Hypoxic but not anoxic stabilization of HIF-1α requires mitochondrial reactive oxygen species

Schroedl, Clara; McClintock, David S.; Budinger, G. R. Scott; Chandel, Navdeep S.

doi:10.1152/ajplung.00014.2002

Cited by 266Cancer, Hypoxia, and MetabolismRedox biology and oxidative stressMitochondrial Function and Pathology

Hypoxic but not anoxic stabilization of HIF-1α requires mitochondrial reactive oxygen species

Schroedl, Clara, McClintock, David S., Budinger, G. R. Scott, Chandel, Navdeep S.·2002·American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI 10.1152/ajplung.00014.2002

Open this paper in CoChat — free account

Abstract

The molecular mechanisms by which cells detect hypoxia (1.5% O2), resulting in the stabilization of hypoxia-inducible factor 1alpha (HIF-1alpha) protein remain unclear. One model proposes that mitochondrial generation of reactive oxygen species is required to stabilize HIF-1alpha protein. Primary evidence for this model comes from the observation that cells treated with complex I inhibitors, such as rotenone, or cells that lack mitochondrial DNA (rho(0)-cells) fail to generate reactive oxygen species or stabilize HIF-1alpha protein in response to hypoxia. In the present study, we investigated the role of mitochondria in regulating HIF-1alpha protein stabilization under anoxia (0% O2). Wild-type A549 and HT1080 cells stabilized HIF-1alpha protein in response to hypoxia and anoxia. The rho(0)-A549 cells and rho(0)-HT1080 cells failed to accumulate HIF-1alpha protein in response to hypoxia. However, both rho(0)-A549 and rho(0)-HT1080 were able to stabilize HIF-1alpha protein levels in response to anoxia. Rotenone inhibited hypoxic, but not anoxic, stabilization of HIF-1alpha protein. These results indicate that a functional electron transport chain is required for hypoxic but not anoxic stabilization of HIF-1alpha protein.

Integrity signals

Registry

Crossref · 10.1152/ajplung.00014.2002

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Under severe hypoxia or anoxia, cytosolic oxygen levels may remain insufficient to restore prolyl hydroxylase activity even following mitochondrial inhibition, thereby limiting HIF-1α destabilization.
“Under severe hypoxia or anoxia, cytosolic oxygen levels may remain insufficient to restore prolyl hydroxylase activity even following mitochondrial inhibition, thereby limiting HIF-1α destabilization [369].”
From HIF inhibition: Current strategies and clinical challenges (2026) · cites this paper as [369]
Treatment with mitochondrial inhibitors is associated with reduced HIF-1α protein levels under hypoxia.
“treatment with mitochondrial inhibitors - including rotenone, oligomycin, the complex I inhibitor IACS-010759, mitochondrial uncouplers, and clinically approved agents such as atovaquone and metformin, has been associated with reduced HIF-1α protein levels under hypoxia [[369], [370], [371], [372], [373], [374], [375]].”
From HIF inhibition: Current strategies and clinical challenges (2026) · cites this paper as [369]
Mitochondrial ROS contribute to HIF-1α accumulation independently of respiratory activity.
“Specifically, mitochondrial ROS contribute to HIF-1α accumulation independently of respiratory activity, highlighting the paradoxical role of mitochondria in regulating hypoxic signaling [369,377].”
From HIF inhibition: Current strategies and clinical challenges (2026) · cites this paper as [369]

