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E2F-Dependent Histone Acetylation and Recruitment of the Tip60 Acetyltransferase Complex to Chromatin in Late G1

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Targeting the RB-E2F pathway in breast cancer

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Regulating the p53 system through ubiquitination

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Regulation of E2Fs and senescence by PML nuclear bodies

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Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kineticsPreprint

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C/EBPβ cooperates with RB:E2F to implement RasV12‐induced cellular senescence

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Cellular Senescence as the Causal Nexus of Aging

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pRB Contains an E2F1-Specific Binding Domain that Allows E2F1-Induced Apoptosis to Be Regulated Separately from Other E2F Activities

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Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescencePreprint

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Rb Regulates DNA Damage Response and Cellular Senescence through E2F-Dependent Suppression of N-Ras Isoprenylation

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A kinase shRNA screen links LATS2 and the pRB tumor suppressorPreprint

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Ras-Raf-Arf Signaling Critically Depends on the Dmp1 Transcription Factor

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Retinoblastoma Tumor Suppressor: Where Cancer Meets the Cell Cycle

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E2f1, E2f2, and E2f3 Control E2F Target Expression and Cellular Proliferation via a p53-Dependent Negative Feedback Loop

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Myc-Mediated Proliferation and Lymphomagenesis, but Not Apoptosis, Are Compromised by E2f1 Loss

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p53-Dependent and -Independent Functions of the Arf Tumor SuppressorPreprint

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Re-Evaluating Cell-Cycle Regulation by E2Fs

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Macrophage Migration Inhibitory Factor MIF Interferes with the Rb-E2F Pathway

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Versatile functions of p53 protein in multicellular organisms

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Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53

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Therapeutic targeting of replicative immortality

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Macrophage Migration Inhibitory Factor Deficiency Is Associated with Altered Cell Growth and Reduced Susceptibility to Ras-mediated Transformation

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E2F-1 regulates expression of FOXO1 and FOXO3a

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ARF tumor suppression in the nucleolus

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Dmp1 and tumor suppression

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p16 and ARF: activation of teenage proteins in old age

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Cell proliferation in the absence of E2F1-3

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Chemotherapy response and resistance

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Impaired DNA damage checkpoint response in MIF‐deficient mice

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NPAT Expression Is Regulated by E2F and Is Essential for Cell Cycle Progression

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Apoptosis-stimulating protein of p53-2 (ASPP2/53BP2L) is an E2F target gene

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Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex

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A G1 Checkpoint Mediated by the Retinoblastoma Protein That Is Dispensable in Terminal Differentiation but Essential for Senescence

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Sin3B Expression Is Required for Cellular Senescence and Is Up-regulated upon Oncogenic Stress

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ORF73-Null Murine Gammaherpesvirus 68 Reveals Roles for mLANA and p53 in Virus Replication

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The Histone Demethylase Jarid1b (Kdm5b) Is a Novel Component of the Rb Pathway and Associates with E2f-Target Genes in MEFs during Senescence

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Small molecule regulators of Rb–E2F pathway as modulators of transcription

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Melanomagenesis: Overcoming the barrier of melanocyte senescence

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Oncogene-induced senescence: An essential role for Runx

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Adenovirus E1B55K Region Is Required To Enhance Cyclin E Expression for Efficient Viral DNA Replication

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ARF Directly Binds DP1: Interaction with DP1 Coincides with the G1 Arrest Function of ARF

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Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control

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RB Reversibly Inhibits DNA Replication via Two Temporally Distinct Mechanisms

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Hierarchical Requirement of SWI/SNF in Retinoblastoma Tumor Suppressor-mediated Repression of Plk1

Gunawardena, R. W., Siddiqui, H., Solomon, D. A., Mayhew, C. N., Held, J. D., Angus, S. P., & Knudsen, E. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400395200 · Cited by 45 · see citing works

Sustained NF‐κB activation produces a short‐term cell proliferation block in conjunction with repressing effectors of cell cycle progression controlled by E2F or FoxM1

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Loss of p21 disrupts p14ARF-induced G1 cell cycle arrest but augments p14ARF-induced apoptosis in human carcinoma cells

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MIF loss impairs Myc-induced lymphomagenesis

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AP-1 dimers regulate transcription of the p14/p19ARF tumor suppressor gene

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Targeting an E2F site in the mouse genome prevents promoter silencing in quiescent and post-mitotic cells

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At the stem of youth and health

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Retinoblastoma Tumor Suppressor: Analyses of Dynamic Behavior in Living Cells Reveal Multiple Modes of Regulation

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Expression of Dmp1 in specific differentiated, nonproliferating cells and its regulation by E2Fs

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Disruption of E2F signaling suppresses the INK4a-induced proliferative defect in M33-deficient mice

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The magnitude of methylmercury-induced cytotoxicity and cell cycle arrest is p53-dependent

