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Endothelial Stat3 activation promotes osteoarthritis development

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The Hippo-YAP signaling pathway drives CD24-mediated immune evasion in esophageal squamous cell carcinoma via macrophage phagocytosis

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Terpenoid-Mediated Targeting of STAT3 Signaling in Cancer: An Overview of Preclinical Studies

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The role of vascular endothelial cells in tumor metastasis

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EFHD1 , a novel mitochondrial regulator of tumor metastasis in clear cell renal cell carcinoma

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Hypoxia-induced TMTC3 expression in esophageal squamous cell carcinoma potentiates tumor angiogenesis through Rho GTPase/STAT3/VEGFA pathway

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MicroRNA-19a-3p inhibits endothelial dysfunction in atherosclerosis by targeting JCAD

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Targeting Hippo pathway: A novel strategy for Helicobacter pylori-induced gastric cancer treatment

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Cancer-Induced Metabolic Rewiring of Tumor Endothelial Cells

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The effectiveness of blood-activating and stasis-transforming traditional Chinese medicines (BAST) in lung cancer progression-a comprehensive review

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Targeting YAP/TAZ mechanosignaling to ameliorate stiffness-induced Schlemm’s canal cell pathobiology

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Nucleoporin93 limits Yap activity to prevent endothelial cell senescence

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Endothelial cell diversity: the many facets of the crystal

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SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors

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Deubiquitinase USP9X controls Wnt signaling for CNS vascular formation and barrier maintenance

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CHRDL2 promotes cell proliferation by activating the YAP/TAZ signaling pathway in gastric cancer

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Elabela-APJ axis mediates angiogenesis via YAP/TAZ pathway in cerebral ischemia/reperfusion injury

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Targeting myeloperoxidase limits myeloid cell immunosuppression enhancing immune checkpoint therapy for pancreatic cancer

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Kindlin-2 Phase Separation in Response to Flow Controls Vascular Stability

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Brassinin Promotes the Degradation of Tie2 and FGFR1 in Endothelial Cells and Inhibits Triple-Negative Breast Cancer Angiogenesis

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Role of N6-methyladenosine in tumor neovascularization

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Mechanotransduction pathways regulating YAP nuclear translocation under Yoda1 and vibration in osteocytes

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YAP/TAZ-associated cell signaling – at the crossroads of cancer and neurodevelopmental disorders

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Gambogic acid suppresses nasopharyngeal carcinoma via rewiring molecular network of cancer malignancy and immunosurveillance

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Smoking aggravates neovascular age-related macular degeneration via Sema4D-PlexinB1 axis-mediated activation of pericytes

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Resistance Mechanisms of the Metastatic Tumor Microenvironment to Anti-Angiogenic Therapy

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Vascular mimicry as a facilitator of melanoma brain metastasis

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Anti-Cancer Activity of Verteporfin in Cholangiocarcinoma

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Forced Overexpression of Signal Transducer and Activator of Transcription 3 (STAT3) Activates Yes-Associated Protein (YAP) Expression and Increases the Invasion and Proliferation Abilities of Small Cell Lung Cancer (SCLC) Cells

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Dysregulated Hippo Signaling Pathway and YAP Activation in Atopic Dermatitis: Insights from Clinical and Animal Studies

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YAP Overexpression in Breast Cancer Cells Promotes Angiogenesis through Activating YAP Signaling in Vascular Endothelial Cells

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The regulation of yes-associated protein/transcriptional coactivator with PDZ-binding motif and their roles in vascular endothelium

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STAT3–mediated up-regulation of DAB2 via SRC-YAP1 signaling axis promotes Helicobacter pylori-driven gastric tumorigenesis

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Astragalus polysaccharide‐containing 3D ‐printed scaffold for traumatized skin repair and proteomic study

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The role of YAP/TAZ mechanosignaling in trabecular meshwork and Schlemm’s canal cell dysfunction

Ghosh, R., & Herberg, S. (2024) · Vision Research · doi:10.1016/j.visres.2024.108477 · Cited by 12 · see citing works

The Role of Yes‐Associated Protein in Inflammatory Diseases and Cancer

Zhong, B., Du, J., Liu, F., & Sun, S. (2025) · MedComm · doi:10.1002/mco2.70128 · Cited by 10 · see citing works

