Angiopoietins: a link between angiogenesis and inflammation
Abstract
The angiopoietin (Ang)-Tie ligand-receptor system has a key regulatory role in regulating vascular integrity and quiescence. Besides its role in angiogenesis, it is an important regulator in numerous diseases including inflammation. Ang-1-mediated Tie2 activation is required to maintain the quiescent resting state of the endothelium. Agonistic Ang-1 functions are antagonized by Ang-2, which is believed to inhibit Ang-1-Tie2 signaling. Ang-2 destabilizes the quiescent endothelium and primes it to respond to exogenous stimuli, thereby facilitating the activities of inflammatory (tumor necrosis factor and interleukin-1) and angiogenic (vascular endothelial growth factor) cytokines. Intriguingly, Ang-2 is expressed weakly by the resting endothelium but becomes strongly upregulated following endothelial activation. Moreover, endothelial cells store Ang-2 in Weibel-Palade bodies from where it can be made available quickly following stimulation, suggesting a role of Ang-2 in controlling rapid vascular adaptive processes. This suggests that Ang-2 is the dynamic regulator of the Ang-Tie2 axis, thereby functioning as a built-in switch controlling the transition of the resting quiescent endothelium towards the activated responsive endothelium.
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- Authors
- Fiedler, U., & Augustin, H. G.
- Affiliations
- German Cancer Research Center (DE)
- Corresponding author
- Augustin, Hellmut G.
- ORCID
- Augustin, Hellmut G.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 27
- Issue
- 12
- Pages
- 552-558
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2120264291
- Cited by
- 606
- References
- 90
- Citations by year
- 2026: 20 · 2025: 12 · 2024: 21 · 2023: 24 · 2022: 31 · 2021: 32 · 2020: 24 · 2019: 32 · 2018: 37 · 2017: 22 · 2016: 36 · 2015: 29 · 2014: 34 · 2013: 48 · 2012: 32
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Keywords
- angiopoietins, angiopoietin-2, angiopoietin-1, Tie2 receptor, angiogenesis, inflammation, endothelial quiescence, endothelial activation, vascular integrity, Weibel-Palade bodies, vascular endothelial growth factor, TNF-α, interleukin-1, vascular adaptation
- MeSH terms
- Animals, Endothelium, Vascular, Homeostasis, Humans, Inflammation, Mice, Inbred C57BL, Mice, Transgenic, Models, Biological, Neovascularization, Physiologic, Angiopoietins, Angiopoietin-2, Receptors, TIE, Mice
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