Guan, Kun-Liang

Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine

Dey, A., Varelas, X., & Guan, K.-L. (2020) · Nature Reviews Drug Discovery

Hippo pathway signaling and YAP/TAZTGF-β signaling in diseases

Cited by 860

Differential regulation of mTORC1 by leucine and glutamine

Jewell, J. L., Kim, Y. C., Russell, R. C., Yu, F.-X., Park, H. W., Plouffe, S. W., Tagliabracci, V. S., & Guan, K.-L. (2015) · Science

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

Cited by 757

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

Alexander, A., Cai, S.-L., Kim, J., Nanez, A., Sahin, M., MacLean, K. H., Inoki, K., Guan, K.-L., Shen, J., Person, M. D., et al. (2010) · Proceedings of the National Academy of Sciences

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

Cited by 717

TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

Chen, C., Liu, Y., Liu, R., Ikenoue, T., Guan, K.-L., Liu, Y., & Zheng, P. (2008) · The Journal of Experimental Medicine

Hematopoietic Stem Cell TransplantationPI3K/AKT/mTOR signaling in cancer

Cited by 682

A gp130–Src–YAP module links inflammation to epithelial regeneration

Taniguchi, K., Wu, L.-W., Grivennikov, S. I., de Jong, P. R., Lian, I., Yu, F.-X., Wang, K., Ho, S. B., Boland, B. S., Chang, J. T., et al. (2015) · Nature

Cytokine Signaling Pathways and InteractionsHippo pathway signaling and YAP/TAZ

Cited by 633

The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR

Egan, D., Kim, J., Shaw, R. J., & Guan, K.-L. (2011) · Autophagy

Autophagy in Disease and TherapyPI3K/AKT/mTOR signaling in cancer

Cited by 627

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

Chen, Y., Zhang, J., Lin, Y., Lei, Q., Guan, K., Zhao, S., & Xiong, Y. (2011) · The EMBO Reports

Sirtuins and Resveratrol in MedicineRedox biology and oxidative stress

Cited by 572

Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway

Mo, J.-S., Meng, Z., Kim, Y. C., Park, H. W., Hansen, C. G., Kim, S., Lim, D.-S., & Guan, K.-L. (2015) · Nature Cell Biology

Hippo pathway signaling and YAP/TAZMetabolism, Diabetes, and Cancer

Cited by 557

mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

Inoki, K., Mori, H., Wang, J., Suzuki, T., Hong, S., Yoshida, S., Blattner, S. M., Ikenoue, T., Rüegg, M. A., Hall, M. N., et al. (2011) · Journal of Clinical Investigation

Renal Diseases and GlomerulopathiesChronic Kidney Disease and Diabetes

Cited by 538

The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCP E3 Ligase

Liu, C.-Y., Zha, Z.-Y., Zhou, X., Zhang, H., Huang, W., Zhao, D., Li, T., Chan, S. W., Lim, C. J., Hong, W., et al. (2010) · Journal of Biological Chemistry

Hippo pathway signaling and YAP/TAZUbiquitin and proteasome pathways

Cited by 525

Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis

Wang, K.-C., Yeh, Y.-T., Nguyen, P., Limqueco, E., Lopez, J., Thorossian, S., Guan, K.-L., Li, Y.-S. J., & Chien, S. (2016) · Proceedings of the National Academy of Sciences

Hippo pathway signaling and YAP/TAZAtherosclerosis and Cardiovascular Diseases

Cited by 471

YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29

Tumaneng, K., Schlegelmilch, K., Russell, R. C., Yimlamai, D., Basnet, H., Mahadevan, N., Fitamant, J., Bardeesy, N., Camargo, F. D., & Guan, K.-L. (2012) · Nature Cell Biology

Hippo pathway signaling and YAP/TAZPI3K/AKT/mTOR signaling in cancer

Cited by 453

Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction

Hallows, W. C., Yu, W., Smith, B. C., Devires, M. K., Ellinger, J. J., Someya, S., Shortreed, M. R., Prolla, T., Markley, J. L., Smith, L. M., et al. (2011) · Molecular Cell

