Ruas, Jorge L.

Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health

Cervenka, I., Agudelo, L. Z., & Ruas, J. L. (2017) · Science

Tryptophan and brain disordersExercise and Physiological Responses

Cited by 1,382

Hypoxia requires Notch signaling to maintain the undifferentiated cell state

Gustafsson, M. V., Zheng, X., Pereira, T., Gradin, K., Jin, S., Lundkvist, J., Ruas, J. L., Poellinger, L., Lendahl, U., & Bondesson, M. (2005) · Developmental Cell

Developmental Biology and Gene RegulationCancer, Hypoxia, and Metabolism

Cited by 1,109

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

Arany, Z., Foo, S.-Y., Ma, Y., Ruas, J. L., Bommi-Reddy, A., Girnun, G., Cooper, M., Laznik, D., Chinsomboon, J., Rangwala, S. M., et al. (2008) · Nature

Angiogenesis and VEGF in CancerCancer, Hypoxia, and Metabolism

Cited by 1,054

Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis

Rao, R. R., Long, J. Z., White, J. P., Svensson, K. J., Lou, J., Lokurkar, I., Jedrychowski, M. P., Ruas, J. L., Wrann, C. D., Lo, J. C., et al. (2014) · Cell

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 973

Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression

Agudelo, L. Z., Femenía, T., Orhan, F., Porsmyr-Palmertz, M., Goiny, M., Martinez-Redondo, V., Correia, J. C., Izadi, M., Bhat, M., Schuppe-Koistinen, I., et al. (2014) · Cell

Tryptophan and brain disordersTreatment of Major Depression

Cited by 739

A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy

Ruas, J. L., White, J. P., Rao, R. R., Kleiner, S., Brannan, K. T., Harrison, B. C., Greene, N. P., Wu, J., Estall, J. L., Irving, B. A., et al. (2012) · Cell

Muscle Physiology and DisordersAdipose Tissue and Metabolism

Cited by 677

Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex

Kajimura, S., Seale, P., Tomaru, T., Erdjument-Bromage, H., Cooper, M. P., Ruas, J. L., Chin, S., Tempst, P., Lazar, M. A., & Spiegelman, B. M. (2008) · Genes & Development

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 468

The transcriptional coactivator PGC-1α mediates exercise-induced angiogenesis in skeletal muscle

Chinsomboon, J., Ruas, J., Gupta, R. K., Thom, R., Shoag, J., Rowe, G. C., Sawada, N., Raghuram, S., & Arany, Z. (2009) · Proceedings of the National Academy of Sciences

Cardiovascular and exercise physiologyAdipose Tissue and Metabolism

Cited by 379

The Unfolded Protein Response Mediates Adaptation to Exercise in Skeletal Muscle through a PGC-1α/ATF6α Complex

Wu, J., Ruas, J. L., Estall, J. L., Rasbach, K. A., Choi, J. H., Ye, L., Boström, P., Tyra, H. M., Crawford, R. W., Campbell, K. P., et al. (2011) · Cell Metabolism

Endoplasmic Reticulum Stress and DiseaseMuscle Physiology and Disorders

Cited by 312

G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy

White, J. P., Wrann, C. D., Rao, R. R., Nair, S. K., Jedrychowski, M. P., You, J.-S., Martínez-Redondo, V., Gygi, S. P., Ruas, J. L., Hornberger, T. A., et al. (2014) · Proceedings of the National Academy of Sciences

Muscle Physiology and DisordersAdipose Tissue and Metabolism

Cited by 123

Loss of Pgc-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation

Sczelecki, S., Besse-Patin, A., Abboud, A., Kleiner, S., Laznik-Bogoslavski, D., Wrann, C. D., Ruas, J. L., Haibe-Kains, B., & Estall, J. L. (2014) · American Journal of Physiology-Endocrinology and Metabolism

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 108

Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice

Wu, H., Petitpré, C., Fontanet, P., Sharma, A., Bellardita, C., Quadros, R. M., Jannig, P. R., Wang, Y., Heimel, J. A., Cheung, K. K. Y., et al. (2021) · Nature Communications

Ion Channels and ReceptorsPain Mechanisms and Treatments

Cited by 86

The mitochondrial mRNA stabilizing protein, SLIRP, regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms

Sylow, L., Pham, T. C. P., Raun, S., Havula, E., Henriquez-Olguín, C., Rubalcava-Gracia, D., Frank, E., Fritzen, A., Jannig, P., Andersen, N., et al. (2024) · Nature Communications

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 19

The mitochondrial mRNA-stabilizing protein SLIRP regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms

Pham, T. C. P., Raun, S. H., Havula, E., Henriquez-Olguín, C., Rubalcava-Gracia, D., Frank, E., Fritzen, A. M., Jannig, P. R., Andersen, N. R., Kruse, R., et al. (2024) · Nature Communications

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 19

The mitochondrial mRNA stabilizing protein, SLIRP, regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms

Pham, T. C. P., Raun, S. H., Havula, E., Henriquez-Olguín, C., Rubalcava-Gracia, D., Frank, E., Fritzen, A. M., Jannig, P. R., Andersen, N. R., Kruse, R., et al. (2023) · Nature Communications

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 19