G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy

White, James P.; Wrann, Christiane D.; Rao, Rajesh R.; Nair, Sreekumaran K.; Jedrychowski, Mark P.; You, Jae-Sung; Martínez-Redondo, Vicente; Gygi, Steven P.; Ruas, Jorge L.; Hornberger, Troy A.; Wu, Zhidan; Glass, David J.; Piao, Xianhua; Spiegelman, Bruce M.

doi:10.1073/pnas.1417898111

Cited by 123Muscle Physiology and DisordersAdipose Tissue and MetabolismGenetics and Physical Performance

G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy

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White, James P., Wrann, Christiane D., Rao, Rajesh R., Nair, Sreekumaran K., Jedrychowski, Mark P., You, Jae-Sung, Martínez-Redondo, Vicente, Gygi, Steven P. +6 more·2014·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1417898111PMC PMC4226111

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Abstract

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha 4 (PGC-1α4) is a protein isoform derived by alternative splicing of the PGC1α mRNA and has been shown to promote muscle hypertrophy. We show here that G protein-coupled receptor 56 (GPR56) is a transcriptional target of PGC-1α4 and is induced in humans by resistance exercise. Furthermore, the anabolic effects of PGC-1α4 in cultured murine muscle cells are dependent on GPR56 signaling, because knockdown of GPR56 attenuates PGC-1α4-induced muscle hypertrophy in vitro. Forced expression of GPR56 results in myotube hypertrophy through the expression of insulin-like growth factor 1, which is dependent on Gα12/13 signaling. A murine model of overload-induced muscle hypertrophy is associated with increased expression of both GPR56 and its ligand collagen type III, whereas genetic ablation of GPR56 expression attenuates overload-induced muscle hypertrophy and associated anabolic signaling. These data illustrate a signaling pathway through GPR56 which regulates muscle hypertrophy associated with resistance/loading-type exercise.

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PGC-1α4 is abundantly expressed in skeletal muscle and appears to play a role in the adaptive response to exercise, particularly in the setting of resistance training.
“PGC-1α4, a transcript from the PGC-1 α gene, is abundantly expressed in skeletal muscle and appears to play a role in the adaptive response to exercise, particularly in the setting of resistance training (Ruas et al., 2012;White et al., 2014).”
From Concurrent exercise training: do opposites distract? (2017) · cites this paper as White et al., 2014
The PGC1α4 splicing variant promotes the expression of IGF1 via upregulation of GPR56.
“Mechanistically, PGC1α4 splicing variant promotes the expression of IGF1 via the upregulation of G protein-coupled receptor (GPR) 5633.”
From Mechanisms of muscle atrophy and hypertrophy: implications in health and disease (2021) · cites this paper as [33]
GPR56 is a transcriptional target of PGC-1α4 and is induced by resistance exercise.
“The G protein-coupled receptor 56 (GPR56) is a transcriptional target of PGC-1α4 and is induced by resistance exercise [15].”
From Apigenin Enhances Skeletal Muscle Hypertrophy and Myoblast Differentiation by Regulating Prmt7 (2017) · cites this paper as [15]
Overexpression of GPR56 increases IGF-1 expression via Gα12/13 and activates mTORC1, resulting in muscle hypertrophy.
“Overexpression of GPR56 increases IGF-1 expression via Gα12/13 and activates mTORC1, which results in muscle hypertrophy [15].”
From Apigenin Enhances Skeletal Muscle Hypertrophy and Myoblast Differentiation by Regulating Prmt7 (2017) · cites this paper as [15]

