Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis

Notch Signaling: Cell Fate Control and Signal Integration in Development

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A simplified system for generating recombinant adenoviruses

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Cancer Statistics, 2002

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A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

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Notch signalling controls pancreatic cell differentiation

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Control of endodermal endocrine development by Hes-1

Jensen, J. N., Pedersen, E. E., Galante, P. E., Hald, J., Heller, R. S., Ishibashi, M., Kageyama, R., Guillemot, F., Serup, P., & Madsen, O. D. (2000) · Nature Genetics · doi:10.1038/71657 · Cited by 1,155 · see citing works

Notch Signaling: From the Outside In

Mumm, J. S., & Kopan, R. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9960 · Cited by 964 · see citing works

Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain

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Multipotential Nestin-Positive Stem Cells Isolated From Adult Pancreatic Islets Differentiate Ex Vivo Into Pancreatic Endocrine, Exocrine, and Hepatic Phenotypes

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Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

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TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas

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Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression.

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A histone deacetylase corepressor complex regulates the Notch signal transduction pathwayPreprint

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Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells

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Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation.

Jensen, J. N., Heller, R. S., Funder-Nielsen, T., Pedersen, E. E., Lindsell, C. E., Weinmaster, G., Madsen, O. D., & Serup, P. (2000) · Diabetes · doi:10.2337/diabetes.49.2.163 · Cited by 440 · see citing works

Notch signaling induces cell cycle arrest in small cell lung cancer cells.

Sriuranpong, V., Borges, M. W., Ravi, R. K., Arnold, D. R., Nelkin, B. D., Baylin, S. B., & Ball, D. W. (2001) · PubMed · Cited by 435 · see citing works

p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma.

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Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action

Finch, P. W., He, X., Kelley, M. J., Üren, A., Schaudies, R. P., Popescu, N. C., Rudikoff, S., Aaronson, S. A., VARMUS, H. E., & Rubin, J. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6770 · Cited by 417 · see citing works

Induction of Cyclin D1 Transcription and CDK2 Activity by Notch ic : Implication for Cell Cycle Disruption in Transformation by Notch ic

Ronchini, C., & Capobianco, A. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.17.5925-5934.2001 · Cited by 413 · see citing works

Vertebrate hairy and Enhancer of split related proteins: transcriptional repressors regulating cellular differentiation and embryonic patterning

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Constitutive activation of NF‐κB and T‐cell leukemia/lymphoma in Notch3 transgenic mice

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Activity-dependent isolation of the presenilin– γ-secretase complex reveals nicastrin and a γ substrate

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Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-κB and PPARγ

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Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression.

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Nestin-EGFP Transgenic Mice: Visualization of the Self-Renewal and Multipotency of CNS Stem Cells

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Discovery of Novel Tumor Markers of Pancreatic Cancer using Global Gene Expression Technology

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Peptidomimetic Probes and Molecular Modeling Suggest That Alzheimer's γ-Secretase Is an Intramembrane-Cleaving Aspartyl Protease

Wolfe, M. S., Xia, W., Moore, C. L., Leatherwood, D. D., Ostaszewski, B., Rahmati, T., Donkor, I. O., & Selkoe, D. J. (1999) · Biochemistry · doi:10.1021/bi982562p · Cited by 289 · see citing works

NF-κB2 Is a Putative Target Gene of Activated Notch-1 via RBP-Jκ

Oswald, F., Liptay, S., Adler, G., & Schmid, R. M. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.4.2077 · Cited by 269 · see citing works

Notch1 is required for neuronal and glial differentiation in the cerebellum

Lütolf, S., Radtke, F., Aguet, M., Suter, U., & Taylor, V. (2002) · Development · doi:10.1242/dev.129.2.373 · Cited by 264 · see citing works

Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis.

