Houtkooper, Riekelt H.

Sirtuins as regulators of metabolism and healthspan

Houtkooper, R. H., Pirinen, E., & Auwerx, J. (2012) · Nature Reviews Molecular Cell Biology

Sirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

Cited by 2,008

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

Timmers, S., Konings, E., Bilet, L., Houtkooper, R. H., van de Weijer, T., Goossens, G. H., Hoeks, J., van der Krieken, S., Ryu, D., Kersten, S., et al. (2011) · Cell Metabolism

Sirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

Cited by 1,320

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

Cantó, C., Houtkooper, R. H., Pirinen, E., Youn, D. Y., Oosterveer, M. H., Cen, Y., Fernandez-Marcos, P. J., Yamamoto, H., Andreux, P. A., Cettour-Rose, P., et al. (2012) · Cell Metabolism

Sirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

Cited by 1,238

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

Mouchiroud, L., Houtkooper, R. H., Moullan, N., Katsyuba, E., Ryu, D., Cantó, C., Mottis, A., Jo, Y.-S., Viswanathan, M., Schoonjans, K., et al. (2013) · Cell

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 1,210

Mitonuclear protein imbalance as a conserved longevity mechanism

Houtkooper, R. H., Mouchiroud, L., Ryu, D., Moullan, N., Katsyuba, E., Knott, G., Williams, R. W., & Auwerx, J. (2013) · Nature

Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology

Cited by 1,035

The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways

Houtkooper, R. H., Cantó, C., Wanders, R. J., & Auwerx, J. (2010) · Endocrine Reviews

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 899

PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

Bai, P., Cantó, C., Oudart, H., Brunyánszki, A., Cen, Y., Thomas, C., Yamamoto, H., Huber, A., Kiss, B., Houtkooper, R. H., et al. (2011) · Cell Metabolism

Sirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

Cited by 837

Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease

Smith, R. L., Soeters, M. R., Wüst, R. C. I., & Houtkooper, R. H. (2018) · Endocrine Reviews

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 787

The metabolic footprint of aging in mice

Houtkooper, R. H., Argmann, C., Houten, S. M., Cantó, C., Jeninga, E. H., Andreux, P. A., Thomas, C., Doenlen, R., Schoonjans, K., & Auwerx, J. (2011) · Scientific Reports

Genetics, Aging, and Longevity in Model OrganismsMetabolomics and Mass Spectrometry Studies

Cited by 528

Pharmacological approaches to restore mitochondrial function

Andreux, P. A., Houtkooper, R. H., & Auwerx, J. (2013) · Nature Reviews Drug Discovery

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 383

Host-microbe-drug-nutrient screen identifies bacterial effectors of metformin therapy

Pryor, R., Norvaisas, P., Marinos, G., Best, L., Thingholm, L. B., Quintaneiro, L. M., De Haes, W., Esser, D., Waschina, S., Lujan, C., et al. (2019) · Cell

Metabolism, Diabetes, and CancerGut microbiota and health

Cited by 274

MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria

Zaltsman, Y., Shachnai, L., Yivgi-Ohana, N., Schwarz, M., Maryanovich, M., Houtkooper, R. H., Vaz, F. M., De Leonardis, F., Fiermonte, G., Palmieri, F., et al. (2010) · Nature Cell Biology

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 218

Metabolic networks of longevity

Houtkooper, R. H., Williams, R. W., & Auwerx, J. (2010) · Cell

Genetics, Aging, and Longevity in Model OrganismsMetabolism, Diabetes, and Cancer

Cited by 217

NAD + metabolism: A therapeutic target for age-related metabolic disease

Mouchiroud, L., Houtkooper, R. H., & Auwerx, J. (2013) · Critical Reviews in Biochemistry and Molecular Biology

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 193

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

Remie, C. M., Roumans, K. H., Moonen, M. P., Connell, N. J., Havekes, B., Mevenkamp, J., Lindeboom, L., de Wit, V. H., van de Weijer, T., Aarts, S. A., et al. (2020) · The American Journal of Clinical Nutrition

Sirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

Cited by 160

Mitochondrial response to nutrient availability and its role in metabolic disease

Gao, A. W., Cantó, C., & Houtkooper, R. H. (2014) · EMBO Molecular Medicine

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 148

Lipoprotein lipase maintains microglial innate immunity in obesity.

Gao, Y., Vidal-Itriago, A., Kalsbeek, M. J., Layritz, C., García-Cáceres, C., Tom, R. Z., Eichmann, T. O., Vaz, F. M., Houtkooper, R. H., van der Wel, N., et al. (2017) · Cell Reports

Neuroinflammation and Neurodegeneration MechanismsAdipokines, Inflammation, and Metabolic Diseases

Cited by 123

Healthy aging and muscle function are positively associated with NAD+ abundance in humans

Janssens, G. E., Grevendonk, L., Perez, R. Z., Schomakers, B. V., de Vogel-van den Bosch, J., Geurts, J. M. W., van Weeghel, M., Schrauwen, P., Houtkooper, R. H., & Hoeks, J. (2022) · Nature Aging

Sirtuins and Resveratrol in MedicineNutrition and Health in Aging

Cited by 103

A sensitive mass spectrometry platform identifies metabolic changes of life history traits in C. elegans

Gao, A. W., Chatzispyrou, I. A., Kamble, R., Liu, Y. J., Herzog, K., Smith, R. L., van Lenthe, H., Vervaart, M. A. T., van Cruchten, A., Luyf, A. C., et al. (2017) · Scientific Reports

Genetics, Aging, and Longevity in Model OrganismsMetabolomics and Mass Spectrometry Studies

Cited by 77

COmplexome Profiling ALignment (COPAL) reveals remodeling of mitochondrial protein complexes in Barth syndrome

Van Strien, J., Guerrero-Castillo, S., Chatzispyrou, I. A., Houtkooper, R. H., Brandt, U., & Huynen, M. A. (2019) · Bioinformatics

Advanced Proteomics Techniques and ApplicationsMitochondrial Function and Pathology

Cited by 42

COmplexome Profiling ALignment (COPAL) reveals remodeling of mitochondrial protein complexes in Barth syndrome

Strien, J. V., Guerrero-Castillo, S., Chatzispyrou, I. A., Houtkooper, R. H., Brandt, U., & Huynen, M. A. (2018) · Bioinformatics

Advanced Proteomics Techniques and ApplicationsMitochondrial Function and Pathology

Cited by 42

Sirtuin activation as a therapeutic approach against inborn errors of metabolism

Bleeker, J. C., & Houtkooper, R. H. (2016) · Journal of Inherited Metabolic Disease

Sirtuins and Resveratrol in MedicineMetabolism and Genetic Disorders

Cited by 11