Weissman, Jonathan S.

Ribosome Profiling Provides Evidence that Large Noncoding RNAs Do Not Encode Proteins

Guttman, M., Russell, P., Ingolia, N. T., Weissman, J. S., & Lander, E. S. (2013) · Cell

RNA and protein synthesis mechanismsCancer-related molecular mechanisms research

Cited by 745

A prudent path forward for genomic engineering and germline gene modification

Baltimore, D., Berg, P., Botchan, M., Carroll, D., Charo, R. A., Church, G., Corn, J. E., Daley, G. Q., Doudna, J. A., Fenner, M., et al. (2015) · Science

CRISPR and Genetic EngineeringBiomedical Ethics and Regulation

Cited by 733

Proto-genes and de novo gene birth

Carvunis, A.-R., Rolland, T., Wapinski, I., Calderwood, M. A., Yildirim, M. A., Simonis, N., Charloteaux, B., Hidalgo, C. A., Barbette, J., Santhanam, B., et al. (2012) · Nature

Chromosomal and Genetic VariationsEvolution and Genetic Dynamics

Cited by 669

MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices

McGinnis, C. S., Patterson, D. M., Winkler, J., Conrad, D. N., Hein, M. Y., Srivastava, V., Hu, J. L., Murrow, L. M., Weissman, J. S., Werb, Z., et al. (2019) · Nature Methods

Single-cell and spatial transcriptomicsGenomics and Phylogenetic Studies

Cited by 643

Decoding Human Cytomegalovirus

Stern-Ginossar, N., Weisburd, B., Michalski, A., Le, V. T. K., Hein, M. Y., Huang, S.-X., Ma, M., Shen, B., Qian, S.-B., Hengel, H., et al. (2012) · Science

Cytomegalovirus and herpesvirus researchRNA and protein synthesis mechanisms

Cited by 589

OpenCell: Endogenous tagging for the cartography of human cellular organization

Cho, N. H., Cheveralls, K. C., Brunner, A.-D., Kim, K., Michaelis, A. C., Raghavan, P., Kobayashi, H., Savy, L., Li, J. Y., Canaj, H., et al. (2022) · Science

Bioinformatics and Genomic NetworksBiotin and Related Studies

Cited by 567

High-Resolution View of the Yeast Meiotic Program Revealed by Ribosome Profiling

Brar, G. A., Yassour, M., Friedman, N., Regev, A., Ingolia, N. T., & Weissman, J. S. (2012) · Science

RNA and protein synthesis mechanismsFungal and yeast genetics research

Cited by 533

CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs

Mandegar, M. A., Huebsch, N., Frolov, E. B., Shin, E., Truong, A., Olvera, M. P., Chan, A. H., Miyaoka, Y., Holmes, K., Spencer, C. I., et al. (2016) · Cell Stem Cell

CRISPR and Genetic EngineeringPluripotent Stem Cells Research

Cited by 525

Direct capture of CRISPR guides enables scalable, multiplexed, and multi-omic Perturb-seq

Replogle, J. M., Xu, A., Norman, T. M., Meer, E. J., Terry, J. M., Riordan, D., Srinivas, N., Mikkelsen, T. S., Weissman, J. S., & Adamson, B. (2018) · Nature Biotechnology

CRISPR and Genetic EngineeringSingle-cell and spatial transcriptomics

Cited by 465

Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing

Replogle, J. M., Norman, T. M., Xu, A., Hussmann, J. A., Chen, J., Cogan, J. Z., Meer, E. J., Terry, J. M., Riordan, D. P., Srinivas, N., et al. (2020) · Nature Biotechnology

CRISPR and Genetic EngineeringSingle-cell and spatial transcriptomics

Cited by 465

Dynamic profiling of the protein life cycle in response to pathogens

Jovanovic, M., Rooney, M. S., Mertins, P., Przybylski, D., Chevrier, N., Satija, R., Rodriguez, E. H., Fields, A. P., Schwartz, S., Raychowdhury, R., et al. (2015) · Science

Advanced Proteomics Techniques and ApplicationsGene Regulatory Network Analysis

Cited by 460

Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element

Cho, S. W., Xu, J., Sun, R., Mumbach, M. R., Carter, A. C., Chen, Y. G., Yost, K. E., Kim, J., He, J., Nevins, S. A., et al. (2018) · Cell