Gansauge, S., Gansauge, F., Ramadani, M., Stobbe, H., Rau, B., Harada, N., & Beger, H. G. (1997) · PubMed · Cited by 261 · see citing works

Notch Inhibition of RAS Signaling Through MAP Kinase Phosphatase LIP-1 During C. elegans Vulval Development

Berset, T., Fröhli, E., Battu, G., Canevascini, S., & Hajnal, A. (2001) · Science · doi:10.1126/science.1055642 · Cited by 257 · see citing works

Role of Growth Factors in Pancreatic Cancer

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Neoplastic Transformation by Truncated Alleles of Human NOTCH1/TAN1 and NOTCH2

Capobianco, A. J., Zagouras, P., Blaumueller, C. M., Artavanis‐Tsakonas, S., & Bishop, J. M. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.11.6265 · Cited by 230 · see citing works

Inhibition of NF-κB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin

Arlt, A., Vorndamm, J., Breitenbroich, M., Fölsch, U. R., Kalthoff, H., Schmidt, W. E., & Schäfer, H. (2001) · Oncogene · doi:10.1038/sj.onc.1204168 · Cited by 227 · see citing works

Notch-1 Regulates NF-κB Activity in Hemopoietic Progenitor Cells

Cheng, P., Zlobin, A., Volgina, V. V., Gottipati, S., Osborne, B. A., Simel, E. J., Miele, L., & Gabrilovich, D. I. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.8.4458 · Cited by 216 · see citing works

Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter

Lechner, A., Leech, C. A., Abraham, E. J., Nolan, A. L., & Habener, J. F. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00275-9 · Cited by 210 · see citing works

Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor α

Song, S. Y., GANNON, M. A., Washington, M. K., Scoggins, C. R., Meszoely, I. M., Goldenring, J. R., Marino, C. R., Sandgren, E. P., Coffey, R. J., Wright, C. V. E., et al. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70292-1 · Cited by 205 · see citing works

A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human diseasePreprint

Wagner, M., Greten, F. R., Weber, C. K., Koschnick, S., Mattfeldt, T., Deppert, W., Kern, H. F., Adler, G., & Schmid, R. M. (2001) · Genes & Development · doi:10.1101/gad.184701 · Cited by 204 · see citing works

Malignant transformation of duct-like cells originating from acini in transforming growth factor α transgenic mice

WAGNER, M., Lührs, H., Klöppel, G., Adler, G., & Schmid, R. M. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70098-8 · Cited by 193 · see citing works

HERP, a New Primary Target of Notch Regulated by Ligand Binding

Iso, T., Sartorelli, V., Chung, G., Shichinohe, T., Kedes, L., & Hamamori, Y. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.17.6071-6079.2001 · Cited by 191 · see citing works

Coexpression of Nestin in Neural and Glial Cells in the Developing Human CNS Defined by a Human-Specific Anti-nestin Antibody

Messam, C. A., Hou, J., & Major, E. O. (2000) · Experimental Neurology · doi:10.1006/exnr.1999.7319 · Cited by 182 · see citing works

Exploring the Host Desmoplastic Response to Pancreatic Carcinoma

Iacobuzio–Donahue, C. A., Ryu, B., Hruban, R. H., & Kern, S. E. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64353-2 · Cited by 178 · see citing works

Nestin is expressed in mesenchymal and not epithelial cells of the developing mouse pancreas

Selander, L., & Edlund, H. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00023-0 · Cited by 171 · see citing works

Nestin-Expressing Cells in the Pancreatic Islets of Langerhans

Hunziker, E., & Stein, M. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2611 · Cited by 160 · see citing works

Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch‐DSL signaling system during brain development

Irvin, D. K., Zurcher, S. D., Nguyen, T., Weinmaster, G., & Kornblum, H. I. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1059 · Cited by 155 · see citing works

Ras pathway signals are required for notch-mediated oncogenesis

Fitzgerald, K. J., Harrington, A. N., & Leder, P. (2000) · Oncogene · doi:10.1038/sj.onc.1203766 · Cited by 147 · see citing works

Notch signaling in T cell development

Deftos, M. L., & Bevan, M. J. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)00067-9 · Cited by 140 · see citing works

Reciprocal Regulatory Interactions between the Notch and Ras Signaling Pathways in the Drosophila Embryonic Mesoderm

Carmena, A., Buff, E. M., Halfon, M. S., Gisselbrecht, S. S., Jiménez, F., Baylies, M. K., & Michelson, A. M. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0606 · Cited by 136 · see citing works

Delta/Notch and Boss/Sevenless Signals Act Combinatorially to Specify the Drosophila R7 Photoreceptor

Tomlinson, A., & Struhl, G. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00196-4 · Cited by 123 · see citing works

Aspartate Mutations in Presenilin and γ‐Secretase Inhibitors Both Impair Notch1 Proteolysis and Nuclear Translocation with Relative Preservation of Notch1 Signaling

Berezovska, O., Jack, C. E., McLean, P. J., Aster, J. C., Hicks, C. D., Xia, W., Wolfe, M. S., Kimberly, W. T., Weinmaster, G., Selkoe, D. J., et al. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750583.x · Cited by 119 · see citing works

HERP1 Is a Cell Type-specific Primary Target of Notch

Iso, T., Chung, G., Hamamori, Y., & Kedes, L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110495200 · Cited by 106 · see citing works

Ductal metaplasia of human exocrine pancreas and its association with carcinoma.