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212 · see citing works
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535 · see citing works
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180 · see citing works
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735 · see citing works
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333 · see citing works
A conserved family of prolyl-4-hydroxylases that modify HIF
Bruick, R. K., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1066373 · Cited by 2,549 · see citing works
Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1α during hypoxia
Chandel, N. S., McClintock, D. S., Feliciano, C. E., Wood, T. M., Melendez, J. A., Rodriguez, A. M., & Schumacker, P. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001914200 · Cited by 2,000 · see citing works
Self-citation
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
Chandel, N. S., Maltepe, E., Goldwasser, E., Mathieu, C. E., Simon, M. C., & Schumacker, P. T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11715 · Cited by 1,926 · see citing works
Self-citation
Regulation of Mammalian O 2 Homeostasis by Hypoxia-Inducible Factor 1
Semenza, G. L. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.551 · Cited by 1,914 · see citing works
Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein
Ohh, M., Park, C. W., Ivan, M., Hoffman, M. A., Kim, T.-Y., Huang, L. E., Pavletich, N., Chau, V., & Kaelin, W. G. (2000) · Nature Cell Biology · doi:10.1038/35017054 · Cited by 1,577 · see citing works
Untitled work
(2000) · PubMed · Cited by 1,445 · see citing works
Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension
Jiang, B. H., Semenza, G. L., Bauer, C., & Marti, H. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.4.c1172 · Cited by 1,213 · see citing works
Non-hypoxic pathway mediates the induction of hypoxia inducible factor 1 alpha (HIF-1 alpha ) in vascular smooth muscle cells
Richard, D. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003325200 · Cited by 584 · see citing works
Insulin-stimulated Hydrogen Peroxide Reversibly Inhibits Protein-tyrosine Phosphatase 1B in Vivo and Enhances the Early Insulin Action Cascade
Mahadev, K., Zilbering, A., Zhu, L., & Goldstein, B. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100109200 · Cited by 509 · see citing works
Nonhypoxic Pathway Mediates the Induction of Hypoxia-inducible Factor 1α in Vascular Smooth Muscle Cells
Richard, D. E., Berra, E., & Pouysségur, J. (2000) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)61441-9 · Cited by 488 · see citing works
Thrombin Activates the Hypoxia-Inducible Factor-1 Signaling Pathway in Vascular Smooth Muscle Cells
Görlach, A., Diebold, I., Schini‐Kerth, V. B., Berchner‐Pfannschmidt, U., Roth, U., Brandes, R. P., Kietzmann, T., & Busse, R. (2001) · Circulation Research · doi:10.1161/hh1301.092678 · Cited by 416 · see citing works
The oxygen dependence of mitochondrial oxidative phosphorylation measured by a new optical method for measuring oxygen concentration.
Wilson, D. F., Rumsey, W. L., Green, T. J., & Vanderkooi, J. M. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69126-4 · Cited by 387 · see citing works
The Relation of Free Radical Production to Hyperoxia
Jamieson, D., Chance, B., Cadenas, E., & Boveris, A. D. (1986) · Annual Review of Physiology · doi:10.1146/annurev.ph.48.030186.003415 · Cited by 384 · see citing works
Model for Hypoxic Pulmonary Vasoconstriction Involving Mitochondrial Oxygen Sensing
Waypa, G. B., Chandel, N. S., & Schumacker, P. T. (2001) · Circulation Research · doi:10.1161/hh1201.091960 · Cited by 367 · see citing works
Self-citation
[27] Isolation of human cell lines lacking mitochondrial DNA
King, M. P., & Attardi, G. M. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)64029-4 · Cited by 355 · see citing works
Intracellular diffusion gradients of O2 and ATP
Jones, D. P. (1986) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1986.250.5.c663 · Cited by 273 · see citing works
A non‐hypoxic, ROS‐sensitive pathway mediates TNF‐α‐dependent regulation of HIF‐1α
Haddad, J. J., & Land, S. C. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02833-2 · Cited by 270 · see citing works
The Role of Mitochondria in the Regulation of Hypoxia-inducible Factor 1 Expression during Hypoxia
Agani, F. H., Pichiule, P., Chavez, J. C., & LaManna, J. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005643200 · Cited by 210 · see citing works
Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain
Vaux, E. C., Metzen, E., Yeates, K. M., & Ratcliffe, P. J. (2001) · Blood · doi:10.1182/blood.v98.2.296 · Cited by 198 · see citing works
Molecular remedy of complex I defects: Rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cells
Seo, B. B., Kitajima‐Ihara, T., Chan, E. K. L., Scheffler, I. E., Matsuno‐Yagi, A., & Yagi, T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9167 · Cited by 187 · see citing works
Induction of Hypoxia-Inducible Factor-1, Erythropoietin, Vascular Endothelial Growth Factor, and Glucose Transporter-1 by Hypoxia: Evidence Against a Regulatory Role for Src Kinase
Gleadle, J., & Ratcliffe, P. J. (1997) · Blood · doi:10.1182/blood.v89.2.503 · Cited by 182 · see citing works
Bcl-2 Family Members and Functional Electron Transport Chain Regulate Oxygen Deprivation-Induced Cell Death
McClintock, D. S., Santore, M. T., Lee, V. Y., Brunelle, J. K., Budinger, G. R. S., Zong, W., Thompson, C. B., Hay, N., & Chandel, N. S. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.1.94-104.2002 · Cited by 182 · see citing works
Self-citation
Rac1 Activity Is Required for the Activation of Hypoxia-inducible Factor 1
Hirota, K., & Semenza, G. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100677200 · Cited by 169 · see citing works
Redox regulation of p53 during hypoxia
Chandel, N. S., Heiden, M. G. V., Thompson, C. B., & Schumacker, P. T. (2000) · Oncogene · doi:10.1038/sj.onc.1203727 · Cited by 167 · see citing works
Self-citation
Divergent roles of glycolysis and the mitochondrial electron transport chain in hypoxic pulmonary vasoconstriction of the rat: identity of the hypoxic sensor
Leach, R. M., Hill, H. M., Snetkov, V. A., Robertson, T. P., & Ward, J. P. T. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00211.x · Cited by 162 · see citing works
Oxygen Sensing and HIF-1 Activation Does Not Require an Active Mitochondrial Respiratory Chain Electron-transfer Pathway
Srinivas, V., Leshchinsky, I., Sang, N., King, M. P., Minchenko, О. H., & Caro, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100177200 · Cited by 143 · see citing works
Free radical production in hypoxic pulmonary artery smooth muscle cells
Killilea, D. W., Hester, R. B., Balczon, R., Babál, P., & Gillespie, M. N. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.2.l408 · Cited by 114 · see citing works
Evidence for the Involvement of Diacylglycerol Kinase in the Activation of Hypoxia-inducible Transcription Factor 1 by Low Oxygen Tension
Aragonés, J., Jones, D. R., Martı́n-Puig, S., Juan, M. A. S., Alfranca, A., Vidal, F., Vara, A., Mérida, I., & Landázuri, M. O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006180200 · Cited by 113 · see citing works
Systemic hypoxia promotes leukocyte-endothelial adherence via reactive oxidant generation
Wood, J. G., Johnson, J. S., Mattioli, L., & González, N. C. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.5.1734 · Cited by 96 · see citing works
Diphenylene Iodonium Inhibits the Induction of Erythropoietin and Other Mammalian Genes by Hypoxia
Gleadle, J., Ebert, B. L., & Ratcliffe, P. J. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.092_c.x · Cited by 87 · see citing works
The NDUFA1 gene product (MWFE protein) is essential for activity of complex I in mammalian mitochondria
Au, H. C., Seo, B. B., Matsuno‐Yagi, A., Yagi, T., & Scheffler, I. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4354 · Cited by 87 · see citing works
A protective role for HIF-1 in response to redox manipulation and glucose deprivation: Implications for tumorigenesis
Williams, K. J., Telfer, B. A., Airley, R. E., Peters, H. P., Sheridan, M. R., van der Kogel, A. J., Harris, A. L., & Stratford, I. J. (2002) · Oncogene · doi:10.1038/sj.onc.1205047 · Cited by 81 · see citing works
Association of calcium channel α 1S and β 1a subunits is required for the targeting of β 1a but not of α 1S into skeletal muscle triads
Neuhuber, B., Gerster, U., Döring, F., Glossmann, H. H., Tanabe, T., & Flucher, B. E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5015 · Cited by 59 · see citing works
Conditionally lethal mutations in Chinese hamster cells. Characterization of a cell line with a possible defect in the krebs cycle
DeFrancesco, L., Werntz, D. A., & Scheffler, I. E. (1975) · Journal of Cellular Physiology · doi:10.1002/jcp.1040850216 · Cited by 43 · see citing works

