Budinger, G. R. Scott

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

Weinberg, F., Hamanaka, R., Wheaton, W. W., Weinberg, S., Joseph, J., Lopez, M., Kalyanaraman, B., Mutlu, G. M., Budinger, G. R. S., & Chandel, N. S. (2010) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismMitochondrial Function and Pathology

Cited by 1,742

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

Reyfman, P. A., Walter, J. M., Joshi, N., Anekalla, K. R., McQuattie-Pimentel, A. C., Chiu, S., Fernandez, R., Akbarpour, M., Chen, C.-I., Ren, Z., et al. (2019) · American Journal of Respiratory and Critical Care Medicine

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisSingle-cell and spatial transcriptomics

Cited by 1,203

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

Misharin, A. V., Morales-Nebreda, L., Reyfman, P. A., Cuda, C. M., Walter, J. M., McQuattie-Pimentel, A. C., Chen, C.-I., Anekalla, K. R., Joshi, N., Williams, K. J. N., et al. (2017) · Journal of Experimental Medicine

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisTransplantation: Methods and Outcomes

Cited by 1,133

The role of macrophages in the resolution of inflammation

Watanabe, S., Alexander, M., Misharin, A. V., & Budinger, G. R. S. (2019) · Journal of Clinical Investigation

Immune cells in cancerWound Healing and Treatments

Cited by 925

Flow Cytometric Analysis of Macrophages and Dendritic Cell Subsets in the Mouse Lung

Misharin, A. V., Morales-Nebreda, L., Mutlu, G. M., Budinger, G. R. S., & Perlman, H. (2013) · American Journal of Respiratory Cell and Molecular Biology

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisImmune cells in cancer

Cited by 838

The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production

Bell, E. L., Klimova, T. A., Eisenbart, J., Moraes, C. T., Murphy, M. P., Budinger, G. R. S., & Chandel, N. S. (2007) · The Journal of Cell Biology

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 568

Local and systemic responses to SARS-CoV-2 infection in children and adults

Yoshida, M., Worlock, K. B., Huang, N., Lindeboom, R. G. H., Butler, C. R., Kumasaka, N., Dominguez Conde, C., Mamanova, L., Bolt, L., Richardson, L., et al. (2022) · Nature

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 365

A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages

Joshi, N., Watanabe, S., Verma, R., Jablonski, R. P., Chen, C.-I., Cheresh, P., Markov, N. S., Reyfman, P. A., McQuattie-Pimentel, A. C., Sichizya, L., et al. (2020) · European Respiratory Journal

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisOccupational and environmental lung diseases

Cited by 344

Lung transplantation for patients with severe COVID-19

Bharat, A., Querrey, M., Markov, N. S., Kim, S., Kurihara, C., Garza-Castillon, R., Manerikar, A., Shilatifard, A., Tomic, R., Politanska, Y., et al. (2020) · Science Translational Medicine

Transplantation: Methods and OutcomesCOVID-19 Clinical Research Studies

Cited by 336

Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio

Emerling, B. M., Weinberg, F., Snyder, C., Burgess, Z., Mutlu, G. M., Viollet, B., Budinger, G. R. S., & Chandel, N. S. (2009) · Free Radical Biology and Medicine

Metabolism, Diabetes, and CancerCancer, Hypoxia, and Metabolism

Cited by 330

Hypoxic but not anoxic stabilization of HIF-1α requires mitochondrial reactive oxygen species

Schroedl, C., McClintock, D. S., Budinger, G. R. S., & Chandel, N. S. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 266

The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease

Schiller, H. B., Montoro, D. T., Simon, L. M., Rawlins, E. L., Meyer, K. B., Strunz, M., Vieira Braga, F. A., Timens, W., Koppelman, G. H., Budinger, G. R. S., et al. (2019) · American Journal of Respiratory Cell and Molecular Biology

Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics

Cited by 245

The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging

McQuattie-Pimentel, A. C., Ren, Z., Joshi, N., Watanabe, S., Stoeger, T., Chi, M., Lu, Z., Sichizya, L., Aillon, R. P., Chen, C.-I., et al. (2021) · Journal of Clinical Investigation

Genetics, Aging, and Longevity in Model OrganismsImmune responses and vaccinations

Cited by 177

PAI-1–regulated extracellular proteolysis governs senescence and survival in Klotho mice

Eren, M., Boe, A. E., Murphy, S. B., Place, A. T., Nagpal, V., Morales-Nebreda, L., Urich, D., Quaggin, S. E., Budinger, G. R. S., Mutlu, G. M., et al. (2014) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 176

Flow Cytometry Reveals Similarities Between Lung Macrophages in Humans and Mice

Bharat, A., Bhorade, S. M., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Soberanes, S., Ridge, K., DeCamp, M. M., Mestan, K. K., Perlman, H., Budinger, G. R. S., et al. (2016) · American Journal of Respiratory Cell and Molecular Biology

Immune cells in cancerTransplantation: Methods and Outcomes

Cited by 175

The heterogeneity of lung macrophages in the susceptibility to disease

Morales-Nebreda, L., Misharin, A. V., Perlman, H., & Budinger, G. R. S. (2015) · European Respiratory Review

Immune cells in cancerPhagocytosis and Immune Regulation

Cited by 162

Metformin targets mitochondrial electron transport to reduce air-pollution-induced thrombosis

Soberanes, S., Misharin, A. V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., et al. (2019) · Cell Metabolism

Air Quality and Health ImpactsMetabolism, Diabetes, and Cancer

Cited by 131

Hyperoxia-induced Apoptosis Does Not Require Mitochondrial Reactive Oxygen Species and Is Regulated by Bcl-2 Proteins

Budinger, G. R. S., Tso, M., McClintock, D. S., Dean, D. A., Sznajder, J. I., & Chandel, N. S. (2002) · Journal of Biological Chemistry

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 95

Association of body mass index with lung transplantation survival in the United States following implementation of the lung allocation score

Fernandez, R., Safaeinili, N., Kurihara, C., Odell, D. D., Jain, M., DeCamp, M. M., Budinger, G. R. S., & Bharat, A. (2018) · The Journal of Thoracic and Cardiovascular Surgery

Transplantation: Methods and OutcomesOrgan Donation and Transplantation

Cited by 44

Wood Smoke Particle Sequesters Cell Iron to Impact a Biological Effect

Ghio, A. J., Soukup, J. M., Dailey, L. A., Tong, H., Kesic, M. J., Budinger, G. R. S., & Mutlu, G. M. (2015) · Chemical Research in Toxicology

Air Quality and Health ImpactsHeavy Metal Exposure and Toxicity

Cited by 41