Cited by 256Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and ObesityAdipose Tissue and Metabolism

The adipocyte as an active participant in energy balance and metabolism

Badman, Michael K., Flier, Jeffrey S.·2007·Gastroenterology

Abstract

Obesity is responsible for the mounting incidence of metabolic disease in adult and pediatric populations. Understanding of the pathogenesis and maintenance of the obese state has advanced rapidly over the past 10 years. Bodily energy reserves are managed actively by complex systems that regulate food intake, substrate partitioning, and energy expenditure. An underlying assumption that circulating factors released from storage organs were able to signal bodily energy reserves was confirmed with the discovery of the leptin system. This proof of concept has spurred on the discovery of a multitude of other adipocyte-generated factors. These circulating factors signal to the brain and other organs of metabolic importance, including adipose tissue, liver, muscle, and the immune system. Adipose-derived factors have numerous implications for the basic biology of obesity and provide prospective targets for the amelioration of obesity and its adverse metabolic consequences. In this review we detail the current understanding of leptin as a prototypical adipose tissue-derived hormone related to appetite and obesity. We also describe other important adipose-derived factors in relation to their metabolic effect.

Integrity signals

Registry

Crossref · 10.1053/j.gastro.2007.03.058

Cites

142 of 142 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The basic formulation of the EBM essentially disregards knowledge about the biological influences on fat storage.

    “By focusing on energy balance—characteristically through conscious control, as highlighted in Supplemental Table 1—the basic formulation of the EBM essentially disregards knowledge about the biological influences on fat storage (24, 25).”

Cites

1 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Badman, M. K., & Flier, J. S.
Affiliations
Beth Israel Deaconess Medical Center (US)
Corresponding author
Flier, Jeffrey S.
Venue
Gastroenterology
Publisher
Elsevier BV
Published
2007-05
Volume
132
Issue
6
Pages
2103-2115
ISSN
0016-5085 (ISSN-L)
OpenAlex
W2161508215
Cited by
256
References
142
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 10 · 2021: 3 · 2020: 7 · 2019: 7 · 2018: 11 · 2017: 7 · 2016: 14 · 2015: 10 · 2014: 15 · 2013: 19 · 2012: 14
FWCI
4.25
Type
journal article
Language
en
Open access
closed
Locations
  • Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Funders
U.S. Public Health Service (DKR37 28082)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
adipocytes, obesity, energy balance, leptin, appetite regulation, energy expenditure, substrate partitioning, food intake regulation, metabolic disorders, adipokines, hormone signaling
MeSH terms
Animals, Eating, Energy Metabolism, Humans, Obesity, Signal Transduction, Adipocytes, Leptin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review