An alternative splicing event amplifies evolutionary differences between vertebrates

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Untitled work

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Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions

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Exon-Mediated Activation of Transcription Starts

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Contributions of alternative splicing to muscle type development and function

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Stargardt disease and progress in therapeutic strategies

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Polypyrimidine tract-binding protein blocks miRNA-124 biogenesis to enforce its neuronal-specific expression in the mouse

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Subcellular Compartmentation of Alternatively Spliced Transcripts Defines SERINE/ARGININE-RICH PROTEIN30 Expression

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Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes

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The lncRNA Malat1 is trafficked to the cytoplasm as a localized mRNA encoding a small peptide in neuronsPreprint

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The V-ATPase/ATG16L1 axis is controlled by the V1H subunit

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PTBP1 mRNA isoforms and regulation of their translation

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PTBP1 as a potential regulator of disease

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Cancer-associated dynamics and potential regulators of intronic polyadenylation revealed by IPAFinder using standard RNA-seq dataPreprint

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Cis‐regulated alternative splicing divergence and its potential contribution to environmental responses in Arabidopsis

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Transcriptome-Wide Analysis Reveals Modulation of Human Macrophage Inflammatory Phenotype Through Alternative Splicing

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A Novel Alternative Splicing Mechanism That Enhances Human 5-HT1A Receptor RNA Stability Is Altered in Major Depression

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Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of stem cell maintenance and neuronal differentiation

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Multiple determinants of splicing repression activity in the polypyrimidine tract binding proteins, PTBP1 and PTBP2

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Re-evaluating the impact of alternative RNA splicing on proteomic diversity

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A mechanism underlying position-specific regulation of alternative splicing

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An improved iCLIP protocolPreprint

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Efficient, specific, and combinatorial control of endogenous exon splicing with dCasRx-RBM25

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Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins

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Schizophyllum commune has an extensive and functional alternative splicing repertoire

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The RNA‐binding protein caper is required for sensory neuron development in Drosophila melanogaster

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Systematic exploration of dynamic splicing networks reveals conserved multistage regulators of neurogenesis

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Transcriptomics of Hirschsprung disease patient-derived enteric neural crest cells reveals a role for oxidative phosphorylation

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hnRNPs: roles in neurodevelopment and implication for brain disorders

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ExOrthist: a tool to infer exon orthologies at any evolutionary distance

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Long-read proteogenomics to connect disease-associated sQTLs to the protein isoform effectors of disease.

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Neurogenesis: Regulation by Alternative Splicing and Related Posttranscriptional Processes

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Genome-wide transcriptome analysis identifies alternative splicing regulatory network and key splicing factors in mouse and human psoriasis

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Expansion and functional analysis of the SR-related protein family across the domains of life

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Specification of neural circuit architecture shaped by context-dependent patterned LAR-RPTP microexons

Han, K. A., Yoon, T.-H., Kim, J., Lee, J., Lee, J. Y., Jang, G., Um, J. W., Kim, J. K., & Ko, J. (2024) · Nature Communications · doi:10.1038/s41467-024-45695-0 · Cited by 23 · see citing works

Alternative Splicing in Tumorigenesis and Cancer Therapy

Chen, H., Tang, J., & Xiang, J. (2025) · Biomolecules · doi:10.3390/biom15060789 · Cited by 22 · see citing works

Genes of the cGMP-PKG-Ca2+ signaling pathway are alternatively spliced in cardiomyopathy: Role of RBFOX2

Wan, X., Belanger, K. K., Widen, S. G., Kuyumcu‐Martinez, M. N., & Garg, N. J. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165620 · Cited by 21 · see citing works

The latest role of nerve‐specific splicing factor PTBP1 in the transdifferentiation of glial cells into neurons

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The Krebs Cycle Connection: Reciprocal Influence Between Alternative Splicing Programs and Cell Metabolism

Biamonti, G., Maita, L., & Montecucco, A. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00408 · Cited by 21 · see citing works

SpyCLIP: an easy-to-use and high-throughput compatible CLIP platform for the characterization of protein–RNA interactions with high accuracy

Zhao, Y., Zhang, Y., Teng, Y., Liu, K., Liu, Y., Li, W., & Wu, L. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz049 · Cited by 21 · see citing works

MAPP unravels frequent co-regulation of splicing and polyadenylation by RNA-binding proteins and their dysregulation in cancer

Bąk, M., van Nimwegen, E., Kouzel, I. U., Gür, T., Schmidt, R. L. J., Zavolan, M., & Gruber, A. J. (2024) · Nature Communications · doi:10.1038/s41467-024-48046-1 · Cited by 17 · see citing works

Multilayered control of exon acquisition permits the emergence of novel forms of regulatory control

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Alternative Splicing Variation: Accessing and Exploiting in Crop Improvement Programs

Dwivedi, S. L., Quiroz, L. F., Reddy, A. S. N., Spillane, C., & Ortiz, R. O. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015205 · Cited by 17 · see citing works

A developmentally regulated spliced variant of PTBP1 is upregulated in type 1 diabetic hearts

