Ruggero, Davide

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

Gordon, D. E., Jang, G. M., Bouhaddou, M., Xu, J., Obernier, K., White, K. M., O’Meara, M. J., Rezelj, V. V., Guo, J. Z., Swaney, D. L., et al. (2020) · Nature

SARS-CoV-2 and COVID-19 ResearchComputational Drug Discovery Methods

Cited by 4,405

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

Kaplan, R. N., Riba, R. D., Zacharoulis, S., Bramley, A. H., Vincent, L., Costa, C., MacDonald, D. D., Jin, D. K., Shido, K., Kerns, S. A., et al. (2005) · Nature

Angiogenesis and VEGF in CancerCancer Cells and Metastasis

Cited by 3,288

The translational landscape of mTOR signalling steers cancer initiation and metastasis

Hsieh, A. C., Liu, Y., Edlind, M. P., Ingolia, N. T., Janes, M. R., Sher, A., Shi, E. Y., Stumpf, C. R., Christensen, C., Bonham, M. J., et al. (2012) · Nature

PI3K/AKT/mTOR signaling in cancerRNA and protein synthesis mechanisms

Cited by 1,313

Autism-related deficits via dysregulated eIF4E-dependent translational control

Gkogkas, C. G., Khoutorsky, A., Ran, I., Rampakakis, E., Nevarko, T., Weatherill, D. B., Vasuta, C., Yee, S., Truitt, M., Dallaire, P., et al. (2013) · Nature

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 522

New frontiers in translational control of the cancer genome

Truitt, M. L., & Ruggero, D. (2016) · Nature Reviews Cancer

RNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 378

Targeting the eIF4F Translation Initiation Complex: A Critical Nexus for Cancer Development

Pelletier, J., Graff, J., Ruggero, D., & Sonenberg, N. (2015) · Cancer Research

RNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 367

Translation control of the immune checkpoint in cancer and its therapeutic targeting

Xu, Y., Poggio, M., Jin, H. Y., Shi, Z., Forester, C. M., Wang, Y., Stumpf, C. R., Xue, L., Devericks, E., So, L., et al. (2019) · Nature Medicine

Cancer Immunotherapy and BiomarkersRNA and protein synthesis mechanisms

Cited by 261

Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer

Cunningham, J. T., Moreno, M. V., Lodi, A., Ronen, S. M., & Ruggero, D. (2014) · Cell

Biochemical and Molecular ResearchRNA and protein synthesis mechanisms

Cited by 260

Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase

Gwinn, D. M., Lee, A. G., Briones-Martin-del-Campo, M., Conn, C. S., Simpson, D. R., Scott, A. I., Le, A., Cowan, T. M., Ruggero, D., & Sweet-Cordero, E. A. (2018) · Cancer Cell

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 230

The Role of Myc-Induced Protein Synthesis in Cancer

Ruggero, D. (2009) · Cancer Research

RNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 186

The Role of Translation Control in Tumorigenesis and Its Therapeutic Implications

Xu, Y., & Ruggero, D. (2020) · Annual Review of Cancer Biology

RNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 67

Small-molecule RNA therapeutics to target prostate cancer

Kuzuoglu-Ozturk, D., Nguyen, H. G., Xue, L., Figueredo, E., Subramanyam, V., Liu, I., Bonitto, K., Noronha, A., Dabrowska, A., Cowan, J. E., et al. (2025) · Cancer Cell

Prostate Cancer Treatment and ResearchRNA and protein synthesis mechanisms

Cited by 24