Huang, Po-Ssu

The coming of age of de novo protein design

Huang, P.-S., Boyken, S. E., & Baker, D. (2016) · Nature

Protein Structure and DynamicsChemical Synthesis and Analysis

Cited by 1,478

Macromolecular modeling and design in Rosetta: recent methods and frameworks

Leman, J. K., Weitzner, B. D., Lewis, S. M., Adolf-Bryfogle, J., Alam, N., Alford, R. F., Aprahamian, M., Baker, D., Barlow, K. A., Barth, P., et al. (2020) · Nature Methods

Protein Structure and DynamicsComputational Drug Discovery Methods

Cited by 888

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

Jardine, J., Julien, J.-P., Menis, S., Ota, T., Kalyuzhniy, O., McGuire, A., Sok, D., Huang, P.-S., MacPherson, S., Jones, M., et al. (2013) · Science

HIV Research and TreatmentSARS-CoV-2 and COVID-19 Research

Cited by 770

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

Pejchal, R., Doores, K. J., Walker, L. M., Khayat, R., Huang, P.-S., Wang, S.-K., Stanfield, R. L., Julien, J.-P., Ramos, A., Crispin, M., et al. (2011) · Science

HIV Research and TreatmentMonoclonal and Polyclonal Antibodies Research

Cited by 694

Protein structure determination using metagenome sequence data

Ovchinnikov, S., Park, H., Varghese, N., Huang, P.-S., Pavlopoulos, G. A., Kim, D. E., Kamisetty, H., Kyrpides, N. C., & Baker, D. (2017) · Science

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 520

De novo design of a fluorescence-activating β-barrel

Dou, J., Vorobieva, A. A., Sheffler, W., Doyle, L. A., Park, H., Bick, M. J., Mao, B., Foight, G. W., Lee, M. Y., Gagnon, L. A., et al. (2018) · Nature

Protein Structure and DynamicsBiochemical and Structural Characterization

Cited by 351

High thermodynamic stability of parametrically designed helical bundles

Huang, P.-S., Oberdorfer, G., Xu, C., Pei, X. Y., Nannenga, B. L., Rogers, J. M., DiMaio, F., Gonen, T., Luisi, B., & Baker, D. (2014) · Science

Protein Structure and DynamicsChemical Synthesis and Analysis

Cited by 277

Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold

Azoitei, M. L., Correia, B. E., Ban, Y.-E. A., Carrico, C., Kalyuzhniy, O., Chen, L., Schroeter, A., Huang, P.-S., McLellan, J. S., Kwong, P. D., et al. (2011) · Science

Protein Structure and DynamicsBiochemical and Structural Characterization

Cited by 224

Theoretical basis for stabilizing messenger RNA through secondary structure design

Wayment-Steele, H. K., Kim, D. S., Choe, C. A., Nicol, J. J., Wellington-Oguri, R., Watkins, A. M., Sperberg, R. A. P., Huang, P.-S., Participants, E., & Das, R. (2020) · Nucleic Acids Research

RNA and protein synthesis mechanismsRNA Research and Splicing

Cited by 199

Theoretical basis for stabilizing messenger RNA through secondary structure design

Wayment-Steele, H. K., Kim, D. S., Choe, C. A., Nicol, J. J., Wellington-Oguri, R., Watkins, A. M., Parra Sperberg, R. A., Huang, P.-S., Participants, E., & Das, R. (2021) · Nucleic Acids Research

RNA and protein synthesis mechanismsRNA Research and Splicing

Cited by 197

Protein sequence design with a learned potential

Anand, N., Eguchi, R., Mathews, I. I., Perez, C. P., Derry, A., Altman, R. B., & Huang, P.-S. (2022) · Nature Communications

Protein Structure and DynamicsMachine Learning in Bioinformatics

Cited by 171

Ig-VAE: Generative Modeling of Protein Structure by Direct 3D Coordinate Generation

Eguchi, R. R., Choe, C. A., & Huang, P.-S. (2020) · PLoS Computational Biology

Protein Structure and DynamicsComputational Drug Discovery Methods

Cited by 141

Ig-VAE: Generative modeling of protein structure by direct 3D coordinate generation

Eguchi, R. R., Choe, C. A., & Huang, P.-S. (2022) · PLOS Computational Biology

Protein Structure and DynamicsComputational Drug Discovery Methods

Cited by 141

Structure-based protein design with deep learning

Ovchinnikov, S., & Huang, P.-S. (2021) · Current Opinion in Chemical Biology

Protein Structure and DynamicsMachine Learning in Bioinformatics

Cited by 93

Computational design of closely related proteins that adopt two well-defined but structurally divergent folds

Wei, K. Y., Moschidi, D., Bick, M. J., Nerli, S., McShan, A. C., Carter, L. P., Huang, P.-S., Fletcher, D. A., Sgourakis, N. G., Boyken, S. E., et al. (2020) · Proceedings of the National Academy of Sciences

Protein Structure and DynamicsChemical Synthesis and Analysis

Cited by 57