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The EGF receptor and N signalling pathways act antagonistically in Drosophila mesothorax bristle patterning

Culí, J., Martı́n-Blanco, E., & Modolell, J. (2001) · Development · doi:10.1242/dev.128.2.299 · Cited by 100 · see citing works

Antagonism of EGFR and Notch signalling in the reiterative recruitment of Drosophila adult chordotonal sense organ precursors

Lage, P. Z., & Jarman, A. P. (1999) · Development · doi:10.1242/dev.126.14.3149 · Cited by 78 · see citing works

Pathology of incipient pancreatic cancer

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Structure, function, and expression of SEL-1, a negative regulator of LIN-12 and GLP-1 in C. elegans

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Transgenic overexpression of amphiregulin induces a mitogenic response selectively in pancreatic duct cells

Wagner, M., Weber, C. K., Bressau, F., Greten, F. R., Stagge, V., Ebert, M. P., Leach, S. D., Adler, G., & Schmid, R. M. (2002) · Gastroenterology · doi:10.1053/gast.2002.33594 · Cited by 65 · see citing works

Fritz: a secreted frizzled-related protein that inhibits Wnt activity

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Dominant Enhancers of Egfr in Drosophila melanogaster: Genetic Links Between the Notch and Egfr Signaling Pathways

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Cloning and characterization of Sel-1l, a murine homolog of the C. elegans sel-1 gene

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Complete cDNA sequence and genomic organization of a human pancreas-specific gene homologous to Caenorhabditis elegans sel-1

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The Importance of the Centroacinar Region in Cerulein-Induced Mouse Pancreatic Growth

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Regional differences in the cellular proliferation activity of the regenerating rat pancreas after partial pancreatectomy.

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Bcl-2 expression related to altered p53 protein and its impact on the progression of human pancreatic carcinoma

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Notch-1 expression levels in 3T3-L1 cells influence ras signaling and transformation by oncogenic ras.

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Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471 · see citing works

Genetics and biology of pancreatic ductal adenocarcinomaPreprint

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Pancreatic cancer: Advances and challenges

Halbrook, C. J., Lyssiotis, C. A., Pasca di Magliano, M., & Maitra, A. (2023) · Cell · doi:10.1016/j.cell.2023.02.014 · Cited by 1,321 · see citing works

Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice

Guerra, C., Schuhmacher, A. J., Cañamero, M., Grippo, P. J., Verdaguer, L., Pérez-Gallego, L., Dubus, P., Sandgren, E. P., & Barbacid, M. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.01.012 · Cited by 1,224 · see citing works

Expression profiling identifies microRNA signature in pancreatic cancer

Lee, E. J., Gusev, Y., Jiang, J., Nuovo, G. J., Lerner, M. R., Frankel, W. L., Morgan, D. L., Postier, R. G., Brackett, D. J., & Schmittgen, T. D. (2006) · International Journal of Cancer · doi:10.1002/ijc.22394 · Cited by 900 · see citing works

Hedgehog signalling in cancer formation and maintenance

di Magliano, M. P., & Hebrok, M. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1229 · Cited by 830 · see citing works

Notch signalling in solid tumours: a little bit of everything but not all the time

Ranganathan, P., Weaver, K. L., & Capobianco, A. J. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3035 · Cited by 818 · see citing works

Notch signaling controls multiple steps of pancreatic differentiation

Murtaugh, L. C., Stanger, B. Z., Kwan, K. M., & Melton, D. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436557100 · Cited by 782 · see citing works

Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice

Collins, M. A., Bednar, F., Zhang, Y., Brisset, J.-C., Galbán, S., Galbán, C. J., Rakshit, S., Flannagan, K. S., Adsay, N. V., & Pasca di Magliano, M. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59227 · Cited by 770 · see citing works