Flagged first, then by citations

Sorted by citations

Mitochondrial formation of reactive oxygen species
Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084 · see citing works
ROS signalling in the biology of cancer
Moloney, J. N., & Cotter, T. G. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.05.023 · Cited by 1,983 · see citing works
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
Guzy, R. D., Hoyos, B., Robin, E., Chen, H., Liu, L., Mansfield, K. D., Simon, M. C., Hammerling, U., & Schumacker, P. T. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.001 · Cited by 1,545 · see citing works
Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation
Hu, C.-J., Wang, L.-Y., Chodosh, L. A., Keith, B., & Simon, M. C. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.24.9361-9374.2003 · Cited by 1,386 · see citing works
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability
Wise, D. R., Ward, P. S., Shay, J. E. S., Cross, J. R., Gruber, J. J., Sachdeva, U. M., Platt, J. M., DeMatteo, R. G., Simon, M. C., & Thompson, C. B. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117773108 · Cited by 975 · see citing works
Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia
Guzy, R. D., & Schumacker, P. T. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2006.033506 · Cited by 881 · see citing works
Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation
Brunelle, J. K., Bell, E. L., Quesada, N. M., Vercauteren, K., Tiranti, V., Zeviani, M., Scarpulla, R. C., & Chandel, N. S. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.002 · Cited by 763 · see citing works
Self-citation
Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism.
Ježek, P., & Hlavatá, L. (2005) · International Journal of Biochemistry and Cell Biology · doi:10.1016/j.biocel.2005.05.013 · Cited by 771 · see citing works
Hypoxic Pulmonary Vasoconstriction
Sylvester, J. T., Shimoda, L. A., Aaronson, P. I., & Ward, J. P. T. (2012) · Physiological Reviews · doi:10.1152/physrev.00041.2010 · Cited by 727 · see citing works
Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation
Mansfield, K. D., Guzy, R. D., Pan, Y., Young, R. M., Cash, T. P., Schumacker, P. T., & Simon, M. C. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.003 · Cited by 606 · see citing works
Hyperbaric Oxygen: Its Mechanisms and Efficacy
Thom, S. R. (2011) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e3181fbe2bf · Cited by 591 · see citing works
Mitochondrial generation of free radicals and hypoxic signaling
Poyton, R. Ο., Ball, K. A., & Castello, P. R. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.04.001 · Cited by 525 · see citing works
Proline hydroxylation and gene expression
Kaelin, W. G. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133142 · Cited by 468 · see citing works
Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factorPreprint
Bruick, R. K. (2003) · Genes & Development · doi:10.1101/gad.1145503 · Cited by 435 · see citing works
Mitochondrial complex III regulates hypoxic activation of HIF
Klimova, T., & Chandel, N. S. (2008) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402307 · Cited by 433 · see citing works
Self-citation
Role and regulation of prolyl hydroxylase domain proteins
Fong, G.-H., & Takeda, K. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.10 · Cited by 423 · see citing works
Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism
Liemburg-Apers, D. C., Willems, P. H. G. M., Koopman, W. J. H., & Grefte, S. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1520-y · Cited by 391 · see citing works
The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease
Giaccia, A. J., Simon, M. C., & Johnson, R. (2004) · Genes & Development · doi:10.1101/gad.1243304 · Cited by 380 · see citing works
Superoxide dismutases in malignant cells and human tumors
Kinnula, V. L., & Crapo, J. D. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.12.010 · Cited by 373 · see citing works
Superoxide generation by complex III: From mechanistic rationales to functional consequences
Bleier, L., & Dröse, S. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.12.002 · Cited by 369 · see citing works
Mitochondria as signaling organelles in the vascular endothelium
Quintero, M., Colombo, S. L., Godfrey, A. R., & Moncada, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601026103 · Cited by 360 · see citing works
Oxidative stress and antioxidants: exposure and impact on female fertility
Ruder, E. H., Hartman, T. J., Blumberg, J., & Goldman, M. B. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn011 · Cited by 351 · see citing works
Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio
Emerling, B. M., Weinberg, F., Snyder, C., Burgess, Z., Mutlu, G. M., Viollet, B., Budinger, G. R. S., & Chandel, N. S. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.02.019 · Cited by 330 · see citing works
Self-citation
Metastasis: cancer cell’s escape from oxidative stress
Pani, G., Galeotti, T., & Chiarugi, P. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9225-4 · Cited by 312 · see citing works
Oxygen sensing in the body
Lahiri, S., Roy, A., Baby, S. M., Hoshi, T., Semenza, G. L., & Prabhakar, N. R. (2006) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2005.07.001 · Cited by 312 · see citing works
Oxidative stress is fundamental to hyperbaric oxygen therapy
Thom, S. R. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91004.2008 · Cited by 310 · see citing works
NRF2 Blockade Suppresses Colon Tumor Angiogenesis by Inhibiting Hypoxia-Induced Activation of HIF-1α
Kim, T., Hur, E.-G., Kang, S., Kim, J., Thapa, D., Lee, Y. M., Ku, S., Jung, Y., & Kwak, M. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3007 · Cited by 292 · see citing works
Negative and positive regulation of HIF-1: A complex network
Bárdos, J. I., & Ashcroft, M. A. (2005) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2005.05.001 · Cited by 282 · see citing works
NADPH Oxidase 4 Promotes Endothelial Angiogenesis Through Endothelial Nitric Oxide Synthase Activation
