Guan, Kun-Liang

The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1

Hansen, C. G., Ng, Y. L. D., Lam, W.-L. M., Plouffe, S. W., & Guan, K.-L. (2015) · Cell Research

Hippo pathway signaling and YAP/TAZPI3K/AKT/mTOR signaling in cancer

Cited by 212

Adiponectin Sensitizes Insulin Signaling by Reducing p70 S6 Kinase-mediated Serine Phosphorylation of IRS-1

Wang, C., Mao, X., Wang, L., Liu, M., Wetzel, M. D., Guan, K.-L., Dong, L. Q., & Liu, F. (2007) · Journal of Biological Chemistry

Adipokines, Inflammation, and Metabolic DiseasesMetabolism, Diabetes, and Cancer

Cited by 210

Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents

Wang, P., Wu, J., Ma, S., Zhang, L., Yao, J., Hoadley, K. A., Wilkerson, M. D., Perou, C. M., Guan, K.-L., Ye, D., et al. (2015) · Cell Reports

Glioma Diagnosis and TreatmentDNA Repair Mechanisms

Cited by 206

Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis

Wang, X., Cai, B., Yang, X., Sonubi, O. O., Zheng, Z., Ramakrishnan, R., Shi, H., Valenti, L., Pajvani, U. B., Sandhu, J., et al. (2020) · Cell Metabolism

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 204

mTOR pathway as a target in tissue hypertrophy

Lee, C.-H., Inoki, K., & Guan, K.-L. (2007) · Annual Review of Pharmacology and Toxicology

PI3K/AKT/mTOR signaling in cancerTuberous Sclerosis Complex Research

Cited by 179

Assembly and activation of the Hippo signalome by FAT1 tumor suppressor

Martin, D., Degese, M. S., Vitale-Cross, L., Iglesias-Bartolome, R., Valera, J. L. C., Wang, Z., Feng, X., Yeerna, H., Vadmal, V., Moroishi, T., et al. (2018) · Nature Communications

Hippo pathway signaling and YAP/TAZCancer-related molecular mechanisms research

Cited by 174

Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth

Lin, H.-P., Cheng, Z.-L., He, R.-Y., Song, L., Tian, M.-X., Zhou, L.-S., Groh, B. S., Liu, W.-R., Ji, M.-B., Ding, C., et al. (2016) · Cancer Research

Cancer, Lipids, and MetabolismLipid metabolism and biosynthesis

Cited by 150

Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease

Nemazanyy, I., Blaauw, B., Paolini, C., Caillaud, C., Protasi, F., Mueller, A., Proikas‐Cezanne, T., Russell, R. C., Guan, K., Nishino, I., et al. (2013) · EMBO Molecular Medicine

Autophagy in Disease and TherapyGlycogen Storage Diseases and Myoclonus

Cited by 126

A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening

Diao, Y., Li, B., Meng, Z., Jung, I., Lee, A. Y., Dixon, J., Maliskova, L., Guan, K.-L., Shen, Y., & Ren, B. (2016) · Genome Research

Genomics and Chromatin DynamicsCRISPR and Genetic Engineering

Cited by 122

Crystal structure of the Gtr1p–Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation

Gong, R., Li, L., Liu, Y., Wang, P., Yang, H., Wang, L., Cheng, J., Guan, K.-L., & Xu, Y. (2011) · Genes & Development

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 98

MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy

Ma, X., Zhang, S., He, L., Rong, Y., Brier, L. W., Sun, Q., Liu, R., Fan, W., Chen, S., Yue, Z., et al. (2017) · Autophagy

Autophagy in Disease and TherapyPI3K/AKT/mTOR signaling in cancer

Cited by 92

SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress

Zhang, M., Wu, J., Sun, R., Tao, X., Wang, X., Kang, Q., Wang, H., Zhang, L., Liu, P., Zhang, J., et al. (2019) · PLOS ONE

Sirtuins and Resveratrol in MedicineMitochondrial Function and Pathology

Cited by 72

YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity

Yu, O. M., Benitez, J. A., Plouffe, S. W., Ryback, D., Klein, A., Smith, J., Greenbaum, J., Delatte, B., Rao, A., Guan, K.-L., et al. (2018) · Oncogene

Hippo pathway signaling and YAP/TAZGlioma Diagnosis and Treatment

Cited by 62

A Class of Disulfide Compounds Suppresses Ferroptosis by Stabilizing GPX4

Liu, J.-P., Cen, S.-Y., Xue, Z., Wang, T.-X., Gao, Y., Zheng, J., Zhang, C., Hu, J., Nie, S., Xiong, Y., et al. (2022) · ACS Chemical Biology

Ferroptosis and cancer prognosisRedox biology and oxidative stress

Cited by 29