The transcriptional coactivator PGC-1α mediates exercise-induced angiogenesis in skeletal muscle
Open accessAbstract
Peripheral arterial disease (PAD) affects 5 million people in the US and is the primary cause of limb amputations. Exercise remains the single best intervention for PAD, in part thought to be mediated by increases in capillary density. How exercise triggers angiogenesis is not known. PPARγ coactivator (PGC)-1α is a potent transcriptional co-activator that regulates oxidative metabolism in a variety of tissues. We show here that PGC-1α mediates exercise-induced angiogenesis. Voluntary exercise induced robust angiogenesis in mouse skeletal muscle. Mice lacking PGC-1α in skeletal muscle failed to increase capillary density in response to exercise. Exercise strongly induced expression of PGC-1α from an alternate promoter. The induction of PGC-1α depended on β-adrenergic signaling. β-adrenergic stimulation also induced a broad program of angiogenic factors, including vascular endothelial growth factor (VEGF). This induction required PGC-1α. The orphan nuclear receptor ERRα mediated the induction of VEGF by PGC-1α, and mice lacking ERRα also failed to increase vascular density after exercise. These data demonstrate that β-adrenergic stimulation of a PGC-1α/ERRα/VEGF axis mediates exercise-induced angiogenesis in skeletal muscle.
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The rise in circulating catecholamines through the β-adrenergic receptor activates CREB, a transcription factor required for the transcriptional upregulation of PGC-1α.
“Last, the rise in circulating catecholamines through the β-adrenergic receptor activates the cyclic AMP response element binding protein (CREB), a transcription factor that is required for the transcriptional upregulation of PGC-1α [40].”
From Using Molecular Biology to Maximize Concurrent Training (2014) · cites this paper as [40]
Cites
Angiogenesis in health and disease
Carmeliet, P. (2003) · Nature Medicine · doi:10.1038/nm0603-653 · Cited by 4,258 · see citing works
Hirsch, A. T., Haskal, Z. J., Hertzer, N. R., Bakal, C. W., Creager, M. A., Halperin, J. L., Hiratzka, L. F., Murphy, W. R. C., Olin, J. W., Puschett, J. B., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.174526 · Cited by 3,708 · see citing works
Angiogenesis as a therapeutic target
Ferrara, N., & Kerbel, R. S. (2005) · Nature · doi:10.1038/nature04483 · Cited by 2,653 · see citing works
Molecular regulation of vessel maturation
Jain, R. K. (2003) · Nature Medicine · doi:10.1038/nm0603-685 · Cited by 2,515 · see citing works
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491 · see citing works
Metabolic control through the PGC-1 family of transcription coactivators
Lin, J., Handschin, C., & Spiegelman, B. M. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.004 · Cited by 2,130 · see citing works
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
Thaker, P. H., Han, L. Y., Kamat, A. A., Arevalo, J. M., Takahashi, R., Lu, C., Jennings, N. B., Armaiz-Pena, G., Bankson, J. A., Ravoori, M., et al. (2006) · Nature Medicine · doi:10.1038/nm1447 · Cited by 1,320 · see citing works
Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
Kelly, D. P., & Scarpulla, R. C. (2004) · Genes & Development · doi:10.1101/gad.1177604 · Cited by 1,243 · see citing works
Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice
Lin, J., Wu, P.-H., Tarr, P. T., Lindenberg, K. S., St-Pierre, J., Zhang, C.-Y., Mootha, V. K., Jäger, S., Vianna, C. R., Reznick, R. M., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.013 · Cited by 1,162 · see citing works
Advances in Male Contraception
Page, S. T., Amory, J. K., & Bremner, W. J. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0041 · Cited by 1,134 · see citing works
Handschin, C., & Spiegelman, B. M. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0037 · Cited by 1,090 · see citing works
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α
Arany, Z., Foo, S.-Y., Ma, Y., Ruas, J. L., Bommi-Reddy, A., Girnun, G., Cooper, M., Laznik, D., Chinsomboon, J., Rangwala, S. M., et al. (2008) · Nature · doi:10.1038/nature06613 · Cited by 1,054 · see citing works