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5‐Aza‐2'‐deoxycytidine reactivates gene expression via degradation of pRb pocket proteins

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Transcriptional control of the proliferation cluster by the tumor suppressor p53

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Molecular Basis for Viral Selective Replication in Cancer Cells: Activation of CDK2 by Adenovirus-Induced Cyclin E

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The flexible evolutionary anchorage-dependent Pardee's restriction point of mammalian cells. How its deregulation may lead to cancer

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Activating E2Fs mediate transcriptional regulation of human E2F6 repressor

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Molecular biology of oncogenic inflammatory processes. I. Non-oncogenic and oncogenic pathogens, intrinsic inflammatory reactions without pathogens, and microRNA/DNA interactions (Review)

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Suppression of the p53-Dependent Replicative Senescence Response by Lysophosphatidic Acid Signaling

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p63α protein up-regulates heat shock protein 70 expression via E2F1 transcription factor 1, promoting Wasf3/Wave3/MMP9 signaling and bladder cancer invasion

Jin, H., Xie, Q., Guo, X., Xu, J., Wang, A., Li, J., Zhu, J., Wu, X., Huang, H., & Huang, C. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.792010 · Cited by 26 · see citing works

Novel ARF/p53-independent senescence pathways in cancer repression

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Hypoxia induces major effects on cell cycle kinetics and protein expression inDrosophila melanogasterembryos

Douglas, R. M., Farahani, R., Morcillo, P., Kanaan, A., Xu, T., & Haddad, G. G. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00520.2004 · Cited by 25 · see citing works

SUMOylation of p53 mediates interferon activities

Marcos-Villar, L., Pérez-Girón, J. V., Vilas, J. M., Soto, A., de la Cruz-Herrera, C. F., Lang, V., Collado, M., Vidal, A., Rodríguez, M. S., Muñoz‐Fontela, C., et al. (2013) · Cell Cycle · doi:10.4161/cc.25868 · Cited by 24 · see citing works

E2f1, E2f2, and E2f3 Control E2F Target Expression and Cellular Proliferation via a p53-Dependent Negative Feedback Loop

Timmers, C. D., Sharma, N., Opavský, R., Maiti, B., Wu, L., Wu, J., Orringer, D. A., Trikha, P., Saavedra, H. I., & Leone, G. W. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02147-06 · Cited by 24 · see citing works

TBX2 controls a proproliferative gene expression program in melanomaPreprint

Lu, S., Louphrasitthiphol, P., Goradia, N., Lambert, J., Schmidt, J., Chauhan, J. S., Rughani, M. G., Larue, L., Wilmanns, M., & Goding, C. R. (2021) · Genes & Development · doi:10.1101/gad.348746.121 · Cited by 21 · see citing works

Context-Dependent Requirement for dE2F during Oncogenic Proliferation

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Stem cell MicroRNAs in senescence and immortalization: novel players in cancer therapy

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Genes and pathways involved in senescence bypass identified by functional genetic screens

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Simultaneous expression of MMB-FOXM1 complex components enables efficient bypass of senescence

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Signal Transduction Involving the Dmp1 Transcription Factor and its Alteration in Human Cancer

Sugiyama, T., Frazier, D. P., Taneja, P., Kendig, R. D., Morgan, R. L., Matise, L. A., Lagedrost, S. J., & Inoue, K. (2008) · Clinical medicine Oncology · doi:10.4137/cmo.s548 · Cited by 13 · see citing works

RB Family Tumor Suppressor Activity May Not Relate to Active Silencing of E2F Target Genes

Vormer, T. L., Wojciechowicz, K., Dekker, M., de Vries, S., van der Wal, A., Delzenne‐Goette, E., Naik, S. H., Song, J., Dannenberg, J., Hansen, J. B., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3706 · Cited by 12 · see citing works

Genetic and epigenetic alterations in lung tumors from bitransgenic Ki‐rasG12C expressing mice

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Keeping the Balance Between Proliferation and Differentiation by the E2F Transcriptional Regulatory Network is Central to Plant Growth and Development

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Regulation of oncogene-induced cell cycle exit and senescence by chromatin modifiers

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Targeted discovery tools: proteomics and chromatin immunoprecipitation‐on‐chip

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Senescence and Cell Cycle Control

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Final checkup of neoplastic DNA replication: evidence for failure in decision-making at the mitotic cell cycle checkpoint G(1)/S.

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Timing will tell

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Next‐generation sequencing revealing TP53 mutation as potential genetic driver in dermal deep‐seated melanoma arising in giant congenital nevus in adult patients: A unique case report and review of the literature

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E2F1 plays a direct role in Rb stabilization and p53-independent tumor suppression

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p19ARF targets certain E2F species for degradation

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Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kineticsPreprint

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Regulation of the Arf Tumor Suppressor by E2F Transcription Factors

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