AP-1 imprints a reversible transcriptional programme of senescent cells.
Open accessAbstract
Senescent cells affect many physiological and pathophysiological processes. While select genetic and epigenetic elements for senescence induction have been identified, the dynamics, epigenetic mechanisms and regulatory networks defining senescence competence, induction and maintenance remain poorly understood, precluding the deliberate therapeutic targeting of senescence for health benefits. Here, we examined the possibility that the epigenetic state of enhancers determines senescent cell fate. We explored this by generating time-resolved transcriptomes and epigenome profiles during oncogenic RAS-induced senescence and validating central findings in different cell biology and disease models of senescence. Through integrative analysis and functional validation, we reveal links between enhancer chromatin, transcription factor recruitment and senescence competence. We demonstrate that activator protein 1 (AP-1) 'pioneers' the senescence enhancer landscape and defines the organizational principles of the transcription factor network that drives the transcriptional programme of senescent cells. Together, our findings enabled us to manipulate the senescence phenotype with potential therapeutic implications.
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This temporal regulation of senescence-associated phenotypes seems to be, at least in part, controlled by the sequential and dynamic activation of diverse transcriptional programmes and hierarchies.
“This temporal regulation of senescence- associated phenotypes seems to be, at least in part, controlled by the sequential and dynamic activation of diverse transcriptional programmes and hierarchies 72-74 .”
From Senescence and cancer — role and therapeutic opportunities (2022) · cites this paper as [74]
Senescence-associated phenotypes are temporal and early-stage senescent cells are phenotypically different from late-stage senescent cells.
“Indeed, senescence- associated phenotypes are temporal and early- stage senescent cells are phenotypically different from late- stage senescent cells 72-74 .”
From Senescence and cancer — role and therapeutic opportunities (2022) · cites this paper as [74]
A hierarchical transcription factor network defines the senescence transcriptional program.
“They demonstrated that a hierarchical transcription factor network defines the senescence transcriptional program and identified activator protein 1 (AP-1) as a master regulator that drives the transcriptional program of senescent cells thereby revealing promising pathways with therapeutic implications for modulation of senescence in vivo.”
From Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype (2021) · cites this paper as Martínez-Zamudio et al., 2020
Activator protein 1 (AP-1) is a master regulator that drives the transcriptional program of senescent cells.
“They demonstrated that a hierarchical transcription factor network defines the senescence transcriptional program and identified activator protein 1 (AP-1) as a master regulator that drives the transcriptional program of senescent cells thereby revealing promising pathways with therapeutic implications for modulation of senescence in vivo.”
From Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype (2021) · cites this paper as Martínez-Zamudio et al., 2020
A recent study by Martínez-Zamudio et al. (2020) revealed links between enhancer chromatin, transcription factor recruitment, and senescence competence.
“A recent study by Martínez-Zamudio et al. (2020), revealed links between enhancer chromatin, transcription factor recruitment, and senescence competence.”
From Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype (2021) · cites this paper as Martínez-Zamudio et al., 2020
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Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
Buenrostro, J. D., Giresi, P. G., Zaba, L. C., Chang, H. Y., & Greenleaf, W. J. (2013) · Nature Methods · doi:10.1038/nmeth.2688 · Cited by 6,422 · see citing works
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206 · see citing works
Histone H3K27ac separates active from poised enhancers and predicts developmental state
Creyghton, M. P., Cheng, A. W., Welstead, G. G., Kooistra, T., Carey, B. W., Steine, E. J., Hanna, J., Lodato, M. A., Frampton, G. M., Sharp, P. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016071107 · Cited by 4,302 · see citing works
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
Gilbert, L. A., Horlbeck, M. A., Adamson, B., Villalta, J. E., Chen, Y., Whitehead, E. H., Guimaraes, C., Panning, B., Ploegh, H. L., Bassik, M. C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.029 · Cited by 2,728 · see citing works
Senolytics improve physical function and increase lifespan in old age
Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0092-9 · Cited by 2,287 · see citing works
Chapuy, B., Stewart, C., Dunford, A. J., Kim, J., Kamburov, A., Redd, R. A., Lawrence, M. S., Roemer, M. G. M., Li, A. J., Ziepert, M., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0016-8 · Cited by 1,941 · see citing works
