq sequencing of pancreatic carcinoma patients in China
Ren, Z., Jiang, J., Xie, H., Li, A., Lu, H., Xu, S., Zhou, L., Zhang, H., Cui, G., Chen, X., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.18820 · Cited by 228 · see citing works
Distinctly altered gut microbiota in the progression of liver disease
Xie, G., Wang, X., Liu, P., Wei, R., Chen, W., Rajani, C., Hernandez, B. Y., Alegado, R., Dong, B., Li, D., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8466 · Cited by 219 · see citing works
Schneider, K. M., Mohs, A., Gui, W., Galvez, E. J. C., Candels, L. S., Hoenicke, L., Muthukumarasamy, U., Holland, C. H., Elfers, C., Kilic, K., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31312-5 · Cited by 225 · see citing works
The influence of the gut microbiome on obesity, metabolic syndrome and gastrointestinal disease
Parekh, P. J., Balart, L. A., & Johnson, D. A. (2015) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2015.16 · Cited by 219 · see citing works
Ochratoxin A induces liver inflammation: involvement of intestinal microbiota
Wang, W., Zhai, S., Xia, Y., Wang, H., Ruan, D., Zhou, T., Zhu, Y., Zhang, H., Zhang, M., Ye, H., et al. (2019) · Microbiome · doi:10.1186/s40168-019-0761-z · Cited by 220 · see citing works
Astbury, S., Atallah, E., Vijay, A., Aithal, G. P., Grove, J. I., & Valdes, A. M. (2019) · Gut Microbes · doi:10.1080/19490976.2019.1681861 · Cited by 214 · see citing works
Intestinal Barrier and Permeability in Health, Obesity and NAFLD
Portincasa, P., Bonfrate, L., Khalil, M., Angelis, M. D., Calabrese, F. M., D’Amato, M., Wang, D. Q. ‐., & Ciaula, A. D. (2021) · Biomedicines · doi:10.3390/biomedicines10010083 · Cited by 212 · see citing works
Lee, P.-C., Wu, C.-J., Hung, Y.-W., Lee, C. J., Chi, C.-T., Lee, I.-C., Yu-Lun, K., Chou, S.-H., Luo, J.-C., Hou, M.-C., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-004779 · Cited by 217 · see citing works
Rao, A., Kosters, A., Mells, J. E., Zhang, W., Setchell, K. D. R., Amanso, A. M., Wynn, G. M., Xu, T., Keller, B. T., Yin, H., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf4823 · Cited by 211 · see citing works
The intestinal microbiota and its role in human health and disease
Kataoka, K. (2016) · The Journal of Medical Investigation · doi:10.2152/jmi.63.27 · Cited by 214 · see citing works
Impact of Nutritional Changes on Nonalcoholic Fatty Liver Disease
Perdomo, C. M., Frühbeck, G., & Escalada, J. (2019) · Nutrients · doi:10.3390/nu11030677 · Cited by 217 · see citing works
Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice
Mazagova, M., Wang, L., Anfora, A. T., Wissmueller, M., Lesley, S. A., Miyamoto, Y., Eckmann, L., Dhungana, S., Pathmasiri, W., Sumner, S., et al. (2015) · The FASEB Journal · doi:10.1096/fj.14-259515 · Cited by 199 · see citing works
Self-citationDoes the microbiota play a role in the pathogenesis of autoimmune diseases?
