Hynes, Richard O.

A framework for advancing our understanding of cancer-associated fibroblasts

Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D. G., Egeblad, M., Evans, R. M., Fearon, D., Greten, F. R., Hingorani, S. R., Hunter, T., et al. (2020) · Nature Reviews Cancer

Cancer Cells and MetastasisTGF-β signaling in diseases

Cited by 3,863

The Extracellular Matrix: Not Just Pretty Fibrils

Hynes, R. O. (2009) · Science

Cellular Mechanics and InteractionsCell Adhesion Molecules Research

Cited by 3,527

Direct signaling between platelets and cancer cells induces an epithelial–mesenchymal-like transition and promotes metastasis

Labelle, M., Begum, S., & Hynes, R. O. (2011) · Cancer Cell

TGF-β signaling in diseasesCancer Cells and Metastasis

Cited by 1,833

Comparative Genomics of the Eukaryotes

Rubin, G. M., Yandell, M. D., Wortman, J. R., Gabor, G. L., Miklos, Nelson, C. R., Hariharan, I. K., Fortini, M. E., Li, P. W., Apweiler, R., et al. (2000) · Science

Genomics and Phylogenetic StudiesBioinformatics and Genomic Networks

Cited by 1,698

The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices

Naba, A., Clauser, K. R., Hoersch, S., Liu, H., Carr, S. A., & Hynes, R. O. (2012) · Molecular & Cellular Proteomics

Advanced Proteomics Techniques and ApplicationsBone and Dental Protein Studies

Cited by 1,354

Overview of the Matrisome--An Inventory of Extracellular Matrix Constituents and Functions

Hynes, R. O., & Naba, A. (2012) · Cold Spring Harbor Perspectives in Biology

Cellular Mechanics and InteractionsCell Adhesion Molecules Research

Cited by 1,349

The Genome of the Sea Urchin Strongylocentrotus purpuratus

Sodergren, E., Weinstock, G. M., Davidson, E. H., Cameron, R. A., Gibbs, R. A., Angerer, R. C., Angerer, L. M., Arnone, M. I., Burgess, D. R., Burke, R. D., et al. (2006) · Science

Genomics and Phylogenetic StudiesDevelopmental Biology and Gene Regulation

Cited by 1,132

The extracellular matrix: tools and insights for the "omics" era

Naba, A., Clauser, K. R., Ding, H., Whittaker, C. A., Carr, S. A., & Hynes, R. O. (2016) · Matrix Biology

Bioinformatics and Genomic NetworksAdvanced Proteomics Techniques and Applications

Cited by 1,037

The Talin Head Domain Binds to Integrin β Subunit Cytoplasmic Tails and Regulates Integrin Activation

Calderwood, D. A., Zent, R., Grant, R., Rees, D. J. G., Hynes, R. O., & Ginsberg, M. H. (1999) · Journal of Biological Chemistry

Cell Adhesion Molecules ResearchCellular Mechanics and Interactions

Cited by 720

Platelets guide the formation of early metastatic niches

Labelle, M., Begum, S., & Hynes, R. O. (2014) · Proceedings of the National Academy of Sciences

Chemokine receptors and signalingCancer Cells and Metastasis

Cited by 555

Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis

Borsig, L., Wong, R., Hynes, R. O., Varki, N. M., & Varki, A. (2002) · Proceedings of the National Academy of Sciences

Cell Adhesion Molecules ResearchGlycosylation and Glycoproteins Research

Cited by 400

Central Roles of α 5 β 1 Integrin and Fibronectin in Vascular Development in Mouse Embryos and Embryoid Bodies

Francis, S. E., Goh, K. L., Hodivala-Dilke, K., Bader, B. L., Stark, M., Davidson, D., & Hynes, R. O. (2002) · Arteriosclerosis, Thrombosis, and Vascular Biology

Cell Adhesion Molecules ResearchAngiogenesis and VEGF in Cancer

Cited by 282

GPR56 Regulates Pial Basement Membrane Integrity and Cortical Lamination

Li, S., Jin, Z., Koirala, S., Bu, L., Xu, L., Hynes, R. O., Walsh, C. A., Corfas, G., & Piao, X. (2008) · The Journal of Neuroscience

Neurogenesis and neuroplasticity mechanismsFetal and Pediatric Neurological Disorders

Cited by 241

Inflamed neutrophils sequestered at entrapped tumor cells via chemotactic confinement promote tumor cell extravasation

Chen, M. B., Hajal, C., Benjamin, D. C., Yu, C., Azizgolshani, H., Hynes, R. O., & Kamm, R. D. (2018) · Proceedings of the National Academy of Sciences

Chemokine receptors and signalingImmune cells in cancer

Cited by 183

The echinoderm adhesome

Whittaker, C. A., Bergeron, K.-F., Whittle, J., Brandhorst, B. P., Burke, R. D., & Hynes, R. O. (2006) · Developmental Biology

Cell Adhesion Molecules ResearchDevelopmental Biology and Gene Regulation

Cited by 183

SRC tyrosine kinase activates the YAP/TAZ axis and thereby drives tumor growth and metastasis

Lamar, J. M., Xiao, Y., Norton, E., Jiang, Z.-G., Gerhard, G. M., Kooner, S., Warren, J. S. A., & Hynes, R. O. (2019) · Journal of Biological Chemistry

Hippo pathway signaling and YAP/TAZProtein Kinase Regulation and GTPase Signaling

Cited by 169

Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis

Stenzel, D., Lundkvist, A., Sauvaget, D., Busse, M., Graupera, M., van der Flier, A., Wijelath, E. S., Murray, J., Sobel, M., Costell, M., et al. (2011) · Development

Angiogenesis and VEGF in CancerAxon Guidance and Neuronal Signaling

Cited by 154

Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin

Astrof, S., Crowley, D., & Hynes, R. O. (2007) · Developmental Biology

RNA Research and SplicingCell Adhesion Molecules Research

Cited by 136

Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways

Li, R., Hebert, J. D., Lee, T. A., Xing, H., Boussommier-Calleja, A., Hynes, R. O., Lauffenburger, D. A., & Kamm, R. D. (2017) · Cancer Research

Immune cells in cancerProtease and Inhibitor Mechanisms

Cited by 100