Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes
Abstract
Hyperglycemia causes many of the pathological consequences of both type 1 and type 2 diabetes. Much of this damage is suggested to be a consequence of elevated production of reactive oxygen species by the mitochondrial respiratory chain during hyperglycemia. Mitochondrial radical production associated with hyperglycemia will also disrupt glucose-stimulated insulin secretion by pancreatic beta-cells, because pancreatic beta-cells are particularly susceptible to oxidative damage. Therefore, mitochondrial radical production in response to hyperglycemia contributes to both the progression and pathological complications of diabetes. Consequently, strategies to decrease mitochondrial radical production and oxidative damage may have therapeutic potential. This could be achieved by the use of antioxidants or by decreasing the mitochondrial membrane potential. Here, we outline the background to these strategies and discuss how antioxidants targeted to mitochondria, or selective mitochondrial uncoupling, may be potential therapies for diabetes.
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Mitochondria are a susceptible target of oxidative damage, which causes a malicious circle of events in endothelial cells.
“Additionally, mitochondria are a susceptible target of oxidative damage, which causes a malicious circle of events in ECs [224,225,226].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [225]
Enzymatic means protect against reactive oxygen species in mitochondria, including conversion of superoxide to H2O2 by MnSOD and scavenging of H2O2 by catalase, glutathione peroxidase, or peroxiredoxin III.
“In addition, several enzymatic means may protect against ROS in mitochondria. These include conversion of superoxide to H2O2 by manganese superoxide dismutase (MnSOD) and scavenging of H2O2 by catalase, glutathione peroxidase (GPX), or peroxiredoxin III (117).”
From Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010) · cites this paper as [117]
Mitochondria are considered the major intracellular site of superoxide production.
“Mitochondria are considered the major intracellular site of superoxide production (57, 117, 263).”
From Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010) · cites this paper as [117]
Mitochondria have adaptive mechanisms that defend against oxidative stress.
“Mitochondria have the capacity to invoke adaptive mechanisms that have evolved to defend against oxidative stress (117).”
From Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010) · cites this paper as [117]
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Nuclear and mitochondrial DNA oxidation in Alzheimer's disease
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Respiratory uncoupling by UCP1 and UCP2 and superoxide generation in endothelial cell mitochondria
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Clusterin ameliorates endothelial dysfunction in diabetes by suppressing mitochondrial fragmentation
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- Authors
- Green, K., Brand, M. D., & Murphy, M. P.
- Affiliations
- Medical Research Council (GB)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2004-02-01
- Volume
- 53
- Issue
- suppl_1
- Pages
- S110-S118
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2104865391
- Cited by
- 490
- References
- 56
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 14 · 2023: 19 · 2022: 13 · 2021: 14 · 2020: 16 · 2019: 16 · 2018: 19 · 2017: 22 · 2016: 28 · 2015: 21 · 2014: 26 · 2013: 29 · 2012: 44
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- mitochondrial oxidative damage, hyperglycemia, reactive oxygen species, mitochondrial respiratory chain, glucose-stimulated insulin secretion, pancreatic beta cells, antioxidants, mitochondrial membrane potential, mitochondrial uncoupling, type 1 diabetes, type 2 diabetes, diabetes complications
- MeSH terms
- Animals, Antioxidants, Diabetes Mellitus, Humans, Mitochondria, Oxygen Consumption, Superoxides, Reactive Oxygen Species, Oxidative Stress
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