Brummelkamp, Thijn R.

A genomic and functional inventory of deubiquitinating enzymes.

Nijman, S. M. B., Luna-Vargas, M. P. A., Velds, A., Brummelkamp, T. R., Dirac, A. M. G., Sixma, T. K., & Bernards, R. (2005) · Cell

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 1,854

YAP1 increases organ size and expands undifferentiated progenitor cells

Camargo, F. D., Gokhale, S., Johnnidis, J. B., Fu, D., Bell, G. W., Jaenisch, R., & Brummelkamp, T. R. (2007) · Current Biology

Hippo pathway signaling and YAP/TAZDevelopmental Biology and Gene Regulation

Cited by 1,252

Regulation of progenitor cell proliferation and granulocyte function by microRNA-223

Johnnidis, J. B., Harris, M. H., Wheeler, R. T., Stehling-Sun, S., Lam, M. H., Kirak, O., Brummelkamp, T. R., Fleming, M. D., & Camargo, F. D. (2008) · Nature

MicroRNA in disease regulationHematopoietic Stem Cell Transplantation

Cited by 1,208

Yap1 acts downstream of α-catenin to control epidermal proliferation

Schlegelmilch, K., Mohseni, M., Kirak, O., Pruszak, J., Rodriguez, J. R., Zhou, D., Kreger, B. T., Vasioukhin, V., Avruch, J., Brummelkamp, T. R., et al. (2011) · Cell

Hippo pathway signaling and YAP/TAZHair Growth and Disorders

Cited by 1,036

Gene essentiality and synthetic lethality in haploid human cells

Blomen, V. A., Májek, P., Jae, L. T., Bigenzahn, J. W., Nieuwenhuis, J., Staring, J., Sacco, R., van Diemen, F. R., Olk, N., Stukalov, A., et al. (2015) · Science

Fungal and yeast genetics researchBioinformatics and Genomic Networks

Cited by 857

The cohesin release factor WAPL restricts chromatin loop extension

Haarhuis, J. H. I., van der Weide, R. H., Blomen, V. A., Yáñez-Cuna, J. O., Amendola, M., van Ruiten, M. S., Krijger, P. H. L., Teunissen, H., Medema, R. H., van Steensel, B., et al. (2017) · Cell

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 793

Identification of CMTM6 and CMTM4 as PD-L1 protein regulators

Mezzadra, R., Sun, C., Jae, L. T., Gomez-Eerland, R., de Vries, E., Wu, W., Logtenberg, M. E. W., Slagter, M., Rozeman, E. A., Hofland, I., et al. (2017) · Nature

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 697

Vasohibins encode tubulin detyrosinating activity

Nieuwenhuis, J., Adamopoulos, A., Bleijerveld, O. B., Mazouzi, A., Stickel, E., Celie, P., Altelaar, M., Knipscheer, P., Perrakis, A., Blomen, V. A., et al. (2017) · Science

Microtubule and mitosis dynamicsGenetic and Kidney Cyst Diseases

Cited by 266

PLA2G16 represents a switch between entry and clearance of Picornaviridae

Staring, J., von Castelmur, E., Blomen, V. A., van den Hengel, L. G., Brockmann, M., Baggen, J., Thibaut, H. J., Nieuwenhuis, J., Janssen, H., van Kuppeveld, F. J. M., et al. (2017) · Nature

Viral Infections and Immunology Researchinterferon and immune responses

Cited by 201

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity

Winter, G. E., Radic, B., Mayor-Ruiz, C., Blomen, V. A., Trefzer, C., Kandasamy, R. K., Huber, K. V. M., Gridling, M., Chen, D., Klampfl, T., et al. (2014) · Nature Chemical Biology

Drug Transport and Resistance MechanismsCancer therapeutics and mechanisms

Cited by 175

A CREB3–ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens

Reiling, J. H., Olive, A. J., Sanyal, S., Carette, J. E., Brummelkamp, T. R., Ploegh, H. L., Starnbach, M. N., & Sabatini, D. M. (2013) · Nature Cell Biology

Cellular transport and secretionEndoplasmic Reticulum Stress and Disease

Cited by 169

TBX-3, the Gene Mutated in Ulnar-Mammary Syndrome, Is a Negative Regulator of p19 and Inhibits Senescence

Brummelkamp, T. R., Kortlever, R. M., Lingbeek, M., Trettel, F., MacDonald, M. E., van Lohuizen, M., & Bernards, R. (2002) · Journal of Biological Chemistry

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 154

BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity

Heijink, A. M., Talens, F., Jae, L. T., van Gijn, S. E., Fehrmann, R. S. N., Brummelkamp, T. R., & van Vugt, M. A. T. M. (2019) · Nature Communications

interferon and immune responsesDNA Repair Mechanisms

Cited by 140

Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling

Brockmann, M., Blomen, V. A., Nieuwenhuis, J., Stickel, E., Raaben, M., Bleijerveld, O. B., Altelaar, A. F. M., Jae, L. T., & Brummelkamp, T. R. (2017) · Nature

Gene Regulatory Network AnalysisProtein Kinase Regulation and GTPase Signaling

Cited by 140

New tools for functional mammalian cancer genetics

Brummelkamp, T. R., & Bernards, R. (2003) · Nature Reviews Cancer

Cancer Genomics and DiagnosticsChromatin Remodeling and Cancer

Cited by 114

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

Tsvetkov, P., Mendillo, M. L., Zhao, J., Carette, J. E., Merrill, P. H., Cikes, D., Varadarajan, M., van Diemen, F. R., Penninger, J. M., Goldberg, A. L., et al. (2015) · eLife

Ubiquitin and proteasome pathwaysHeat shock proteins research

Cited by 83

Posttranslational modification of microtubules by the MATCAP detyrosinase

Landskron, L., Bak, J., Adamopoulos, A., Kaplani, K., Moraiti, M., van den Hengel, L. G., Song, J.-Y., Bleijerveld, O. B., Nieuwenhuis, J., Heidebrecht, T., et al. (2022) · Science

Microtubule and mitosis dynamicsGenetic and Kidney Cyst Diseases

Cited by 78

Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism

Loregger, A., Raaben, M., Nieuwenhuis, J., Tan, J. M. E., Jae, L. T., van den Hengel, L. G., Hendrix, S., van den Berg, M., Scheij, S., Song, J.-Y., et al. (2020) · Nature Communications

Cancer, Lipids, and MetabolismCholesterol and Lipid Metabolism

Cited by 51

Condensin II activation by M18BP1

Borsellini, A., Conti, D., Cutts, E., Harris, R. J., Walstein, K., Graziadei, A., Cecatiello, V., Aarts, T. F., Xie, R., Mazouzi, A., et al. (2024) · Molecular Cell

Genomics and Chromatin DynamicsMicrotubule and mitosis dynamics

Cited by 24