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Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.008 · Cited by 1,440 · see citing works
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Rao, R. R., Long, J. Z., White, J. P., Svensson, K. J., Lou, J., Lokurkar, I., Jedrychowski, M. P., Ruas, J. L., Wrann, C. D., Lo, J. C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.03.065 · Cited by 973 · see citing works
Self-citation
Effects of Resistance Training on Older Adults
Hunter, G. R., McCarthy, J. P., & Bamman, M. M. (2004) · Sports Medicine · doi:10.2165/00007256-200434050-00005 · Cited by 764 · see citing works
A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy
Ruas, J. L., White, J. P., Rao, R. R., Kleiner, S., Brannan, K. T., Harrison, B. C., Greene, N. P., Wu, J., Estall, J. L., Irving, B. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.10.050 · Cited by 677 · see citing works
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Goodman, C. A., Mabrey, D. M., Frey, J. W., Miu, M. H., Schmidt, E. K., Pierre, P., & Hornberger, T. A. (2010) · The FASEB Journal · doi:10.1096/fj.10-168799 · Cited by 478 · see citing works
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Araç, D., Boucard, A. A., Bolliger, M. F., Nguyen, J., Soltis, S. M., Südhof, T. C., & Brünger, A. T. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.26 · Cited by 450 · see citing works
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Drummond, M. J., Fry, C. S., Glynn, E. L., Dreyer, H. C., Dhanani, S., Timmerman, K. L., Volpi, E., & Rasmussen, B. B. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.163816 · Cited by 439 · cited 2× · see citing works
“Mechanical overload in both mouse (11) and humans (12) increases mTOR phosphorylation and its downstream target p70S6K.”
Background
PI3 kinase regulation of skeletal muscle hypertrophy and atrophy.
Glass, D. (2010) · Current Topics in Microbiology and Immunology · doi:10.1007/82_2010_78 · Cited by 330 · see citing works
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Spangenburg, E. E., Roith, D. L., Ward, C. W., & Bodine, S. C. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.141507 · Cited by 254 · see citing works
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Tesch, P. A. (1988) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198810001-00008 · Cited by 241 · see citing works
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Li, S., Jin, Z., Koirala, S., Bu, L., Xu, L., Hynes, R. O., Walsh, C. A., Corfas, G., & Piao, X. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0853-08.2008 · Cited by 241 · see citing works
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White, J., Reecy, J. M., Washington, T. A., Sato, S., Le, M., Davis, J. M., Wilson, L., & Carson, J. A. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.02029.x · Cited by 63 · see citing works
Self-citation
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Minetti, G., Feige, J. N., Bombard, F., Heier, A., Morvan, F., Nürnberg, B., Leiss, V., Birnbaumer, L., Glass, D. J., & Fornaro, M. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00957-13 · Cited by 48 · see citing works
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Wu, M. P., Doyle, J. R., Barry, B. J., Beauvais, A., Rozkalne, A., Piao, X., Lawlor, M. W., Kopin, A. S., Walsh, C. A., & Gussoni, E. (2013) · FEBS Journal · doi:10.1111/febs.12529 · Cited by 47 · see citing works
Self-citation
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RhoA induction by functional overload and nandrolone decanoate administration in rat skeletal muscle
McClung, J. M., Lee, W. J., Thompson, R. W., Lowe, L. L., & Carson, J. A. (2003) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1151-7 · Cited by 35 · see citing works
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Kumar, R. N., Ha, J. H., Radhakrishnan, R., & Dhanasekaran, D. N. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.26.1.50-62.2006 · Cited by 29 · see citing works