Direct inhibition of the NOTCH transcription factor complex

Moellering, R. E., Cornejo, M., Davis, T. N., Bianco, C. D., Aster, J. C., Blacklow, S. C., Kung, A. L., Gilliland, D. G., Verdine, G. L., & Bradner, J. E. (2009) · Nature · doi:10.1038/nature08543 · Cited by 752 · see citing works

Pancreatic Cancer

Maitra, A., & Hruban, R. H. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.3.121806.154305 · Cited by 707 · see citing works

Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma

Kopp, J. L., von Figura, G., Mayes, E., Liu, F.-F., Dubois, C. L., Morris, J. P., Pan, F. C., Akiyama, H., Wright, C. V. E., Jensen, K., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.10.025 · Cited by 697 · see citing works

NOTCH Pathway Blockade Depletes CD133-Positive Glioblastoma Cells and Inhibits Growth of Tumor Neurospheres and Xenografts

Fan, X., Khaki, L., Zhu, T. S., Soules, M. E., Talsma, C. E., Gul, N., Koh, C. M., Zhang, J., Li, Y., Maciaczyk, J., et al. (2009) · Stem Cells · doi:10.1002/stem.254 · Cited by 646 · see citing works

Stem cell fate in cancer growth, progression and therapy resistance

Lytle, N. K., Barber, A. G., & Reya, T. (2018) · Nature reviews. Cancer · doi:10.1038/s41568-018-0056-x · Cited by 645 · see citing works

Notch Pathway Inhibition Depletes Stem-like Cells and Blocks Engraftment in Embryonal Brain Tumors

Fan, X., Matsui, W. H., Khaki, L., Stearns, D. S., Chun, J., Li, Y., & Eberhart, C. G. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0858 · Cited by 619 · see citing works

KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma

Morris, J. P., Wang, S. C., & Hebrok, M. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2899 · Cited by 567 · see citing works

Notch Signaling in Development and Cancer

Bolós, V., Grego‐Bessa, J., & de la Pompa, J. L. (2007) · Endocrine Reviews · doi:10.1210/er.2006-0046 · Cited by 546 · see citing works

NOTCH1 mediates a switch between two distinct secretomes during senescence

Hoare, M., Ito, Y., Kang, T.-W., Weekes, M. P., Matheson, N. J., Patten, D. A., Shetty, S., Parry, A. J., Menon, S., Salama, R., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3397 · Cited by 522 · see citing works

Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression

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EGF Receptor is Required for KRAS-induced Pancreatic Tumorigenesis

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Recent insights into the role of Notch signaling in tumorigenesis

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Biomarker Discovery from Pancreatic Cancer Secretome Using a Differential Proteomic Approach

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The SmoA1 Mouse Model Reveals That Notch Signaling Is Critical for the Growth and Survival of Sonic Hedgehog-Induced Medulloblastomas

Hallahan, A. R., Pritchard, J. I., Hansen, S. J., Benson, M. D., Stoeck, J., Hatton, B. A., Russell, T. L., Ellenbogen, R. G., Bernstein, I. D., Beachy, P. A., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1813 · Cited by 438 · see citing works

Biology and management of pancreatic cancer

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Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice

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Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

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Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia

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From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling

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Notch as a tumour suppressor

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The ZEB1/miR‐200 feedback loop controls Notch signalling in cancer cells

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Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice.

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Metaplasia: tissue injury adaptation and a precursor to the dysplasia–cancer sequence

Giroux, V., & Rustgi, A. (2017) · Nature Reviews. Cancer · doi:10.1038/nrc.2017.68 · Cited by 331 · see citing works

Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration.

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Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas

Parsons, M. J., Pisharath, H., Yusuff, S., Moore, J. C., Siekmann, A., Lawson, N., & Leach, S. (2009) · Mechanisms of Development · doi:10.1016/j.mod.2009.07.002 · Cited by 354 · see citing works

Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates

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Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras

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Notch and cancer: a double-edged sword

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Notch signaling.