Craige, S. M., Chen, K., Pei, Y., Li, C., Huang, X., Chen;, C., Shibata, R., Sato, K., Walsh, K., & Keaney, J. F. (2011) · Circulation · doi:10.1161/circulationaha.111.030775 · Cited by 283 · see citing works
Hypoxia: A master regulator of microRNA biogenesis and activity
Nallamshetty, S., Chan, S. Y., & Loscalzo, J. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.022 · Cited by 281 · see citing works
HIF and the Lung: Role of Hypoxia-inducible Factors in Pulmonary Development and Disease
Shimoda, L. A., & Semenza, G. L. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201009-1393pp · Cited by 272 · see citing works
Sensing and Signalling in Response to Oxygen Deprivation in Plants and Other Organisms
Bailey-Serres, J. N., & Chang, R. (2005) · Annals of Botany · doi:10.1093/aob/mci206 · Cited by 274 · see citing works
Follicle-stimulating Hormone Activation of Hypoxia-inducible Factor-1 by the Phosphatidylinositol 3-Kinase/AKT/Ras Homolog Enriched in Brain (Rheb)/Mammalian Target of Rapamycin (mTOR) Pathway Is Necessary for Induction of Select Protein Markers of Follicular Differentiation
Alam, H., Maizels, E. T., Park, Y., Ghaey, S., Feiger, Z. J., Chandel, N. S., & Hunzicker-Dunn, M. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401235200 · Cited by 267 · see citing works
Self-citation
Hypoxia Inducible-Factor1α Regulates the Metabolic Shift of Pulmonary Hypertensive Endothelial Cells
Fijałkowska, I. J., Xu, W., COMHAIR, S. A. A., Janocha, A. J., Mavrakis, L. A., Krishnamachary, B., Zhen, L., Mao, T., Richter, A., ERZURUM, S. C., et al. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090832 · Cited by 263 · see citing works
Mitochondrial Reactive Oxygen Species Activation of p38 Mitogen-Activated Protein Kinase Is Required for Hypoxia Signaling
Emerling, B. M., Platanias, L. C., Black, E. V. I., Nebreda, Á. R., Davis, R. J., & Chandel, N. S. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.12.4853-4862.2005 · Cited by 257 · see citing works
Self-citation
Regulation of hypoxia-inducible factor-1α by nitric oxide through mitochondria-dependent and -independent pathways
Mateo, J., García‐Lecea, M., Cadenas, S., HERNÁNDEZ, C., & Moncada, S. (2003) · Biochemical Journal · doi:10.1042/bj20031155 · Cited by 256 · see citing works
Hypoxia-inducible factor 1α stabilization by carbon monoxide results in cytoprotective preconditioning
Chin, B. Y., Jiang, G., Wegiel, B., Wang, H. J., MacDonald, T. Y., Zhang, X., Gallo, D. J., Cszimadia, E., Bach, F. H., Lee, P. J., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609611104 · Cited by 228 · see citing works
Oxygen sensors in context
Ward, J. P. T. (2007) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2007.10.010 · Cited by 221 · see citing works
Role of redox metabolism for adaptation of aquatic animals to drastic changes in oxygen availability
Welker, A. F., Moreira, D. C., Campos, E. G., & Hermes‐Lima, M. (2013) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2013.04.003 · Cited by 214 · see citing works
Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function
Wang, C., Li, Z., Lu, Y., Du, R., Katiyar, S., Yang, J., Fu, M., Leader, J. E., Quong, A. A., Novikoff, P. M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603363103 · Cited by 208 · see citing works
Mitochondrial Dynamics, ROS, and Cell Signaling: A Blended Overview
Brillo, V., Chieregato, L., Leanza, L., Muccioli, S., & Costa, R. (2021) · Life · doi:10.3390/life11040332 · Cited by 202 · see citing works
Reactive Oxygen Species Regulate Hypoxia-Inducible Factor 1α Differentially in Cancer and Ischemia
Qutub, A. A., & Popel, A. S. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00060-08 · Cited by 190 · see citing works
HIF-1: the knowns and unknowns of hypoxia sensing.
Zagórska, A., & Dulak, J. (2004) · Acta Biochimica Polonica · doi:10.18388/abp.2004_3545 · Cited by 192 · see citing works
Stabilization of Hypoxia-inducible Factor-1α Protein in Hypoxia Occurs Independently of Mitochondrial Reactive Oxygen Species Production
Chua, Y. L., Dufour, E., Dassa, E. P., Rustin, P., Jacobs, H. T., Taylor, C. T., & Hagen, T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.158485 · Cited by 189 · see citing works
Reactive oxygen species and cellular oxygen sensing
Cash, T. P., Pan, Y., & Simon, M. C. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.07.001 · Cited by 186 · see citing works
Hypoxia-inducible factors link iron homeostasis and erythropoiesis
Shah, Y. M., & Xie, L. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.12.031 · Cited by 187 · see citing works
Redox regulation of the hypoxia-inducible factor
Pouysségur, J., & Mechta-Grigoriou, F. (2006) · Biological Chemistry · doi:10.1515/bc.2006.167 · Cited by 186 · see citing works
Oxygen Sensitivity of Mitochondrial Reactive Oxygen Species Generation Depends on Metabolic Conditions
Hoffman, D. L., & Brookes, P. S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809512200 · Cited by 182 · see citing works
Innate immune response in CF airway epithelia: hyperinflammatory?
Machen, T. E. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00605.2005 · Cited by 182 · see citing works
Hypoxia Inducible Factor Pathway and Physiological Adaptation: A Cell Survival Pathway?
Kumar, H., & Choi, D. (2015) · Mediators of Inflammation · doi:10.1155/2015/584758 · Cited by 183 · see citing works
Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase
Palacios‐Callender, M., Quintero, M., Hollis, V., Springett, R., & Moncada, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401723101 · Cited by 181 · see citing works
Tumor Hypoxia as a Barrier in Cancer Therapy: Why Levels Matter
Hompland, T., Fjeldbo, C. S., & Lyng, H. (2021) · Cancers · doi:10.3390/cancers13030499 · Cited by 179 · see citing works
Molecular targeting of hypoxia in radiotherapy
Rey, S., Schito, L., Koritzinsky, M., & Wouters, B. G. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.10.002 · Cited by 171 · see citing works
Zebrafish as an Animal Model for Drug Discovery in Parkinson’s Disease and Other Movement Disorders: A Systematic Review
