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Patel, N., Huang, X., Grandner, J. M., Johansson, L. C., Stauch, B., McCorvy, J. D., Liu, Y., Roth, B. L., & Katritch, V. (2020) · eLife · doi:10.7554/elife.53779 · Cited by 48 · see citing works

Illuminating the complexity of GPCR pathway selectivity – advances in biosensor development

Wright, S. C., & Bouvier, M. (2021) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2021.04.006 · Cited by 43 · see citing works

Removing melatonin receptor type 1 signaling leads to selective leptin resistance in the arcuate nucleus

Buonfiglio, D. D. C., Tchio, C. I. M., Furigo, I. C., Donato, J., Baba, K., Cipolla‐Neto, J., & Tosini, G. (2019) · Journal of Pineal Research · doi:10.1111/jpi.12580 · Cited by 43 · see citing works

Conformation- and activation-based BRET sensors differentially report on GPCR–G protein coupling

Wright, S. C., Avet, C., Gaitonde, S. A., Arrate, I. M., Gouill, C. L., Hogue, M., Breton, B., Koutsilieri, S., Dı́ez-Alarcia, R., Héroux, M., et al. (2024) · Science Signaling · doi:10.1126/scisignal.adi4747 · Cited by 29 · see citing works

Pharmacological evidence for transactivation within melatonin MT 2 and serotonin 5‐HT 2C receptor heteromers in mouse brain

Gerbier, R., Ndiaye‐Lobry, D., de Morentin, P. B. M., Cecon, E., Heisler, L. K., Delagrange, P., Gbahou, F., & Jockers, R. (2020) · The FASEB Journal · doi:10.1096/fj.202000305r · Cited by 29 · see citing works

Anti-Inflammatory Effects of Melatonin in Rats with Induced Type 2 Diabetes Mellitus

Yapışlar, H., Hacıosmanoğlu, E., Sarıoğlu, T., Değirmencioğlu, S., Söğüt, İ., Poteser, M., & Ekmekçioğlu, C. (2022) · Life · doi:10.3390/life12040574 · Cited by 29 · see citing works

Mitochondria-targeted melatonin photorelease supports the presence of melatonin MT1 receptors in mitochondria inhibiting respiration

Somalo-Barranco, G., Zottola, A. C. P., Abdulrahman, A. O., Zein, R. M. E., Cannich, A., Muñoz, L., Serra, C., Oishi, A., Marsicano, G., Masri, B., et al. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2023.07.009 · Cited by 22 · see citing works

Melatonin Potentiates the Therapeutic Effects of Metformin in Women with Metabolic Syndrome

Abood, S. J., Abdulsahib, W. K., Hussain, S. A., & Ismail, S. H. (2020) · Scientia Pharmaceutica · doi:10.3390/scipharm88020028 · Cited by 22 · see citing works

Melatonergic systems of AANAT, melatonin, and its receptor MT2 in the corpus luteum are essential for reproductive success in mammals†

Wang, J., Zhu, T., Ma, X., Wang, Y., Liu, J., Li, G., Liu, Y., Ji, P., Zhang, Z., Zhang, L., et al. (2020) · Biology of Reproduction · doi:10.1093/biolre/ioaa190 · Cited by 21 · see citing works

Journal of pineal research guideline for authors: Defining and characterizing melatonin targets

Cecon, E., Legros, C., Boutin, J. A., & Jockers, R. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12712 · Cited by 17 · see citing works

Human physiology of genetic defects causing beta-cell dysfunction.

Kettunen, J., & Tuomi, T. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.12.038 · Cited by 17 · see citing works

MT2 melatonin receptors expressed in the olfactory bulb modulate depressive-like behavior and olfaction in the 6-OHDA model of Parkinson's disease

Noseda, A. C. D., Rodrigues, L. S., Targa, A., Ilkiw, J. L., Fagotti, J., dos Santos, P. D., Cecon, E., Markus, R. P., Solimena, M., Jockers, R., et al. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173722 · Cited by 16 · see citing works

The Role of Melatonin in Chronic Kidney Disease and Its Associated Risk Factors: A New Tool in Our Arsenal?

Theofilis, P., Vordoni, A., & Kalaitzidis, R. (2022) · American Journal of Nephrology · doi:10.1159/000525441 · Cited by 15 · see citing works

Melatonin protects against oxybenzone-induced deterioration of mouse oocytes during maturation

Jin, L. G., Zhu, H., Kang, X., Lin, L., Zhang, P.-Y., Tan, T., Yu, Y., & Fan, Y. (2020) · Aging · doi:10.18632/aging.202323 · Cited by 15 · see citing works

Functional genetics reveals the contribution of delta opioid receptor to type 2 diabetes and beta-cell function

Meulebrouck, S., Merrheim, J., Quéniat, G., Bourouh, C., Derhourhi, M., Boissel, M., Yi, X., Badreddine, A., Boutry, R., Leloire, A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51004-6 · Cited by 15 · see citing works