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Ng, K., Chen, T., Stacey, M. A., & Lin, H. (2021) · Cells · doi:10.3390/cells10123352 · Cited by 33 · see citing works
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Seufert, F., Chung, Y. K., Hildebrand, P. W., & Langenhan, T. (2023) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2023.05.007 · Cited by 32 · see citing works
Regulation of muscle hypertrophy: Involvement of the Akt-independent pathway and satellite cells in muscle hypertrophy
Fukada, S., & Ito, N. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112907 · Cited by 31 · see citing works
Gα13 ablation reprograms myofibers to oxidative phenotype and enhances whole-body metabolism
Koo, J. H., Kim, T. H., Park, S., Joo, M. S., Han, C. Y., Choi, C. S., & Kim, S. G. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92067 · Cited by 33 · see citing works
Cancer Cell Mechanics: Adhesion G Protein-coupled Receptors in Action?
Scholz, N. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00059 · Cited by 32 · see citing works
Unveiling Mechanical Activation: GAIN Domain Unfolding and Dissociation in Adhesion GPCRs
Fu, C., Huang, W., Tang, Q., Niu, M., Guo, S., Langenhan, T., Song, G., & Yan, J. (2023) · Nano Letters · doi:10.1021/acs.nanolett.3c01163 · Cited by 31 · see citing works
GPR56: An adhesion GPCR involved in brain development, neurological disorders and cancer
Ganesh, R. A., Venkataraman, K., & Sirdeshmukh, R. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147055 · Cited by 31 · see citing works
Extracellular transglutaminase 2 induces myotube hypertrophy through G protein-coupled receptor 56
Kitakaze, T., Yoshikawa, M., Kobayashi, Y., Kimura, N., Goshima, N., Ishikawa, T., Ogata, Y., Yamashita, Y., Ashida, H., Harada, N., et al. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2019.118563 · Cited by 30 · see citing works
ADGRG1 Is a Predictor of Chemoresistance and Poor Survival in Cervical Squamous Carcinoma
Zhang, S., Guo, K., Liang, Y., Wang, K., Liu, S., & Yang, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.671895 · Cited by 29 · see citing works
The Activation and Signaling Mechanisms of GPR56/ADGRG1 in Melanoma Cell
Huang, K., & Lin, H. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00304 · Cited by 29 · see citing works
Structural basis for CD97 recognition of the decay-accelerating factor CD55 suggests mechanosensitive activation of adhesion GPCRs
Niu, M., Xu, S., Yang, J., Yao, D., Li, N., Yan, J., Zhong, G., & Song, G. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100776 · Cited by 29 · see citing works
AAV‐Mediated nuclear localized PGC1α4 delivery in muscle ameliorates sarcopenia and aging‐associated metabolic dysfunctions
Guo, M., Zhang, J., Ma, Y., Zhu, Z., Zuo, H., Yao, J., Wu, X., Wang, D., Yu, J., Meng, M., et al. (2023) · Aging Cell · doi:10.1111/acel.13961 · Cited by 29 · see citing works
Adhesion G-protein coupled receptors: Implications for metabolic function
Olaniru, O. E., & Persaud, S. J. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.02.012 · Cited by 23 · see citing works
Crucial contribution of GPR56/ADGRG1, expressed by breast cancer cells, to bone metastasis formation
Sasaki, S., Zhang, D., Iwabuchi, S., Tanabe, Y., Hashimoto, S., 山内, 明., Hayashi, K., Tsuchiya, H., Hayakawa, Y., Baba, T., et al. (2021) · Cancer Science · doi:10.1111/cas.15150 · Cited by 23 · see citing works
BAF57/SMARCE1 Interacting with Splicing Factor SRSF1 Regulates Mechanical Stress-Induced Alternative Splicing of Cyclin D1
Feng, J., Xu, X., Fan, X., Yi, Q., & Tang, L. (2021) · Genes · doi:10.3390/genes12020306 · Cited by 22 · see citing works
Functions of G protein‐coupled receptor 56 in health and disease
Su, T., Guan, Q., Cheng, H., Zhu, Z., Jiang, C., Guo, P., Tai, Y., Sun, H., Wang, M., Wei, W., et al. (2022) · Acta Physiologica · doi:10.1111/apha.13866 · Cited by 20 · see citing works
Specific and direct modulation of the interaction between adhesion GPCR GPR56/ADGRG1 and tissue transglutaminase 2 using synthetic ligands
Salzman, G., Zhang, S., Fernandez, C., Araç, D., & Koide, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-74044-6 · Cited by 20 · see citing works
BMAL1/PGC1α4-FNDC5/irisin axis impacts distinct outcomes of time-of-day resistance exercise
Guo, M., Shen, F., Guo, X., Zhang, J., Ma, Y., Wu, X., Zuo, H., Yao, J., Hu, Y., Wang, D., et al. (2024) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2024.100968 · Cited by 19 · see citing works
Adhesion G‐protein coupled receptor 56 is required for 3T3‐L1 adipogenesis
Hasan, M. A., Roy, P., Dolan, S., Martin, P. E., Patterson, S., & Bartholomew, C. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29079 · Cited by 18 · see citing works
TGM2 positively regulates myoblast differentiation via enhancing the mTOR signaling
Wang, D., Zhao, D., Li, Y., Dai, T., Liu, F., & Yan, C. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2021.119173 · Cited by 17 · see citing works
Quantitative Biology of Exercise-Induced Signal Transduction Pathways
Liu, T. C., Liu, G., Hu, S., Zhu, L., Yang, X.-B., & Zhang, Q.-G. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55231-6_54 · Cited by 16 · see citing works
Anabolic and Catabolic Signaling Pathways That Regulate Skeletal Muscle Mass
McCarthy, J. J., & Murach, K. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813922-6.00024-2 · Cited by 16 · see citing works
PRMT7: A Pivotal Arginine Methyltransferase in Stem Cells and Development
Wang, B., Zhang, M., Liu, Z., Mu, Y., & Li, K. (2021) · Stem Cells International · doi:10.1155/2021/6241600 · Cited by 15 · see citing works
Exercise protects against cardiac and skeletal muscle dysfunction in a mouse model of inflammatory arthritis
Huffman, K. M., Andonian, B. J., Abraham, D., Bareja, A., Lee, D. E., Katz, L. H., Huebner, J. L., Kraus, W. E., & White, J. P. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00576.2020 · Cited by 14 · see citing works
Self-citation
Structure, function and therapeutic potential of adhesion GPCRs
Araç, D., & Leon, K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816228-6.00002-7 · Cited by 12 · see citing works
Effect of irradiation on Akt signaling in atrophying skeletal muscle
Fix, D. K., Hardee, J. P., Bateman, T. A., & Carson, J. A. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00218.2016 · Cited by 12 · see citing works
Adhesion GPCR GPR56 Expression Profiling in Human Tissues
Kaiser, F., Morawski, M., Krohn, K., Rayes, N., Hsiao, C., Quaas, M., & Aust, G. (2021) · Cells · doi:10.3390/cells10123557 · Cited by 12 · see citing works
Adhesion G protein-coupled receptors
Langenhan, T., Anderson, G. R., Araç, D., Aust, G., Avila-Zozaya, M., Bagger, S. M., Barth, P., Berndt, S., Blacklow, S. C., Blanco-Redondo, B., et al. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100116 · Cited by 13 · see citing works