The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1
Angel, P., Hattori, K., Smeal, T., & Karin, M. (1988) · Cell · doi:10.1016/0092-8674(88)90143-2 · Cited by 1,239 · see citing works
Senescence-associated reprogramming promotes cancer stemness
Milanovic, M., Fan, D. N. Y., Belenki, D., Däbritz, J. H. M., Zhao, Z., Yu, Y., Dörr, J. R., Dimitrova, L., Lenze, D., Monteiro Barbosa, I. A., et al. (2018) · Nature · doi:10.1038/nature25167 · Cited by 1,131 · see citing works
Self-citationThakore, P. I., D'Ippolito, A. M., Song, L., Safi, A., Shivakumar, N. K., Kabadi, A. M., Reddy, T. E., Crawford, G. E., & Gersbach, C. A. (2015) · Nature Methods · doi:10.1038/nmeth.3630 · Cited by 1,012 · see citing works
The selection and function of cell type-specific enhancers
Heinz, S., Romanoski, C. E., Benner, C., & Glass, C. K. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3949 · Cited by 1,010 · see citing works
Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis
Novershtern, N., Subramanian, A., Lawton, L. N., Mak, R. H., Haining, W. N., McConkey, M. E., Habib, N., Yosef, N., Chang, C. Y., Shay, T., et al. (2011) · Cell · doi:10.1016/j.cell.2011.01.004 · Cited by 942 · see citing works
Latent Enhancers Activated by Stimulation in Differentiated Cells
Ostuni, R., Piccolo, V., Barozzi, I., Polletti, S., Termanini, A., Bonifacio, S., Curina, A., Prosperini, E., Ghisletti, S., & Natoli, G. (2013) · Cell · doi:10.1016/j.cell.2012.12.018 · Cited by 867 · see citing works
Pioneer Transcription Factors Target Partial DNA Motifs on Nucleosomes to Initiate Reprogramming
Soufi, A., Garcia, M. F., Jaroszewicz, A., Osman, N., Pellegrini, M., & Zaret, K. S. (2015) · Cell · doi:10.1016/j.cell.2015.03.017 · Cited by 780 · see citing works
An expansive human regulatory lexicon encoded in transcription factor footprints
Neph, S. J., Vierstra, J. D., Stergachis, A. B., Reynolds, A. P., Haugen, E., Vernot, B., Thurman, R. E., John, S., Sandstrom, R. S., Johnson, A., et al. (2012) · Nature · doi:10.1038/nature11212 · Cited by 746 · see citing works
Kaikkonen, M. U., Spann, N. J., Heinz, S., Romanoski, C. E., Allison, K. A., Stender, J. D., Chun, H. B., Tough, D. F., Prinjha, R. K., Benner, C., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.07.010 · Cited by 672 · see citing works
Synthetic lethal metabolic targeting of cellular senescence in cancer therapy
Dörr, J. R., Yu, Y., Milanovic, M., Beuster, G., Zasada, C., Däbritz, J. H. M., Lisec, J., Lenze, D., Gerhardt, A., Schleicher, K., et al. (2013) · Nature · doi:10.1038/nature12437 · Cited by 541 · see citing works
Self-citationNOTCH1 mediates a switch between two distinct secretomes during senescence
Hoare, M., Ito, Y., Kang, T.-W., Weekes, M. P., Matheson, N. J., Patten, D. A., Shetty, S., Parry, A. J., Menon, S., Salama, R., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3397 · Cited by 522 · see citing works
Methods to Detect Biomarkers of Cellular Senescence
Itahana, K., Campisi, J., & Dimri, G. P. (2007) · Methods in molecular biology · doi:10.1007/978-1-59745-361-5_3 · Cited by 516 · see citing works
Sherwood, R. I., Hashimoto, T., O'Donnell, C. W., Lewis, S., Barkal, A. A., van Hoff, J. P., Karun, V., Jaakkola, T., & Gifford, D. K. (2014) · Nature Biotechnology · doi:10.1038/nbt.2798 · Cited by 416 · see citing works
BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance
Tasdemir, N., Banito, A., Roe, J.-S., Alonso-Curbelo, D., Camiolo, M., Tschaharganeh, D. F., Huang, C.-H., Aksoy, O., Bolden, J. E., Chen, C.-C., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0217 · Cited by 415 · see citing works
Use of Chromatin Immunoprecipitation To Clone Novel E2F Target Promoters
Weinmann, A. S., Bartley, S. M., Zhang, T., Zhang, M. Q., & Farnham, P. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.20.6820-6832.2001 · Cited by 381 · see citing works
Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development
Nateri, A. S., Spencer‐Dene, B., & Behrens, A. (2005) · Nature · doi:10.1038/nature03914 · Cited by 376 · see citing works
Visco, C., Li, Y., Xu-Monette, Z. Y., Miranda, R. N., Green, T. M., Li, Y., Tzankov, A., Wen, W., Liu, W.-M., Kahl, B. S., et al. (2012) · Leukemia · doi:10.1038/leu.2012.83 · Cited by 370 · see citing works
Garber, M., Yosef, N., Goren, A., Raychowdhury, R., Thielke, A., Guttman, M., Robinson, J., Minie, B., Chevrier, N., Itzhaki, Z., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.07.030 · Cited by 369 · see citing works
Transcription factor binding dynamics during human ES cell differentiation
Tsankov, A. M., Gu, H., Akopian, V., Ziller, M. J., Donaghey, J., Amit, I., Gnirke, A., & Meissner, A. (2015) · Nature · doi:10.1038/nature14233 · Cited by 349 · see citing works
The Ubiquitin Ligase SCF Fbw7 Antagonizes Apoptotic JNK Signaling
Nateri, A. S., Riera-Sans, L., Costa, C. D., & Behrens, A. (2004) · Science · doi:10.1126/science.1092880 · Cited by 339 · see citing works
JunD Protects Cells from p53-Dependent Senescence and Apoptosis
Weitzman, J. B., Fiette, L., Matsuo, K., & Yaniv, M. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00109-x · Cited by 269 · see citing works
The Dual Role of Cellular Senescence in Developing Tumors and Their Response to Cancer Therapy
