Lichtarge, Olivier

Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma

Ally, A., Balasundaram, M., Carlsen, R., Chuah, E., Clarke, A., Dhalla, N., Holt, R. A., Jones, S. J. M., Lee, D., Ma, Y., et al. (2017) · Cell

Cancer Genomics and DiagnosticsHepatocellular Carcinoma Treatment and Prognosis

Cited by 2,490

A large-scale evaluation of computational protein function prediction

Radivojac, P., Clark, W. T., Oron, T. R., Schnoes, A. M., Wittkop, T., Sokolov, A., Graim, K., Funk, C., Verspoor, K., Ben-Hur, A., et al. (2013) · Nature Methods

Bioinformatics and Genomic NetworksMachine Learning in Bioinformatics

Cited by 1,028

Identification of a candidate therapeutic autophagy-inducing peptide

Shoji-Kawata, S., Sumpter, R., Leveno, M., Campbell, G. R., Zou, Z., Kinch, L., Wilkins, A. D., Sun, Q., Pallauf, K., MacDuff, D., et al. (2013) · Nature

Autophagy in Disease and TherapyRNA Interference and Gene Delivery

Cited by 760

The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens

Zhou, N., Jiang, Y., Bergquist, T. R., Lee, A. J., Kacsoh, B. Z., Crocker, A. W., Lewis, K. A., Georghiou, G., Nguyen, H. N., Hamid, M. N., et al. (2019) · Genome Biology

Bioinformatics and Genomic NetworksGenomics and Phylogenetic Studies

Cited by 452

An AT-hook domain in MeCP2 determines the clinical course of Rett syndrome and related disorders

Baker, S. A., Chen, L., Wilkins, A. D., Yu, P., Lichtarge, O., & Zoghbi, H. Y. (2013) · Cell

Genetics and Neurodevelopmental DisordersGenomics and Rare Diseases

Cited by 225

Identity and function of a large gene network underlying mutagenic repair of DNA breaks

Al Mamun, A. A. M., Lombardo, M.-J., Shee, C., Lisewski, A. M., Gonzalez, C., Lin, D., Nehring, R. B., Saint-Ruf, C., Gibson, J. L., Frisch, R. L., et al. (2012) · Science

Bacterial Genetics and BiotechnologyDNA Repair Mechanisms

Cited by 224

Integrated analysis of TP53 gene and pathway alterations in the cancer genome atlas

Donehower, L. A., Soussi, T., Korkut, A., Liu, Y., Schultz, A., Cardenas, M., Li, X., Babur, O., Hsu, T.-K., Lichtarge, O., et al. (2019) · Cell Reports

Cancer-related Molecular PathwaysCancer Genomics and Diagnostics

Cited by 150

A formal perturbation equation between genotype and phenotype determines the evolutionary action of protein-coding variations on fitness

Katsonis, P., & Lichtarge, O. (2014) · Genome Research

Evolution and Genetic DynamicsGenomics and Rare Diseases

Cited by 137

Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor

Peterson, S. M., Pack, T. F., Wilkins, A. D., Urs, N. M., Urban, D. J., Bass, C. E., Lichtarge, O., & Caron, M. G. (2015) · Proceedings of the National Academy of Sciences

Receptor Mechanisms and SignalingNeurotransmitter Receptor Influence on Behavior

Cited by 91

Type 2 diabetes–associated variants of the MT 2 melatonin receptor affect distinct modes of signaling

Karamitri, A., Plouffe, B., Bonnefond, A., Chen, M., Gallion, J., Guillaume, J.-L., Hegron, A., Boissel, M., Canouil, M., Langenberg, C., et al. (2018) · Science Signaling

Circadian rhythm and melatoninReceptor Mechanisms and Signaling

Cited by 62

Human GLP1R variants affecting GLP1R cell surface expression are associated with impaired glucose control and increased adiposity

Gao, W., Liu, L., Huh, E., Gbahou, F., Cecon, E., Oshima, M., Houzé, L., Katsonis, P., Hegron, A., Fan, Z., et al. (2023) · Nature Metabolism

Diabetes Treatment and ManagementPancreatic function and diabetes

Cited by 56

Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome

Bocchini, C. E., Nahmod, K., Katsonis, P., Kim, S., Kasembeli, M. M., Freeman, A., Lichtarge, O., Makedonas, G., & Tweardy, D. J. (2016) · Blood

Immunodeficiency and Autoimmune DisordersCytokine Signaling Pathways and Interactions

Cited by 36