Leist, Marcel

Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis

Leist, M., Single, B., Castoldi, A. F., Kühnle, S., & Nicotera, P. (1997) · The Journal of Experimental Medicine

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 1,871

Adverse outcome pathways: opportunities, limitations and open questions

Leist, M., Ghallab, A., Graepel, R., Marchan, R., Hassan, R., Bennekou, S. H., Limonciel, A., Vinken, M., Schildknecht, S., Waldmann, T., et al. (2017) · Archives of Toxicology

Animal testing and alternativesAgricultural safety and regulations

Cited by 394

Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity

Hansson, O., Petersén, Å., Leist, M., Nicotera, P., Castilho, R. F., & Brundin, P. (1999) · Proceedings of the National Academy of Sciences

Genetic Neurodegenerative DiseasesNeuroscience and Neuropharmacology Research

Cited by 228

Oxidative and nitrative alpha‐synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies

Schildknecht, S., Gerding, H. R., Karreman, C., Drescher, M., Lashuel, H. A., Outeiro, T. F., Di Monte, D. A., & Leist, M. (2013) · Journal of Neurochemistry

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 148

A 3-dimensional human embryonic stem cell (hESC)-derived model to detect developmental neurotoxicity of nanoparticles

Hoelting, L., Scheinhardt, B., Bondarenko, O., Schildknecht, S., Kapitza, M., Tanavde, V., Tan, B., Lee, Q. Y., Mecking, S., Leist, M., et al. (2013) · Archives of Toxicology

Pluripotent Stem Cells ResearchAnimal testing and alternatives

Cited by 129

An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition

Members, E. W. E., Terron, A., Bal-Price, A., Paini, A., Monnet-Tschudi, F., Bennekou, S. H., Leist, M., & Schildknecht, S. (2018) · Archives of Toxicology

Parkinson's Disease Mechanisms and TreatmentsPesticide Exposure and Toxicity

Cited by 124

Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes

Fritsche, E., Grandjean, P., Crofton, K. M., Aschner, M., Goldberg, A., Heinonen, T., Hessel, E. V. S., Hogberg, H. T., Bennekou, S. H., Lein, P. J., et al. (2018) · Toxicology and Applied Pharmacology

Animal testing and alternativesImmunotoxicology and immune responses

Cited by 124

Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells

Schildknecht, S., Pöltl, D., Nagel, D. M., Matt, F., Scholz, D., Lotharius, J., Schmieg, N., Salvo-Vargas, A., & Leist, M. (2009) · Toxicology and Applied Pharmacology

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 115

Establishment of an a priori protocol for the implementation and interpretation of an in-vitro testing battery for the assessment of developmental neurotoxicity

Masjosthusmann, S., Blum, J., Bartmann, K., Dolde, X., Holzer, A., Stürzl, L., Keßel, E. H., Förster, N., Dönmez, A., Klose, J., et al. (2020) · EFSA Supporting Publications

Animal testing and alternativesImmunotoxicology and immune responses

Cited by 110

Design Principles of Concentration-Dependent Transcriptome Deviations in Drug-Exposed Differentiating Stem Cells

Waldmann, T., Rempel, E., Balmer, N. V., König, A., Kolde, R., Gaspar, J. A., Henry, M., Hescheler, J., Sachinidis, A., Rahnenführer, J., et al. (2014) · Chemical Research in Toxicology

Pharmacological Effects and Toxicity StudiesCarcinogens and Genotoxicity Assessment

Cited by 106

Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals

Blum, J., Masjosthusmann, S., Bartmann, K., Bendt, F., Dolde, X., Dönmez, A., Förster, N., Holzer, A.-K., Hübenthal, U., Keßel, H. E., et al. (2023) · Chemosphere

Animal testing and alternativesImmunotoxicology and immune responses

Cited by 105

Validation and quality control of replacement alternatives - current status and future challenges

Leist, M., Hasiwa, N., Daneshian, M., & Hartung, T. (2012) · Toxicology Research

Animal testing and alternativesImmunotoxicology and immune responses

Cited by 100

Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility

Pamies, D., Ekert, J., Zurich, M.-G., Frey, O., Werner, S., Piergiovanni, M., Freedman, B. S., Keong Teo, A. K., Erfurth, H., Reyes, D. R., et al. (2024) · Stem Cell Reports

3D Printing in Biomedical ResearchBiomedical Ethics and Regulation

Cited by 88

https://www.altex.org/index.php/altex/article/view/1339

Krebs, A., Waldmann, T., Wilks, M. F., van Vugt-Lussenburg, B. M. A., van der Burg, B., Terron, A., Steger-Hartmann, T., Ruegg, J., Rovida, C., Pedersen, E., et al. (2019) · ALTEX

Animal testing and alternativesAgricultural safety and regulations

Cited by 77

Highlight report: Launch of a large integrated European in vitro toxicology project: EU-ToxRisk

Daneshian, M., Kamp, H., Hengstler, J., Leist, M., & van de Water, B. (2016) · Archives of Toxicology

Animal testing and alternativesImmunotoxicology and immune responses

Cited by 65

Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery

Klose, J., Pahl, M., Bartmann, K., Bendt, F., Blum, J., Dolde, X., Förster, N., Holzer, A.-K., Hübenthal, U., Keßel, H. E., et al. (2022) · Cell Biology and Toxicology

Toxic Organic Pollutants ImpactFlame retardant materials and properties

Cited by 58

New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project

Tal, T., Myhre, O., Fritsche, E., Rüegg, J., Craenen, K., Aiello-Holden, K., Agrillo, C., Babin, P. J., Escher, B. I., Dirven, H., et al. (2024) · Frontiers in Toxicology

Animal testing and alternativesImmunotoxicology and immune responses

Cited by 58

The NOX1/4 Inhibitor GKT136901 as Selective and Direct Scavenger of Peroxynitrite

Schildknecht, S., Weber, A., Gerding, H., Pape, R., Robotta, M., Drescher, M., Marquardt, A., Daiber, A., Ferger, B., & Leist, M. (2013) · Current Medicinal Chemistry

Redox biology and oxidative stressNitric Oxide and Endothelin Effects

Cited by 55

Major Histocompatibility Complex class I proteins are critical for maintaining neuronal structural complexity in the aging brain

Lazarczyk, M. J., Kemmler, J. E., Eyford, B. A., Short, J. A., Varghese, M., Sowa, A., Dickstein, D. R., Yuk, F. J., Puri, R., Biron, K. E., et al. (2016) · Scientific Reports

Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 55

Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift

Gutbier, S., May, P., Berthelot, S., Krishna, A., Trefzer, T., Behbehani, M., Efremova, L., Delp, J., Gstraunthaler, G., Waldmann, T., et al. (2018) · Archives of Toxicology

Carcinogens and Genotoxicity AssessmentParkinson's Disease Mechanisms and Treatments

Cited by 49

Uncoupling of ATP-depletion and cell death in human dopaminergic neurons

Pöltl, D., Schildknecht, S., Karreman, C., & Leist, M. (2012) · NeuroToxicology

Parkinson's Disease Mechanisms and TreatmentsMitochondrial Function and Pathology

Cited by 49

Revolutionizing developmental neurotoxicity testing - a journey from animal models to advanced in vitro systems

Smirnova, L., Högberg, H. T., Leist, M., & Härtung, T. (2024) · ALTEX

Animal testing and alternativesImmunotoxicology and immune responses

Cited by 28