Vaz, R. L., Outeiro, T. F., & Ferreira, J. J. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00347 · Cited by 169 · see citing works
Hypoxia Leads to Na,K-ATPase Downregulation via Ca 2+ Release-Activated Ca 2+ Channels and AMPK Activation
Gusarova, G. A., Bittar, H. E. T., Dada, L. A., Briva, A., Welch, L. C., Hamanaka, R. B., Mutlu, G. M., Chandel, N. S., Prakriya, M., & Sznajder, J. I. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05114-11 · Cited by 159 · see citing works
Self-citation
Hypoxia‐inducible factors as neuroprotective agent in Alzheimer's disease
(2016) · doi:10.1111/1440-1681.12717 · Cited by 150 · see citing works
Acute hypoxia produces a superoxide burst in cells
Hernansanz‐Agustín, P., Izquierdo-Álvarez, A., Sánchez-Gómez, F. J., Ramos, E. M., Villa-Piña, T., Lamas, S., Bogdanova, A. Y., & Martı́nez-Ruiz, A. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.03.011 · Cited by 137 · see citing works
Hypoxia-induced reactive oxygen species mediate N-cadherin and SERPINE1 expression, EGFR signalling and motility in MDA-MB-468 breast cancer cells
Azimi, I., Petersen, R. M., Thompson, E. W., Roberts‐Thomson, S. J., & Monteith, G. R. (2017) · Scientific Reports · doi:10.1038/s41598-017-15474-7 · Cited by 137 · see citing works
Reactive oxygen species mediate human hepatocyte injury during hypoxia/reoxygenation
Bhogal, R. H., Curbishley, S. M., Weston, C. J., Adams, D., & Afford, S. C. (2010) · Liver Transplantation · doi:10.1002/lt.22157 · Cited by 135 · see citing works
A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF‐1α
Sanjuán-Pla, A., Cervera, A. M., Apostolova, N., Garcia-Bou, R., Víctor, V. M., Murphy, M. P., & McCreath, K. J. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.03.088 · Cited by 134 · see citing works
Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact
Doege, K., Heine, S., Jensen, I., Jelkmann, W., & Metzen, E. (2005) · Blood · doi:10.1182/blood-2005-03-1138 · Cited by 128 · see citing works
Mitochondrial regulation of oxygen sensing
Bell, E. L., Emerling, B. M., & Chandel, N. S. (2005) · Mitochondrion · doi:10.1016/j.mito.2005.06.005 · Cited by 130 · see citing works
Self-citation
Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1α and vascular endothelial growth factor
Wang, M., Kirk, J. S., Venkataraman, S., Domann, F. E., Zhang, H. J., Schafer, F. Q., Flanagan, S. W., Weydert, C. J. D., Spitz, D. R., Buettner, G. R., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1208986 · Cited by 129 · see citing works
Hypoxia. 1. Intracellular sensors for oxygen and oxidative stress: novel therapeutic targets
Miyata, T., Takizawa, S., & de Strihou, C. V. Y. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00430.2010 · Cited by 128 · see citing works
Antioxidant Strategies in Respiratory Medicine
Christofidou‐Solomidou, M., & Muzykantov, V. R. (2006) · Treatments in Respiratory Medicine · doi:10.2165/00151829-200605010-00004 · Cited by 128 · see citing works
Renal Cell Carcinoma: New Developments in Molecular Biology and Potential for Targeted Therapies
Costa, L. J., & Drabkin, H. A. (2007) · The Oncologist · doi:10.1634/theoncologist.12-12-1404 · Cited by 125 · see citing works
Hypoxia-Mediated Degradation of Na,K-ATPase via Mitochondrial Reactive Oxygen Species and the Ubiquitin-Conjugating System
Comellas, A. P., Dada, L. A., Lecuona, E., Pesce, L. M., Chandel, N. S., Quesada, N. M., Budinger, G. R. S., Strous, G. J., Ciechanover, A. J., & Sznajder, J. I. (2006) · Circulation Research · doi:10.1161/01.res.0000222418.99976.1d · Cited by 123 · see citing works
Self-citation
Role of the Phosphatidylinositol-3-Kinase and Extracellular Regulated Kinase Pathways in the Induction of Hypoxia-Inducible Factor (HIF)-1 Activity and the HIF-1 Target Vascular Endothelial Growth Factor in Ovarian Granulosa Cells in Response to Follicle-Stimulating Hormone
Alam, H., Weck, J., Maizels, E. T., Park, Y., Lee, E. J., Ashcroft, M. A., & Hunzicker-Dunn, M. E. (2008) · Endocrinology · doi:10.1210/en.2008-0850 · Cited by 121 · see citing works
HIF-1 regulates hypoxia- and insulin-induced expression of apelin in adipocytes
Glassford, A. J., Yue, P., Sheikh, A. Y., Chun, H. J., Zarafshar, S., Chan, D. A., Reaven, G. M., Quertermous, T., & Tsao, P. S. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00490.2007 · Cited by 121 · see citing works
Hypoxia-inducible factor as a therapeutic target for cardioprotection
Ong, S., & Hausenloy, D. J. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.07.005 · Cited by 111 · see citing works
Death by a Thousand Cuts in Alzheimer’s Disease: Hypoxia—The Prodrome
Daulatzai, M. A. (2013) · Neurotoxicity Research · doi:10.1007/s12640-013-9379-2 · Cited by 111 · see citing works
Mitochondrial Cristae Morphology Reflecting Metabolism, Superoxide Formation, Redox Homeostasis, and Pathology
Ježek, P., Jabůrek, M., Holendová, B., Engstová, H., & Dlasková, A. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0173 · Cited by 111 · see citing works
Chapter 3 Effects of Hypoxia on Fish Reproduction and Development
Wu, R. S. S. (2009) · Fish physiology · doi:10.1016/s1546-5098(08)00003-4 · Cited by 104 · see citing works
Hypoxic reduction in cellular glutathione levels requires mitochondrial reactive oxygen species
Mansfield, K. D., Simon, M. C., & Keith, B. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00449.2004 · Cited by 104 · see citing works
Manganese Superoxide Dismutase Modulates Hypoxia-Inducible Factor-1α Induction via Superoxide
Kaewpila, S., Venkataraman, S., Buettner, G. R., & Oberley, L. W. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2635 · Cited by 103 · see citing works
HIF and reactive oxygen species regulate oxidative phosphorylation in cancer
Hervouet, É., Vrbacká-Čížková, A., Demont, J., Pecinová, A., Pecina, P., Hal, N. L. W. F.-V., Keijer, J., Simonnet, H., Ivánek, R., Kmoch, S., et al. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn125 · Cited by 99 · see citing works
Mitochondrial Reactive Oxygen Species are Required for Hypoxic HIFα Stabilization
Celeste Simon, M. (2007) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-387-34817-9_15 · Cited by 97 · see citing works