McLean, M. H., Dieguez, D., Miller, L. M., & Young, H. A. (2014) · Gut · doi:10.1136/gutjnl-2014-308514 · Cited by 207 · see citing works
The gut microbiota metabolite indole alleviates liver inflammation in mice
Beaumont, M., Neyrinck, A. M., Olivares, M., Rodriguez, J., Nédélec, A., Roumain, M., Bindels, L. B., Cani, P. D., Evenepoel, P., Muccioli, G. G., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201800544 · Cited by 208 · see citing works
Intestinal microbiome and NAFLD: molecular insights and therapeutic perspectives
Hu, H., Lin, A., Kong, M., Yao, X., Yin, M., Xia, H., Ma, J., & Liu, H. (2019) · Journal of Gastroenterology · doi:10.1007/s00535-019-01649-8 · Cited by 208 · see citing works
Systematic review: microbial dysbiosis and nonalcoholic fatty liver disease
Wieland, A. C., Frank, D. N., Harnke, B., & Bambha, K. M. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13376 · Cited by 209 · see citing works
Liu, Q., Li, F., Zhuang, Y., Xu, J., Wang, J., Mao, X., Zhang, Y., & Liu, X. (2019) · Gut Pathogens · doi:10.1186/s13099-018-0281-6 · Cited by 208 · see citing works
Recent advances in alcohol-related liver disease (ALD): summary of a Gut round table meeting
Avila, M., Dufour, J., Gerbes, A., Zoulim, F., Bataller, R., Burra, P., Cortez-Pinto, H., Gao, B., Gilmore, I., Mathurin, P., et al. (2019) · Gut · doi:10.1136/gutjnl-2019-319720 · Cited by 179 · see citing works
Self-citationLiang, D., Leung, R. K., Guan, W., & Au, W. W. (2018) · Gut Pathogens · doi:10.1186/s13099-018-0230-4 · Cited by 198 · see citing works
Hendrikx, T., & Schnabl, B. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12892 · Cited by 202 · see citing works
Self-citationLeFort, K. R., Rungratanawanich, W., & Song, B.-J. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-05061-7 · Cited by 202 · see citing works
Novel therapeutic targets for cholestatic and fatty liver disease
Trauner, M., & Fuchs, C. D. (2022) · Gut · doi:10.1136/gutjnl-2021-324305 · Cited by 204 · see citing works
Recent Advances in Characterizing the Gastrointestinal Microbiome in Crohnʼs Disease
Wright, E. K., Kamm, M. A., Teo, S. M., Inouye, M., Wagner, J., & Kirkwood, C. D. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000382 · Cited by 207 · see citing works
Li, F., Hao, X., Chen, Y., Bai, L., Gao, X., Lian, Z., Wei, H., Sun, R., & Tian, Z. (2017) · Nature Communications · doi:10.1038/ncomms13839 · Cited by 191 · see citing works
The Gut Microbiota and Liver Disease
Llorente, C., & Schnabl, B. (2015) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2015.04.003 · Cited by 189 · see citing works
Self-citationSharpton, S. R., Maraj, B., Harding-Theobald, E. R., Vittinghoff, E., & Terrault, N. A. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz042 · Cited by 190 · see citing works
Wang, J., Wang, Y., Zhang, X., Liu, J., Zhang, Q., Zhao, Y., Peng, J., Feng, Q., Dai, J., Sun, S., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02222 · Cited by 187 · see citing works
Gut dysbiosis associated with hepatitis C virus infection
Inoue, T., Nakayama, J., Moriya, K., Kawaratani, H., Momoda, R., Ito, K., Iio, E., Nojiri, S., Fujiwara, K., Yoneda, M., et al. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy205 · Cited by 183 · see citing works
Alcohol or gut microbiota: who is the guilty?
Meroni, M., Longo, M., & Dongiovanni, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184568 · Cited by 183 · see citing works
Microbial Contribution to the Human Metabolome: Implications for Health and Disease
Treuren, W. V., & Dodd, D. (2019) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-020117-043559 · Cited by 176 · see citing works
Neyrinck, A. M., Etxeberría, U., Taminiau, B., Daube, G., Hul, M. V., Everard, A., Cani, P. D., Bindels, L. B., & Delzenne, N. M. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500899 · Cited by 181 · see citing works
Intestinal Microbiota and Nonalcoholic Steatohepatitis
Brandl, K., & Schnabl, B. (2017) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000349 · Cited by 169 · see citing works
Self-citationMacrophage Phenotype and Function in Liver Disorder
Dou, L., Shi, X., He, X., & Gao, Y. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03112 · Cited by 183 · see citing works
