DeGrado, William F.

The α v β 1 integrin plays a critical in vivo role in tissue fibrosis

Reed, N. I., Jo, H., Chen, C., Tsujino, K., Arnold, T. D., DeGrado, W. F., & Sheppard, D. (2015) · Science Translational Medicine

Cell Adhesion Molecules ResearchTGF-β signaling in diseases

Cited by 311

Development of α-Helical Calpain Probes by Mimicking a Natural Protein–Protein Interaction

Jo, H., Meinhardt, N., Wu, Y., Kulkarni, S., Hu, X., Low, K. E., Davies, P. L., DeGrado, W. F., & Greenbaum, D. C. (2012) · Journal of the American Chemical Society

Calpain Protease Function and RegulationChemical Synthesis and Analysis

Cited by 261

Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ

Belsare, K. D., Wu, H., Mondal, D., Bond, A., Castillo, E., Jin, J., Jo, H., Roush, A. E., Pilla, K. B., Sali, A., et al. (2022) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 68

Noncovalent self-assembly of a heterotetrameric diiron protein

Marsh, E. N. G., & DeGrado, W. F. (2002) · Proceedings of the National Academy of Sciences

Metal-Catalyzed Oxygenation MechanismsProtein Structure and Dynamics

Cited by 66

Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer’s disease pathology in Down syndrome

Maxwell, A. M., Yuan, P., Rivera, B. M., Schaaf, W., Mladinov, M., Prasher, V. P., Robinson, A. C., DeGrado, W. F., & Condello, C. (2021) · Acta Neuropathologica Communications

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 23

Computational Design and Experimental Characterization of Peptides Intended for pH-Dependent Membrane Insertion and Pore Formation

Zhang, Y., Bartz, R., Grigoryan, G., Bryant, M., Aaronson, J., Beck, S., Innocent, N., Klein, L., Procopio, W., Tucker, T., et al. (2015) · ACS Chemical Biology

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 23

EMBER multidimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains

Yang, H., Yuan, P., Wu, Y., Shi, M., Caro, C. D., Tengeiji, A., Yamanoi, S., Inoue, M., DeGrado, W. F., & Condello, C. (2023) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsAdvanced Fluorescence Microscopy Techniques

Cited by 19

A Designed Zn 2+ Sensor Domain Transmits Binding Information to Transmembrane Histidine Kinases

Hatstat, A. K., Kormos, R., Xu, V., Du, G., Liu, L., Zhang, S.-Q., & DeGrado, W. F. (2025) · Journal of the American Chemical Society

Protein Structure and DynamicsBiochemical and Structural Characterization

Cited by 1

A designed Zn 2+ sensor domain transmits binding information to transmembrane histidine kinases

Hatstat, A. K., Kormos, R., Xu, V., & DeGrado, W. F. (2024) · Journal of the American Chemical Society

Protein Structure and DynamicsBiochemical and Structural Characterization

Cited by 1