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Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis

Carrer, A., Trefely, S., Zhao, S., Campbell, S. L., Norgard, R. J., Schultz, K. C., Sidoli, S., Parris, J. L. D., Affronti, H. C., Sivanand, S., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0567 · Cited by 313 · see citing works

DCLK1 Marks a Morphologically Distinct Subpopulation of Cells With Stem Cell Properties in Preinvasive Pancreatic Cancer

Bailey, J. M., Alsina, J., Rasheed, Z. A., McAllister, F. M., Fu, Y., Plentz, R. R., Zhang, H., Pasricha, P. J., Bardeesy, N. M., Matsui, W. H., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.09.050 · Cited by 312 · see citing works

Hedgehog/Ras interactions regulate early stages of pancreatic cancerPreprint

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Pten constrains centroacinar cell expansion and malignant transformation in the pancreas

Stanger, B. Z., Stiles, B. L., Lauwers, G. Y., Bardeesy, N. M., Mendoza, M. J., Wang, Y., Greenwood, A. L., Cheng, K., McLaughlin, M. M., Brown, D., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.07.015 · Cited by 294 · see citing works

Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas

Rovira, M., Scott, S.-G., Liss, A., Jensen, J., Thayer, S., & Leach, S. (2009) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0912589107 · Cited by 313 · see citing works

Pancreatic Cancer: Basic and Clinical Aspects

Schneider, G., Siveke, J. T., Eckel, F., & Schmid, R. M. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.04.001 · Cited by 285 · see citing works

Leukemia-Associated Mutations within the NOTCH1 Heterodimerization Domain Fall into at Least Two Distinct Mechanistic Classes

Malecki, M. J., Sanchez-Irizarry, C., Mitchell, J., Histen, G., Xu, M. L., Aster, J. C., & Blacklow, S. C. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01655-05 · Cited by 274 · see citing works

Molecular genetics of pancreatic intraepithelial neoplasia

Feldmann, G., Beaty, R., Hruban, R. H., & Maitra, A. (2007) · Journal of Hepato-Biliary-Pancreatic Surgery · doi:10.1007/s00534-006-1166-5 · Cited by 269 · see citing works

Notch inhibitors for cancer treatment

Espinoza, I. C., & Miele, L. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.02.003 · Cited by 272 · see citing works

In Vivo Lineage Tracing Defines the Role of Acinar-to-Ductal Transdifferentiation in Inflammatory Ductal Metaplasia

Strobel, O., Dor, Y., Alsina, J., Stirman, A., Lauwers, G. Y., Trainor, A. G., del Castillo, C. F., Warshaw, A. L., & Thayer, S. P. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.09.009 · Cited by 268 · see citing works

γ-Secretase Inhibitor Prevents Notch3 Activation and Reduces Proliferation in Human Lung Cancers

Konishi, J. S., Kawaguchi, K. S., Vo, H., Haruki, N., González, A., Carbone, D. P., & Dang, T. P. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1022 · Cited by 253 · see citing works

Crossing paths with Notch in the hyper-network

Hurlbut, G. D., Kankel, M. W., Lake, R. J., & Artavanis‐Tsakonas, S. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.012 · Cited by 250 · see citing works

Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice

Maniati, E., Bossard, M., Cook, N., Candido, J. B., Emami-Shahri, N., Nedospasov, S. A., Balkwill, F. R., Tuveson, D. A., & Hagemann, T. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45797 · Cited by 249 · see citing works

The Use of Targeted Mouse Models for Preclinical Testing of Novel Cancer Therapeutics

Olive, K. P., & Tuveson, D. A. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0436 · Cited by 242 · see citing works

Gene Expression Profiles in Pancreatic Intraepithelial Neoplasia Reflect the Effects of Hedgehog Signaling on Pancreatic Ductal Epithelial Cells

Prasad, N. B., Biankin, A. V., Fukushima, N., Maitra, A., Dhara, S., ELKAHLOUN, A. G., Hruban, R. H., Goggins, M., & Leach, S. D. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-1413 · Cited by 240 · see citing works

Overcoming drug resistance in pancreatic cancer

Long, J., Zhang, Y., Yu, X., Yang, J., LeBrun, D. G., Chen, C., Yao, Q. C., & Li, M. (2011) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2011.566216 · Cited by 239 · see citing works

Common Activation of Canonical Wnt Signaling in Pancreatic Adenocarcinoma

di Magliano, M. P., Biankin, A. V., Heiser, P. W., Cano, D. A., Gutiérrez, P. J. A., Deramaudt, T. B., Segara, D., Dawson, A. C., Kench, J. G., Henshall, S. M., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001155 · Cited by 236 · see citing works

