Cited by 202Epigenetics and DNA MethylationChromatin Remodeling and CancerGenomics and Chromatin Dynamics

Epigenetic regulation of the INK4b-ARF-INK4a locus: In sickness and in health

Open access
Popov, Nikolay, Gil, Jesús·2010·Epigenetics

Abstract

The INK4b-ARF-INK4a locus encodes for two cyclin-dependent kinase inhibitors, p15(INK4b) and p16(INK4a) and a regulator of the p53 pathway, ARF. In addition ANRIL, a non-coding RNA, is also transcribed from the locus. ARF, p15(INK4b) and p16(INK4a) are well-established tumor suppressors which function is frequently disabled in human cancers. Recent studies showed that single nucleotide polymorphisms mapping in the vicinity of ANRIL are linked to a wide spectrum of conditions, including cardiovascular disease, ischemic stroke, type 2 diabetes, frailty and Alzheimer's disease. The INK4b-ARF-INK4a locus is regulated by Polycomb repressive complexes (PRCs), and its expression can be invoked by activating signals. Other epigenetic modifiers such as the histone demethylases JMJD3 and JHDM1B, the SWI/SNF chromatin remodeling complex and DNA methyltransferases regulate the locus interplaying with PRCs. In view of the intimate involvement of the INK4b-ARF-INK4a locus on disease, to understand its regulation is the first step for manipulate it to therapeutic benefit.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.4161/epi.5.8.12996

Cites

71 of 71 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • p16 is under epigenetic regulation, which plays an important role in mediating the stress-induced activation of p16 transcription.

    “Moreover, p16 is under the control of epigenetic regulation, which plays an important role in mediating the stress-induced activation of p16 transcription [18].”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 72 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Freedberg DE, Rigas SH, Russak J, Gai W, Kaplow M, Osman I, et al. Frequent p16-independent inacti- vation of p14 ARF in human melanoma. J Natl Cancer Inst 2008; 100:784-95.

Cited by

Sorted by citations

Authors
Popov, N., & Gil, J.
Affiliations
Imperial College London (GB)
Corresponding author
Gil, Jesús
Venue
Epigenetics
Published
2010-11
Volume
5
Issue
8
Pages
685-690
ISSN
  • 1559-2294 (ISSN-L)
  • 1559-2308
OpenAlex
W1969204301
Cited by
202
References
72
Citations by year
2026: 2 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 8 · 2021: 9 · 2020: 15 · 2019: 14 · 2018: 14 · 2017: 16 · 2016: 13 · 2015: 24 · 2014: 21 · 2013: 26 · 2012: 18
FWCI
1.51
Type
journal article
Language
en
Open access
Locations
  • Epigenetics (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • LifeArc
  • Cancer Research UK
  • Medical Research Council
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
p16INK4a, CDKN2B, ARF, ANRIL, non-coding RNA, polycomb repressive complex, histone demethylase, JMJD3, SWI/SNF chromatin remodeling, DNA methyltransferases, tumor suppressor, single nucleotide polymorphisms, epigenetic regulation, cancer
MeSH terms
Alzheimer Disease, Animals, Cardiovascular Diseases, Chromatin, Diabetes Mellitus, Type 2, Humans, Repressor Proteins, Transcription, Genetic, DNA Modification Methylases, Signal Transduction, Tumor Suppressor Protein p53, G1 Phase, Cyclin-Dependent Kinase Inhibitor p16, ADP-Ribosylation Factors, RNA, Untranslated, Epigenesis, Genetic, Cyclin-Dependent Kinase Inhibitor p15, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, Proto-Oncogene Proteins c-mdm2, Genetic Loci, Histone Demethylases, Polycomb-Group Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review