Self-citation
Crystal Structure of the Extracellular Domains of GPR110
Wang, F., Wang, Y., Qiu, W., Zhang, Q., Yang, H., & Song, G. (2023) · Journal of Molecular Biology · doi:10.1016/j.jmb.2023.167979 · Cited by 11 · see citing works
Hexahydroquinoline Derivatives Are Selective Agonists for the Adhesion G Protein-Coupled Receptor ADGRG1/GPR56
Vizurraga, A., Robertson, M. J., Yu, M., Skiniotis, G., & Tall, G. G. (2023) · Molecular Pharmacology · doi:10.1124/molpharm.123.000688 · Cited by 11 · see citing works
Network model of skeletal muscle cell signalling predicts differential responses to endurance and resistance exercise training
Fowler, A., Knaus, K. R., Khuu, S., Khalilimeybodi, A., Schenk, S., Ward, S. R., Fry, A. C., Rangamani, P., & McCulloch, A. D. (2024) · Experimental Physiology · doi:10.1113/ep091712 · Cited by 9 · see citing works
Intron retention of an adhesion GPCR generates 1TM isoforms required for 7TM-GPCR function
Bormann, A., Körner, M. B., Dahse, A.-K., Gläser, M. S., Irmer, J., Lede, V., Alenfelder, J., Lehmann, J., Hall, D. C. N., Thane, M., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.115078 · Cited by 11 · see citing works
Control of Skeletal Muscle Cell Growth and Size Through Adhesion GPCRs
White, J. P. (2016) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-41523-9_13 · Cited by 11 · see citing works
Self-citation
Structural basis of GAIN domain autoproteolysis and cleavage-resistance in the adhesion G-protein coupled receptors
Pohl, F., Seufert, F., Chung, Y. K., Schick, R., Kieslich, B., Schöneberg, T., Langenhan, T., Hildebrand, P. W., & Sträter, N. (2026) · Nature Communications · doi:10.1038/s41467-026-71225-1 · Cited by 10 · see citing works
Acute and chronic effects of exercise on mRNA expression in the skeletal muscle of two mouse models of peripheral artery disease
Nagase, H., Yao, S., & Ikeda, S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182456 · Cited by 10 · see citing works
Mechanical force induced activation of adhesion G protein–coupled receptor
Xu, Y., Xu, H., Yan, J., & Song, G. (2024) · Mechanobiology in Medicine · doi:10.1016/j.mbm.2024.100078 · Cited by 9 · see citing works
Weighted gene co-expression network analysis identified underlying hub genes and mechanisms in the occurrence and development of viral myocarditis
Ma, Z., Shen, Z., Gong, Y., Zhou, J., Chen, X., Lv, Q., Wang, M., Chen, J. C., Yu, M. Y., Fu, G., et al. (2020) · Annals of Translational Medicine · doi:10.21037/atm-20-3337 · Cited by 9 · see citing works
Introduction: History of the Adhesion GPCR Field
Hamann, J., & Petrenko, A. G. (2016) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-41523-9_1 · Cited by 8 · see citing works
Identification and validation of G protein-coupled receptors modulating flow-dependent signaling pathways in vascular endothelial cells
Qiu, D., Xu, K., Chung, N., Robbins, J., Luo, R., Lawrence, M., He, A., Yu, F., Alt, A. J., Miller, M. M., et al. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1198079 · Cited by 7 · see citing works
Skeletal muscle growth to combat diabetes and obesity: the potential role of muscle‐secreted factors
Sammut, M. J., Thorne, B. R., & Melling, C. W. J. (2025) · Obesity · doi:10.1002/oby.24223 · Cited by 7 · see citing works
GPCR targets in type 2 diabetes
Atanes, P., & Persaud, S. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816228-6.00018-0 · Cited by 7 · see citing works
Comparison of long- and short-rest periods during high-intensity interval exercise on transcriptomic responses in equine skeletal muscle
Takahashi, K., Mukai, K., Takahashi, Y., Ebisuda, Y., Hatta, H., & Kitaoka, Y. (2024) · Physiological Genomics · doi:10.1152/physiolgenomics.00066.2024 · Cited by 7 · see citing works
Loss of cardiomyocyte-specific adhesion G-protein-coupled receptor G1 (ADGRG1/GPR56) promotes pressure overload-induced heart failure
Einspahr, J. M., Xu, H., Roy, R., Dietz, N., Melchior, J., Raja, J., Carter, R. L., Piao, X., & Tilley, D. G. (2024) · Bioscience Reports · doi:10.1042/bsr20240826 · Cited by 5 · see citing works
Self-citation
Exercise Intensity and Rest Intervals Effects on Intracellular Signals and Anabolic Response of Skeletal Muscle to Resistance Training
Moro, T., Monaco, L., Naro, F., Reggiani, C., & Paoli, A. (2022) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000004209 · Cited by 5 · see citing works
A Microfluidic Stretch System Upregulates Resistance Exercise-Related Pathway
Ahn, J., Kim, J.-S., Jeon, J. S., & Jang, Y. J. (2022) · BioChip Journal · doi:10.1007/s13206-022-00051-6 · Cited by 5 · see citing works
Gq Signaling in Autophagy Control: Between Chemical and Mechanical Cues
Navarro‐Lérida, I., Aragay, A. M., Asensio, A., & Ribas, C. (2022) · Antioxidants · doi:10.3390/antiox11081599 · Cited by 6 · see citing works
Computer program for evaluating coal washer performance
Wizzard, J. T. (1983) · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) · Cited by 5 · see citing works
Decoding ADGRE5: How Proteolytic Cleavage and Mechanical Forces Unleash Cellular Signals
Moreno-Salinas, A. L., Mancini, A. D., Aouad, S., Kandasamy, H., Morissette, S., Maïga, A., Bouvier, M., Leduc, R., & Sabbagh, L. (2025) · Cells · doi:10.3390/cells14161284 · Cited by 4 · see citing works
Physiological Regulation of Skeletal Muscle Mass
Pérez‐Schindler, J., & Handschin, C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-810422-4.00011-7 · Cited by 4 · see citing works
Step-wise mechanical unfolding and dissociation of the GAIN domains of ADGRG1/GPR56, ADGRL1/Latrophilin-1 and ADGRB3/BAI3: insights into the mechanical activation hypothesis of adhesion G protein-coupled receptorsPreprint
Fu, C., Huang, W., Tang, Q., Niu, M., Guo, S., Langenhan, T., Song, G., & Yan, J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.14.532526 · Cited by 4 · see citing works
Extracellular vesicles from cartilage progenitors stimulate type II collagen expression and wound healing in meniscal cells
Betensky, D. J., Chen, M. D., Trivedi, J., Desai, S., Twomey-Kozak, J. N., Wen, S., & Jayasuriya, C. T. (2024) · Journal of Orthopaedic Research® · doi:10.1002/jor.26013 · Cited by 3 · see citing works
Intron retention of an adhesion GPCR generates single transmembrane-helix isoforms to enable 7TM-adhesion GPCR functionPreprint
Bormann, A., Körner, M. B., Dahse, A.-K., Gläser, M. S., Irmer, J., Lede, V., Alenfelder, J., Lehmann, J., Hall, D. C. N., Thane, M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.11.521585 · Cited by 3 · see citing works
Mechanosensitive adhesion G protein-coupled receptors: Insights from health and disease
Sun, S., & Wang, W. (2024) · Genes & Diseases · doi:10.1016/j.gendis.2024.101267 · Cited by 2 · see citing works

