Flier, Jeffrey S.

Unraveling the central nervous system pathways underlying responses to leptin

Elmquist, J. K., Maratos-Flier, E., Saper, C. B., & Flier, J. S. (1998) · Nature Neuroscience

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 520

Novel Adipose Tissue–Mediated Resistance to Diet-Induced Visceral Obesity in 11β-Hydroxysteroid Dehydrogenase Type 1–Deficient Mice

Morton, N. M., Paterson, J. M., Masuzaki, H., Holmes, M. C., Staels, B., Fievet, C., Walker, B. R., Flier, J. S., Mullins, J. J., & Seckl, J. R. (2004) · Diabetes

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 512

Leptin Prevents Fasting-Induced Suppression of Prothyrotropin-Releasing Hormone Messenger Ribonucleic Acid in Neurons of the Hypothalamic Paraventricular Nucleus*

Légrádi, G., Emerson, C. H., Ahima, R. S., Flier, J. S., & Lechan, R. M. (1997) · Endocrinology

Regulation of Appetite and ObesityThyroid Disorders and Treatments

Cited by 505

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3

Howard, J. K., Cave, B. J., Oksanen, L. J., Tzameli, I., Bjørbæk, C., & Flier, J. S. (2004) · Nature Medicine

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 490

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice

Masuzaki, H., Yamamoto, H., Kenyon, C. J., Elmquist, J. K., Morton, N. M., Paterson, J. M., Shinyama, H., Sharp, M. G. F., Fleming, S., Mullins, J. J., et al. (2003) · Journal of Clinical Investigation

Renin-Angiotensin System StudiesHormonal Regulation and Hypertension

Cited by 434

Divergent Roles of SHP-2 in ERK Activation by Leptin Receptors

Bjørbæk, C., Buchholz, R. M., Davis, S. M., Bates, S. H., Pierroz, D. D., Gu, H., Neel, B. G., Myers, M. G., & Flier, J. S. (2001) · Journal of Biological Chemistry

Protein Tyrosine PhosphatasesRegulation of Appetite and Obesity

Cited by 364

Fibroblast Growth Factor 21-Deficient Mice Demonstrate Impaired Adaptation to Ketosis

Badman, M. K., Koester, A., Flier, J. S., Kharitonenkov, A., & Maratos-Flier, E. (2009) · Endocrinology

Fibroblast Growth Factor ResearchDietary Effects on Health

Cited by 362

Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling

Harris, M., Aschkenasi, C., Elias, C. F., Chandrankunnel, A., Nillni, E. A., Bjørbæk, C., Elmquist, J. K., Flier, J. S., & Hollenberg, A. N. (2001) · Journal of Clinical Investigation

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 341

Evidence Against Altered Expression of GLUT1 or GLUT4 in Skeletal Muscle of Patients With Obesity or NIDDM

Pedersen, O., Bak, J. F., Andersen, P. H., Lund, S., Moller, D. E., Flier, J. S., & Kahn, B. B. (1990) · Diabetes

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 329

The metabolic derangements and treatment of diabetic ketoacidosis

Flier, J. S., Moore, M. J., Foster, D. W., & McGarry, J. D. (1983) · New England Journal of Medicine

Diabetes Management and ResearchDiabetes Treatment and Management

Cited by 318

α-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors

Robins, S. C., Stewart, I., McNay, D. E., Taylor, V., Giachino, C., Goetz, M., Ninkovic, J., Briancon, N., Maratos-Flier, E., Flier, J. S., et al. (2013) · Nature Communications

Neurogenesis and neuroplasticity mechanismsRegulation of Appetite and Obesity

Cited by 306

Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women

Licinio, J., Negrão, A. B., Mantzoros, C., Kaklamani, V., Wong, M.-L., Bongiorno, P. B., Mulla, A., Cearnal, L., Veldhuis, J. D., Flier, J. S., et al. (1998) · Proceedings of the National Academy of Sciences

Hypothalamic control of reproductive hormonesOvarian function and disorders

Cited by 287

Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets

Fisher, F. M., Chui, P. C., Nasser, I. A., Popov, Y., Cunniff, J. C., Lundasen, T., Kharitonenkov, A., Schuppan, D., Flier, J. S., & Maratos-Flier, E. (2014) · Gastroenterology

