Christopoulos, Arthur

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

Jeffrey Conn, P., Christopoulos, A., & Lindsley, C. W. (2009) · Nature Reviews Drug Discovery

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 1,063

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: g protein-coupled receptors

Alexander, S. P., Christopoulos, A., Davenport, A. P., Kelly, E., Marrion, N. V., Peters, J. A., Faccenda, E., Harding, S. D., Pawson, A. J., Sharman, J. L., et al. (2017) · British Journal of Pharmacology

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 588

Emerging paradigms in GPCR allostery: implications for drug discovery

Wootten, D., Christopoulos, A., & Sexton, P. M. (2013) · Nature Reviews Drug Discovery

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 498

Muscarinic acetylcholine receptors: novel opportunities for drug development

Kruse, A. C., Kobilka, B. K., Gautam, D., Sexton, P. M., Christopoulos, A., & Wess, J. (2014) · Nature Reviews Drug Discovery

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 437

Novel Allosteric Modulators of G Protein-coupled Receptors

Gentry, P. R., Sexton, P. M., & Christopoulos, A. (2015) · Journal of Biological Chemistry

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 199

Receptor Activity-Modifying Proteins Differentially Modulate the G Protein-Coupling Efficiency of Amylin Receptors

Morfis, M., Tilakaratne, N., Furness, S. G. B., Christopoulos, G., Werry, T. D., Christopoulos, A., & Sexton, P. M. (2008) · Endocrinology

Receptor Mechanisms and SignalingNeuropeptides and Animal Physiology

Cited by 134

Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy

Furness, S. G. B., Liang, Y.-L., Nowell, C. J., Halls, M. L., Wookey, P. J., Dal Maso, E., Inoue, A., Christopoulos, A., Wootten, D., & Sexton, P. M. (2016) · Cell

Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

Cited by 134

Allostery and biased agonism at class B G protein-coupled receptors

Wootten, D., Miller, L. J., Koole, C., Christopoulos, A., & Sexton, P. M. (2017) · Chemical Reviews

Receptor Mechanisms and SignalingNeuropeptides and Animal Physiology

Cited by 112

Prolonged Calcitonin Receptor Signaling by Salmon, but Not Human Calcitonin, Reveals Ligand Bias

Andreassen, K. V., Hjuler, S. T., Furness, S. G., Sexton, P. M., Christopoulos, A., Nosjean, O., Karsdal, M. A., & Henriksen, K. (2014) · PLoS ONE

Receptor Mechanisms and SignalingNeuropeptides and Animal Physiology

Cited by 89

Structural Basis of Receptor Sulfotyrosine Recognition by a CC Chemokine: The N-Terminal Region of CCR3 Bound to CCL11/Eotaxin-1

Millard, C. J., Ludeman, J. P., Canals, M., Bridgford, J. L., Hinds, M. G., Clayton, D. J., Christopoulos, A., Payne, R. J., & Stone, M. J. (2014) · Structure

Chemokine receptors and signalingReceptor Mechanisms and Signaling

Cited by 75

Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs

Hollingsworth, S. A., Kelly, B., Valant, C., Michaelis, J. A., Mastromihalis, O., Thompson, G., Venkatakrishnan, A. J., Hertig, S., Scammells, P. J., Sexton, P. M., et al. (2019) · Nature Communications

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 73

Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias

van der Westhuizen, E. T., Choy, K. H. C., Valant, C., McKenzie-Nickson, S., Bradley, S. J., Tobin, A. B., Sexton, P. M., & Christopoulos, A. (2021) · Frontiers in Pharmacology

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 63

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

Vuckovic, Z., Wang, J., Pham, V., Mobbs, J. I., Belousoff, M. J., Bhattarai, A., Burger, W. A., Thompson, G., Yeasmin, M., Nawaratne, V., et al. (2023) · eLife

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 34

Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite

Maher, A. R., Arif, S., Madhani, M., Abozguia, K., Ahmed, I., Fernandez, B. O., Feelisch, M., O'Sullivan, A., Christopoulos, A., Sverdlov, A. L., et al. (2013) · British Journal of Pharmacology

Nitric Oxide and Endothelin EffectsHeart Failure Treatment and Management

Cited by 26