Melatonin and its Relationships with Diabetes and Obesity: A Literature Review

Ramirez, A. V. G., Filho, D. R., & de Sá, L. B. P. C. (2020) · Current Diabetes Reviews · doi:10.2174/1573399816666200727102357 · Cited by 13 · see citing works

Molecular Characterization and Pharmacology of Melatonin Receptors in Animals

Cecon, E., Boutin, J. A., & Jockers, R. (2023) · Receptors · doi:10.3390/receptors2020008 · Cited by 12 · see citing works

Circadian, Sleep and Caloric Intake Phenotyping in Type 2 Diabetes Patients With Rare Melatonin Receptor 2 Mutations and Controls: A Pilot Study

Imam, A., Winnebeck, E. C., Buchholz, N., Froguel, P., Bonnefond, A., Solimena, M., Ivanova, A., Bouvier, M., Plouffe, B., Charpentier, G., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.564140 · Cited by 12 · see citing works

Investigating G-protein coupled receptor signalling with light-emitting biosensors

Demby, A., & Zaccolo, M. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2023.1310197 · Cited by 11 · see citing works

Modeling the Heterodimer Interfaces of Melatonin Receptors

Tse, L. H., & Wong, Y. H. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.725296 · Cited by 11 · see citing works

Monoamines' role in islet cell function and type 2 diabetes risk

Roberts, F. L., Cataldo, L. R., & Fex, M. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.08.009 · Cited by 11 · see citing works

Identification of Key Regions Mediating Human Melatonin Type 1 Receptor Functional Selectivity Revealed by Natural Variants

Hégron, A., Huh, E., Deupí, X., Sokrat, B., Gao, W., Gouill, C. L., Canouil, M., Boissel, M., Charpentier, G., Roussel, R., et al. (2021) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.1c00157 · Cited by 11 · see citing works

Biased signaling in drug discovery and precision medicine

Ji, R., & Tao, Y. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108804 · Cited by 9 · see citing works

Ackr3-Venus knock-in mouse lights up brain vasculature

Ehrlich, A. T., Semache, M., Couvineau, P., Wojcik, S., Kobayashi, H., Thelen, M., Gross, F., Hogue, M., Gouill, C. L., Darcq, E., et al. (2021) · Molecular Brain · doi:10.1186/s13041-021-00862-y · Cited by 9 · see citing works

Functional Investigation of Melatonin Receptor Activation by Homogenous cAMP Assay

Cecon, E., Guillaume, J., & Jockers, R. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2593-4_22 · Cited by 8 · see citing works

Pistacia vera Extract Potentiates the Effect of Melatonin on Human Melatonin MT1 and MT2 Receptors with Functional Selectivity

Labani, N., Gbahou, F., Noblet, M., Masri, B., Broussaud, O., Liu, J., & Jockers, R. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15071845 · Cited by 7 · see citing works

Pharmacology of Melatonin and Its Receptors

Singh, S., Rana, A., Kaur, S., Singh, J., Rahi, V., Choudhury, H., & Kumar, P. (2020) · Springer eBooks · doi:10.1007/978-981-15-3556-7_9 · Cited by 6 · see citing works

Pharmacogenomics of GPCR genes in type 2 diabetes and obesity

Gao, W., & Jockers, R. (2020) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2020.11.008 · Cited by 6 · see citing works

Association between MTNR1B polymorphisms and obesity in African American: findings from the Jackson Heart Study

Tchio, C. I. M., Musani, S. K., Quarshie, A., & Tosini, G. (2021) · BMC Medical Genomics · doi:10.1186/s12920-021-00983-2 · Cited by 6 · see citing works

G Protein-Coupled Receptors and the Rise of Type 2 Diabetes in Children

Dallatana, A., Cremonesi, L., Trombetta, M., Fracasso, G., Nocini, R., Giacomello, L., & Innamorati, G. (2023) · Biomedicines · doi:10.3390/biomedicines11061576 · Cited by 6 · see citing works

CRISPR/Cas9 mediated mutation of the mtnr1a melatonin receptor gene causes rod photoreceptor degeneration in developing Xenopus tropicalis

Wiechmann, A. F., Martin, T., & Horb, M. E. (2020) · Scientific Reports · doi:10.1038/s41598-020-70735-2 · Cited by 5 · see citing works

Structural Elements Directing G Proteins and β-Arrestin Interactions with the Human Melatonin Type 2 Receptor Revealed by Natural Variants

Plouffe, B., Karamitri, A., Flock, T., Gallion, J. M., Houston, S., Daly, C. A., Bonnefond, A., Guillaume, J., Gouill, C. L., Froguel, P., et al. (2022) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.1c00239 · Cited by 4 · see citing works

High-Throughput GPCRome Screen of Pollutants Reveals the Activity of Polychlorinated Biphenyls at Melatonin and Sphingosine-1-phosphate Receptors

Wilkinson, J. C., Lehmler, H., & Roman, D. L. (2024) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.3c00388 · Cited by 4 · see citing works

Analyse approfondie du lien entre le récepteur MT2 de la mélatonine et le diabète de type 2

Hégron, A., & Jockers, R. (2019) · médecine/sciences · doi:10.1051/medsci/2019088 · Cited by 3 · see citing works

Melatonin and glucose metabolism.