3D Mechanical Response Stem Cell Complex Repairs Spinal Cord Injury by Promoting Neurogenesis and Regulating Tissue Homeostasis

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Fe-doped carbon dots: a novel fluorescent nanoprobe for cellular hypochlorous acid imaging

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Cancer-associated fibroblasts induce almonertinib resistance in non-small cell lung cancer

Wei, G., Nie, Y., Sun, M., Zhou, W., Zhao, H., Chen, F., & Zhu, C. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-024-06064-z · Cited by 9 · see citing works

The effects of STAT3 acetylation on the transcriptional activity and tumorigenesis

Yan, H., Tang, L., Zhu, Y., & Zhang, Y. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117076 · Cited by 9 · see citing works

YAP/TAZ activation predicts clinical outcomes in mesothelioma and is conserved in in vitro model of driver mutations

Cunningham, R., Jia, S., Purohit, K. P., Salem, O., Hui, N. S., Lin, Y., Carragher, N. O., & Hansen, C. G. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1190 · Cited by 9 · see citing works

Magnetically Integrated Tumor–Vascular Interface System to Mimic Pro-angiogenic Endothelial Dysregulations for On-Chip Drug Testing

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Endothelial Pim3 kinase protects the vascular barrier during lung metastasis

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DUOX2-Induced Oxidative Stress Inhibits Intestinal Angiogenesis through MMP3 in a Low-Birth-Weight Piglet Model

Zou, D., Yang, Y., Ji, F., Lv, R., Xu, T., & Hu, C. (2023) · Antioxidants · doi:10.3390/antiox12101800 · Cited by 8 · see citing works

Hitchhiking of Cas9 with nucleus-localized proteins impairs its controllability and leads to efficient genome editing of NLS-free Cas9

Zhang, W., Wang, H., Luo, Z., Jian, Y.-Z., Gong, C., Wang, H., Lin, X., Liu, M., Wang, Y., & Shao, H. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.02.008 · Cited by 8 · see citing works

WISP2/CCN5 Suppresses Vasculogenic Mimicry through Inhibition of YAP/TAZ Signaling in Breast Cancer Cells

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YAP1/TAZ activity maintains vascular integrity and organismal survival

Uemura, S., Yamashita, M., Aoyama, K., Yokomizo‐Nakano, T., Oshima, M., Nishio, M., Masuko, M., Takizawa, J., Sone, H., Yamada, Y., et al. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.06.050 · Cited by 8 · see citing works

Recent insight into the role and therapeutic potential of YAP/TAZ in gastrointestinal cancers

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Klotho promotes AMPK activity and maintains renal vascular integrity by regulating the YAP signaling pathway

Luo, L., Guo, J., Li, Y., Liu, T., & Lai, L. (2023) · International Journal of Medical Sciences · doi:10.7150/ijms.80220 · Cited by 8 · see citing works

Mouse Models to Evaluate the Functional Role of the Tumor Microenvironment in Cancer Progression and Therapy ResponsesPreprint

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Matrix Stiffness Regulates Interleukin‐10 Secretion in Human Microglia (HMC3) via YAP‐Mediated Mechanotransduction

Fang, X., Jia, H., Pan, S., Liu, Q., Wang, Q., Feng, Y., Ding, W., & Luo, T. (2025) · Cell Biochemistry and Function · doi:10.1002/cbf.70061 · Cited by 7 · see citing works

Nuclear localization of YAP in pancreatic cancer: More players besides Hippo pathway

Xie, Y., Qin, C. Y., Zhang, X., Li, Z., Zhao, B., Li, T., Zhao, Y., Yan, Y., Shi, H., Huang, L., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217864 · Cited by 7 · see citing works

RGS16 regulates Hippo-YAP activity to promote esophageal cancer cell proliferation and migration

Zhang, Y., Zhu, Q. J., Cao, X., & Ni, B. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.04.033 · Cited by 7 · see citing works

Unravelling the molecular interplay: SUMOylation, PML nuclear bodies and vascular cell activity in health and disease

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PATJ regulates cell stress responses and vascular remodeling post-stroke

