Szostak, Jack W.

Chemoselective Multicomponent One-Pot Assembly of Purine Precursors in Water

Powner, M. W., Sutherland, J. D., & Szostak, J. W. (2010) · Journal of the American Chemical Society

Origins and Evolution of LifeMulticomponent Synthesis of Heterocycles

Cited by 150

Semipermeable lipid bilayers exhibit diastereoselectivity favoring ribose

Sacerdote, M. G., & Szostak, J. W. (2005) · Proceedings of the National Academy of Sciences

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 147

Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides

Prywes, N., Blain, J. C., Del Frate, F., & Szostak, J. W. (2016) · eLife

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 141

Nonenzymatic, template-directed ligation of oligoribonucleotides is highly regioselective for the formation of 3′-5′ phosphodiester bonds

Rohatgi, R., Bartel, D. P., & Szostak, J. W. (1996) · Journal of the American Chemical Society

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 134

An optimal degree of physical and chemical heterogeneity for the origin of life?

Szostak, J. W. (2011) · Philosophical Transactions of the Royal Society B: Biological Sciences

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 133

Formation of Protocell-like Vesicles in a Thermal Diffusion Column

Budin, I., Bruckner, R. J., & Szostak, J. W. (2009) · Journal of the American Chemical Society

Origins and Evolution of LifeLipid Membrane Structure and Behavior

Cited by 132

Aptamers selected for higher-affinity binding are not more specific for the target ligand

Carothers, J. M., Oestreich, S. C., & Szostak, J. W. (2006) · Journal of the American Chemical Society

RNA and protein synthesis mechanismsAdvanced biosensing and bioanalysis techniques

Cited by 132

Rapid RNA Exchange in Aqueous Two-Phase System and Coacervate Droplets

Jia, T. Z., Hentrich, C., & Szostak, J. W. (2014) · Origins of Life and Evolution of Biospheres

Origins and Evolution of LifeChemical and Physical Properties in Aqueous Solutions

Cited by 125

Confronting risks of mirror life

Adamala, K. P., Agashe, D., Belkaid, Y., Bittencourt, D. M. D. C., Cai, Y., Chang, M. W., Chen, I. A., Church, G. M., Cooper, V. S., Davis, M. M., et al. (2024) · Science

Space Science and Extraterrestrial LifeOrigins and Evolution of Life

Cited by 125

Photochemically driven redox chemistry induces protocell membrane pearling and division

Zhu, T. F., Adamala, K., Zhang, N., & Szostak, J. W. (2012) · Proceedings of the National Academy of Sciences

Origins and Evolution of LifeEvolution and Genetic Dynamics

Cited by 121

Effect of Stalling after Mismatches on the Error Catastrophe in Nonenzymatic Nucleic Acid Replication

Rajamani, S., Ichida, J. K., Antal, T., Treco, D. A., Leu, K., Nowak, M. A., Szostak, J. W., & Chen, I. A. (2010) · Journal of the American Chemical Society

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 118

A multisubunit ribozyme that is a catalyst of and template for complementary strand RNA synthesis

Doudna, J. A., Couture, S., & Szostak, J. W. (1991) · Science

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 117

Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides

Stairs, S., Nikmal, A., Bučar, D.-K., Zheng, S.-L., Szostak, J. W., & Powner, M. W. (2017) · Nature Communications

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 113

Functional RNAs exhibit tolerance for non-heritable 2’-5’ versus 3’-5’ backbone heterogeneity

Engelhart, A. E., Powner, M. W., & Szostak, J. W. (2013) · Nature Chemistry

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 107

Efficient and Rapid Template-Directed Nucleic Acid Copying Using 2′-Amino-2′,3′-dideoxyribonucleoside−5′-Phosphorimidazolide Monomers

Schrum, J. P., Ricardo, A., Krishnamurthy, M., Blain, J. C., & Szostak, J. W. (2009) · Journal of the American Chemical Society

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 103

An in Vitro Selection System for TNA

Ichida, J. K., Zou, K., Horhota, A., Yu, B., McLaughlin, L. W., & Szostak, J. W. (2005) · Journal of the American Chemical Society

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 103

A Highly Reactive Imidazolium-Bridged Dinucleotide Intermediate in Nonenzymatic RNA Primer Extension

Walton, T., & Szostak, J. W. (2016) · Journal of the American Chemical Society

Origins and Evolution of LifePhysical Organic Chemistry and Reaction Kinetics

Cited by 102

Common and Potentially Prebiotic Origin for Precursors of Nucleotide Synthesis and Activation

Fahrenbach, A. C., Giurgiu, C., Tam, C. P., Li, L., Hongo, Y., Aono, M., & Szostak, J. W. (2017) · Journal of the American Chemical Society

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 96

Copying of Mixed-Sequence RNA Templates inside Model Protocells

O’Flaherty, D. K., Kamat, N. P., Mirza, F. N., Li, L., Prywes, N., & Szostak, J. W. (2018) · Journal of the American Chemical Society

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 90

Chain-length heterogeneity allows for the assembly of fatty acid vesicles in dilute solutions

Budin, I., Prywes, N., Zhang, N., & Szostak, J. W. (2014) · Biophysical Journal

Origins and Evolution of LifeLipid Membrane Structure and Behavior

Cited by 88

The Mechanism of Nonenzymatic Template Copying with Imidazole‐Activated Nucleotides

Walton, T., Zhang, W., Li, L., Tam, C. P., & Szostak, J. W. (2019) · Angewandte Chemie International Edition

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 83

Fast and accurate nonenzymatic copying of an RNA-like synthetic genetic polymer

Zhang, S., Blain, J. C., Zielinska, D., Gryaznov, S. M., & Szostak, J. W. (2013) · Proceedings of the National Academy of Sciences

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 80

Replacing Uridine with 2-Thiouridine Enhances the Rate and Fidelity of Nonenzymatic RNA Primer Extension

Heuberger, B. D., Pal, A., Del Frate, F., Topkar, V. V., & Szostak, J. W. (2015) · Journal of the American Chemical Society

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 78

Solution structure of an informationally complex high-affinity RNA aptamer to GTP

CAROTHERS, J. M., DAVIS, J. H., CHOU, J. J., & SZOSTAK, J. W. (2006) · RNA

RNA and protein synthesis mechanismsDNA and Nucleic Acid Chemistry

Cited by 78