Cancer-related molecular mechanisms researchGenomics and Chromatin Dynamics

Cited by 459

Exploring genetic interaction manifolds constructed from rich single-cell phenotypes

Norman, T. M., Horlbeck, M. A., Replogle, J. M., Ge, A. Y., Xu, A., Jost, M., Gilbert, L. A., & Weissman, J. S. (2019) · Science

Gene Regulatory Network AnalysisBioinformatics and Genomic Networks

Cited by 392

Targeting and plasticity of mitochondrial proteins revealed by proximity-specific ribosome profiling

Williams, C. C., Jan, C. H., & Weissman, J. S. (2014) · Science

RNA and protein synthesis mechanismsMitochondrial Function and Pathology

Cited by 391

A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility

Bassik, M. C., Kampmann, M., Lebbink, R. J., Wang, S., Hein, M. Y., Poser, I., Weibezahn, J., Horlbeck, M. A., Chen, S., Mann, M., et al. (2013) · Cell

Toxin Mechanisms and ImmunotoxinsRNA Interference and Gene Delivery

Cited by 365

Molecular recording of mammalian embryogenesis

Chan, M. M., Smith, Z. D., Grosswendt, S., Kretzmer, H., Norman, T. M., Adamson, B., Jost, M., Quinn, J. J., Yang, D., Jones, M. G., et al. (2019) · Nature

Single-cell and spatial transcriptomicsDevelopmental Biology and Gene Regulation

Cited by 364

Conservation and Rewiring of Functional Modules Revealed by an Epistasis Map in Fission Yeast

Roguev, A., Bandyopadhyay, S., Zofall, M., Zhang, K., Fischer, T., Collins, S. R., Qu, H., Shales, M., Park, H.-O., Hayles, J., et al. (2008) · Science

Bioinformatics and Genomic NetworksFungal and yeast genetics research

Cited by 352

Mapping the Genetic Landscape of Human Cells

Horlbeck, M. A., Xu, A., Wang, M., Bennett, N. K., Park, C. Y., Bogdanoff, D., Adamson, B., Chow, E. D., Kampmann, M., Peterson, T. R., et al. (2018) · Cell

CRISPR and Genetic EngineeringBioinformatics and Genomic Networks

Cited by 319

Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids

Piccolis, M., Bond, L. M., Kampmann, M., Pulimeno, P., Chitraju, C., Jayson, C. B. K., Vaites, L. P., Boland, S., Lai, Z. W., Gabriel, K. R., et al. (2019) · Molecular Cell

Lipid metabolism and biosynthesisCancer, Lipids, and Metabolism

Cited by 269

Defining the Glycan Destruction Signal for Endoplasmic Reticulum-Associated Degradation

Quan, E. M., Kamiya, Y., Kamiya, D., Denic, V., Weibezahn, J., Kato, K., & Weissman, J. S. (2008) · Molecular Cell

Endoplasmic Reticulum Stress and DiseaseGlycosylation and Glycoproteins Research

Cited by 242

An expanded universe of cancer targets

Hahn, W. C., Bader, J. S., Braun, T. P., Califano, A., Clemons, P. A., Druker, B. J., Ewald, A. J., Fu, H., Jagu, S., Kemp, C. J., et al. (2021) · Cell

Cancer Genomics and DiagnosticsChromatin Remodeling and Cancer

Cited by 213

Cellular Noise Regulons Underlie Fluctuations in Saccharomyces cerevisiae

Stewart-Ornstein, J., Weissman, J. S., & El-Samad, H. (2012) · Molecular Cell

Gene Regulatory Network AnalysisFungal and yeast genetics research

Cited by 177

A CRISPR/Cas9-Engineered ARID1A -Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation

Lo, Y.-H., Kolahi, K. S., Du, Y., Chang, C.-Y., Krokhotin, A., Nair, A., Sobba, W. D., Karlsson, K., Jones, S. J., Longacre, T. A., et al. (2021) · Cancer Discovery

Chromatin Remodeling and CancerCRISPR and Genetic Engineering

Cited by 174

Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs

Jost, M., Santos, D. A., Saunders, R. A., Horlbeck, M. A., Hawkins, J. S., Scaria, S. M., Norman, T. M., Hussmann, J. A., Liem, C. R., Gross, C. A., et al. (2020) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 164