Szostak, Jack W.

Origin of Life on Earth

Ricardo, A., & Szostak, J. W. (2009) · Scientific American

Origins and Evolution of LifePaleontology and Stratigraphy of Fossils

Cited by 72

Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity

Trevino, S. G., Zhang, N., Elenko, M. P., Lupták, A., & Szostak, J. W. (2011) · Proceedings of the National Academy of Sciences

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 59

A Kinetic Model of Nonenzymatic RNA Polymerization by Cytidine-5′-phosphoro-2-aminoimidazolide

Walton, T., & Szostak, J. W. (2017) · Biochemistry

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 55

The Emergence of RNA from the Heterogeneous Products of Prebiotic Nucleotide Synthesis

Kim, S. C., O’Flaherty, D. K., Giurgiu, C., Zhou, L., & Szostak, J. W. (2021) · Journal of the American Chemical Society

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 55

Freeze-thaw cycles enable a prebiotically plausible and continuous pathway from nucleotide activation to nonenzymatic RNA copying

Zhang, S. J., Duzdevich, D., Ding, D., & Szostak, J. W. (2022) · Proceedings of the National Academy of Sciences

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 54

Activated Ribonucleotides Undergo a Sugar Pucker Switch upon Binding to a Single-Stranded RNA Template

Zhang, N., Zhang, S., & Szostak, J. W. (2012) · Journal of the American Chemical Society

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 53

Ribozyme-catalyzed primer extension by trinucleotides: a model for the RNA-catalyzed replication of RNA

Doudna, J. A., Usman, N., & Szostak, J. W. (1993) · Biochemistry

RNA and protein synthesis mechanismsOrigins and Evolution of Life

Cited by 51

Synthesis of N3’-P5’-linked phosphoramidate DNA by nonenzymatic template-directed primer extension

Zhang, S., Zhang, N., Blain, J. C., & Szostak, J. W. (2013) · Journal of the American Chemical Society

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 50

Structural insights into the effects of 2’-5’ linkages on the RNA duplex

Sheng, J., Li, L., Engelhart, A. E., Gan, J., Wang, J., & Szostak, J. W. (2014) · Proceedings of the National Academy of Sciences

RNA and protein synthesis mechanismsOrigins and Evolution of Life

Cited by 50

Enzymatic Primer-Extension with Glycerol-Nucleoside Triphosphates on DNA Templates

Chen, J. J., Tsai, C.-H., Cai, X., Horhota, A. T., McLaughlin, L. W., & Szostak, J. W. (2009) · PLoS ONE

DNA and Nucleic Acid ChemistryRNA and protein synthesis mechanisms

Cited by 29

Cyclophospholipids Enable a Protocellular Life Cycle

Toparlak, Ö. D., Sebastianelli, L., Egas Ortuno, V., Karki, M., Xing, Y., Szostak, J. W., Krishnamurthy, R., & Mansy, S. S. (2023) · ACS Nano

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 26

Overcoming nucleotide bias in the nonenzymatic copying of RNA templates

Duzdevich, D., Carr, C. E., Colville, B. W. F., Aitken, H. R. M., & Szostak, J. W. (2024) · Nucleic Acids Research

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 10