Pancreatic ductal cells in development, regeneration, and neoplasia

Reichert, M., & Rustgi, A. K. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57131 · Cited by 235 · see citing works

Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma

Mazur, P. K., Einwächter, H., Lee, M., Sipos, B., Nakhai, H., Rad, R., Zimber‐Strobl, U., Strobl, L. J., Radtke, F., Klöppel, G., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002423107 · Cited by 219 · see citing works

YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK–STAT3 Signaling

Gruber, R., Panayiotou, R., Nye, E. L., Spencer‐Dene, B., Stamp, G., & Behrens, A. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.05.006 · Cited by 214 · see citing works

K-Ras Promotes Growth Transformation and Invasion of Immortalized Human Pancreatic Cells by Raf and Phosphatidylinositol 3-Kinase Signaling

Campbell, P. M., Groehler, A. L., Lee, K. M., Ouellette, M. M., Khazak, V., & Der, C. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3752 · Cited by 215 · see citing works

Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas

Esni, F., Ghosh, B., Biankin, A., Lin, J. W., Albert, M. A., Yu, X., MacDonald, R. J., Civin, C., Real, F., Pack, M., et al. (2004) · Development · doi:10.1242/dev.01280 · Cited by 235 · see citing works

Acinar Cells Contribute to the Molecular Heterogeneity of Pancreatic Intraepithelial Neoplasia

Zhu, L., Shi, G., Schmidt, C. M., Hruban, R. H., & Konieczny, S. F. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.061176 · Cited by 213 · see citing works

DCAMKL-1 Regulates Epithelial–Mesenchymal Transition in Human Pancreatic Cells through a miR-200a –Dependent Mechanism

Sureban, S. M., May, R. J., Lightfoot, S. A., Hoskins, A. B., Lerner, M. R., Brackett, D. J., Postier, R. G., Ramanujam, R. P., Mohammed, A., Rao, C. V., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2738 · Cited by 213 · see citing works

Multiple niches for Notch in cancer: context is everything

Weng, A. P., & Aster, J. C. (2003) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2003.11.004 · Cited by 210 · see citing works

Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis

Zhang, Y., Morris, J. P., Yan, W., Schofield, H. K., Gurney, A. L., Simeone, D. M., Millar, S. E., Hoey, T., Hebrok, M., & di Magliano, M. P. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4384 · Cited by 207 · see citing works

Hedgehog Signaling Is Required for Effective Regeneration of Exocrine Pancreas

Fendrich, V., Esni, F., Garay, M. V. R., Feldmann, G., Habbe, N., Jensen, J. N., Dor, Y., Stoffers, D., Jensen, J., Leach, S. D., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.011 · Cited by 191 · see citing works

Lineage tracing reveals the dynamic contribution of Hes1 + cells to the developing and adult pancreas

Kopinke, D., Brailsford, M., Shea, J., Leavitt, R., Scaife, C. L., & Murtaugh, L. C. (2011) · Development · doi:10.1242/dev.053843 · Cited by 192 · see citing works

Regulation of Notch Endosomal Sorting and Signaling by Drosophila Nedd4 Family Proteins

Wilkin, M. B., Carbery, A.-M., Fostier, M., Aslam, H., Mazaleyrat, S., Higgs, J. E., Myat, A., Evans, D. A. P., Cornell, M. J., & Baron, M. (2004) · Current Biology · doi:10.1016/j.cub.2004.11.030 · Cited by 190 · see citing works

Ligand-dependent Notch Signaling Is Involved in Tumor Initiation and Tumor Maintenance in Pancreatic Cancer

Mullendore, M. E., Koorstra, J.-B. M., Li, Y., Offerhaus, G. J. A., Fan, X., Henderson, C. M., Matsui, W. H., Eberhart, C. G., Maitra, A., & Feldmann, G. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2004 · Cited by 188 · see citing works

Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition

Miele, L., Espinoza, I. C., Pochampally, Watabe, & Xing, F. (2013) · OncoTargets and Therapy · doi:10.2147/ott.s36162 · Cited by 185 · see citing works

Clinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis)

Kummar, S., O'Sullivan Coyne, G., Do, K. T., Turkbey, B., Meltzer, P. S., Polley, E., Choyke, P. L., Meehan, R., Vilimas, R., Horneffer, Y., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2016.71.1994 · Cited by 183 · see citing works

