Gil, Jesús

Cellular Senescence: Defining a Path Forward

Gorgoulis, V., Adams, P. D., Alimonti, A., Bennett, D. C., Bischof, O., Bishop, C., Campisi, J., Collado, M., Evangelou, K., Ferbeyre, G., et al. (2019) · Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 3,225

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

Acosta, J. C., Banito, A., Wuestefeld, T., Georgilis, A., Janich, P., Morton, J. P., Athineos, D., Kang, T.-W., Lasitschka, F., Andrulis, M., et al. (2013) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 2,278

Chemokine signaling via the CXCR2 receptor reinforces senescence

Acosta, J. C., O'Loghlen, A., Banito, A., Guijarro, M. V., Augert, A., Raguz, S., Fumagalli, M., Da Costa, M., Brown, C., Popov, N., et al. (2008) · Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,801

Senescence in premalignant tumours

Collado, M., Gil, J., Efeyan, A., Guerra, C., Schuhmacher, A. J., Barradas, M., Benguría, A., Zaballos, A., Flores, J. M., Barbacid, M., et al. (2005) · Nature

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 1,482

Molecular Interplay of the Noncoding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a

Yap, K. L., Li, S., Muñoz-Cabello, A. M., Raguz, S., Zeng, L., Mujtaba, S., Gil, J., Walsh, M. J., & Zhou, M.-M. (2010) · Molecular Cell

Epigenetics and DNA MethylationCancer-related molecular mechanisms research

Cited by 1,391

Senescence and aging: Causes, consequences, and therapeutic avenues

McHugh, D., & Gil, J. (2018) · Journal of Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,233

Mechanisms and functions of cellular senescence

Herranz, N., & Gil, J. (2018) · Journal of Clinical Investigation

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,232

Senescence and the SASP: many therapeutic avenues

Birch, J., & Gil, J. (2020) · Genes & Development

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,177

Regulation of the INK4b–ARF–INK4a tumour suppressor locus: all for one or one for all

Gil, J., & Peters, G. (2006) · Nature Reviews Molecular Cell Biology

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 843

Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action

García, M. A., Gil, J., Ventoso, I., Guerra, S., Domingo, E., Rivas, C., & Esteban, M. (2006) · Microbiology and Molecular Biology Reviews

interferon and immune responsesEndoplasmic Reticulum Stress and Disease

Cited by 818

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

Herranz, N., Gallage, S., Mellone, M., Wuestefeld, T., Klotz, S., Hanley, C. J., Raguz, S., Acosta, J. C., Innes, A. J., Banito, A., et al. (2015) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 788

Senescence impairs successful reprogramming to pluripotent stem cells

Banito, A., Rashid, S. T., Acosta, J. C., Li, S., Pereira, C. F., Geti, I., Pinho, S., Silva, J. C., Azuara, V., Walsh, M., et al. (2009) · Genes & Development

Pluripotent Stem Cells ResearchTelomeres, Telomerase, and Senescence

Cited by 642

Cardiac glycosides are broad-spectrum senolytics

Guerrero, A., Herranz, N., Sun, B., Wagner, V., Gallage, S., Guiho, R., Wolter, K., Pombo, J., Irvine, E. E., Innes, A. J., et al. (2019) · Nature Metabolism

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 359

Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS

Barradas, M., Anderton, E., Acosta, J. C., Li, S., Banito, A., Rodriguez-Niedenführ, M., Maertens, G., Banck, M., Zhou, M.-M., Walsh, M. J., et al. (2009) · Genes & Development

Epigenetics and DNA MethylationTelomeres, Telomerase, and Senescence

Cited by 352

Polycomb CBX7 has a unifying role in cellular lifespan.

Gil, J., Bernard, D., Martínez, D., & Beach, D. (2004) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceEpigenetics and DNA Methylation

Cited by 341

Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer

Haston, S., Gonzalez-Gualda, E., Morsli, S., Ge, J., Reen, V., Calderwood, A., Moutsopoulos, I., Panousopoulos, L., Deletic, P., Carreno, G., et al. (2023) · Cancer Cell

Telomeres, Telomerase, and SenescenceImmune cells in cancer

Cited by 251

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells

Georgilis, A., Klotz, S., Hanley, C. J., Herranz, N., Weirich, B., Morancho, B., Leote, A. C., D'Artista, L., Gallage, S., Seehawer, M., et al. (2018) · Cancer Cell

Telomeres, Telomerase, and SenescenceRNA Research and Splicing

Cited by 237

AP-1 imprints a reversible transcriptional programme of senescent cells.

Martínez-Zamudio, R. I., Roux, P.-F., de Freitas, J. A. N. L. F., Robinson, L., Doré, G., Sun, B., Belenki, D., Milanovic, M., Herbig, U., Schmitt, C. A., et al. (2020) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceGenomics and Chromatin Dynamics

Cited by 236

Epigenetic regulation of the INK4b-ARF-INK4a locus: In sickness and in health

Popov, N., & Gil, J. (2010) · Epigenetics

Epigenetics and DNA MethylationChromatin Remodeling and Cancer

Cited by 202

Induction of Apoptosis by Double-Stranded-RNA-Dependent Protein Kinase (PKR) Involves the α Subunit of Eukaryotic Translation Initiation Factor 2 and NF-κB

Gil, J., Alcamí, J., & Esteban, M. (1999) · Molecular and Cellular Biology

Endoplasmic Reticulum Stress and DiseaseNF-κB Signaling Pathways

Cited by 199

Galactose‐modified duocarmycin prodrugs as senolytics

Guerrero, A., Guiho, R., Herranz, N., Uren, A., Withers, D. J., Martínez‐Barbera, J. P., Tietze, L. F., & Gil, J. (2020) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 172

Similarities and interplay between senescent cells and macrophages

Behmoaras, J., & Gil, J. (2021) · Journal of Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 158

Senescence as a therapeutically relevant response to CDK4/6 inhibitors

Wagner, V., & Gil, J. (2020) · Oncogene

Telomeres, Telomerase, and SenescenceAdvanced Breast Cancer Therapies

Cited by 148

Control of senescence by CXCR2 and its ligands

Acosta, J. C., Loghlen, A., Banito, A., Raguz, S., & Gil, J. (2008) · Cell Cycle

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 106