Schosserer, M., Grillari, J., & Breitenbach, M. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00278 · Cited by 261 · see citing works
Benhamed, M., Herbig, U., Ye, T., Dejean, A., & Bischof, O. (2012) · Nature Cell Biology · doi:10.1038/ncb2443 · Cited by 252 · see citing works
Self-citationDynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation
Goode, D. K., Obier, N., Vijayabaskar, M. S., Lie‐A‐Ling, M., Lilly, A. J., Hannah, R., Lichtinger, M., Batta, K., Florkowska, M., Patel, R., et al. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.01.024 · Cited by 239 · see citing works
Georgilis, A., Klotz, S., Hanley, C. J., Herranz, N., Weirich, B., Morancho, B., Leote, A. C., D'Artista, L., Gallage, S., Seehawer, M., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.06.007 · Cited by 237 · see citing works
Self-citationLong noncoding RNA PANDA and scaffold-attachment-factor SAFA control senescence entry and exit
Pavan Kumar, P., Desetty, R. D., Pineau, P., Marchio, A., Moon, A., Dejean, A., & Bischof, O. (2014) · Nature Communications · doi:10.1038/ncomms6323 · Cited by 200 · see citing works
Self-citationLi, T., Hu, J., Qiu, X., Ling, J., Chen, H., Wang, S., Hou, A., Vu, T. H., & Hoffman, A. R. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00204-08 · Cited by 197 · see citing works
Tumor Stroma-Derived TGF-β Limits Myc-Driven Lymphomagenesis via Suv39h1-Dependent Senescence
Reimann, M., Lee, S., Loddenkemper, C., Dörr, J. R., Tabor, V., Aichele, P., Stein, H., Dörken, B., Jenuwein, T., & Schmitt, C. A. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.043 · Cited by 184 · see citing works
Self-citationHistone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence
Sen, P., Lan, Y., Li, C. Y., Sidoli, S., Donahue, G., Dou, Z., Frederick, B., Chen, Q., Luense, L. J., Garcia, B. A., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.01.021 · Cited by 164 · see citing works
Rai, T. S., Cole, J. J., Nelson, D. M., Dikovskaya, D., Faller, W. J., Vizioli, M. G., Hewitt, R. N., Anannya, O., McBryan, T., Manoharan, I., et al. (2014) · Genes & Development · doi:10.1101/gad.247528.114 · Cited by 162 · see citing works
Martínez, O., & Reyes‐Valdés, M. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803479105 · Cited by 148 · see citing works
SnapShot: Cellular Senescence Pathways
Martínez‐Zamudio, R. I., Robinson, L. J., Roux, P., & Bischof, O. (2017) · Cell · doi:10.1016/j.cell.2017.07.049 · Cited by 129 · see citing works
Self-citationLoeffler‐Wirth, H., Kalcher, M., & Binder, H. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btv342 · Cited by 116 · see citing works
van Oevelen, C. J. C., Collombet, S., Vicent, G. P., Hoogenkamp, M., Lepoivre, C., Badeaux, A. I., Bussmann, L. H., Sardina, J. L., Thieffry, D., Beato, M., et al. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.06.007 · Cited by 108 · see citing works
C/EBPγ Suppresses Senescence and Inflammatory Gene Expression by Heterodimerizing with C/EBPβ
Huggins, C. J., Malı́k, R., Lee, S., Salotti, J., Thomas, S., Martín, N. C. R., Quiñones, O. A., Alvord, W. G., Olanich, M. E., Keller, J. R., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01674-12 · Cited by 102 · see citing works
Ren, X., & Kerppola, T. K. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05088-11 · Cited by 72 · see citing works
Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice
Overman, J. P., Fontaine, F. R., Moustaqil, M. D., Mittal, D., Sierecki, E., Sacilotto, N., Zuegg, J., Robertson, A. A. B., Holmes, K. A., Salim, A. A., et al. (2017) · eLife · doi:10.7554/elife.21221 · Cited by 63 · see citing works
Minireview: Pioneer Transcription Factors in Cell Fate Specification
Drouin, J. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1084 · Cited by 51 · see citing works
Guo, Y., & Gifford, D. K. (2017) · BMC Genomics · doi:10.1186/s12864-016-3434-3 · Cited by 37 · see citing works
SnapShot: Cellular Senescence in Pathophysiology
Martínez‐Zamudio, R. I., Robinson, L. J., Roux, P., & Bischof, O. (2017) · Cell · doi:10.1016/j.cell.2017.08.025 · Cited by 22 · see citing works
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Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
Kumari, R., & Jat, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.645593 · Cited by 1,622 · see citing works
The senescence-associated secretory phenotype and its physiological and pathological implications
Wang, B., Han, J., Elisseeff, J. H., & Demaria, M. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00727-x · Cited by 948 · see citing works
Senescence and cancer — role and therapeutic opportunities
Schmitt, C. A., Wang, B., & Demaria, M. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00668-4 · Cited by 794 · see citing works
Self-citationTargeting CDK4 and CDK6 in cancer
Goel, S., Bergholz, J. S., & Zhao, J. J. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00456-3 · Cited by 555 · see citing works
Ogrodnik, M. (2021) · Aging Cell · doi:10.1111/acel.13338 · Cited by 349 · see citing works
Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy
Prasanna, P. G. S., Citrin, D. E., Hildesheim, J., Ahmed, M. M., Venkatachalam, S., Riscuta, G., Xi, D., Zheng, G., van Deursen, J., Goronzy, J. J., et al. (2021) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djab064 · Cited by 351 · see citing works
Self-citationA blood atlas of COVID-19 defines hallmarks of disease severity and specificity
Ahern, D. J., Ai, Z., Ainsworth, M., Allan, C., Allcock, A., Angus, B., Ansari, M. A., Arancibia-Cárcamo, C. V., Aschenbrenner, D., Attar, M., et al. (2022) · Cell · doi:10.1016/j.cell.2022.01.012 · Cited by 328 · see citing works
Mesenchymal Stem/Stromal Cell Senescence: Hallmarks, Mechanisms, and Combating Strategies
Weng, Z., Wang, Y., Ouchi, T., Liu, H., Qiao, X., Wu, C., Zhao, Z., Li, L., & Li, B. (2022) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szac004 · Cited by 291 · see citing works
Gerhardt, L. M. S., Liu, J., Koppitch, K. A., Cippà, P. E., & McMahon, A. P. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2026684118 · Cited by 232 · see citing works
Martínez‐Zamudio, R. I., Dewald, H. K., Vasilopoulos, T., Gittens‐Williams, L., Fitzgerald‐Bocarsly, P., & Herbig, U. (2021) · Aging Cell · doi:10.1111/acel.13344 · Cited by 213 · see citing works
Self-citationCellular adaptation to cancer therapy along a resistance continuum
França, G. S., Baron, M., King, B. R., Bossowski, J. P., Bjornberg, A., Pour, M., Rao, A. N., Patel, A. S., Misirlioğlu, S., Barkley, D., et al. (2024) · Nature · doi:10.1038/s41586-024-07690-9 · Cited by 227 · see citing works
The Cancer SENESCopedia: A delineation of cancer cell senescence
Jochems, F., Thijssen, B., De Conti, G., Jansen, R., Pogacar, Z., Groot, K., Wang, L., Schepers, A., Wang, C., Jin, H., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109441 · Cited by 201 · see citing works
Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo
Omori, S., Wang, T.-W., Johmura, Y., Kanai, T., Nakano, Y., Kido, T., Susaki, E. A., Nakajima, T., Shichino, S., Ueha, S., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.09.006 · Cited by 194 · see citing works
COVID-19 and cellular senescence
Schmitt, C. A., Tchkonia, T., Niedernhofer, L. J., Robbins, P. D., Kirkland, J. L., & Lee, S. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-022-00785-2 · Cited by 153 · see citing works
Self-citationWatt, A. C. S., & Goel, S. (2022) · Breast Cancer Research · doi:10.1186/s13058-022-01510-6 · Cited by 151 · see citing works
INX-315, a Selective CDK2 Inhibitor, Induces Cell Cycle Arrest and Senescence in Solid Tumors
Dietrich, C. A., Trub, A. G., Ahn, A., Taylor, M., Ambani, K., Chan, K. T., Lu, K., Mahendra, C. A., Blyth, C., Coulson, R. S., et al. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-0954 · Cited by 141 · see citing works
Senescent glia link mitochondrial dysfunction and lipid accumulation
Byrns, C. N., Perlegos, A. E., Miller, K. N., Jin, Z., Carranza, F. R., Manchandra, P., Beveridge, C. H., Randolph, C. E., Chaluvadi, V. S., Zhang, S., et al. (2024) · Nature · doi:10.1038/s41586-024-07516-8 · Cited by 141 · see citing works
Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer
Troiani, M., Colucci, M., D’Ambrosio, M., Guccini, I., Pasquini, E., Varesi, A., Valdata, A., Mosole, S., Revandkar, A., Attanasio, G., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29824-1 · Cited by 129 · see citing works
The m6A mRNA demethylase FTO in granulosa cells retards FOS-dependent ovarian aging
Jiang, Z., Wang, Y.-N., Li, Z.-Y., Dai, Z., He, Y., Chu, K., Gu, J., Ji, Y., Sun, N., Yang, F., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04016-9 · Cited by 120 · see citing works
Cellular senescence: Neither irreversible nor reversible
Reimann, M., Lee, S., & Schmitt, C. A. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20232136 · Cited by 120 · see citing works
Self-citationParamos-de-Carvalho, D., Jacinto, A., & Saúde, L. (2021) · eLife · doi:10.7554/elife.72449 · Cited by 111 · see citing works
Xu, P., Wang, M., Song, W.-M., Wang, Q., Yuan, G.-C., Sudmant, P. H., Zare, H., Tu, Z., Orr, M. E., & Zhang, B. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00507-7 · Cited by 114 · see citing works
Chromatin basis of the senescence-associated secretory phenotype
Hao, X., Wang, C., & Zhang, R. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.12.003 · Cited by 94 · see citing works
Selective remodelling of the adipose niche in obesity and weight loss
Miranda, A. M. A., McAllan, L., Mazzei, G., Andrew, I., Davies, I., Ertuğrul, M. S., Kenkre, J. S., Kudo, H., Carrelha, J., Patel, B., et al. (2025) · Nature · doi:10.1038/s41586-025-09233-2 · Cited by 107 · see citing works
Liu, C., Fan, L., Guan, M., Zheng, Q., Jin, J., Kang, X., Gao, Z., Deng, X., Shen, Y., Chu, G., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c01713 · Cited by 91 · see citing works
ATF3 drives senescence by reconstructing accessible chromatin profiles
Zhang, C., Zhang, X., Huang, L., Guan, Y., Huang, X., Tian, X., Zhang, L., & Tao, W. (2021) · Aging Cell · doi:10.1111/acel.13315 · Cited by 84 · see citing works
“When our project was about to be completed, we found that Ricardo et al.(Martinez-Zamudio et al., 2020) recently published research on the regulation of AP-1 transcription factors to senescence program and our work can confirm and complement each other.”