Pancreatic Carcinogenesis

Koorstra, J.-B. M., Hustinx, S. R., Offerhaus, G. J. A., & Maitra, A. (2008) · Pancreatology · doi:10.1159/000123838 · Cited by 180 · see citing works

Notch activates cell cycle reentry and progression in quiescent cardiomyocytes

Campa, V. M., Gutiérrez-Lanza, R., Cerignoli, F., Dı́az-Trelles, R., Nelson, B., Tsuji, T., Barcová, M., Jiang, W. B., & Mercola, M. A. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200806104 · Cited by 179 · see citing works

Genetically engineered mouse models of pancreatic adenocarcinoma

Guerra, C. E., & Barbacid, M. (2013) · Molecular Oncology · doi:10.1016/j.molonc.2013.02.002 · Cited by 179 · see citing works

Notch signaling: Emerging molecular targets for cancer therapy

Yin, L., Velazquez, O. C., & Liu, Z. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.03.026 · Cited by 177 · see citing works

Notch1 Functions as a Tumor Suppressor in a Model of K-ras–Induced Pancreatic Ductal Adenocarcinoma

Hanlon, L., Avila, J. L., Demarest, R. M., Troutman, S. A., Allen, M., Ratti, F., Rustgi, A. K., Stanger, B. Z., Radtke, F., Adsay, V. N., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4645 · Cited by 172 · see citing works

Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasia

Shi, G., Zhu, L., Sun, Y., Bettencourt, R., Damsz, B., Hruban, R. H., & Konieczny, S. F. (2009) · Gastroenterology · doi:10.1053/j.gastro.2008.12.066 · Cited by 168 · see citing works

The Notch Pathway Is Important in Maintaining the Cancer Stem Cell Population in Pancreatic Cancer

Abel, E. V., Kim, E. J.-H., Wu, J., Hynes, M. J., Bednar, F., Proctor, E., Wang, L., Dziubinski, M. L., & Simeone, D. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091983 · Cited by 168 · see citing works

Notch signaling contributes to the pathogenesis of human osteosarcomas

Engin, F., Bertin, T., Ma, O., Jiang, M., Wang, L., Sutton, R. E., Donehower, L. A., & Lee, B. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp057 · Cited by 167 · see citing works

Wnt/β-catenin signaling is required for development of the exocrine pancreas

Wells, J. M., Esni, F., Boivin, G. P., Aronow, B. J., Stuart, W. D., Combs, C., Sklenka, A. M., Leach, S. D., & Lowy, A. M. (2007) · BMC Developmental Biology · doi:10.1186/1471-213x-7-4 · Cited by 164 · see citing works

Expression of HOXB2, a Retinoic Acid Signaling Target in Pancreatic Cancer and Pancreatic Intraepithelial Neoplasia

Segara, D., Biankin, A. V., Kench, J. G., Langusch, C., Dawson, A. C., Skalicky, D. A., Gotley, D. C., Coleman, M. J., Sutherland, R. L., & Henshall, S. M. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1813 · Cited by 163 · see citing works

Plasticity and Dedifferentiation within the Pancreas: Development, Homeostasis, and Disease

Puri, S., Folias, A. E., & Hebrok, M. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.11.001 · Cited by 158 · see citing works

Inhibition of γ-Secretase Activity Inhibits Tumor Progression in a Mouse Model of Pancreatic Ductal Adenocarcinoma

Plentz, R. R., Park, J., Rhim, A. D., Abravanel, D. L., Hezel, A. F., Sharma, S. V., Gurumurthy, S., Deshpande, V., Kenific, C. M., Settleman, J. E., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.008 · Cited by 162 · see citing works

Notch Signaling Is Required for Exocrine Regeneration After Acute Pancreatitis

Siveke, J. T., Lubeseder–Martellato, C., Lee, M., Mazur, P. K., Nakhai, H., Radtke, F., & Schmid, R. M. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.003 · Cited by 162 · see citing works

The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes

Shimoda, M., Kanda, Y., Hamamoto, S., Tawaramoto, K., Hashiramoto, M., Matsuki, M., & Kaku, K. (2011) · Diabetologia · doi:10.1007/s00125-011-2069-9 · Cited by 161 · see citing works