Belanger, K. K., Nutter, C. A., Li, J., Yu, P., & Kuyumcu‐Martinez, M. N. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.12.150 · Cited by 17 · see citing works

An extended catalogue of tandem alternative splice sites in human tissue transcriptomes

Mironov, A. A., Denisov, S., Greß, A., Kalinina, O. V., & Pervouchine, D. D. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1008329 · Cited by 16 · see citing works

Computational Analysis of Alternative Splicing Using VAST-TOOLS and the VastDB Framework

Gohr, A., Mantica, F., Hermoso, A., Tapial, J., Márquez, Y., & Irimia, M. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2521-7_7 · Cited by 13 · see citing works

Cell-type-resolved alternative splicing patterns in mouse liver

Wu, P., Zhou, D., Lin, W., Li, Y., Wei, H., Qian, X., Jiang, Y., & He, F. (2017) · DNA Research · doi:10.1093/dnares/dsx055 · Cited by 13 · see citing works

Microexons: novel regulators of the transcriptome

Curry‐Hyde, A., Chen, B. J., Mills, J. D., & Janitz, M. (2018) · Journal of Human Transcriptome · doi:10.1080/23324015.2018.1491940 · Cited by 13 · see citing works

Post-transcriptional regulation of the transcriptional apparatus in neuronal development

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Mapping human brain cell type origin and diseases through single-cell transcriptomics

Soorajkumar, A., Balan, B., Nassir, N., Akter, H., Shahin, Z., Berdiev, B. K., Woodbury‐Smith, M., Khalil, R., Cisse, B., Benamer, H. T. S., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03562-6 · Cited by 13 · see citing works

All differential on the splicing front: Host alternative splicing alters the landscape of virus-host conflict

Mann, J. T., Riley, B. A., & Baker, S. F. (2023) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2023.01.013 · Cited by 13 · see citing works

Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox

Schertzer, M. D., Stirn, A., Isaev, K., Pereira, L., Park, S. H., Das, A., Réal, A., Jeffery, E. D., Harbison, C., Wessels, H., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62066-5 · Cited by 11 · see citing works

DeepASmRNA: Reference-free prediction of alternative splicing events with a scalable and interpretable deep learning model

Cao, L., Zhang, Q., Song, H., Lin, K., & Pang, E. (2022) · iScience · doi:10.1016/j.isci.2022.105345 · Cited by 11 · see citing works

Reviewing PTBP1 Domain Modularity in the Pre-Genomic Era: A Foundation to Guide the Next Generation of Exploring PTBP1 Structure–Function Relationships

Carico, C., & Placzek, W. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311218 · Cited by 10 · see citing works

Understanding species-specific and conserved RNA-protein interactions in vivo and in vitro

Harris, S. E., Alexis, M. S., Giri, G., Cavazos, F. F., Hu, Y., Murn, J., Aleman, M. M., Burge, C. B., & Dominguez, D. (2024) · Nature Communications · doi:10.1038/s41467-024-52231-7 · Cited by 10 · see citing works

LPS Administration Impacts Glial Immune Programs by Alternative Splicing

Babenko, V. N., Shishkina, G. T., Lanshakov, D. A., Sukhareva, E. V., & Дыгало, Н. Н. (2022) · Biomolecules · doi:10.3390/biom12020277 · Cited by 10 · see citing works

Inference of domain-disease associations from domain-protein, protein-disease and disease-disease relationships

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hnRNP A1B, a Splice Variant of HNRNPA1, Is Spatially and Temporally Regulated

Gagné, M., Deshaies, J.-E., Sidibé, H., Benchaar, Y., Arbour, D., Dubinski, A. F., Litt, G., Peyrard, S., Robitaille, R., Sephton, C. F., et al. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.724307 · Cited by 9 · see citing works

Do Fragile X Syndrome and Other Intellectual Disorders Converge at Aberrant Pre-mRNA Splicing?

Shah, S., & Richter, J. D. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.715346 · Cited by 9 · see citing works

Combining local and global evolutionary trajectories of brain–behaviour relationships through game theory

Plinio, S. D., & Ebisch, S. J. H. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14883 · Cited by 8 · see citing works

Transcript Isoform Diversity of Ampliconic Genes on the Y Chromosome of Great Apes

Tomaszkiewicz, M., Sahlin, K., Medvedev, P., & Makova, K. D. (2023) · Genome Biology and Evolution · doi:10.1093/gbe/evad205 · Cited by 8 · see citing works

Functional Consequences of Mammalian-Specific Alternative Splicing Events in RNA Binding Proteins

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Identification and Characterization of PTBP1-Regulated Splicing Events During Neuronal Differentiation.

Linares, A. J. (2015) · eScholarship (California Digital Library)

Alternative Splicing of Brain-Specific PTB Defines a Tissue-Specific Isoform Pattern That Predicts Distinct Functional Roles

Rahman, L., Bliskovski, V., Reinhold, W. C., & Zajac‐Kaye, M. (2002) · Genomics · doi:10.1006/geno.2002.6826 · Cited by 42 · see citing works

Development: Alternative splicing switches on the brain

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Evolution of alternative splicing in primate brain transcriptomes

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