Self-citationHenry, T. D., Annex, B. H., McKendall, G. R., Azrin, M., López, J. J., Giordano, F. J., Shah, P. K., Willerson, J. T., Benza, R. L., Berman, D. S., et al. (2003) · Circulation · doi:10.1161/01.cir.0000061911.47710.8a · Cited by 1,025 · see citing works
Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1
Baar, K., Wende, A. R., Jones, T. E., Marison, M., Nolte, L. A., Chen, M., Kelly, D. P., & Holloszy, J. O. (2002) · The FASEB Journal · doi:10.1096/fj.02-0367com · Cited by 1,020 · see citing works
Calcium Ion in Skeletal Muscle: Its Crucial Role for Muscle Function, Plasticity, and Disease
Berchtold, M. W., Brinkmeier, H., & Müntener, M. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.1215 · Cited by 1,007 · see citing works
Signaling Pathways in Skeletal Muscle Remodeling
Bassel‐Duby, R., & Olson, E. N. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142622 · Cited by 799 · see citing works
Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization
Isner, J. M., & Asahara, T. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6889 · Cited by 774 · see citing works
Cytokine Stimulation of Energy Expenditure through p38 MAP Kinase Activation of PPARγ Coactivator-1
Puigserver, P., Rhee, J., Lin, J., Wu, Z., Yoon, J. C., Zhang, C.-Y., Krauss, S., Mootha, V. K., Lowell, B. B., & Spiegelman, B. M. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00390-2 · Cited by 732 · see citing works
Handschin, C., Rhee, J., Lin, J., Tarr, P. T., & Spiegelman, B. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1232352100 · Cited by 729 · see citing works
Molecular and cellular adaptation of muscle in response to exercise: perspectives of various models
Booth, F. W., & Thomason, D. B. (1991) · Physiological Reviews · doi:10.1152/physrev.1991.71.2.541 · Cited by 703 · see citing works
Invited Review: Contractile activity-induced mitochondrial biogenesis in skeletal muscle
Hood, D. A. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.3.1137 · Cited by 692 · see citing works
Regulation of mitochondrial biogenesis in skeletal muscle by CaMK
Wu, H., Kanatous, S. B., Thurmond, F. A., Gallardo, T., Isotani, E., Bassel-Duby, R., & Williams, R. S. (2002) · Science · doi:10.1126/science.1071163 · Cited by 684 · see citing works
Transcriptional coactivator PGC-1α integrates the mammalian clock and energy metabolism
Liu, C., Li, S., Liu, T., Borjigin, J., & Lin, J. D. (2007) · Nature · doi:10.1038/nature05767 · Cited by 643 · see citing works
Angiogenesis in skeletal and cardiac muscle
HUDLICKÁ, O., Brown, M. D., & Egginton, S. (1992) · Physiological Reviews · doi:10.1152/physrev.1992.72.2.369 · Cited by 615 · see citing works
Handschin, C., Chin, S., Li, P., Liu, F., Maratos-Flier, E., LeBrasseur, N. K., Yan, Z., & Spiegelman, B. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704817200 · Cited by 611 · see citing works
What makes vessels grow with exercise training?
Prior, B. M., Yang, H. T., & Terjung, R. L. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00035.2004 · Cited by 511 · see citing works
Benefit of exercise conditioning for patients with peripheral arterial disease.
Hiatt, W. R., Regensteiner, J. G., Hargarten, M. E., Wolfel, E. E., & Brass, E. P. (1990) · Circulation · doi:10.1161/01.cir.81.2.602 · Cited by 501 · see citing works
Koves, T. R., Li, P., An, J., Akimoto, T., Slentz, D., Ilkayeva, O., Dohm, G. L., Yan, Z., Newgard, C. B., & Muoio, D. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507621200 · Cited by 464 · see citing works
Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation
Xue, Y., Petrovič, N., Cao, R., Larsson, O. S., Lim, S., Chen, S., Feldmann, H. M., Liang, Z., Zhu, Z., Nedergaard, J., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.11.009 · Cited by 379 · see citing works
Biological control through regulated transcriptional coactivators
Spiegelman, B. M., & Heinrich, R. (2004) · Cell · doi:10.1016/j.cell.2004.09.037 · Cited by 377 · see citing works
Exercise, MAPK, and NF-κB signaling in skeletal muscle
Kramer, H. F., & Goodyear, L. J. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00085.2007 · Cited by 375 · see citing works
VEGF gene therapy: stimulating angiogenesis or angioma-genesis?