G protein coupled receptor 56 is a target gene of the PGC‐1α4 isoform and regulates overload‐induced muscle hypertrophy (1163.15)
White, J. P., Wrann, C. D., Rao, R. R., Wu, Z., Glass, D. J., & Spiegelman, B. M. (2014) · The FASEB Journal · doi:10.1096/fasebj.28.1_supplement.1163.15
Self-citation
A novel PGC‐1á isoform induced by resistance training regulates skeletal muscle hypertrophy
White, J. P., Ruas, J. L., Rao, R. R., Kleiner, S., Wu, J., & Spiegelman, B. M. (2013) · The FASEB Journal · doi:10.1096/fasebj.27.1_supplement.940.18 · Cited by 1 · see citing works
Self-citation
A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy
Ruas, J. L., White, J. P., Rao, R. R., Kleiner, S., Brannan, K. T., Harrison, B. C., Greene, N. P., Wu, J., Estall, J. L., Irving, B. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.10.050 · Cited by 677 · see citing works
Self-citation
PGC‐1α4 gene expression is suppressed by the IL‐6—MEK—ERK 1/2 MAPK signalling axis and altered by resistance exercise, obesity and muscle injury
Brown, J. L., Rosa-Caldwell, M., Lee, D. E., Brown, L., Perry, R. A., Shimkus, K., Blackwell, T. A., Fluckey, J., Carson, J. A., Dridi, S., et al. (2017) · Acta Physiologica · doi:10.1111/apha.12826 · Cited by 33 · see citing works
Is muscle hypertrophy following resistance exercise regulated by truncated splice variants of PGC-1α?
Perry, C. G. R. (2014) · Acta Physiologica · doi:10.1111/apha.12348 · Cited by 3 · see citing works