Sirtuins and Resveratrol in MedicineAutophagy in Disease and Therapy

Cited by 389

Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth

Lin, R., Tao, R., Gao, X., Li, T., Zhou, X., Guan, K.-L., Xiong, Y., & Lei, Q.-Y. (2013) · Molecular Cell

Cancer, Lipids, and MetabolismLipid metabolism and biosynthesis

Cited by 384

RAP2 mediates mechanoresponses of the Hippo pathway

Meng, Z., Qiu, Y., Lin, K. C., Kumar, A., Placone, J. K., Fang, C., Wang, K.-C., Lu, S., Pan, M., Hong, A. W., et al. (2018) · Nature

Hippo pathway signaling and YAP/TAZCellular Mechanics and Interactions

Cited by 377

Sestrins inhibit mTORC1 kinase activation through the GATOR complex

Parmigiani, A., Nourbakhsh, A., Ding, B., Wang, W., Kim, Y. C., Akopiants, K., Guan, K.-L., Karin, M., & Budanov, A. V. (2014) · Cell Reports

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

Cited by 336

Characterization of Hippo Pathway Components by Gene Inactivation

Plouffe, S. W., Meng, Z., Lin, K. C., Lin, B., Hong, A. W., Chun, J. V., & Guan, K.-L. (2016) · Molecular Cell

Hippo pathway signaling and YAP/TAZMicrotubule and mitosis dynamics

Cited by 275

A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells

Diao, Y., Fang, R., Li, B., Meng, Z., Yu, J., Qiu, Y., Lin, K. C., Huang, H., Liu, T., Marina, R. J., et al. (2017) · Nature Methods

Genomics and Chromatin DynamicsCRISPR and Genetic Engineering

Cited by 259

Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2 -deficient Mesothelioma

Tang, T. T., Konradi, A. W., Feng, Y., Peng, X., Ma, M., Li, J., Yu, F.-X., Guan, K.-L., & Post, L. (2021) · Molecular Cancer Therapeutics

Hippo pathway signaling and YAP/TAZSignaling Pathways in Disease

Cited by 245

Metabolism, Activity, and Targeting of D- and L-2-Hydroxyglutarates

Ye, D., Guan, K.-L., & Xiong, Y. (2018) · Trends in Cancer

Cancer, Hypoxia, and MetabolismBiochemical Acid Research Studies

Cited by 242

The Stress-inducted Proteins RTP801 and RTP801L Are Negative Regulators of the Mammalian Target of Rapamycin Pathway

Corradetti, M. N., Inoki, K., & Guan, K.-L. (2005) · Journal of Biological Chemistry

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 237

TSC1 Stabilizes TSC2 by Inhibiting the Interaction between TSC2 and the HERC1 Ubiquitin Ligase

Chong-Kopera, H., Inoki, K., Li, Y., Zhu, T., Garcia-Gonzalo, F. R., Rosa, J. L., & Guan, K.-L. (2006) · Journal of Biological Chemistry

Tuberous Sclerosis Complex ResearchPI3K/AKT/mTOR signaling in cancer

Cited by 234

Estrogen regulates Hippo signaling via GPER in breast cancer

Zhou, X., Wang, S., Wang, Z., Feng, X., Liu, P., Lv, X.-B., Li, F., Yu, F.-X., Sun, Y., Yuan, H., et al. (2015) · Journal of Clinical Investigation

Hippo pathway signaling and YAP/TAZEstrogen and related hormone effects

Cited by 232

Insights into recent findings and clinical application of YAP and TAZ in cancer

Franklin, J. M., Wu, Z., & Guan, K.-L. (2023) · Nature Reviews Cancer

Hippo pathway signaling and YAP/TAZCancer-related molecular mechanisms research

Cited by 213