Carmeliet, P. (2000) · Nature Medicine · doi:10.1038/80430 · Cited by 370 · see citing works
Nuclear receptor coregulators: multiple modes of modification.
Hermanson, O., Glass, C., & Rosenfeld, M. (2002) · Trends in endocrinology and metabolism · doi:10.1016/s1043-2760(01)00527-6 · Cited by 341 · see citing works
Fan, M., Rhee, J., St-Pierre, J., Handschin, C., Puigserver, P., Lin, J., Jäeger, S., Erdjument-Bromage, H., Tempst, P., & Spiegelman, B. M. (2004) · Genes & Development · doi:10.1101/gad.1152204 · Cited by 309 · see citing works
Li, S., Czubryt, M. P., McAnally, J., Bassel‐Duby, R., Richardson, J. A., Wiebel, F. F., Nordheim, A., & Olson, E. N. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409103102 · Cited by 295 · see citing works
PGC-1α mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle
Norrbom, J., Sundberg, C. J., Rundqvist, H., Kraus, W. E., Jansson, E., & Gustafsson, T. P. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00765.2003 · Cited by 263 · see citing works
Invited Review: Intracellular signaling in contracting skeletal muscle
Sakamoto, K., & Goodyear, L. J. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00167.2002 · Cited by 260 · see citing works
Invited review: activity-induced angiogenesis
Egginton, S. (2008) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-008-0563-9 · Cited by 259 · see citing works
PGC-1 coactivators and skeletal muscle adaptations in health and disease
Arany, Z. P. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.07.018 · Cited by 244 · see citing works
Self-citationPeroxisome Proliferator Activator Receptor γ Coactivator-1 Expression Is Reduced in Obesity
Crunkhorn, S., Dearie, F., Mantzoros, C., Gami, H., da Silva, W. S., Espinoza, D., Faucette, R., Barry, K., Bianco, A. C., & Patti, M. E. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611214200 · Cited by 236 · see citing works
Voluntary running induces fiber type-specific angiogenesis in mouse skeletal muscle
Waters, R. E., Rotevatn, S., Li, P., Annex, B. H., & Yan, Z. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00247.2004 · Cited by 214 · see citing works
Angiogenesis during exercise and training.
Bloor, C. M. (2005) · Angiogenesis · doi:10.1007/s10456-005-9013-x · Cited by 206 · see citing works
Miura, S., Kawanaka, K., Kai, Y., Tamura, M., Goto, M., Shiuchi, T., Minokoshi, Y., & Ezaki, O. (2007) · Endocrinology · doi:10.1210/en.2006-1646 · Cited by 183 · see citing works
Ischemic Neoangiogenesis Enhanced by β2-Adrenergic Receptor Overexpression
Iaccarino, G., Ciccarelli, M., Sorriento, D., Galasso, G., Campanile, A., Santulli, G., Cipolletta, E., Cerullo, V., Cimini, V., Altobelli, G. G., et al. (2005) · Circulation Research · doi:10.1161/01.res.0000191541.06788.bb · Cited by 176 · see citing works
Mensink, M., Hesselink, M. K. C., Russell, A. P., Schaart, G., Sels, J.-P., & Schrauwen, P. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803567 · Cited by 160 · see citing works
Miura, S., Kai, Y., Kamei, Y., & Ezaki, O. (2008) · Endocrinology · doi:10.1210/en.2008-0466 · Cited by 150 · see citing works
PGC-1α mediates exercise-induced skeletal muscle VEGF expression in mice
Leick, L., Hellsten, Y., Fentz, J., Lyngby, S. S., Wojtaszewski, J. F. P., Hidalgo, J., & Pilegaard, H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00076.2009 · Cited by 124 · see citing works
HIF-1α in endurance training: suppression of oxidative metabolism