Role of Notch signaling in colorectal cancer

Qiao, L., & Wong, B. C. Y. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp236 · Cited by 154 · see citing works

The fundamental role of mechanical properties in the progression of cancer disease and inflammation

Mierke, C. T. (2014) · Reports on Progress in Physics · doi:10.1088/0034-4885/77/7/076602 · Cited by 158 · see citing works

Genetic evolution of pancreatic cancer: lessons learnt from the pancreatic cancer genome sequencing project

Iacobuzio–Donahue, C. A. (2011) · Gut · doi:10.1136/gut.2010.236026 · Cited by 158 · see citing works

Cellular Plasticity within the Pancreas— Lessons Learned from Development

Puri, S., & Hebrok, M. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.02.005 · Cited by 154 · see citing works

β-Cell Mass Dynamics and Islet Cell Plasticity in Human Type 2 Diabetes

Hanley, S. C., Austin, E. B., Assouline-Thomas, B., Kapeluto, J., Blaichman, J. I., Moosavi, M., Petropavlovskaia, M., & Rosenberg, L. C. (2010) · Endocrinology · doi:10.1210/en.2009-1277 · Cited by 155 · see citing works

Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN.

Siveke, J., Einwächter, H., Sipos, B., Lubeseder-Martellato, C., Klöppel, G., & Schmid, R. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.08.002 · Cited by 162 · see citing works

Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesis

Mittal, S., Subramanyam, D., Dey, D., Kumar, R. V., & Rangarajan, A. (2009) · Molecular Cancer · doi:10.1186/1476-4598-8-128 · Cited by 154 · see citing works

Dominant-Negative Notch3 Receptor Inhibits Mitogen-Activated Protein Kinase Pathway and the Growth of Human Lung Cancers

Haruki, N., Kawaguchi, K. S., Eichenberger, S., Massion, P. P., Olson, S. J., González, A., Carbone, D. P., & Dang, T. P. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3132 · Cited by 154 · see citing works

Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism

Sureban, S. M., May, R. J., Mondalek, F. G., Qu, D., Ponnurangam, S., Pantazis, P., Anant, S., Ramanujam, R. P., & Houchen, C. W. (2011) · Journal of Nanobiotechnology · doi:10.1186/1477-3155-9-40 · Cited by 153 · see citing works

Pancreatic Lkb1 Deletion Leads to Acinar Polarity Defects and Cystic Neoplasms

Hezel, A. F., Gurumurthy, S., Granot, Z., Swisa, A., Chu, G. C., Bailey, G., Dor, Y., Bardeesy, N. M., & DePinho, R. A. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01621-07 · Cited by 151 · see citing works

Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation

Tanaka, M., Setoguchi, T., Hirotsu, M., Gao, H., Sasaki, H., Matsunoshita, Y., & Komiya, S. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6605060 · Cited by 149 · see citing works

Duct Cells Contribute to Regeneration of Endocrine and Acinar Cells Following Pancreatic Damage in Adult Mice

Criscimanna, A., Speicher, J. A., Houshmand, G., Shiota, C., Prasadan, K. L., Ji, B., Logsdon, C. D., Gittes, G. K., & Esni, F. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.003 · Cited by 149 · see citing works

Precursor Lesions of Pancreatic Cancer: Molecular Pathology and Clinical Implications

Singh, M., & Maitra, A. (2007) · Pancreatology · doi:10.1159/000101873 · Cited by 148 · see citing works

Primers on Molecular Pathways — Notch

Lomberk, G. A., & Urrutia, R. A. (2008) · Pancreatology · doi:10.1159/000123603 · Cited by 12 · see citing works

Progress in Role of Notch Signaling Pathway in Pancreas Development and Pancreatic Cancer

Yu-pe, Z. (2010) · Zhongguo pu-wai jichu yu linchuang zazhi

Notch signaling pathway in pancreatic tumorigenesis

Chung, W.-C., & Xu, K. (2023) · Advances in cancer research · doi:10.1016/bs.acr.2023.02.001 · Cited by 11 · see citing works

Epithelial differentiation in pancreatic development and neoplasia: new niches for nestin and Notch.

Leach, S. (2005) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000155547.83901.a3 · Cited by 43 · see citing works

Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer

Zhang, S.-Y., Chung, W.-C., & Xu, K. (2015) · Oncogene · doi:10.1038/onc.2015.306 · Cited by 41 · see citing works