ResultColucci, M., Zumerle, S., Bressan, S., Gianfanti, F., Troiani, M., Valdata, A., D’Ambrosio, M., Pasquini, E., Varesi, A., Cogo, F., et al. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.02.004 · Cited by 85 · see citing works
Glaviano, A., Wander, S. A., Baird, R. D., Yap, K. C.-Y., Lam, H. Y., Toi, M., Carbone, D., Geoerger, B., Serra, V., Jones, R. H., et al. (2024) · Drug Resistance Updates · doi:10.1016/j.drup.2024.101103 · Cited by 85 · see citing works
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Dasgupta, N., Arnold, R., Equey, A., Gandhi, A., & Adams, P. D. (2024) · npj Aging · doi:10.1038/s41514-024-00172-2 · Cited by 86 · see citing works
Tighanimine, K., de Freitas, J. A. N. L. F., Nemazanyy, I., Bankolé, A., Benarroch, D., Brodesser, S., Doré, G. R. G., Robinson, L. J., Bénit, P., Ladraa, S., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-023-00972-y · Cited by 77 · see citing works
Self-citationGiroud, J., Bouriez, I., Paulus, H., Pourtier, A., Debacq‐Chainiaux, F., & Pluquet, O. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310788 · Cited by 77 · see citing works
Patrick, R., Naval-Sánchez, M., Deshpande, N., Huang, Y., Zhang, J., Chen, X., Yang, Y., Tiwari, K., Esmaeili, M., Tran, M., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.06.006 · Cited by 73 · see citing works
CDK4/6 Inhibitors in Combination Therapies: Better in Company Than Alone: A Mini Review
Vinciguerra, G. L. R., Sonego, M., Segatto, I., Dall’Acqua, A., Vecchione, A. M., Baldassarre, G., & Belletti, B. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.891580 · Cited by 71 · see citing works
TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state
Matsuda, S., Revandkar, A., Dubash, T. D., Ravi, A., Wittner, B. S., Lin, M., Morris, R. T., Burr, R., Guo, H., Seeger, K., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112129 · Cited by 72 · see citing works
Rosenberg, N., Van Haele, M., Lanton, T., Brashi, N., Bromberg, Z., Adler, H., Giladi, H., Peled, A., Goldenberg, D. S., Axelrod, J. H., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.07.029 · Cited by 72 · see citing works
Giorgio, E. D., Paluvai, H., Dalla, E., Ranzino, L., Renzini, A., Moresi, V., Minisini, M., Picco, R., & Brancolini, C. (2021) · Genome biology · doi:10.1186/s13059-021-02340-z · Cited by 67 · see citing works
AP ‐1 is a regulatory transcription factor of inflammaging in the murine kidney and liver
Yu, X., Wang, Y., Song, Y., Gao, X., & Deng, H. (2023) · Aging Cell · doi:10.1111/acel.13858 · Cited by 61 · see citing works
Sahu, S. K., Reddy, P., Lu, J. Y., Shao, Y., Wang, C., Tsuji, M., Núñez‐Delicado, E., Esteban, C. R., & Belmonte, J. C. I. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adg1777 · Cited by 66 · see citing works
Reck, M., Baird, D., Veizades, S. A., Sutherland, C., Bell, R. M. B., Hur, H., Cairns, C., Janas, P. P., Campbell, R., Nam, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59997-4 · Cited by 60 · see citing works
Irreversible cell cycle exit associated with senescence is mediated by constitutive MYC degradation
Afifi, M., Crncec, A., Cornwell, J., Cataisson, C., Paul, D., Ghorab, L. M., Hernandez, M. O., Wong, M., Kedei, N., & Cappell, S. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113079 · Cited by 58 · see citing works
AP-1 transcription factor network explains diverse patterns of cellular plasticity in melanoma cells
Comandante-Lou, N., Baumann, D. G., & Fallahi‐Sichani, M. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111147 · Cited by 51 · see citing works
Dynamic 3D genome reorganization during senescence: defining cell states through chromatin
Shaban, H. A., & Gasser, S. M. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01197-y · Cited by 55 · see citing works
Cellular senescence in the tumor microenvironment and context‐specific cancer treatment strategies
Yasuda, T., Baba, H., & Ishimoto, T. (2021) · FEBS Journal · doi:10.1111/febs.16231 · Cited by 52 · see citing works
Wang, Y., Liu, L., Song, Y., Yu, X., & Deng, H. (2022) · Protein & Cell · doi:10.1007/s13238-021-00894-z · Cited by 49 · see citing works
AP-1 activation mediates post-natal cardiomyocyte maturation
Zhang, H., Pei, L., Ouyang, Z., Wang, H., Chen, X., Jiang, K., Huang, S., Jiang, R., Xiang, Y., & Wei, K. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac088 · Cited by 52 · see citing works
Schwab, N., Taskina, D., Leung, E., Innes, B. T., Bader, G. D., & Hazrati, L. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1027116 · Cited by 52 · see citing works