Intermittent hypoxia promotes melanoma lung metastasis via oxidative stress and inflammation responses in a mouse model of obstructive sleep apnea
Li, L., Ren, F., Qi, C., Xu, L., Fang, Y., Liang, M., Feng, J., Chen, B.-Y., Ning, W., & Cao, J. (2018) · Respiratory Research · doi:10.1186/s12931-018-0727-x · Cited by 95 · see citing works
Mitochondrial Regulation of Oxygen Sensing
Chandel, N. S. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-60761-500-2_22 · Cited by 91 · see citing works
Self-citation
Autophagy
Bhogal, R. H., Weston, C. J., Curbishley, S. M., Adams, D., & Afford, S. C. (2012) · Autophagy · doi:10.4161/auto.19012 · Cited by 91 · see citing works
Distinctions and similarities of cell bioenergetics and the role of mitochondria in hypoxia, cancer, and embryonic development
Ježek, P., Plecitá‐Hlavatá, L., Smolková, K., & Rossignol, R. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.11.008 · Cited by 91 · see citing works
Mitochondrial oxygen sensing: regulation of hypoxia-inducible factor by mitochondrial generated reactive oxygen species
Bell, E. L., & Chandel, N. S. (2007) · Essays in Biochemistry · doi:10.1042/bse0430017 · Cited by 90 · see citing works
Self-citation
Respiratory complex I is essential to induce a Warburg profile in mitochondria-defective tumor cells
Calabrese, C., Iommarini, L., Kurelac, I., Calvaruso, M. A., Capristo, M., Lollini, P., Nanni, P., Bergamini, C., Nicoletti, G., Giovanni, C. D., et al. (2013) · Cancer & Metabolism · doi:10.1186/2049-3002-1-11 · Cited by 89 · see citing works
A computational model of intracellular oxygen sensing by hypoxia-inducible factor HIF1α
Qutub, A. A., & Popel, A. S. (2006) · Journal of Cell Science · doi:10.1242/jcs.03087 · Cited by 87 · see citing works
Mitochondrial Complex III is Required for Hypoxia-Induced ROS Production and Gene Transcription in Yeast
Guzy, R. D., Mack, M. M., & Schumacker, P. T. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1708 · Cited by 86 · see citing works
Oxidative Stress and Hypoxia Modify Mitochondrial Homeostasis During Glaucoma
Jassim, A. H., Fan, Y., Pappenhagen, N., Nsiah, N. Y., & Inman, D. M. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8180 · Cited by 84 · see citing works
Molecular and Cellular Response of Co-cultured Cells toward Cobalt Chloride (CoCl2)-Induced Hypoxia
Tripathi, V., Subramaniyan, S. A., & Hwang, I. (2019) · ACS Omega · doi:10.1021/acsomega.9b01474 · Cited by 83 · see citing works
Effects of Hypoxia on the Alveolar Epithelium
Jain, M., & Sznajder, J. I. (2005) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200501-006ac · Cited by 83 · see citing works
Hypoxia induces B-type natriuretic peptide release in cell lines derived from human cardiomyocytes
Casals, G., Ros, J., Sionís, A., Davidson, M. M., Morales‐Ruiz, M., & Jiménez, W. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00250.2009 · Cited by 82 · see citing works
Mitochondrial Regulation of Cell Survival and Death During Low-Oxygen Conditions
Snyder, C. M., & Chandel, N. S. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2730 · Cited by 82 · see citing works
Self-citation
The twisted survivin connection to angiogenesis
Sanhueza, C. T., Wehinger, S., Bennett, J., Valenzuela, M., Owen, G. I., & Quest, A. F. G. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0467-1 · Cited by 81 · see citing works
Vasculogenic stem cell mobilization and wound recruitment in diabetic patients: Increased cell number and intracellular regulatory protein content associated with hyperbaric oxygen therapy
Thom, S. R., Milovanova, T. N., Yang, M., Bhopale, V. M., Sorokina, E. M., Uzun, G., Malay, D. S., Troiano, M. A., Hardy, K. R., Lambert, D. S., et al. (2011) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2010.00660.x · Cited by 79 · see citing works
Mesenchymal stem cells reduce hypoxia-induced apoptosis in alveolar epithelial cells by modulating HIF and ROS hypoxic signaling
Bernard, O., Jeny, F., Uzunhan, Y., Dondi, E., Terfous, R., Label, R., Sutton, A., Larghero, J., Vanneaux, V., Nunès, H., et al. (2017) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00153.2017 · Cited by 79 · see citing works
Molecular mechanisms of hypoxia‐inducible factor‐induced pulmonary arterial smooth muscle cell alterations in pulmonary hypertension
Veith, C., SCHERMULY, R. T., Brandes, R. P., & Weißmann, N. (2015) · The Journal of Physiology · doi:10.1113/jp270689 · Cited by 75 · see citing works
Up-regulated HIF-1α is involved in the hypoxic tolerance induced by hyperbaric oxygen preconditioning
Peng, Z., Ren, P., Kang, Z., Du, J., Lian, Q.-L., Liu, Y., Zhang, J. H., & Sun, X. (2008) · Brain Research · doi:10.1016/j.brainres.2008.03.027 · Cited by 76 · see citing works
Integrating acute lung injury and regulation of alveolar fluid clearance
Guidot, D. M., Folkesson, H. G., Jain, L., Sznajder, J. I., Pittet, J., & Matthay, M. A. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00153.2006 · Cited by 75 · see citing works
The Drosophila mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4‐driven growth
Frei, C., Galloni, M., Hafen, E., & Edgar, B. A. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600523 · Cited by 75 · see citing works
Methylalpinumisoflavone Inhibits Hypoxia-inducible Factor-1 (HIF-1) Activation by Simultaneously Targeting Multiple Pathways
Liu, Y., Veena, C. K., Morgan, J. B., Mohammed, K. A., Jekabsons, M. B., Nagle, D. G., & Zhou, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806744200 · Cited by 74 · see citing works
Transcription of mammalian cytochrome c oxidase subunit IV‐2 is controlled by a novel conserved oxygen responsive element
Hüttemann, M., Lee, I., Liu, J., & Grossman, L. I. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.06093.x · Cited by 69 · see citing works
Deferoxamine Promotes MDA-MB-231 Cell Migration and Invasion through Increased ROS-Dependent HIF-1a Accumulation
Liu, Y., Cui, Y., Shi, M., Zhang, Q., Wang, Q., & Chen, X. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000358674 · Cited by 69 · see citing works

