Lin, Charles Y.

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

Whyte, W. A., Orlando, D. A., Hnisz, D., Abraham, B. J., Lin, C. Y., Kagey, M. H., Rahl, P. B., Lee, T. I., & Young, R. A. (2013) · Cell

Genomics and Chromatin DynamicsPluripotent Stem Cells Research

Cited by 4,143

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

Lovén, J., Hoke, H. A., Lin, C. Y., Lau, A., Orlando, D. A., Vakoc, C. R., Bradner, J. E., Lee, T. I., & Young, R. A. (2013) · Cell

Protein Degradation and InhibitorsChromatin Remodeling and Cancer

Cited by 2,961

c-Myc Regulates Transcriptional Pause Release

Rahl, P. B., Lin, C. Y., Seila, A. C., Flynn, R. A., McCuine, S., Burge, C. B., Sharp, P. A., & Young, R. A. (2010) · Cell

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 1,279

Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma

Chapuy, B., McKeown, M. R., Lin, C. Y., Monti, S., Roemer, M. G. M., Qi, J., Rahl, P. B., Sun, H. H., Yeda, K. T., Doench, J. G., et al. (2013) · Cancer Cell

Protein Degradation and InhibitorsChromatin Remodeling and Cancer

Cited by 735

Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer

Shu, S., Lin, C. Y., He, H. H., Witwicki, R. M., Tabassum, D. P., Roberts, J. M., Janiszewska, M., Jin Huh, S., Liang, Y., Ryan, J., et al. (2016) · Nature

Protein Degradation and InhibitorsChromatin Remodeling and Cancer

Cited by 632

Revisiting Global Gene Expression Analysis

Lovén, J., Orlando, D. A., Sigova, A. A., Lin, C. Y., Rahl, P. B., Burge, C. B., Levens, D. L., Lee, T. I., & Young, R. A. (2012) · Cell

Gene expression and cancer classificationBioinformatics and Genomic Networks

Cited by 616

NF-κB Directs Dynamic Super Enhancer Formation in Inflammation and Atherogenesis

Brown, J. D., Lin, C. Y., Duan, Q., Griffin, G., Federation, A. J., Paranal, R. M., Bair, S., Newton, G., Lichtman, A. H., Kung, A. L., et al. (2014) · Molecular Cell

Genomics and Chromatin DynamicsNF-κB Signaling Pathways

Cited by 614

Convergence of Developmental and Oncogenic Signaling Pathways at Transcriptional Super-Enhancers

Hnisz, D., Schuijers, J., Lin, C. Y., Weintraub, A. S., Abraham, B. J., Lee, T. I., Bradner, J. E., & Young, R. A. (2015) · Molecular Cell

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 476

BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment

Winter, G. E., Mayer, A., Buckley, D. L., Erb, M. A., Roderick, J. E., Vittori, S., Reyes, J. M., di Iulio, J., Souza, A., Ott, C. J., et al. (2017) · Molecular Cell

Protein Degradation and InhibitorsGenomics and Chromatin Dynamics

Cited by 465

BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure

Anand, P., Brown, J. D., Lin, C. Y., Qi, J., Zhang, R., Artero, P. C., Alaiti, M. A., Bullard, J., Alazem, K., Margulies, K. B., et al. (2013) · Cell

Protein Degradation and InhibitorsGenomics and Chromatin Dynamics

Cited by 406

Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation

Stratton, M. S., Bagchi, R. A., Felisbino, M. B., Hirsch, R. A., Smith, H. E., Riching, A. S., Enyart, B. Y., Koch, K. A., Cavasin, M. A., Alexanian, M., et al. (2019) · Circulation Research

Cardiac Fibrosis and RemodelingCongenital heart defects research

Cited by 179

High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program

Labbé, D. P., Zadra, G., Yang, M., Reyes, J. M., Lin, C. Y., Cacciatore, S., Ebot, E. M., Creech, A. L., Giunchi, F., Fiorentino, M., et al. (2019) · Nature Communications

Cancer, Lipids, and MetabolismProstate Cancer Treatment and Research

Cited by 174

Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription

Struntz, N. B., Chen, A., Deutzmann, A., Wilson, R. M., Stefan, E., Evans, H. L., Ramirez, M. A., Liang, T., Caballero, F., Wildschut, M. H. E., et al. (2019) · Cell Chemical Biology

Chemical Synthesis and AnalysisCancer-related Molecular Pathways

Cited by 130

Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors

Richters, A., Doyle, S. K., Freeman, D. B., Lee, C., Leifer, B. S., Jagannathan, S., Kabinger, F., Koren, J. V., Struntz, N. B., Urgiles, J., et al. (2021) · Cell Chemical Biology

Prostate Cancer Treatment and ResearchProtein Degradation and Inhibitors

Cited by 86

Impact of the gut microbiota on enhancer accessibility in gut intraepithelial lymphocytes

Semenkovich, N. P., Planer, J. D., Ahern, P. P., Griffin, N. W., Lin, C. Y., & Gordon, J. I. (2016) · Proceedings of the National Academy of Sciences

Gut microbiota and healthGenomics and Chromatin Dynamics

Cited by 45

A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia

Harada, T., Heshmati, Y., Kalfon, J., Ferrucio, J. X., Perez, M., Ewers, J., Kossenkov, A., Ellegast, J. M., Yi, J. S., Bowker, A., et al. (2021) · Genes & Development

Acute Myeloid Leukemia ResearchGenomics and Chromatin Dynamics

Cited by 31