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Focusing on the Immune Cells: Recent Advances in Immunotherapy for Biliary Tract Cancer

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Expression of YAP suppresses cell proliferation and elevates the sensitivity of chemotherapy in retinoblastoma cells through lipid-peroxidation induced ferroptosis

Zhong, L., Meng, X., Huang, J., Hao, W., & Zuo, Y. (2023) · Chinese Clinical Oncology · doi:10.21037/cco-23-97 · Cited by 6 · see citing works

Editorial: Tumor Vessels as Directors of the Tumor Microenvironment: New Findings, Current Challenges & Perspectives

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Th9-arterial endothelial cell crosstalk promotes psoriatic atherosclerosis

Baral, I., Baumer, Y., Burma, A. M., Sylvester, M., Jones, K., Kitakule, M. M., Dey, A. K., Rodante, J. A., Gutierrez‐Huerta, C. A., Taramangalam, B., et al. (2025) · Annals of the Rheumatic Diseases · doi:10.1016/j.ard.2025.11.008 · Cited by 6 · see citing works

CD48 is a novel immune checkpoint on tumour‐associated macrophages in hepatocellular carcinoma

Shi, G., Xiao, Y., Li, Z., Qiu, Y., Zhou, Y., Zhang, J., Li, W., He, L., Xie, F., Cao, H., et al. (2026) · Gut · doi:10.1136/gutjnl-2025-336744 · Cited by 7 · see citing works

O-GlcNAcylation-dependent liquid-liquid phase separation regulates the nuclear translocation of YAP to exacerbate vascular neointimal hyperplasia

Weng, P., Wen, Y., Yuan, Z., Ma, L., Yang, L. M., Li, C., Zhang, W., & Yu, C. (2025) · Theranostics · doi:10.7150/thno.113303 · Cited by 5 · see citing works

Loss of Endothelial YAP/TAZ Reduces the Size of Chronic Stroke Lesions and Alters the Endothelial Environment

Göttert, R., Kikhia, M., Herzog, M., Pan, W. Q., Klaus‐Bergmann, A., Weiner, J. M., Beule, D., Knauß, S., Kronenberg, G., Potente, M., et al. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.040079 · Cited by 6 · see citing works

Knockdown of CCM3 promotes angiogenesis through activation and nuclear translocation of YAP/TAZ

Tang, L., Zhou, M., Xu, Y., Peng, B., Gao, Y., & Mo, Y. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.149525 · Cited by 5 · see citing works

YAP/TAZ Signaling Enhances Angiogenesis of Retinal Microvascular Endothelial Cells in a High-Glucose Environment

Wang, X.-L., Yang, X. Z., & Chen, X. (2024) · Current Eye Research · doi:10.1080/02713683.2024.2309217 · Cited by 5 · see citing works

A review on decoding the roles of YAP/TAZ signaling pathway in cardiovascular diseases: Bridging molecular mechanisms to therapeutic insights

Zhang, Y., Ren, Y., Li, X., Li, M., Fu, M., Zhou, W., Yu, Y., & Xiong, Y. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.132473 · Cited by 5 · see citing works

Mechanistic insights and therapeutic prospects of targeting the signal transducer and activator of transcription 3 signaling pathway in cerebrovascular diseases

Wu, J., Wang, B., Sha, X.-W., Wang, P., Du, S., Lu, X.-J., Miao, Z., Zhou, Y., & Zhao, X.-D. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117375 · Cited by 4 · see citing works

GLP-1RA in JBMMSCs promoted osteogenic differentiation via modulating CREB and BRD4 signaling mediated proliferation and stemness

Liu, H., Tian, Y., Bao, X., & Li, Y.-K. (2025) · Scientific Reports · doi:10.1038/s41598-025-24633-0 · Cited by 4 · see citing works

E-cadherin inhibits the proliferation and migration of human colorectal cancer cells through Hippo signaling pathway

Wang, Z., Qin, X., Liu, S., Wen, Y., Lan, B., Liao, H., & Wei, H. (2025) · European Journal of Histochemistry · doi:10.4081/ejh.2025.4196 · Cited by 3 · see citing works