Úbeda, M., Lario, M., Muñoz, L., Borrero, M.-J., Rodríguez-Serrano, M., Sánchez-Díaz, A.-M., del Campo, R., Lledó, L., Pastor, Ó., García-Bermejo, L., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2015.12.010 · Cited by 178 · see citing works
Alterations of the Human Gut Microbiome in Chronic Kidney Disease
Ren, Z., Fan, Y., Li, A., Shen, Q., Wu, J., Ren, L., Lu, H., Ding, S., Ren, H., Liu, C., et al. (2020) · Advanced Science · doi:10.1002/advs.202001936 · Cited by 173 · see citing works
Gut microbiota and liver diseases
Minemura, M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i6.1691 · Cited by 175 · see citing works
Sharpton, S. R., Ajmera, V. H., & Loomba, R. S. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.08.065 · Cited by 170 · see citing works
Microbiota changes and intestinal microbiota transplantation in liver diseases and cirrhosis
Bajaj, J. S., & Khoruts, A. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.01.017 · Cited by 170 · see citing works
The gut-liver axis in sepsis: interaction mechanisms and therapeutic potential
Zhang, X., Liu, H., Hashimoto, K., Yuan, S., & Zhang, J. (2022) · Critical Care · doi:10.1186/s13054-022-04090-1 · Cited by 200 · see citing works
Nonalcoholic Fatty Liver Disease, the Gut Microbiome, and Diet
Mokhtari, Z., Gibson, D. L., & Hekmatdoost, A. (2017) · Advances in Nutrition · doi:10.3945/an.116.013151 · Cited by 168 · see citing works
Intestinal mycobiota in health and diseases: from a disrupted equilibrium to clinical opportunities
Wu, X., Xia, Y., He, F., Zhu, C., & Ren, W. (2021) · Microbiome · doi:10.1186/s40168-021-01024-x · Cited by 167 · see citing works
Pang, Y., Kartsonaki, C., Turnbull, I. J., Yu, C., Clarke, R., Chen, Y., Bragg, F., Yang, L., Bian, Z., Millwood, I. Y., et al. (2018) · Hepatology · doi:10.1002/hep.30083 · Cited by 166 · see citing works
Gut microbiota influence tumor development and Alter interactions with the human immune system
Ge, Y., Wang, X., Guo, Y., Yan, J., Abuduwaili, A., Aximujiang, K., Yan, J., & Wu, M. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-01845-6 · Cited by 169 · see citing works
Ciaula, A. D., Baj, J., Garruti, G., Celano, G., Angelis, M. D., Wang, H. H., Palo, D. M. D., Bonfrate, L., Wang, D. Q. ‐., & Portincasa, P. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9082648 · Cited by 164 · see citing works
Pathophysiology of Liver Fibrosis
Pinzani, M. (2015) · Digestive Diseases · doi:10.1159/000374096 · Cited by 161 · see citing works
Metabolic aspects of adult patients with nonalcoholic fatty liver disease
Abenavoli, L., Milić, N., Renzo, L. D., Preveden, T., Medic‐Stojanoska, M., & LORENZO, A. D. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i31.7006 · Cited by 159 · see citing works
Dysbiosis in gastrointestinal disorders
Chang, C., & Lin, H. C. (2016) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2016.02.001 · Cited by 159 · see citing works
Reversal of liver fibrosis: From fiction to reality
Zoubek, M. E., Trautwein, C., & Strnad, P. (2017) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2017.04.005 · Cited by 157 · see citing works
- Authors
- Schnabl, B., & Brenner, D. A.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Schnabl, Bernd
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 146
- Issue
- 6
- Pages
- 1513-1524
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC3996054
- OpenAlex
- W1975691929
- Cited by
- 971
- References
- 86
- Citations by year
- 2026: 37 · 2025: 56 · 2024: 88 · 2023: 101 · 2022: 88 · 2021: 92 · 2020: 102 · 2019: 88 · 2018: 89 · 2017: 58 · 2016: 64 · 2015: 77 · 2014: 31
- FWCI
- 7.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (U01 AA021856, R01 AA020703, 2 P42 ES010337, K08 DK081830)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- gut microbiota, gut-liver axis, non-alcoholic fatty liver disease, steatohepatitis, alcoholic liver disease, liver cirrhosis, dysbiosis, intestinal homeostasis, intestinal barrier dysfunction, intestinal inflammation, microbial translocation, microbial metabolites, Western diet, alcohol
- MeSH terms
- Animals, Bacteria, Bile Acids and Salts, Fatty Liver, Humans, Intestines, Liver Cirrhosis, Liver Diseases, Liver Diseases, Alcoholic, Risk Factors, Host-Pathogen Interactions, Microbiota, Dysbiosis, Non-alcoholic Fatty Liver Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
