Giera, Martin

Identification of bioactive metabolites using activity metabolomics

Rinschen, M. M., Ivanisevic, J., Giera, M., & Siuzdak, G. (2019) · Nature Reviews Molecular Cell Biology

Metabolomics and Mass Spectrometry StudiesBioinformatics and Genomic Networks

Cited by 1,008

Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit

Li, Z., Yi, C.-X., Katiraei, S., Kooijman, S., Zhou, E., Chung, C. K., Gao, Y., van den Heuvel, J. K., Meijer, O. C., Berbée, J. F. P., et al. (2018) · Gut

Regulation of Appetite and ObesityGut microbiota and health

Cited by 674

Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease

Giacomelli, E., Meraviglia, V., Campostrini, G., Cochrane, A., Cao, X., van Helden, R. W. J., Krotenberg Garcia, A., Mircea, M., Kostidis, S., Davis, R. P., et al. (2020) · Cell Stem Cell

Pluripotent Stem Cells ResearchCardiac electrophysiology and arrhythmias

Cited by 622

Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition

Colombo, A. V., Sadler, R. K., Llovera, G., Singh, V., Roth, S., Heindl, S., Sebastian Monasor, L., Verhoeven, A., Peters, F., Parhizkar, S., et al. (2021) · eLife

Alzheimer's disease research and treatmentsGut microbiota and health

Cited by 354

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

van der Kant, R., Langness, V. F., Herrera, C. M., Williams, D. A., Fong, L. K., Leestemaker, Y., Steenvoorden, E., Rynearson, K. D., Brouwers, J. F., Helms, J. B., et al. (2019) · Cell Stem Cell

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 350

Macrophage-mediated myelin recycling fuels brain cancer malignancy

Kloosterman, D. J., Erbani, J., Boon, M., Farber, M., Handgraaf, S. M., Ando-Kuri, M., Sánchez-López, E., Fontein, B., Mertz, M., Nieuwland, M., et al. (2024) · Cell

Immune cells in cancerGlioma Diagnosis and Treatment

Cited by 231

Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination

Hubler, Z., Allimuthu, D., Bederman, I., Elitt, M. S., Madhavan, M., Allan, K. C., Shick, H. E., Garrison, E., T. Karl, M., Factor, D. C., et al. (2018) · Nature

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 226

Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis

Kaji, S., Berghoff, S. A., Spieth, L., Schlaphoff, L., Sasmita, A. O., Vitale, S., Büschgens, L., Kedia, S., Zirngibl, M., Nazarenko, T., et al. (2024) · Immunity

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 104

Dectin-1/2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses

Kaisar, M. M. M., Ritter, M., del Fresno, C., Jónasdóttir, H. S., van der Ham, A. J., Pelgrom, L. R., Schramm, G., Layland, L. E., Sancho, D., Prazeres da Costa, C., et al. (2018) · PLOS Biology

Immunotherapy and Immune ResponsesParasites and Host Interactions

Cited by 79

The whipworm ( Trichuris suis ) secretes prostaglandin E2 to suppress proinflammatory properties in human dendritic cells

Laan, L. C., Williams, A. R., Stavenhagen, K., Giera, M., Kooij, G., Vlasakov, I., Kalay, H., Kringel, H., Nejsum, P., Thamsborg, S. M., et al. (2017) · The FASEB Journal

Parasites and Host InteractionsParasitic Diseases Research and Treatment

Cited by 63

The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases

Feringa, F. M., Koppes-den Hertog, S. J., Wang, L. Y., Derks, R. J. E., Kruijff, I., Erlebach, L., Heijneman, J., Miramontes, R., Pömpner, N., Blomberg, N., et al. (2025) · Nature Metabolism

Metabolomics and Mass Spectrometry StudiesAlzheimer's disease research and treatments

Cited by 56

Haloperidol Disrupts Lipid Rafts and Impairs Insulin Signaling in SH-SY5Y Cells

Sánchez-Wandelmer, J., Dávalos, A., de la Peña, G., Cano, S., Giera, M., Canfrán-Duque, A., Bracher, F., Martín-Hidalgo, A., Fernández-Hernando, C., Lasunción, M. A., et al. (2010) · Neuroscience

Lipid Membrane Structure and BehaviorCholesterol and Lipid Metabolism

Cited by 49

Arachidonic acid-derived lipid mediators in multiple sclerosis pathogenesis: fueling or dampening disease progression?

Broos, J. Y., van der Burgt, R. T. M., Konings, J., Rijnsburger, M., Werz, O., de Vries, H. E., Giera, M., & Kooij, G. (2024) · Journal of Neuroinflammation

Multiple Sclerosis Research StudiesFatty Acid Research and Health

Cited by 41

Association of Arachidonic Acid–Derived Lipid Mediators With Disease Severity in Patients With Relapsing and Progressive Multiple Sclerosis

Broos, J. Y., Loonstra, F. C., de Ruiter, L. R. J., Gouda, M., Fung, W. H., Schoonheim, M. M., Heijink, M., Strijbis, E. M. M., Teunissen, C., Killestein, J., et al. (2023) · Neurology

Multiple Sclerosis Research StudiesFatty Acid Research and Health

Cited by 29

The ORP9-ORP11 dimer promotes sphingomyelin synthesis

Cabukusta, B., Borst Pauwels, S., Akkermans, J. J., Blomberg, N., Mulder, A. A., Koning, R. I., Giera, M., & Neefjes, J. (2024) · eLife

Sphingolipid Metabolism and SignalingLipid metabolism and biosynthesis

Cited by 8

Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis

Kaji, S., Berghoff, S. A., Spieth, L., Schlaphoff, L., Sasmita, A. O., Vitale, S., Büschgens, L., Kedia, S., Zirngibl, M., Nazarenko, T., et al. (2025) · Immunity

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 7

APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics

Cuní-López, C., Root, J. T., Hao, Y., Blomberg, N., Koppes-den Hertog, S. J., Sacks, D., Trujillo, A. E., Ghirlando, R., Kowal, I., Epstein, J., et al. (2026) · Nature Communications

Lipid metabolism and biosynthesisAlzheimer's disease research and treatments

Cited by 0