Mechanical stress and mechanosensitive protein in skin tumors

Li, B., Zhao, S., Zhang, L., Xie, D., & Jiang, Z. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189419 · Cited by 3 · see citing works

Methylated circPTK2 as a driver of fibroblast activation in pulmonary fibrosis

Zhu, Y., Zhao, L., Qin, J., Guo, B., Luo, X., Feng, Z., Wei, J., Huang, X., Chen, X., Lin, Y., et al. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.12.013 · Cited by 3 · see citing works

DNAJB4/HLJ1 deficiency sensitizes diethylnitrosamine-induced hepatocarcinogenesis with peritumoral STAT3 activation

Luo, W., Hsu, W.-L., Lu, C.-Y., Chien, M.-H., Chang, J., & Su, K. (2024) · Cell Biology and Toxicology · doi:10.1007/s10565-024-09978-y · Cited by 3 · see citing works

Targeting Vascular and Inflammatory Crosstalk: Cannabigerol as a Dual-Pathway Modulator in Rosacea

Kim, S., & Lee, J. H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146840 · Cited by 3 · see citing works

Complement Factor H Promotes the Growth of Lung Adenocarcinoma Cells through the JAK2/STAT3 Signaling Pathway

Wang, K., Wang, X., Li, J., Wang, Y., & Gao, P. (2025) · Current Cancer Drug Targets · doi:10.2174/0115680096339892241202092052 · Cited by 3 · see citing works

An allosteric inhibitor targeting the STAT3 coiled-coil domain selectively suppresses proliferation of breast cancer

Huang, M., Wang, W., Cao, L., Liu, J., Du, C., & Zhang, J. (2025) · RSC Medicinal Chemistry · doi:10.1039/d4md00926f · Cited by 2 · see citing works

TRIM3 suppressed the tumorigenicity of melanoma cells by ubiquitinating YAP1

Wang, Y.-T., Zhao, J.-C., Song, D.-M., & Chen, J.-J. (2025) · Scientific Reports · doi:10.1038/s41598-025-11317-y · Cited by 2 · see citing works

Neurotrophin NGF/TrkA and BDNF/TrkB signaling orchestrates the immune microenvironment in osteosarcoma

Liu, H., Wang, G., Wang, C., Hou, D., Li, S., Fan, Y., & Liu, B. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1727434 · Cited by 2 · see citing works

Ginsenoside Rh3 enhances regorafenib efficacy in hepatocellular carcinoma by modulating FGFR4-STAT3-YAP signaling pathway

Jeon, Y., Kwon, H., Yoo, J. E., Park, K., Chung, T., Park, Y. N., Sim, J., Kim, T., Ham, J., & Kim, Y. H. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.117679 · Cited by 2 · see citing works

Nuclear PD-L1 regulates YAP-driven transcription via the PGE2-EP4-YAP-importin α3 axis in solid tumors

Satapathy, S. R., & Sjölander, A. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.116963 · Cited by 2 · see citing works

Liquid-liquid phase separation of EphB4 drives pulmonary hypertension via YAP activation

Liu, J.-Y., Chen, J., Chen, Q.-Y., Li, H., Gui, L., Zhou, J., & Lin, M. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.116992 · Cited by 2 · see citing works

Complement factor H inhibits endothelial cell migration through suppression of STAT3 signaling

Li, J., Huang, H., Xu, S., Fan, M., Wang, K., Wang, X., Zhang, J., Huang, S., Gatt, A., & Liu, J. (2023) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2023.12107 · Cited by 2 · see citing works

A Fibroblast State Choreographs an Epithelial YAP-dependent Regenerative Program Essential to (Pre)malignancy via ECM-mediated MechanotransductionPreprint

Pan, D., Gascard, P. D., Caruso, J. A., Chen‐Tanyolac, C., Sangwan, V., Bertos, N., Camilleri‐Broët, S., Bérubé, J., Oikonomopoulos, S., Strasser, M. K., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.11.661192 · Cited by 2 · see citing works

Yes-Associated Protein Promotes Angiogenesis via Signal Transducer and Activator of Transcription 3 in Endothelial Cells

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NF-YA promotes invasion and angiogenesis by upregulating EZH2-STAT3 signaling in human melanoma cells

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