Authors: White, J. P., Wrann, C. D., Rao, R. R., Nair, S. K., Jedrychowski, M. P., You, J.-S., Martínez-Redondo, V., Gygi, S. P., Ruas, J. L., Hornberger, T. A., Wu, Z., Glass, D. J., Piao, X., & Spiegelman, B. M.
Affiliations: Harvard University (US)
Mayo Clinic (US)
University of Wisconsin–Madison (US)
Karolinska Institutet (SE)
Novartis Institutes for Biomedical Research, Cambridge, MA 02139; and
Boston Children's Hospital (US)
ORCID: White, James P.
Wrann, Christiane D.
You, Jae-Sung
Gygi, Steven P.
Ruas, Jorge L.
Hornberger, Troy A.
Wu, Zhidan
Glass, David J.
Piao, Xianhua
Spiegelman, Bruce M.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2014-10-21
Volume: 111
Issue: 44
Pages: 15756-15761
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1417898111
PMC: PMC4226111
OpenAlex: W1977223822
Cited by: 123
References: 26
Citations by year: 2026: 12 · 2025: 6 · 2024: 12 · 2023: 9 · 2022: 9 · 2021: 17 · 2020: 12 · 2019: 9 · 2018: 5 · 2017: 10 · 2016: 15 · 2015: 5 · 2014: 1
FWCI: 4.24
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Novo Nordisk Fonden (NNF12OC1016062)
National Institute of Diabetes and Digestive and Kidney Diseases (DK061562, R01DK061562)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR-057347, R56AR057347, R01AR057347)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
Keywords: GPR56, muscle hypertrophy, mechanical overload, resistance training, insulin-like growth factor I, type III collagen, myotube hypertrophy, transcriptional regulation
MeSH terms: Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Animals, Gene Expression Regulation, Hypertrophy, Insulin-Like Growth Factor I, Male, Muscle Proteins, Physical Conditioning, Animal, Transcription Factors, Signal Transduction, Muscle Fibers, Skeletal, Collagen Type III, Receptors, G-Protein-Coupled, Mice

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G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy

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