Fibroblast Growth Factor ResearchLiver Disease Diagnosis and Treatment

Cited by 263

The adipocyte as an active participant in energy balance and metabolism

Badman, M. K., & Flier, J. S. (2007) · Gastroenterology

Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

Cited by 256

Absence of CC Chemokine Ligand 2 Does Not Limit Obesity-Associated Infiltration of Macrophages Into Adipose Tissue

Inouye, K. E., Shi, H., Howard, J. K., Daly, C. H., Lord, G. M., Rollins, B. J., & Flier, J. S. (2007) · Diabetes

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 252

Leptin, nutrition, and the thyroid: the why, the wherefore, and the wiring

Flier, J. S., Harris, M., & Hollenberg, A. N. (2000) · Journal of Clinical Investigation

Thyroid Disorders and TreatmentsRegulation of Appetite and Obesity

Cited by 230

Synchronicity of Frequently Sampled Thyrotropin (TSH) and Leptin Concentrations in Healthy Adults and Leptin-Deficient Subjects: Evidence for Possible Partial TSH Regulation by Leptin in Humans

Mantzoros, C. S., Ozata, M., Negrao, A. B., Suchard, M. A., Ziotopoulou, M., Caglayan, S., Elashoff, R. M., Cogswell, R. J., Negro, P., Liberty, V., et al. (2001) · The Journal of Clinical Endocrinology & Metabolism

Thyroid Disorders and TreatmentsRegulation of Appetite and Obesity

Cited by 229

Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice

Douris, N., Stevanovic, D. M., Fisher, F. M., Cisu, T. I., Chee, M. J., Nguyen, N. L., Zarebidaki, E., Adams, A. C., Kharitonenkov, A., Flier, J. S., et al. (2015) · Endocrinology

Fibroblast Growth Factor ResearchAdipose Tissue and Metabolism

Cited by 215

Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury

Desai, B. N., Singhal, G., Watanabe, M., Stevanovic, D., Lundasen, T., Fisher, F. M., Mather, M. L., Vardeh, H. G., Douris, N., Adams, A. C., et al. (2017) · Molecular Metabolism

Fibroblast Growth Factor ResearchAlcohol Consumption and Health Effects

Cited by 150

Arcuate nucleus ablation prevents fasting-induced suppression of ProTRH mRNA in the hypothalamic paraventricular nucleus

Legradi, G., Emerson, C. H., Ahima, R. S., Rand, W. M., Flier, J. S., & Lechan, R. M. (1998) · Neuroendocrinology

Regulation of Appetite and ObesityThyroid Disorders and Treatments

Cited by 131

Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling

Kienesberger, P. C., Lee, D., Pulinilkunnil, T., Brenner, D. S., Cai, L., Magnes, C., Koefeler, H. C., Streith, I. E., Rechberger, G. N., Haemmerle, G., et al. (2009) · Journal of Biological Chemistry

Lipid metabolism and biosynthesisLipid metabolism and disorders

Cited by 120

Endocrine function of neuropeptide Y knockout mice

Erickson, J. C., Ahima, R. S., Hollopeter, G., Flier, J. S., & Palmiter, R. D. (1997) · Regulatory Peptides

Neuropeptides and Animal PhysiologyRegulation of Appetite and Obesity

Cited by 96

Characterization of Insulin Resistance and NIDDM in Transgenic Mice With Reduced Brown Fat

Hamann, A., Benecke, H., Marchand-Brustel, Y. L., Susulic, V. S., Lowell, B. B., & Flier, J. S. (1995) · Diabetes

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 89

Deficiency of fibroblast growth factor 21 (FGF21) promotes hepatocellular carcinoma (HCC) in mice on a long term obesogenic diet

Singhal, G., Kumar, G., Chan, S., Fisher, F. M., Ma, Y., Vardeh, H. G., Nasser, I. A., Flier, J. S., & Maratos-Flier, E. (2018) · Molecular Metabolism

Fibroblast Growth Factor ResearchLiver Disease Diagnosis and Treatment

Cited by 87