Mason, S. D., Rundqvist, H., Papandreou, I., Duh, R., McNulty, W., Howlett, R. A., Olfert, I. M., Sundberg, C. J., Denko, N. C., Poellinger, L., et al. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00335.2007 · Cited by 114 · see citing works
Roberts, D. H., Mcloughlin, G., Tsao, Y., & Breckenridge, A. M. (1987) · The Lancet · doi:10.1016/s0140-6736(87)92441-x · Cited by 109 · see citing works
Neuroendocrine influences on cancer biology
Thaker, P. H., & Sood, A. K. (2007) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2007.12.005 · Cited by 103 · see citing works
Beta blockers for peripheral arterial disease
Paravastu, S. C. V., Mendonca, D. A., & Silva, A. D. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005508.pub2 · Cited by 93 · see citing works
Zwetsloot, K. A., Westerkamp, L. M., Holmes, B. F., & Gavin, T. P. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.159871 · Cited by 78 · see citing works
Jové, M., Salla, J., Planavila, A., Cabrero, À., Michalik, L., Wahli, W., Laguna, J. C., & Vázquez‐Carrera, M. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300208-jlr200 · Cited by 63 · see citing works
Training-induced vascular adaptations to ischemic muscle.
Yang, H. T., Prior, B. M., Lloyd, P. G., Taylor, J. C., Li, Z., Laughlin, M. H., & Terjung, R. L. (2008) · PubMed · Cited by 60 · see citing works
Semenza, G. L. (2006) · Circulation Research · doi:10.1161/01.res.0000223485.43020.9e · Cited by 20 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works
Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation
Egan, B., & Zierath, J. R. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.012 · Cited by 2,084 · see citing works
Rao, R. R., Long, J. Z., White, J. P., Svensson, K. J., Lou, J., Lokurkar, I., Jedrychowski, M. P., Ruas, J. L., Wrann, C. D., Lo, J. C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.03.065 · Cited by 973 · see citing works
Self-citationOncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF
Haq, R., Shoag, J., Andreu-Perez, P., Yokoyama, S., Edelman, H., Rowe, G. C., Frederick, D. T., Hurley, A. D., Nellore, A., Kung, A. L., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.02.003 · Cited by 818 · see citing works
Self-citationAgudelo, L. Z., Femenía, T., Orhan, F., Porsmyr-Palmertz, M., Goiny, M., Martinez-Redondo, V., Correia, J. C., Izadi, M., Bhat, M., Schuppe-Koistinen, I., et al. (2014) · Cell · doi:10.1016/j.cell.2014.07.051 · Cited by 739 · see citing works
Self-citationA PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy
Ruas, J. L., White, J. P., Rao, R. R., Kleiner, S., Brannan, K. T., Harrison, B. C., Greene, N. P., Wu, J., Estall, J. L., Irving, B. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.10.050 · Cited by 677 · see citing works
Self-citationImpairment of an endothelial NAD(+)-H2S signaling network is a reversible cause of vascular aging
Das, A., Huang, G. X., Bonkowski, M. S., Longchamp, A., Li, C., Schultz, M. B., Kim, L.-J., Osborne, B., Joshi, S., Lu, Y., et al. (2018) · Cell · doi:10.1016/j.cell.2018.02.008 · Cited by 496 · see citing works
“Indeed, mice lacking PGC-1a have limited angiogenesis after exercise (Chinsomboon et al., 2009) whereas mice overexpressing PGC-1a in muscle have increased mitochondria and capillary density (Lin et al.”
Self-citationPGC-1α regulation by exercise training and its influences on muscle function and insulin sensitivity
Lira, V. A., Benton, C. R., Yan, Z., & Bonen, A. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00755.2009 · Cited by 412 · see citing works
AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: implications for obesity.
O’Neill, H. M., Holloway, G. P., & Steinberg, G. R. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.06.019 · Cited by 364 · see citing works
Effects of aging on angiogenesis
Lähteenvuo, J., & Rosenzweig, A. (2012) · Circulation Research · doi:10.1161/circresaha.111.246116 · Cited by 292 · see citing works
Metabolic adaptation in obesity and type ii diabetes: myokines, adipokines and hepatokines
Oh, K.-J., Lee, D., Kim, W., Han, B., Lee, S., & Bae, K.-H. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms18010008 · Cited by 210 · see citing works
Unravelling the mechanisms regulating muscle mitochondrial biogenesis
Hood, D. A., Tryon, L. D., Carter, H. N., Kim, Y., & Chen, C. C. W. (2016) · Biochemical Journal · doi:10.1042/bcj20160009 · Cited by 159 · see citing works
Influence of vitamin C and vitamin E on redox signaling: implications for exercise adaptations
Cobley, J. N., McHardy, H., Morton, J. P., Nikolaidis, M. G., & Close, G. L. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.03.018 · Cited by 118 · see citing works
Using Molecular Biology to Maximize Concurrent Training
Baar, K. (2014) · Sports Medicine · doi:10.1007/s40279-014-0252-0 · Cited by 118 · see citing works
“Active CaMK can increase both the capacity for glucose uptake through upregulation of the glucose transporter GLUT4 [31], and mitochondrial mass by transcriptional upregulation of the mitochondrial biogenesis regulator PGC-1a (peroxisome proliferator c coactivator 1a) [32].”
BackgroundInfluentialPhysical activity and the endocannabinoid system: an overview
Tantimonaco, M., Ceci, R., Sabatini, S., Catani, M. V., Rossi, A., Gasperi, V., & Maccarrone, M. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1575-6 · Cited by 112 · see citing works
Finley, L. W. S., Lee, J., Souza, A., Desquiret-Dumas, V., Bullock, K., Rowe, G. C., Procaccio, V., Clish, C. B., Arany, Z., & Haigis, M. C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115813109 · Cited by 102 · see citing works
Self-citationYdfors, M., Fischer, H., Mascher, H., Blomstrand, E., Norrbom, J., & Gustafsson, T. (2013) · Physiological Reports · doi:10.1002/phy2.140 · Cited by 77 · see citing works
Thompson, C., Wylie, L. J., Blackwell, J. R., Fulford, J., Black, M. I., Kelly, J., McDonagh, S. T. J., Carter, J., Bailey, S. J., Vanhatalo, A., et al. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00909.2016 · Cited by 51 · see citing works
Steinbacher, P., Feichtinger, R. G., Kedenko, L., Kedenko, I., Reinhardt, S., Schönauer, A.-L., Leitner, I., Sänger, A. M., Stoiber, W., Kofler, B., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0123881 · Cited by 33 · see citing works
- Authors
- Chinsomboon, J., Ruas, J., Gupta, R. K., Thom, R., Shoag, J., Rowe, G. C., Sawada, N., Raghuram, S., & Arany, Z.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Tokyo Medical and Dental University (JP)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-12-15
- Volume
- 106
- Issue
- 50
- Pages
- 21401-21406
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2795492
- OpenAlex
- W2020972070
- Cited by
- 379
- References
- 55
- Citations by year
- 2026: 16 · 2025: 16 · 2024: 13 · 2023: 14 · 2022: 22 · 2021: 13 · 2020: 19 · 2019: 14 · 2018: 32 · 2017: 35 · 2016: 26 · 2015: 33 · 2014: 34 · 2013: 26 · 2012: 30
- FWCI
- 53.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- PGC-1α, exercise-induced angiogenesis, skeletal muscle, peripheral arterial disease, capillary density, beta-adrenergic signaling, vascular endothelial growth factor, estrogen-related receptor alpha, alternative promoters, transcriptional coactivator, vascularization
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Animals, Gene Expression Regulation, Mice, Inbred C57BL, Physical Conditioning, Animal, Promoter Regions, Genetic, Receptors, Adrenergic, beta, Transcription Factors, Transcriptional Activation, Trans-Activators, Peripheral Vascular Diseases, Muscle, Skeletal, Neovascularization, Physiologic, Angiogenic Proteins, Mice
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