Glial AP1 is activated with aging and accelerated by traumatic brain injury
Byrns, C. N., Saikumar, J., & Bonini, N. M. (2021) · Nature Aging · doi:10.1038/s43587-021-00072-0 · Cited by 48 · see citing works
Li, Y., Li, C., Zhou, Q., Liu, X., Qiao, Y., Xie, T., Sun, H., Ong, M. T., & Wang, H. (2025) · Nature Communications · doi:10.1038/s41467-025-61403-y · Cited by 56 · see citing works
Subcellular structure, heterogeneity, and plasticity of senescent cells
Bitencourt, T. C., Vargas, J. E., Silva, A. O., Fraga, L. R., & Filippi‐Chiela, E. C. (2024) · Aging Cell · doi:10.1111/acel.14154 · Cited by 46 · see citing works
Benítez, S., Cordero, A., Santamaría, P. G., Redondo-Pedraza, J., Rocha, A. S., Collado-Solé, A., Jimenez, M., Sanz-Moreno, A., Yoldi, G., Santos, J. C., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.04.022 · Cited by 41 · see citing works
Escape from oncogene-induced senescence is controlled by POU2F2 and memorized by chromatin scars
Martínez‐Zamudio, R. I., Stefa, A., de Freitas, J. A. N. L. F., Vasilopoulos, T., Simpson, M., Doré, G. R. G., Roux, P., Galan, M. A., Chokshi, R. J., Bischof, O., et al. (2023) · Cell Genomics · doi:10.1016/j.xgen.2023.100293 · Cited by 44 · see citing works
Self-citationShetty, A., Tripathi, S. K., Junttila, S., Buchacher, T., Biradar, R., Bhosale, S. D., Envall, T., Laiho, A., Moulder, R., Rasool, O., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac256 · Cited by 44 · see citing works
Integrated multi-omics approach revealed cellular senescence landscape
Song, Q., Hou, Y., Zhang, Y., Liu, J., Wang, Y., Fu, J., Zhang, C., Cao, M., Cui, Y., Zhang, X., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac885 · Cited by 42 · see citing works
Redmer, T., Raigel, M., Sternberg, C., Ziegler, R., Probst, C., Lindner, D., Aufinger, A., Limberger, T., Trachtová, K., Kodajova, P., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02022-x · Cited by 39 · see citing works
Spurious intragenic transcription is a feature of mammalian cellular senescence and tissue aging
Sen, P., Donahue, G., Li, C. Y., Egervári, G., Yang, N., Lan, Y., Robertson, N., Shah, P. P., Kerkhoven, E., Schultz, D., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00384-3 · Cited by 37 · see citing works
Autophagy inhibition signals through senescence to promote tumor suppression
Peng, N., Kang, H. H., Feng, Y., Minikes, A. M., & Jiang, X. (2022) · Autophagy · doi:10.1080/15548627.2022.2155794 · Cited by 36 · see citing works
Early growth response 2 (EGR2) is a novel regulator of the senescence programme
Tyler, E. J., del Arroyo, A. G., Wallis, R., Hughes, B., Garbe, J. C., Stampfer, M. R., Koh, J., Lowe, R., Philpott, M. P., & Bishop, C. L. (2021) · Aging Cell · doi:10.1111/acel.13318 · Cited by 34 · see citing works
Fernández-Duran, I., Quintanilla, A., Tarrats, N., Birch, J., Hari, P., Millar, F. R., Lagnado, A. B., Smer-Barreto, V., Muir, M., Brunton, V. G., et al. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00917-6 · Cited by 34 · see citing works
Giorgio, E. D., Ranzino, L., Tolotto, V., Dalla, E., Burelli, M., Gualandi, N., & Brancolini, C. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06548-2 · Cited by 32 · see citing works
Early response evaluation by single cell signaling profiling in acute myeloid leukemia
Tislevoll, B. S., Hellesøy, M., Fagerholt, O. H. E., Gullaksen, S., Srivastava, A., Birkeland, E., Kleftogiannis, D., Durán, P. A., Piechaczyk, L., Tadele, D. S., et al. (2023) · Nature Communications · doi:10.1038/s41467-022-35624-4 · Cited by 32 · see citing works
Netterfield, T. S., Ostheimer, G. J., Tentner, A. R., Joughin, B. A., Dakoyannis, A. M., Sharma, C. D., Sorger, P. K., Janes, K. A., Lauffenburger, D. A., & Yaffe, M. B. (2023) · Cell Systems · doi:10.1016/j.cels.2023.06.005 · Cited by 31 · see citing works
Yu, D., Yang, P., Lu, X., Huang, S., Liu, L., & Fan, X. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01184-3 · Cited by 30 · see citing works
Beyond cell cycle regulation: The pleiotropic function of CDK4 in cancer
Ziegler, D. V., Parashar, K., & Lluis Fajas, A. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.12.002 · Cited by 30 · see citing works
Rising from the ashes: cellular senescence in regeneration
Walters, H., & Yun, M. H. (2020) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2020.06.002 · Cited by 29 · see citing works
Biomarkers of Aging and Relevant Evaluation Techniques: A Comprehensive Review
Xue, T., Zhu, Z., Wang, L., Li, C., Sun, L., Wang, W., & Gong, W. (2023) · Aging and Disease · doi:10.14336/ad.2023.00808-1 · Cited by 34 · see citing works
