Weissman, Jonathan S.

Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells

Kampmann, M., Bassik, M. C., & Weissman, J. S. (2013) · Proceedings of the National Academy of Sciences

Bioinformatics and Genomic NetworksRNA Interference and Gene Delivery

Cited by 123

Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins

Martinko, A. J., Truillet, C., Julien, O., Diaz, J. E., Horlbeck, M. A., Whiteley, G., Blonder, J., Weissman, J. S., Bandyopadhyay, S., Evans, M. J., et al. (2018) · eLife

Protein Kinase Regulation and GTPase SignalingProtein Degradation and Inhibitors

Cited by 91

CRISPR Approaches to Small Molecule Target Identification

Jost, M., & Weissman, J. S. (2018) · ACS Chemical Biology

CRISPR and Genetic EngineeringComputational Drug Discovery Methods

Cited by 88

Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

Miller-Vedam, L. E., Bräuning, B., Popova, K. D., Schirle Oakdale, N. T., Bonnar, J. L., Prabu, J. R., Boydston, E. A., Sevillano, N., Shurtleff, M. J., Stroud, R. M., et al. (2020) · eLife

Cellular transport and secretionEndoplasmic Reticulum Stress and Disease

Cited by 87

Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

Miller-Vedam, L. E., Bräuning, B., Popova, K. D., Oakdale, N. T. S., Bonnar, J. L., Prabu, J. R., Boydston, E. A., Sevillano, N., Shurtleff, M. J., Stroud, R. M., et al. (2020) · eLife

Cellular transport and secretionEndoplasmic Reticulum Stress and Disease

Cited by 86

Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether

Torres, S. E., Gallagher, C. M., Plate, L., Gupta, M., Liem, C. R., Guo, X., Tian, R., Stroud, R. M., Kampmann, M., Weissman, J. S., et al. (2019) · eLife

Endoplasmic Reticulum Stress and DiseaseIon Channels and Receptors

Cited by 76

Transcriptome-wide analysis of differential expression in perturbation atlases

Nadig, A., Replogle, J. M., Pogson, A. N., Murthy, M., McCarroll, S. A., Weissman, J. S., Robinson, E. B., & O’Connor, L. J. (2025) · Nature Genetics

Single-cell and spatial transcriptomicsCRISPR and Genetic Engineering

Cited by 70

Large-scale CRISPR screening in primary human 3D gastric organoids enables comprehensive dissection of gene-drug interactions

Lo, Y.-H., Horn, H. T., Huang, M.-F., Yu, W.-C., Young, C.-M., Liu, Q., Tomaske, M., Towers, M., Dominguez, A., Bassik, M. C., et al. (2025) · Nature Communications

CRISPR and Genetic EngineeringChromatin Remodeling and Cancer

Cited by 37

Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology

Muthukumar, G., Stevens, T. A., Inglis, A. J., Esantsi, T. K., Saunders, R. A., Schulte, F., Voorhees, R. M., Guna, A., & Weissman, J. S. (2024) · Molecular Cell

Mitochondrial Function and PathologyHeat shock proteins research

Cited by 34

Approaches to maximize sgRNA-barcode coupling in Perturb-seq screens

Adamson, B., Norman, T. M., Jost, M., & Weissman, J. S. (2018) · bioRxiv (Cold Spring Harbor Laboratory)

CRISPR and Genetic EngineeringSingle-cell and spatial transcriptomics

Cited by 34

Triaging of ⍺-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology

Muthukumar, G., Stevens, T. A., Inglis, A. J., Esantsi, T. K., Saunders, R. A., Schulte, F., Voorhees, R. M., Guna, A., & Weissman, J. S. (2023) · Molecular Cell

Mitochondrial Function and PathologyHeat shock proteins research

Cited by 34