Watanabe, K., Katagiri, S., & Hattori, A. (2020) · doi:10.24659/gsr.7.1_105 · Cited by 3 · see citing works

Disruption of Melatonin Signaling Leads to Lipids Accumulation in the Liver of Melatonin Proficient Mice

Goyal, V., & Tosini, G. (2024) · Journal of Pineal Research · doi:10.1111/jpi.70007 · Cited by 1 · see citing works

G Protein-Coupled Receptors in Pancreatic β-Cells: From Trafficking and Localization to Insulin Secretion and Diabetes

Tecucianu, R., Tunaru, S., & Petrescu, S. M. (2026) · Diabetology · doi:10.3390/diabetology7040068 · Cited by 1 · see citing works

A systematic analysis of prostaglandin E2 type 3 receptor isoform signaling reveals isoform- and species-dependent L798106 Gαz-biased agonist responses

Normand, C., Breton, B., Salze, M., Barbeau, E., Mancini, A. D., & Audet, M. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175043 · Cited by 1 · see citing works

Nutrition, Epigenetics, and Circadian Rhythms

Cai, D., Liu, H., Li, K., & Zhu, Y. (2024) · Epigenetics and human health · doi:10.1007/978-3-031-54215-2_8 · Cited by 1 · see citing works

Impact of Melatonin on Brain Metabolism in Diabetes: A Narrative Review

Nwaji, A. R., Bisong, S. A., Antai, A. B., Okakpu, C. M., Okechukwu, M. P., Igwe, E. O., Okafor, C., Odoh, P. C., Chukwu, M. C., Esinulo, J. I., et al. (2025) · Natural Product Communications · doi:10.1177/1934578x251340772 · Cited by 2 · see citing works

Faculty Opinions recommendation of Biased signaling of the mu opioid receptor revealed in native neurons.

Bockaert, J. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735418905.793559380

Rare MTNR1B variants causing diminished MT2 signalling associate with elevated HbA1c levels but not with type 2 diabetes

Sørensen, K. V., Justesen, J. M., Ängquist, L. H., Bork‐Jensen, J., Hartmann, B., Jørgensen, N. R., Rungby, J., Sørensen, H. T., Vaag, A. A., Nielsen, J. S., et al. (2025) · Diabetologia · doi:10.1007/s00125-025-06381-y

Agomelatine and the potential inverse risk of metabolic disorders: a nationwide cohort study with an active comparator design in Taiwan

Wen, Y.-L., Huang, Y.-C., Liao, C.-C., Kao, S., Pan, K., Yang, H.-W., To, S.-Y., Yeh, C. B., & Kao, L. (2026) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-026-02130-2

Functional profiling of rare GLP-1R variants, an important drug target gene of type 2 diabetes

Gao, W. (2020) · doi:10.70675/3449077ezf725z4fa5zb9afz571bb5a987fa

Identification of Melatonin-like activities in plant extracts

Labani, N. (2021) · theses.fr (ABES) · doi:10.70675/495441a7z7c22z4734za4fdzc81458e209ef

Functional assessment of MT2 melatonin receptor variants that are associated with type 2 diabetes

Wu, Y., Chan, K. H., & Wong, Y. H. (2016)

Identification of key regions mediating human melatonin type 1 receptor biased signaling revealed by natural variants

Hégron, A., Plouffe, B., Bonnefond, A., Gao, W., Froguel, P., Gouill, C. L., Jockers, R., & Bouvier, M. (2018) · The FASEB Journal · doi:10.1096/fasebj.2018.32.1_supplement.555.10

Molecular Mechanisms of the Melatonin Receptor Pathway Linking Circadian Rhythm to Type 2 Diabetes Mellitus

Xia, A., Zhu, H., Zhao, Z., Liu, H., Wang, P.-H., Ji, L., & Xu, J. (2023) · Nutrients · doi:10.3390/nu15061406 · Cited by 28 · see citing works

Melatonin receptors in diabetes: A potential new therapeutical target?

She, M., Laudon, M., & Yin, W. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.08.012 · Cited by 65 · see citing works

New evidence for a role of melatonin in glucose regulation

Peschke, E., & Mühlbauer, E. (2010) · Best Practice &amp; Research Clinical Endocrinology &amp; Metabolism · doi:10.1016/j.beem.2010.09.001 · Cited by 137 · see citing works