Wang, H., Yu, Y., Li, R., Zhang, H., Chen, Z., Sun, C., & Zhuang, J. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.07.022 · Cited by 32 · see citing works
HDAC4 in cancer: A multitasking platform to drive not only epigenetic modifications
Cuttini, E., Goi, C., Pellarin, E., Vida, R., & Brancolini, C. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1116660 · Cited by 28 · see citing works
Grosse, L., & Bulavin, D. V. (2020) · Aging · doi:10.18632/aging.103492 · Cited by 27 · see citing works
Interactome Networks of FOSL1 and FOSL2 in Human Th17 Cells
Shetty, A., Bhosale, S. D., Tripathi, S. K., Buchacher, T., Biradar, R., Rasool, O., Moulder, R., Galande, S., & Lahesmaa, R. (2021) · ACS Omega · doi:10.1021/acsomega.1c03681 · Cited by 25 · see citing works
A NRF2-induced secretory phenotype activates immune surveillance to remove irreparably damaged cells
Baird, L., Taguchi, K., Zhang, A., Takahashi, Y., Suzuki, T., Kensler, T. W., & Yamamoto, M. P. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102845 · Cited by 26 · see citing works
Ozdemir, S. A., Faizan, M. I., Kaur, G., Shaikh, S. B., Islam, K. U., & Rahman, I. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199687 · Cited by 26 · see citing works
Chen, X., Wang, P., Qiu, H., Zhu, Y., Zhang, X., Zhang, Y., Duan, F., Ding, S., Guo, J., Huang, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30789-4 · Cited by 25 · see citing works
Neutrophil-activating secretome characterizes palbociclib-induced senescence of breast cancer cells
Favaretto, G., Rossi, M. N., Cuollo, L., Laffranchi, M., Cervelli, M., Soriani, A., Sozzani, S., Santoni, A., & Antonangeli, F. (2024) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-024-03695-5 · Cited by 24 · see citing works
Giorgio, E. D., Dalla, E., Tolotto, V., D’Este, F., Paluvai, H., Ranzino, L., & Brancolini, C. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae501 · Cited by 24 · see citing works
SMARCA4 regulates the NK-mediated killing of senescent cells
Reen, V., D’Ambrosio, M., Søgaard, P. P., Tyson, K., Leeke, B. J., Clément, I., Dye, I. C., Pombo, J., Kuba, A., Lan, Y., et al. (2025) · Science Advances · doi:10.1126/sciadv.adn2811 · Cited by 25 · see citing works
Self-citationTransposable element 5mC methylation state of blood cells predicts age and disease
Morandini, F., Lu, J. Y., Rechsteiner, C., Shadyab, A. H., Casanova, R., Snively, B. M., Seluanov, A., & Gorbunova, V. A. (2024) · Nature Aging · doi:10.1038/s43587-024-00757-2 · Cited by 24 · see citing works
Pietrogrande, G., Shaker, M. R., Stednitz, S. J., Soheilmoghaddam, M., Aguado, J., Morrison, S. D., Zambrano, S., Tabassum, T., Javed, I., Cooper-White, J. J., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02732-0 · Cited by 22 · see citing works
The Evolving Pathways of the Efficacy of and Resistance to CDK4/6 Inhibitors in Breast Cancer
Gomes, I., Abreu, C., Costa, L., & Casimiro, S. (2023) · Cancers · doi:10.3390/cancers15194835 · Cited by 23 · see citing works
Ferreira, F. J., Galhardo, M., Nogueira, J. M., Teixeira, J., Logarinho, E., & Bessa, J. (2025) · Nature Communications · doi:10.1038/s41467-025-57503-4 · Cited by 24 · see citing works
Liu, X., Zhang, X., Yao, C., Liang, J., Noble, P. W., & Jiang, D. (2024) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2023-0363oc · Cited by 25 · see citing works
Ahn, A., Rodger, E. J., Motwani, J., Gimenez, G., Stockwell, P. A., Parry, M. F., Hersey, P., Chatterjee, A., & Eccles, M. R. (2021) · Cancers · doi:10.3390/cancers13174250 · Cited by 19 · see citing works
Aging at the Crossroads of Organ Interactions: Implications for the Heart
Sen, I., Trzaskalski, N. A., Hsiao, Y., Liu, P. P., Shimizu, I., & Dérumeaux, G. (2025) · Circulation Research · doi:10.1161/circresaha.125.325637 · Cited by 20 · see citing works
Chen, Z., Mao, Z., Tang, W., Shi, Y., Liu, J., & You, Y. (2025) · Translational Neurodegeneration · doi:10.1186/s40035-025-00517-1 · Cited by 21 · see citing works
Al‐razaq, M. A. A., Freyter, B. M., Isermann, A., Tewary, G., Mangelinck, A., Mann, C., & Rübe, C. E. (2023) · Cells · doi:10.3390/cells12060916 · Cited by 19 · see citing works
Pan, C. C., Maeso‐Díaz, R., Lewis, T. R., Xiang, K., Tan, L., Liang, Y., Wang, L., Yang, F., Yin, T., Wang, C., et al. (2023) · Cell Research · doi:10.1038/s41422-023-00820-4 · Cited by 19 · see citing works
Senescence: A program in the road to cell elimination and cancer
Moiseeva, O., Guillon, J., & Ferbeyre, G. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.12.017 · Cited by 25 · see citing works