Stabilization of Hypoxia-inducible Factor-1α Protein in Hypoxia Occurs Independently of Mitochondrial Reactive Oxygen Species Production
Chua, Y. L., Dufour, E., Dassa, E. P., Rustin, P., Jacobs, H. T., Taylor, C. T., & Hagen, T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.158485 · Cited by 189 · see citing works
Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1α during hypoxia
Chandel, N. S., McClintock, D. S., Feliciano, C. E., Wood, T. M., Melendez, J. A., Rodriguez, A. M., & Schumacker, P. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001914200 · Cited by 2,000 · see citing works
Self-citation
A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF‐1α
Sanjuán-Pla, A., Cervera, A. M., Apostolova, N., Garcia-Bou, R., Víctor, V. M., Murphy, M. P., & McCreath, K. J. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.03.088 · Cited by 134 · see citing works
Role of mitochondria in the regulation of hypoxia-inducible factor-1α in the rat carotid body glomus cells
Baby, S. M., Roy, A., & Lahiri, S. (2005) · Histochemistry and Cell Biology · doi:10.1007/s00418-005-0028-6 · Cited by 24 · see citing works
Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain
Vaux, E. C., Metzen, E., Yeates, K. M., & Ratcliffe, P. J. (2001) · Blood · doi:10.1182/blood.v98.2.296 · Cited by 198 · see citing works

