Zoncu, Roberto

mTOR: from growth signal integration to cancer, diabetes and ageing

Zoncu, R., Efeyan, A., & Sabatini, D. M. (2011) · Nature Reviews Molecular Cell Biology

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 3,941

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

Bersuker, K., Hendricks, J. M., Li, Z., Magtanong, L., Ford, B., Tang, P. H., Roberts, M. A., Tong, B., Maimone, T. J., Zoncu, R., et al. (2019) · Nature

Ferroptosis and cancer prognosisCoenzyme Q10 studies and effects

Cited by 3,703

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S., & Sabatini, D. M. (2010) · Cell

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

Cited by 2,464

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H + -ATPase

Zoncu, R., Bar-Peled, L., Efeyan, A., Wang, S., Sancak, Y., & Sabatini, D. M. (2011) · Science

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

Cited by 1,673

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

Sahay, G., Querbes, W., Alabi, C., Eltoukhy, A., Sarkar, S., Zurenko, C., Karagiannis, E., Love, K., Chen, D., Zoncu, R., et al. (2013) · Nature Biotechnology

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 948

The lysosome as a cellular centre for signalling, metabolism and quality control

Lawrence, R. E., & Zoncu, R. (2019) · Nature Cell Biology

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 920

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

Bar-Peled, L., Schweitzer, L. D., Zoncu, R., & Sabatini, D. M. (2012) · Cell

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

Cited by 918

Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism

Perera, R. M., Stoykova, S., Nicolay, B. N., Ross, K. N., Fitamant, J., Boukhali, M., Lengrand, J., Deshpande, V., Selig, M. K., Ferrone, C. R., et al. (2015) · Nature

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 799

DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy

Nguyen, T. B., Louie, S. M., Daniele, J. R., Tran, Q., Dillin, A., Zoncu, R., Nomura, D. K., & Olzmann, J. A. (2017) · Developmental Cell

Lipid metabolism and biosynthesisAutophagy in Disease and Therapy

Cited by 610

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

Tsun, Z.-Y., Bar-Peled, L., Chantranupong, L., Zoncu, R., Wang, T., Kim, C., Spooner, E., & Sabatini, D. M. (2013) · Molecular Cell

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

Cited by 565

Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

Castellano, B. M., Thelen, A. M., Moldavski, O., Feltes, M., van der Welle, R. E. N., Mydock-McGrane, L., Jiang, X., van Eijkeren, R. J., Davis, O. B., Louie, S. M., et al. (2017) · Science

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

Cited by 562

Recruitment and regulation of phosphatidylinositol phosphate kinase type 1γ by the FERM domain of talin

Di Paolo, G., Pellegrini, L., Letinic, K., Cestra, G., Zoncu, R., Voronov, S., Chang, S., Guo, J., Wenk, M. R., & De Camilli, P. (2002) · Nature

Protein Kinase Regulation and GTPase SignalingCell Adhesion Molecules Research

Cited by 441

Amino acids and mTORC1: from lysosomes to disease

Efeyan, A., Zoncu, R., & Sabatini, D. M. (2012) · Trends in Molecular Medicine

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

Cited by 436

NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C

Davis, O. B., Shin, H. R., Lim, C.-Y., Wu, E. Y., Kukurugya, M., Maher, C. F., Perera, R. M., Ordonez, M. P., & Zoncu, R. (2021) · Developmental Cell

Lysosomal Storage Disorders ResearchBiomedical Research and Pathophysiology

Cited by 200

Dynamics and architecture of the NRBF2-containing phosphatidylinositol 3-kinase complex I of autophagy

Young, L. N., Cho, K., Lawrence, R., Zoncu, R., & Hurley, J. H. (2016) · Proceedings of the National Academy of Sciences

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 89