Ji, M.-L., Li, Z., Hu, X. Y., Zhang, W. T., Zhang, H. X., & Lu, J. (2023) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2023.02.011 · Cited by 19 · see citing works
Targeting cellular senescence to combat cancer and ageing
Wang, C., Hao, X., & Zhang, R. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13266 · Cited by 19 · see citing works
Han, Y., Micklem, G., & Kim, S. Y. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101849 · Cited by 16 · see citing works
Sargahydroquinoic acid (SHQA) suppresses cellular senescence through Akt/mTOR signaling pathway
Cao, L., Lee, S. G., Park, S., & Kim, H. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111406 · Cited by 17 · see citing works
Turano, P. S., Akbulut, E., Dewald, H. K., Vasilopoulos, T., Fitzgerald-Bocarsly, P., Herbig, U., & Martínez-Zamudio, R. I. (2026) · Cell Reports · doi:10.1016/j.celrep.2025.116795 · Cited by 16 · see citing works
Self-citationThe Role of Endothelial Senescence in the Pathogenesis of Diabetic Retinopathy
Gandhi, M., Haider, S., Chang, H. Z. Y., & Kazlauskas, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115211 · Cited by 16 · see citing works
Guerrero, A., Innes, A. J., Roux, P., Buisman, S. C., Jung, J., Ortet, L., Moiseeva, V., Wagner, V., Robinson, L. J., Ausema, A., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00279-9 · Cited by 15 · see citing works
Self-citationMolecular Characteristics and Promoter Analysis of Porcine COL1A1
Xiang, G., Huang, L., Zhang, X., Wang, N., Wang, H., Mu, Y., Li, K., & Liu, Z. (2022) · Genes · doi:10.3390/genes13111971 · Cited by 17 · see citing works
Ding, M., Huang, W., Liu, G., Zhai, B., Yan, H., & Zhang, Y. (2023) · BMC Genomics · doi:10.1186/s12864-023-09349-7 · Cited by 16 · see citing works
Senescence-associated lineage-aberrant plasticity evokes T-cell-mediated tumor control
Belenki, D., Richter‐Pechańska, P., Shao, Z., Bhattacharya, A., Lau, A., de Freitas, J. A. N. L. F., Kandler, G., Hick, T., Cai, X., Scharnagl, E., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57429-x · Cited by 15 · see citing works
Self-citationSteinhoff, M. S., Alam, M. A., Ahmad, A., Shahab Uddin, M. S., & Buddenkotte, J. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.11.009 · Cited by 15 · see citing works
Chen, Y., Li, Z., Ge, X., Lv, H., & Geng, Z. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1359631 · Cited by 15 · see citing works
Salmiņa, K., Vainshelbaum, N. M., Kreišmane, M., Inashkina, I., Cragg, M. S., Pjanova, D., & Erenpreisa, J. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043237 · Cited by 14 · see citing works
Carroll, C., Manaprasertsak, A., Castro, A. B., van den Bos, H., Spierings, D. C. J., Wardenaar, R., Bukkuri, A., Engström, N., Baratchart, E., Yang, M., et al. (2024) · Cancer Research Communications · doi:10.1158/2767-9764.crc-23-0396 · Cited by 14 · see citing works
- Authors
- Martínez-Zamudio, R. I., Roux, P.-F., de Freitas, J. A. N. L. F., Robinson, L., Doré, G., Sun, B., Belenki, D., Milanovic, M., Herbig, U., Schmitt, C. A., Gil, J., & Bischof, O.
- Affiliations
- Inserm (FR)
- MRC London Institute of Medical Sciences (GB)
- Max Delbrück Center (DE)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- Rutgers, The State University of New Jersey (US)
- Johannes Kepler University of Linz (AT)
- Corresponding author
- Bischof, Oliver
- ORCID
- Venue
- Nature Cell Biology
- Published
- 2020-06-08
- Volume
- 22
- Issue
- 7
- Pages
- 842-855
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- PMC
- PMC7899185
- OpenAlex
- W3033840227
- Cited by
- 236
- References
- 48
- Citations by year
- 2026: 38 · 2025: 40 · 2024: 39 · 2023: 51 · 2022: 35 · 2021: 26 · 2020: 7
- FWCI
- 18.64
- Type
- journal article
- Language
- en
- Update notices
- correction (2020-09-16)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Funders
- Cancer Research UK (28647)
- Agence Nationale de la Recherche (ANR-19-CE13-0017)
- National Cancer Institute (R01CA136533)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- cellular senescence, AP-1, transcriptional regulatory networks, epigenetic regulation, Ras-induced senescence, transcriptional programs, transcription factor recruitment, time-resolved transcriptomics, senescence therapy
- MeSH terms
- Animals, Chromatin, Female, Fibroblasts, Gene Expression Regulation, Histones, Humans, Mice, Inbred C57BL, Cellular Senescence, Transcription Factor AP-1, Epigenesis, Genetic, Transcriptome
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