Authors: Schroedl, C., McClintock, D. S., Budinger, G. R. S., & Chandel, N. S.
Affiliations: Northwestern University (US)
ORCID: Schroedl, Clara
McClintock, David S.
Budinger, G. R. Scott
Chandel, Navdeep S.
Venue: American Journal of Physiology-Lung Cellular and Molecular Physiology
Publisher: American Physiological Society
Published: 2002-11-01
Volume: 283
Issue: 5
Pages: L922-L931
ISSN: 1040-0605 (ISSN-L)
1522-1504
DOI: 10.1152/ajplung.00014.2002
OpenAlex: W2095062583
Cited by: 266
References: 39
Citations by year: 2026: 2 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 13 · 2020: 4 · 2019: 9 · 2018: 5 · 2017: 14 · 2016: 9 · 2015: 11 · 2014: 8 · 2013: 14 · 2012: 11
FWCI: 5.72
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Lung Cellular and Molecular Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (R01GM060472, GM60472-03)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords: HIF-1α stabilization, hypoxia, anoxia, mitochondrial reactive oxygen species, electron transport chain, rotenone, mitochondrial DNA deletions, mitochondrial complex I inhibition, A549 cells, HT1080 cells
MeSH terms: Adenosine Triphosphate, Animals, Hypoxia, Cell Line, Cricetinae, Humans, Kinetics, Lung, Mitochondria, Oxygen Consumption, Recombinant Proteins, Transcription Factors, Transfection, Cell Hypoxia, Apoptosis, Reactive Oxygen Species, Genes, Reporter, Urothelium, Respiratory Mucosa, Hypoxia-Inducible Factor 1, alpha Subunit

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Hypoxic but not anoxic stabilization of HIF-1α requires mitochondrial reactive oxygen species

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks