Irimia, Manuel

A compendium of RNA-binding motifs for decoding gene regulation

Ray, D., Kazan, H., Cook, K. B., Weirauch, M. T., Najafabadi, H. S., Li, X., Gueroussov, S., Albu, M., Zheng, H., Yang, A., et al. (2013) · Nature

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 1,480

The Evolutionary Landscape of Alternative Splicing in Vertebrate Species

Barbosa-Morais, N. L., Irimia, M., Pan, Q., Xiong, H. Y., Gueroussov, S., Lee, L. J., Slobodeniuc, V., Kutter, C., Watt, S., Çolak, R., et al. (2012) · Science

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 1,063

A Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains

Irimia, M., Weatheritt, R. J., Ellis, J. D., Parikshak, N. N., Gonatopoulos-Pournatzis, T., Babor, M., Quesnel-Vallières, M., Tapial, J., Raj, B., O’Hanlon, D., et al. (2014) · Cell

RNA Research and SplicingRNA regulation and disease

Cited by 693

Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism

Parikshak, N. N., Swarup, V., Belgard, T. G., Irimia, M., Ramaswami, G., Gandal, M. J., Hartl, C., Leppa, V., Ubieta, L. D. L. T., Huang, J., et al. (2016) · Nature

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 685

Widespread intron retention in mammals functionally tunes transcriptomes

Braunschweig, U., Barbosa-Morais, N. L., Pan, Q., Nachman, E. N., Alipanahi, B., Gonatopoulos-Pournatzis, T., Frey, B., Irimia, M., & Blencowe, B. J. (2014) · Genome Research

RNA Research and SplicingCancer-related molecular mechanisms research

Cited by 664

Tissue-specific alternative splicing remodels protein-protein interaction networks

Ellis, J. D., Barrios-Rodiles, M., Çolak, R., Irimia, M., Kim, T., Calarco, J. A., Wang, X., Pan, Q., O'Hanlon, D., Kim, P. M., et al. (2012) · Molecular Cell

RNA Research and SplicingCancer-related molecular mechanisms research

Cited by 431

Algal genomes reveal evolutionary mosaicism and the fate of nucleomorphs

Curtis, B. A., Tanifuji, G., Burki, F., Gruber, A., Irimia, M., Maruyama, S., Arias, M. C., Ball, S. G., Gile, G. H., Hirakawa, Y., et al. (2012) · Nature

Protist diversity and phylogenyChromosomal and Genetic Variations

Cited by 417

Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders

Quesnel-Vallières, M., Dargaei, Z., Irimia, M., Gonatopoulos-Pournatzis, T., Ip, J. Y., Wu, M., Sterne-Weiler, T., Nakagawa, S., Woodin, M. A., Blencowe, B. J., et al. (2016) · Molecular Cell

RNA Research and SplicingGenetics and Neurodevelopmental Disorders

Cited by 178

Alternative splicing: decoding an expansive regulatory layer

Irimia, M., & Blencowe, B. J. (2012) · Current Opinion in Cell Biology

RNA Research and SplicingCancer-related molecular mechanisms research

Cited by 177

Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development

Quesnel-Vallières, M., Irimia, M., Cordes, S. P., & Blencowe, B. J. (2015) · Genes & Development

RNA Research and SplicingGenetics and Neurodevelopmental Disorders

Cited by 155

An alternative splicing event amplifies evolutionary differences between vertebrates

Gueroussov, S., Gonatopoulos-Pournatzis, T., Irimia, M., Raj, B., Lin, Z.-Y., Gingras, A.-C., & Blencowe, B. J. (2015) · Science

RNA Research and SplicingRNA regulation and disease

Cited by 148

Extensive conservation of ancient microsynteny across metazoans due to cis -regulatory constraints

Irimia, M., Tena, J. J., Alexis, M. S., Fernandez-Miñan, A., Maeso, I., Bogdanović, O., de la Calle-Mustienes, E., Roy, S. W., Gómez-Skarmeta, J. L., & Fraser, H. B. (2012) · Genome Research

Genomics and Chromatin DynamicsChromosomal and Genetic Variations

Cited by 146

A Global Regulatory Mechanism for Activating an Exon Network Required for Neurogenesis

Raj, B., Irimia, M., Braunschweig, U., Sterne-Weiler, T., O’Hanlon, D., Lin, Z.-Y., Chen, G. I., Easton, L. E., Ule, J., Gingras, A.-C., et al. (2014) · Molecular Cell

RNA Research and SplicingRNA regulation and disease

Cited by 132

Transphyletic conservation of developmental regulatory state in animal evolution

Royo, J. L., Maeso, I., Irimia, M., Gao, F., Peter, I. S., Lopes, C. S., D'Aniello, S., Casares, F., Davidson, E. H., Garcia-Fernández, J., et al. (2011) · Proceedings of the National Academy of Sciences

Developmental Biology and Gene RegulationGenomics and Chromatin Dynamics

Cited by 93

Stepwise assembly of the Nova -regulated alternative splicing network in the vertebrate brain

Irimia, M., Denuc, A., Burguera, D., Somorjai, I., Martín-Durán, J. M., Genikhovich, G., Jimenez-Delgado, S., Technau, U., Roy, S. W., Marfany, G., et al. (2011) · Proceedings of the National Academy of Sciences

RNA Research and SplicingDevelopmental Biology and Gene Regulation

Cited by 47

Evolutionarily conserved A-to-I editing increases protein stability of the alternative splicing factor Nova1

Irimia, M., Denuc, A., Ferran, J. L., Pernaute, B., Puelles, L., Roy, S. W., Garcia-Fernàndez, J., & Marfany, G. (2012) · RNA Biology

RNA regulation and diseaseRNA Research and Splicing

Cited by 38

E93 controls adult differentiation by repressing broad in Drosophila

Cruz, J., Ureña, E., Iñiguez, L. P., Irimia, M., Franch-Marro, X., & Martín, D. (2024) · Proceedings of the National Academy of Sciences

Developmental Biology and Gene RegulationNeurobiology and Insect Physiology Research

Cited by 20